Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex

ABSTRACT

The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.

TECHNICAL FIELD OF THE INVENTION

The present invention relates to methods of screening for compounds that inhibit or activate bacterial growth by binding to the complex formed between ribosomal protein L11 and the 23S ribosomal RNA region that interacts with it in vivo.

BACKGROUND

The elongation cycle of protein synthesis is driven by two elongation factors that bind to nearly identical sites on the large (50S) ribosomal subunit (Spahn and Nierhaus, 1998; Wilson and Noller, 1998). EF-Tu delivers aminoacyl tRNAs to the ribosome, whereas EF-G catalyzes the translocation of the ribosome by one codon relative to the mRNA and the concomitant movement of the A and P site tRNAs. Both elongation factors are G proteins, and their interactions with the ribosome are coupled to the binding and hydrolysis of GTP. Like most G proteins, EF-Tu and EF-G are molecular switches that have limited inherent GTPase activity, and they rely on an accessory factor to stimulate activity at the appropriate time. This accessory factor is an integral part of the 50S ribosomal subunit and has usually been referred to as the “GTPase center,” but by analogy with the functionally equivalent GAP proteins that stimulate GTPase activity in G-proteins, it seems more appropriate to refer to it as the “GTPase activating region” (hereafter abbreviated as the GAR). Early work on the identification of the molecular components of the GAR implicated a complex between ribosomal protein L11 and a highly conserved 58-nucleotide stretch of 23S ribosomal RNA (rRNA), nucleotides 1051-1108 in Escherichia coli (Schmidt et al., 1981; Thompson et al., 1979). The L11-RNA complex is the target for a family of thiazole antibiotics that includes thiostrepton and micrococcin. Thiostrepton binds essentially irreversibly to 50S subunits (Sopori and Lengyel, 1972) and inhibits hydrolysis of GTP by EF-G (Pestka, 1970; Rodnina et al., 1997), while micrococcin binds to the same complex and stimulates GTP hydrolysis by EF-G (Cundliffe and Thompson, 1981).

Other components of the ribosome have also been implicated in stimulation of GTP hydrolysis by elongation factors. Classical work suggested that protein L7/L12, which together with L10 forms the “stalk” of the 50S subunit that lies adjacent to L11, is involved in stimulation of GTPase activity in EF-Tu (Donner et al., 1978). However, recently it has been shown that protein L7/L12, although essential for stalk formation, is not required for viability in yeast (Briones et al., 1998). The sarcin/ricin loop, a small, highly conserved stem-loop in the 23S rRNA that is known to be essential for ribosome function, has been footprinted by the elongation factors (Moazed et al., 1988), and is also considered a candidate for being part of the GAR. Therefore, it is not yet clear whether the L11-RNA complex per se should be considered the GAR, or whether the GAR should be defined as a more extensive region of the 50S subunit. In any event, it appears that the L11-RNA complex is at the heart of the GAR; the complex of L11 with its cognate RNA will be referred to herein as the GAR.

The GAR is one of the most thoroughly characterized RNA-protein complexes. The secondary structure of the RNA was first inferred from biochemical and genetic studies (Glotz et al., 1981; Noller et al., 1981). It consists of a junction of four double-helical stems (FIG. 1A). Approximately one-third of the residues in the GAR RNA are very highly conserved. The structure, thermodynamic stability, and ion-binding affinities of the RNA component have been extensively probed by a variety of biophysical and biochemical techniques; these data suggest that the 1067 and 1095 stem-loops are folded into a compact tertiary structure (Conn et al., 1998; Rosendahl and Douthwaite, 1994). Protein L11 consists of two domains: the C-terminal domain binds tightly to the RNA tertiary structure, while the N-terminal domain is required for the cooperative interaction with thiostrepton (Xing and Draper, 1996). The structure of the C-terminal domain has been determined by NMR techniques (Hinck et al., 1997; Markus et al., 1997). Footprinting studies (Rosendahl and Douthwaite, 1993) have identified regions of RNA involved in the interaction with L11, while NMR chemical shift measurements (Hinck et al., 1997) have identified an RNA-binding surface on the C-terminal domain of the protein.

It is an object of the invention to provide a detailed view of a functionally important protein-RNA complex in the ribosome.

It is also an object of the invention to provide a high-resolution structure of a ribosomal protein-RNA complex.

Yet another object of the invention is to provide new principles of RNA folding, of RNA-protein recognition, and of indirect RNA tertiary structure stabilization.

Yet another object of the invention is to solve the three dimensional structure of L11 complexed with GAR RNA and to determine its structure coordinates.

SUMMARY OF THE INVENTION

The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex.

The invention encompasses use of the structure coordinates of an L11/GAR crystal to define the atomic details of regions of the L11/GAR complex, such as the GTPase activating region and one or more binding sites of accessory factors, which are target sites for inhibitors or activators.

The invention also encompasses use of the structure coordinates and atomic details of the L11/GAR RNA complex or its co-complexes to design, evaluate computationally, synthesize and use inhibitors or activators of the L11/GAR.

Structure coordinates for L11/GAR RNA complex according to Table II may be modified from this original set by mathematical manipulation. Such manipulations include, but are not limited to, crystallographic permutations, fractionalizations, or inversion of the raw structure coordinates, integer additions or subtractions to sets of the raw structure coordinates, and any combination of the above.

The crystal structure of the GAR allows the screening and design of novel classes of GAR inhibitory or activating compounds with great medical potential, for example, to prevent or stimulate growth of certain bacteria.

The invention encompasses a method for identifying a potential modulator of ribosomal protein L11/GAR activity, comprising the steps of: a) using a three-dimensional structure of the L11/GAR complex as defined by atomic coordinates of the L11/GAR according to FIG. 7; b) employing the three-dimensional structure to design or select the potential modulator; c) providing the potential modulator; and d) contacting the potential modulator with L11/GAR in the presence of an activity to determine the ability of the potential modulator to modulate the activity, for example, L11/GAR activity.

In one embodiment of the invention, the potential modulator is designed de novo.

In another embodiment of the invention, the potential modulator is designed from a known modulator.

In another embodiment of the invention, the step of employing the three-dimensional structure to design or select the compound comprises the steps of: a) identifying chemical entities or fragments capable of associating with the L11/GAR; and b) assembling the identified chemical entities or fragments into a single molecule to provide the structure of the potential modulator. Relative to this embodiment, the potential modulator may be designed de novo or designed from a known modulator.

The invention further encompasses a method for screening L11/GAR-binding compounds comprising the steps of: 1) incubating in vitro one or more compounds, a known L11/GAR binding activity and labeled RNA comprising GAR RNA; 2) separating that fraction of the labeled RNA bound to the known L11/GAR binding activity from that fraction of the labeled RNA not bound to the known L11/GAR binding activity; and 3) detecting labeled RNA, wherein a decrease in the level of the labeled RNA bound to the known L11 /GAR binding activity in the presence of one or more compounds indicates the binding of one or more of the compounds to L11/GAR.

The invention further encompasses a method for screening L11/GAR-binding compounds comprising the steps of: 1) incubating in vitro one or more compounds, a labeled known L11/GAR binding activity and an RNA comprising GAR RNA; 2) separating that fraction of the labeled known L11/GAR binding activity bound to the RNA from that fraction of the labeled known L11/GAR binding activity not bound to the RNA; and 3) detecting labeled known L11/GAR binding activity wherein a decrease in the level of the labeled known L11/GAR binding activity bound to the RNA in the presence of one or more compounds indicates that one or more of the compounds binds L11/GAR.

In one embodiment of the the method of screening L11/GAR-binding compounds, the known L11/GAR binding activity is an antibiotic. In another embodiment the antibiotic is micrococcin. In a preferred embodiment the antibiotic is thiostrepton.

In another embodiment of the method of screening L11/GAR-binding compounds, the RNA comprising GAR RNA is contained within a ribosome.

In another embodiment of the method of screening L11/GAR-binding compounds, a plurality of compounds is screened for L11/GAR binding in a plurality of separate, simultaneous assays.

The invention further encompasses a method for screening L11/GAR-binding compounds comprising the steps of: 1) incubating in vitro one or more compounds with a translationally competent cell extract and a translatable RNA; and 2) detecting translation, wherein a decrease in the level of translation indicates binding of one or more of the compounds to L11/GAR.

In one embodiment, the translatable RNA encodes an enzyme and the step of detecting translation comprises detecting the activity of the enzyme.

In a preferred embodiment, the enzyme is luciferase.

In another embodiment, the translatable RNA is poly-U, and the step of detecting translation detects the incorporation of labeled phenylalanine into polyphenylalanine.

In another embodiment, the translationally competent cell extract comprises isolated ribosomes.

The invention further encompasses a method for screening L11/GAR-binding compounds comprising the steps of: 1) incubating in vitro one or more compounds, isolated 70S ribosomes, isolated EF-G and gamma-labeled GTP; and 2) detecting GTP hydrolysis wherein a decrease in GTP hydrolysis indicates one or more of the compounds binds L11/GAR.

The invention further encompasses a method for screening anti-bacterial compounds comprising the steps of: 1) incubating in vitro one or more compounds, a known L11/GAR binding activity and labeled RNA comprising GAR RNA; 2) separating that fraction of the labeled RNA bound to the known L11/GAR binding activity from that fraction of the labeled RNA not bound to the known L11/GAR binding activity; and 3) detecting labeled RNA, wherein a decrease in the level of the labeled RNA bound to the known L11/GAR binding activity in the presence of one or more compounds indicates that one or more of the compounds has anti-bacterial properties.

The invention further encompasses a method for screening anti-bacterial compounds comprising the steps of: 1) incubating in vitro one or more compounds, a labeled known L11/GAR binding activity and an RNA comprising GAR RNA; 2) separating that fraction of the labeled known L11/GAR binding activity bound to the RNA from that fraction of the labeled known L11/GAR binding activity not bound to the RNA; and 3) detecting labeled known L11/GAR binding activity wherein a decrease in the level of the labeled known L11/GAR binding activity bound to the RNA in the presence of one or more compounds indicates that one or more of the compounds has anti-bacterial properties.

In one embodiment of the the method of screening anti-bacterial compounds, the known L11/GAR binding activity is an antibiotic. In another embodiment the antibiotic is micrococcin. In a preferred embodiment the antibiotic is thiostrepton.

In another embodiment of the method of screening anti-bacterial compounds, the RNA comprising GAR RNA is contained within a ribosome.

In another embodiment of the method of screening anti-bacterial compounds, a plurality of compounds is screened for L11/GAR binding in a plurality of separate, simultaneous assays.

The invention further encompasses a method for screening anti-bacterial compounds comprising the steps of: 1) incubating in vitro one or more compounds with a translationally competent cell extract and a translatable RNA; and 2) detecting translation, wherein a decrease in the level of translation indicates that one or more of the compounds has anti-bacterial properties.

In one embodiment, the translatable RNA encodes an enzyme and the step of detecting translation comprises detecting the activity of the enzyme.

In a preferred embodiment, the enzyme is luciferase.

In another embodiment, the translatable RNA is poly-U, and the step of detecting translation detects the incorporation of labeled phenylalanine into polyphenylalanine.

In another embodiment, the translationally competent cell extract comprises isolated ribosomes.

The invention further encompasses a method for screening anti-bacterial compounds comprising the steps of: 1) incubating in vitro one or more compounds, isolated 70S ribosomes, isolated EF-G and gamma-labeled GTP; and 2) detecting GTP hydrolysis wherein a decrease in GTP hydrolysis indicates that one or more of the compounds has anti-bacterial properties. Further features and advantages of the invention are embodied in the following description of the invention and in the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an overview of the secondary and tertiary structure of the GTPase activating region RNA from Thermotoga maritima: a) RNA secondary structure derived from the crystal structure (RNA sequence is SEQ ID NO: 5). Lines indicate long-range base triples and the long-range 1088-1060 base pair; b) ribbon-and-stick schematic of the RNA tertiary structure (For clarity, protein L11 has been omitted from view); c) same as (b), but the view is down the major groove of the 1095 stem to emphasize the compactness to the RNA fold. FIGS. 1 b and 1 c were made with the program RIBBONS (Carson, 1991).

FIG. 2 shows selected details of the tertiary structure of the GTPase activating region RNA from Thermotoga maritima; in (a) and (b), the RNA backbone is represented by a ribbon and the phosphates are not shown: a) the ribose zipper that mediates the minor-groove to minor-groove association of the terminal stem and the 1082 hairpin loop (Hydrogen bonds are indicated by dotted lines); b) the major-groove to major-groove association of the 1067 and 1095 stem-loops, in a view emphasizing the high-five, S-turn, and dinucleotide platform motifs. The high-five motif consists of the long-range stacking of two bulged residues, U1061 and A1070. The S-turn comprises the inverted nucleotide U1060 and the bulged residue U1061. The dinucleotide platform motif consists of G1089 and U1090, on which the bulged residues G1071 and C1072 rest, as part of the long-range triples G1071-(G1091-C1100) and C1072-(C1092-G1099).

c) Geometries of the noncanonical base pairs and base triples. Top panel, the three major groove base triples in the core of the structure: G1089-(U1090-U1101), G1071-(G1091-C1100), and C1072-(C1092-G1099). Bottom left panel, the minor groove docking interactions (U1082-A1086)-(G1056-A1103) and A1085-(G1054-C1104). Bottom right panel, the long-range pair A1088-U1060. FIGS. 2 a and 2 b were made with RIBBONS (Carson, 1991); 2 c with MOLSCRIPT (Kraulis, 1991).

FIG. 3. RNA-metal ion interactions in the tertiary structure of the GTPase activating region RNA from Thermotoga maritima: a) overview of the locations of the metal ions, showing that they are primarily in the interacting major grooves of the 1067 and 1095 stems. Magnesium ions are gold, cadmium ions are magenta, and the mercury ion is rose. b) close-up of the central cadmium ion that stabilizes sharp turns at the 1056-1057 and 1086-1087 phosphodiester linkages at the center of the 4-way junction. Direct ligation of the cadmium ion is indicated by solid lines, and second-shell ligation is indicated by dotted lines. FIG. 3 a was made with RIBBONS (Carson, 1991), and FIG. 3 b was made with MOLSCRIPT (Kraulis, 1991).

FIG. 4 shows the RNA-L11 complex within the GTPase activating region from Thermotoga maritima: a) alignment of four widely divergent L11 sequences (“E coli” is Escherichia coli, SEQ ID NO: 1; “T marit” is Thermotoga maritima, SEQ ID NO: 2; “Sulf ac” is Sulfolobus acidocaldarius, SEQ ID NO: 3; and “Sacc cor” is Saccharomyces cerevisiae, SEQ ID NO: 4), together with a schematic of the protein's secondary structure. The sidechains of residues shown in forward-slanting narrow hatch marks participate in the hydrophobic core in the crystal structure. Residues involved in RNA binding are shown with backward-slanting narrow hatch marks for side-chain contacts, backward slanting wide hatch marks for main-chain contacts or cross-hatched if both the side-chain and main-chain interact with RNA. Abbreviations: E. coli, Echerichia coli (eubacterium); T. marit, Thermotoga maritima (eubacterium); Sulf ac, Sulfolobus acidocaldarius (archaea); Sacc cer, Saccharomyces cerevisiae (eukaryote). The numbering is based on the Thermotoga maritima sequence present in the crystal structure. b) stereoview of the complex. The L11 N- and C-terminal domains are labled. Note that the N-terminal domain straddles the interface of the 1067 and 1095 stem-loops. c) orthogonal stereoview of the complex. This view emphasizes the relatively loose association of the L11 N-terminal domain with the RNA. FIGS 4 b and 4 c were made with RIBBONS (Carson, 1991).

FIG. 5 shows Protein-RNA recognition within the GTPase activating region from Thermotoga maritima: a) schematic of RNA-CTD interactions observed in the crystal structure. Unusual RNA conformational features are also indicated (see inset for key). Water molecules that mediate protein-RNA interactions are indicated by a “W”. b) Detail of the recognition of the conserved long-range A1088-U1060 pair by conserved L11 residues Gly 130 and Thr131 from helix 5, and by the N-terminus of helix 3. FIG. 5 b was made with MOLSCRIPT (Kraulis, 1991).

FIG. 6 shows that the sites of mutations conferring resistance to thiostrepton and micrococcin are clustered around a cleft between the RNA and the proline-rich helix in the L11 N-terminal domain. Residues implicated in thiostrepton binding (A1067, A1095, and Pro22) are labeled. The position of Tyr61, which is protected by thiostrepton in protein footprinting experiments, is also indicated. Other labeled residues are those that confer micrococcin resistance (see text for details). The figure was made with RIBBONS (Carson, 1991).

Table II shows the atomic structure coordinates for the complex between ribosomal L11 protein and the GAR RNA as derived by X-ray diffraction from a crystal of L11 complexed with 23S rRNA nucleotides 1051-1108.

DETAILED DESCRIPTION OF THE INVENTION

The invention is based on the discovery of the crystal structure of the ribosomal GAR from the hyperthermophilic eubacterium Thermotoga maritima, which is disclosed herein

Definitions

As used herein, the term “binding site” or “binding pocket” refers to a region of a protein or protein/RNA complex which binds or interacts with a particular compound. It is understood that the composition of the protein or RNA residues and/or the protein or RNA backbone, as well as the interaction of such moieties with their solvent including ions defines the specificity of the binding pocket.

As used herein, the term “exposed residue” refers to an amino acid or RNA residue which is located on the surface of a protein, RNA or RNA/protein complex.

As used herein the term “N terminus” or “N terminal lobe” or “NTD” when used in reference to L11 means amino acids 1-70 of L11.

As used herein, the term “C terminus” or “C terminal lobe” or “CTD” when used in reference to L11 means amino acids 76-141 of L11.

As used herein, the term “tether” or “tether sequence” when used in reference to L11 means amino acids 71 to 75 of L11.

As used herein, the term “flexible” when applied to a protein or RNA domain means that that domain allows one or more domains adjoining or flanking it to move or flex in space relative to the flexible domain.

As used herein, the term “backbone” or “backbone residue” when applied to an RNA molecule refers to the sugar-phosphate moieties that are covalently linked to form an RNA polymer. When applied to a protein molecule, “backbone” or “backbone residue” refers to the alternating N—C—C—N moieties of amino acids that are covalently linked to form a peptide polymer.

As used herein, the term “interface” means the point or surface at which two or more domains of one or more molecules associate with each other.

As used herein, the term “GAR” refers to the region of the ribosome responsible for activating the GTPase activity of translation elongation factors. The term “GAR RNA” refers to nucleotides 1051 to 1108 of E. coli 23S rRNA or to its functional and structurally equivalent from any other bacterial rRNA. As used herein, GAR RNA refers to the nucleotides including and limited to (i.e., an RNA molecule consisting of GAR RNA) nucleotides 1051 to 1108 of E. Coli 23S rRNA (or the functionally and structurally equivalent region in other bacterial rRNAs); or it refers to that nucleotide region (1051 to 1108) within a longer nucleotide sequence (i.e., an RNA molecule consisting essentially of GAR RNA) where the GAR RNA (nucleotides 1051 to 1108) is the only active region in the longer sequence (in terms of binding and/or another activity), whether the extra sequence be a homologous sequence from the 23S rRNA (short of the complete sequence) or a heterologous sequence; or it refers to the 1051 to 1108 region within a complete functional 23S rRNA (i.e., an RNA molecule comprising the GAR RNA).

As used herein, the term “L11/GAR” refers to the portions of L 11 and GAR RNA which, when engaged in a complex, provide the L11/GAR binding site and/or activity, and preferably both the binding site and the activity. The term “L11/GAR” refers to a complex which consists of the ribosomal protein L11 and consists of the GAR RNA (nucleotides 1051 to 1108) in their native association; or it can refer to a complex consisting essentially of ribosomal protein L11 and consisting of or consisting essentially of or comprising GAR RNA (i.e., including other proteins which are inactive or do not otherwise affect the activity of the L11/GAR complex; or it can refer to a complex comprising ribosomal protein L11 and consisting of, consisting essentially of, or comprising GAR RNA. When ribosomal protein L11 is referred to, the complete protein is referred to; however, where an L11/GAR activity is referred to, the portion of L11 sufficient to provide the activity when associated in a complex with GAR ma be less than the complete L11 protein; “portion” referring to those combined L11 residues which provide for L11/GARcomplex formation and activity, the portions being one or more of the N-terminal, C-terminal or tether regions, as defined herein, or ant combination thereof.

“L11/GAR activity” may include one or more of the following: movement of the N-terminal lobe of L11; binding or displacement of thiostrepton or micrococcin; RNA translation, translation elongation, inhibition of amino acid addition, GTPase activity, and/or inhibition of elongation factor G (EF-G)-dependent GTP hydrolysis.

As used herein, the term “known L11/GAR binding activity” refers to an activity known in the art to associate with the L11/GAR either in vitro or in vivo. Known L11/GAR binding activities include, but are not limited to, the binding of agents such as thiostrepton and micrococcin.

As used herein, “stem loop” refers to a stretch of nucleic acid sequence on a single molecule comprising two lengths of sequence capable of forming hydrogen bonded base pairs with each other separated by a region which cannot participate in the same base pairing interaction, such that base pairing between the sequences capable of forming hydrogen bonded base pairs forms a loop of non-base paired nucleic acid consisting of the region which cannot participate in base pairing.

As used herein, the term “alpha helix” refers to a secondary structure arrangement of amino acids wherein hydrogen bonding between the C═O group of one peptide and the —NH group of the peptide bond four residues further down the same peptide polymer results in a right handed twist or helix formation.

As used herein, “four way junction” refers to a region in the tertiary structure of GAR RNA in which four helices interact simultaneously with each other, as defined by the crystal structure coordinates given in Table II.

As used herein, the term “translationally competent cell extract” refers to any fraction of a cell lysate, including a whole cell lysate, which is capable of directing the RNA-dependent polymerization of peptide bonds.

As used herein, the term “translatable RNA” refers to an RNA which, when incubated with factors necessary for translation can direct the synthesis of acid-precipitable protein.

As used herein, the term “decrease” when used in reference to a level of labeled RNA, a level of known L11/GAR binding activity, a level of translation, or a level of GTP hydrolysis means that the detected level is reduced by at least 10%, and preferably by 20% to 50% or more.

As used herein, the term “anti-bacterial properties” refers to the ability of a particular compound to inhibit the growth of bacteria. A compound can be said to have anti-bacterial properties if the rate of bacterial cell proliferation is reduced by at least 50%, and preferably by more than 50%.

As used herein, the term “naturally occurring amino acids” means the L-isomers of the naturally occurring amino acids. The naturally occurring amino acids are glycine (G, Gly), alanine (A, Ala), valine (V, Val), leucine (L, Leu), isoleucine (I, Ile), serine (S, Ser), methionine (M, Met), threonine (T, Thr), phenylalanine (F, Phe), tyrosine (Y, Tyr), tryptophan (W, Trp), cysteine (C, Cys), proline (P, Pro), histidine (H, His), aspartic acid (D, Asp), asparagine (N, Asn), glutamic acid (E, Glu), glutamine (Q, Gln), gamma-carboxyglutamic acid, arginine (R, Arg), ornithine and lysine (K, Lys). Unless specifically indicated, all amino acids referred to in this application are in the L-form.

As used herein, the term “unnatural amino acids” means amino acids that are not naturally found in proteins. Examples of unnatural amino acids used herein include racemic mixtures of selenocysteine and selenomethionine.

The term “positively charged amino acid” includes any naturally occurring or unnatural amino acid having a positively charged side chain under normal physiological conditions. Examples of positively charged naturally occurring amino acids are arginine, lysine and histidine.

The term “negatively charged amino acid” includes any naturally occurring or unnatural amino acid having a negatively charged side chain under normal physiological conditions. Examples of negatively charged naturally occurring amino acids are aspartic acid and glutamic acid.

The term “hydrophobic amino acid” means any amino acid having an uncharged, nonpolar side chain that is relatively insoluble in water. Examples of naturally occurring hydrophobic amino acids are alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan and methionine.

The term “hydrophilic amino acid” means any amino acid having an uncharged, polar side chain that is relatively soluble in water. Examples of naturally occurring hydrophilic amino acids are serine, threonine, tyrosine, asparagine, glutamine, and cysteine.

As used herein, a “competitive” inhibitor is one that inhibits GAR activity by binding to the same kinetic form of the GAR as its accessory factors bind—thus directly competing with the accessory factors for the active site of the GAR. Competitive inhibition can be reversed completely by increasing the accessory factor concentration.

As used herein, the term “kinetic form” of the GAR means the condition of the GAR when either bound to an accessory factor or not, and in either its active or inactive state. That is, a kinetic form can be any conformation the GAR can assume under physiological conditions.

As used herein, the term “accessory factor” means an endogenous factor or protein that interacts with the L11/GAR. As used herein, EF-G is included in the term “accessory factor”.

As used herein, an “uncompetitive” inhibitor is one that inhibits GAR activity by binding to a different kinetic form of the GAR than do the accessory factors. Such inhibitors bind to GAR already bound with the accessory factor and not to the accessory factor-free GAR. Uncompetitive inhibition cannot be reversed completely by increasing the accessory factor concentration.

As used herein, the term “co-complex” means L11 protein in covalent or non-covalent association with GAR RNA. As used herein, a co-complex may also encompass accessory factors and/or inhibitors or activators complexed with L11 or L11/GAR RNA.

As used herein, the terms “associates with” or “interacts with” refers to a condition of proximity between a chemical entity or compound, or portions thereof, with another chemical entity, compound or portion thereof. The association or interaction may be non-covalent—wherein the juxtaposition is energetically favored by hydrogen bonding or van der Waals or electrostatic interactions—or it may be covalent.

The term “beta-sheet” refers to the conformation of a polypeptide chain stretched into an extended zig-zig conformation. Portions of polypeptide chains that run “parallel” all run in the same direction. Polypeptide chains that are “antiparallel” run in the opposite direction from the parallel chains.

As used herein, the term “target” means a region of the L11/GAR complex, as defined by the crystal structure coordinates of Table II, which when bound by a candidate inhibitor or activator results in inhibition or activation of L11/GAR function.

As used herein, the term “modulate” refers to a change, either an increase or a decrease in some activity.

As used herein, the term “modulator” means a compound that modulates some activity.

As used herein, the term “inhibits” or “decreases” means that a candidate modulator reduces the activity of the L11/GAR. A candidate modulator may be said to inhibit or decrease activity if the activity of L11/GAR as measured by inhibition of GTP hydrolysis and/or translational activity is reduced by more than 50% in the presence of 50 uM or less of inhibitor compared to values obtained in the absence of inhibitor. Candidate modulators will preferably inhibit by more than 50% the presence of 10 uM or less of inhibitor and most preferably in the presence of 1 uM or less of inhibitor.

As used herein, the term “activates” or “increases” means that a candidate modulator raises the activity of the L11/GAR. A candidate modulator may be said to activate or increase activity if the activity of L11/GAR as measured by an increase of GTP hydrolysis by more than 50% in the presence of 50 uM or less of activator compared to values obtained in the absence of activator. Candidate modulators will preferably activate by more than 50% in the presence of 10 uM or less of inhibitor and most preferably in the presence of 1 uM or less of inhibitor.

As used herein, the term “structure coordinates” refers to mathematical coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of an L11/GAR RNA complex in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are used to establish the positions of the individual atoms within the unit cell of the crystal.

As used herein, the term “heavy atom derivatization” refers to the method of producing a chemically modified form of a crystal of L11/GAR RNA. In practice, a crystal is soaked in a solution containing heavy metal atom salts, or organometallic compounds, e.g., methyl mercury nitrate, lead chloride, gold thiomalate, thimerosal or uranyl acetate, which can diffuse through the crystal and bind to the surface of the protein. The location(s) of the bound heavy metal atom(s) can be determined by X-ray diffraction analysis of the soaked crystal. This information, in turn, is used to generate the phase information used to construct three-dimensional structure of the protein or protein:RNA complex (Blundel, T. L. and N. L. Johnson, 1976, Protein Crystallography, Academic Press).

Those of skill in the art understand that a set of structure co-ordinates determined by X-ray crystallography is not without standard error. For the purpose of this invention, any set of structure coordinates for an L11/GAR RNA complex that has a root mean square deviation of protein backbone atoms (N, Cα, C and O) of less than 0.75 when superimposed on the structure coordinates of Table II, using backbone atoms, shall be considered identical.

The term “unit cell” refers to a basic parallelipiped shaped block. The entire volume of a crystal may be constructed by regular assembly of such blocks. Each unit cell comprises a complete representation of the unit of pattern, the repetition of which builds up the crystal. Using the structure coordinates of the L11/GAR RNA complex provided by this invention, molecular replacement may be used to determine the structure coordinates of a crystalline mutant or homologue of the L11/GAR RNA complex or of a different crystal form of the L11/GAR RNA complex.

Detailed Description of the High Resolution Structure of the L11/GAR Complex

The GAR RNA from the T. maritima 23S rRNA consists of nucleotides 1111-1168, which correspond to nucleotides 1051-1108 in the E. coli sequence. Hereafter, the E. coli numbering will be used in order to facilitate comparison with the available biochemical and genetic data. As described in detail in Example 1, crystals of the GAR RNA complexed with ribosomal protein L11 from T. maritima were prepared and used to solve the structure to 2.6 Å resolution using multi-wavelength anomalous diffraction on a mercury derivative of the crystal. Data collection, phasing and refinement statistics are shown in Table I. The asymmetric unit in the crystal consists of two 1:1 L11-RNA complexes stacked in a head-to-head manner. The two complexes are nearly identical except for a subtle bend in the terminal three base pairs of the RNA, and a difference in the degree of disorder of the two L11 N-terminal domains. Several observations strongly suggest that the conformation observed in the crystal structure is extremely similar to the structure of the GAR in situ in the ribosome. The RNA contains all of the predicted secondary structure; the two complexes in the asymmetric unit are virtually identical; and, most significantly, the structure explains most of the large body of experimental data on this system.

Structure of the GAR RNA

The predicted secondary structure of the GAR RNA (Glotz et al., 1981; Noller et al., 1981) is almost identical to that derived from the crystal structure (FIG. 1 a). The RNA secondary structure contains four double-helical segments, referred to as the terminal stem (defined by nucleotides (nt) 1051-1056 base paired with nt 1103-1108), the 1067 stem-loop (defined by nt 1062-1076), the 1082 hairpin (defined by nt 1082-1086) and the 1095 stem-loop (defined by nt 1090-1101).

In the tertiary structure, the terminal stem stacks on the 1095 stem-loop, and the 1067 stem-loop stacks on the 1082 hairpin. Thus the four double-helical segments stack pairwise to form two extended helical subdomains. These two subdomains have irregular yet complementary shapes, so that the entire GAR RNA folds into a single compact globular domain (FIGS. 1 b, c). The helical subdomains associate in a roughly parallel fashion, with the terminal stem packed against the 1082 hairpin, and the 1067 and 1095 stem-loops packed against each other. Bulged-out residues in the 1067 and 1095 stem-loops mediate long-range tertiary interactions between the two subdomains. The fold requires two sharp turns in the backbone at the 1056-1057 and 1086-1087 phosphodiester linkages in the center of the junction, where the chain crosses over from one helical subdomain to the other. The molecule also contains a relatively large number of well-ordered metal ions that are integral to the

A Ribose Zipper Joins the Terminal Stem and the 1082 Hairpin

The association of the terminal stem with the 1082 hairpin occurs via their minor grooves. This rather intimate packing is stabilized primarily by a dense network of hydrogen bonds between the riboses of nucleotides A1084-A1086 and C1104-A1106 (FIG. 2 a). A similar structural motif has been observed in the P4-P6 domain of the group I intron, and has been referred to as a ribose zipper (Cate et al., 1996). At the center of the four-way junction, the 2′ OH of A1086 appears to be a particularly crucial component of the ribose zipper. It makes hydrogen bonds to A1103 N1 and G1056 2′OH, and also directly ligates a crucial central cadmium ion (see below). A1086 has an unusual syn conformation that is necessary for the very tight packing of its sugar against the G1056-A1103 pair, and for the reverse-Watson-Crick geometry of the U1082-A1086 pair (FIG. 2 c). Another noteworthy feature of the ribose zipper is a minor groove A-(G-C) triple involving nucleotides A1085, G1055 and C1104 (FIG. 2 c). This minor-groove triple has also been found previously in large RNA tertiary folds (Cate et al., 1996; Ferre-D'Amare et al., 1998).

Intimate Association of the 1067 and 1095 Stem-loops by Reciprocal Donation of Bulges

The interaction between the 1067 and the 1095 stem-loops occurs primarily in their major grooves and is mediated largely by a reciprocal donation of highly conserved bulged-out bases. This unusually intimate major-groove packing is the primary reason for the compactness of the overall fold, and it requires substantial distortions from regular helical geometry. This portion of the structure contains a large number of tertiary interactions, some of which are novel structural motifs.

The 1095 stem donates a bulged-out base, A1088, to a pocket created by a distortion in the 1067 stem (FIG. 1). A1088 forms a universally conserved reverse-Hoogsteen pair with U1060 (FIG. 2 c). Because of steric constraints, A1088 must be in the syn conformation, which together with the reverse-Hoogsteen pairing geometry requires that U1060 must be flipped over. The inversion of U1060 is in turn facilitated by bulging out of the base of U1061. This inversion-bulge, or S-turn motif, has an S-shaped backbone conformation that has been observed previously (Szewczak et al., 1993; Wimberly, 1994; Wimberly et al., 1993). The insertion of A1088 also requires that residues A1077 and U1078 are unpaired and rotated out to open up the pocket. The unpaired conformation of these residues is stabilized by three hydrogen bonds to the sugar-phosphate backbone of the 1095 stem loop at A1088 and G1089. Two of these hydrogen bonds are to the base of A1077 which explains its universal conservation.

The reciprocal donation of a bulge from the 1067 stem-loop to the 1095 stem involves nucleotides G1071 and C1072, which form two novel interdomain base triples with the base pairs G1091-C1100 and C1092-G1099 respectively (FIGS. 2 b, c). Within the 1095 stem loop, nucleotides G1089-(U1090-U1101) also form a triple (FIG. 2 c), with G1089 acting as a stacking platform for the other two triples (FIG. 2 b). The stacking of G1071 on G1089 is further stabilized by hydrogen bonds between the 1089 2′ OH and 1071 N3, and between the 1071 2′ OH and the 1089 phosphate. These three base triples explain the sequence conservation of all these residues. The 1072-(1092-1099) triple was previously predicted and subsequently experimentally confirmed, although the geometry proposed for the triple (Conn et al., 1998) differs from that seen in the crystal structure.

The 1067 and 1095 Hairpin Loops

The highly conserved 1067 hairpin loop consists of two parts, a hairpin portion (U1066-A1069) that stacks on the sheared U1065-A1073 pair, and a three-nucleotide bulge (A1070-C1072) that participates in two different long-range tertiary interactions. The hairpin portion has a conformation commonly found in small hairpin loops, with a U-turn motif (Quigley and Rich, 1976) at U1066 and regular stacking of A1067-G1068-A1069. A1069 stacks on A1073, and its 2′ OH hydrogen bonds to the N3 of U1065, thereby stabilizing the location of the 1069 sugar as well as the sheared geometry of the U1065-A1073 pair. The three-nucleotide bulge has a corkscrew-like conformation in which A1070 is bulged to one side, and G1071 and C1072 are bulged into the major groove of the 1095 stem-loop. A1070 makes a novel long-range stacking interaction with U1061 which will be referred to herein as a “high-five” motif (FIG. 2 b), while 1071 and 1072 participate in the long-range base triples described above. The high-five motif makes several hydrogen-bonding and van der Waals interactions with the 1095 hairpin loop, thereby stabilizing the relative orientations of the two hairpins.

The 1095 hairpin loop is also very highly conserved, and has a regular conformation stabilized by a U-turn at U1094 and a sheared G1093-A1098 pair. Part of the base of G1093 stacks over the base of C1072, so that the long-range base triples are tightly wedged between an overhang from the sheared G-A pair on one side, and the G1089-(U1090-U1101) triple on the other side. The structure of the 1095 hairpin loop is very similar to an NMR-derived structure of a small stem-loop containing the same hairpin loop sequence (Fountain et al., 1996). The structural basis for the very high sequence conservation of several of the residues in the 1095 hairpin loop (i.e. A1095, A1096 and U/C1097) is not completely clear, but it may arise from interactions with the N-terminal domain of L11 (see below) or with other components of the ribosome.

Metal Ion Interactions with RNA

Three cadmium ions and at least seven magnesium ions are visible in the experimental electron density map. One of the cadmium ions stabilizes the association of the two complexes in the asymmetric unit, but the other two are integral to the RNA structure, and these two sites are probably occupied by magnesium ions in vivo. Most of the ions mediate the close approach of phosphates in the interacting major grooves of the 1067 and 1095 stems, and five of these ions stabilize the location and conformation of the 1070-1072 bulge between the 1067 and 1095 stems (FIG. 3 a). A cadmium ion occupies a crucial location at the center of the four-way junction, where it makes either direct or water-mediated contacts with residues from all four double-helical stems (FIG. 3 b). This ion appears to stabilize both of the sharp turns at the center of the junction, i.e. the 1056-1057 and 1086-1087 turns, and thereby plays an important role in determining the overall structure of the four-way junction.

Despite the accelerating pace of RNA structure determination, extremely little is known about RNA tertiary structure because only about five RNA folds have been determined. The crystal structure of the GAR RNA reveals an unexpectedly complex and compact fold that contains both well-known and novel structural motifs. The GAR RNA is in fact the most compact RNA structure yet reported, exposing only 138 Å² of solvent accessible surface area per nucleotide (Nicholls et al., 1991). This extreme compactness is a result of extensive tertiary interactions along the entire length of the structure, in both the major and minor grooves. The other relatively compact known RNA folds exhibit primarily minor-groove packing (e.g., the P4-P6 domain of the group I intron) or primarily major-groove packing (e.g., tRNA), and are therefore less efficiently folded. It is probable that very efficient packing of RNA will be found to be common in the ribosome.

The crystal structure explains the molecular basis for a number of important mutagenesis results. In particular, the RNA residues most sensitive to mutation are involved in tertiary interactions. For example, mutation of any of the universally conserved residues within the A1085-G1055-C1104 triple, a crucial part of the ribose zipper joining the terminal stem and the 1082 hairpin, dramatically destabilizes the RNA structure and greatly reduces the affinity for L11 (Lu and Draper, 1995). Mutation of C1072 to U within the 1072-(1092-1099) triple destroys the RNA tertiary structure, which demonstrates the energetic importance of this triple. Finally, the unusual observation that U1061A and U1061G mutants are more stable (Lu and Draper, 1994; Lu and Draper, 1995) is explained by the 1061-1070 “high five” tertiary stacking motif, since purine stacking is more stable than pyrimidine stacking.

Stabilization of the RNA Tertiary Structure by Metal Ions

The crystal structure also reveals important new information about how metal ions interact with and stabilize unusual RNA structures. Biochemical experiments suggest that the GAR RNA contains relatively high affinity binding sites for two divalent cations (Bukhman and Draper, 1997) and one K+ or NH4+ ion (Wang et al., 1993). The crystal structure reveals no fewer than seven magnesium sites and two cadmium sites, most of which stabilize the close approach of phosphates in the interacting major grooves of the 1067 and 1095 stem-loops. The metal-ion stabilization of the 1070-1072 bulge conformation is qualitatively similar—though different in detail—to that seen in the A-rich bulge of the P4-P6 domain of the group I intron (Cate et al., 1996). The striking structural role played by the central cadmium ion suggests that this site corresponds to one of the thermodynamically important ions. While more experiments will be necessary to test this hypothesis, it is worth noting that this cadmium ion is one of the two sites in the structure that ligates a guanosine N7. Both Mn⁺⁺ and Cd⁺⁺ preferentially bind to guanosine N7, and it has been observed that Mn⁺⁺ stabilizes the tertiary structure more than other divalent cations (Bukhman and Draper, 1997).

The Major-groove Dinucleotide Platform: a Generalization of the Adenosine Platform

The crystal structure also reveals a new variant of a known tertiary structure motif, the adenosine platform. In the structure of the P4-P6 domain, two successive adenines adopt a coplanar conformation—an adenosine platform—that serves as a stacking platform for a long-range tertiary interaction (Cate et al., 1996). In the GAR structure, two successive nucleotides, G1089 and U1090, adopt the same conformation seen in the adenosine platform (FIG. 2C). The two bases are coplanar, with a single N2-O4 hydrogen bond between them, and they also serve as a stacking platform, for the 1071-1072 bulge involved in base triples (FIG. 2B). There are, however, some differences between the GU platform seen here and the AA platform. In the P4-P6 structure, the motif is displayed in the minor groove rather than in the major groove, as is seen here. Moreover, in the P4-P6 structure it is the 3′ adenosine upon which the long-range stacking interaction occurs, while here G1071 rests upon the 5′residue of the motif, G1089. Finally, the tertiary stacking interaction occurs on opposite faces of the motif in the two structures. Despite these differences, the near-identity of the conformations and functions of the motifs in these two structures leads to the suggestion that the motif be referred to as a “dinucleotide platform”, since it is clearly not restricted to adenosines. The few available data suggest that a GU dinucleotide platform may generally be more stable than an AA platform for major groove display. In the GAR, residues 1089 and 1090 are strictly conserved as either GU or AA, but mutation from AA to GU results in a significant stabilization of the RNA tertiary structure (Lu and Draper, 1994; Lu and Draper 1995). The major-groove GU dinucleotide platform motif has also been found in small RNA structures lacking tertiary interactions (Szewczak et al., 1993; Wimberly et al., 1993), which suggests that in large structured RNAs, the GU dinucleotide platform may in some cases function as a pre-formed stacking platform supporting major-groove base triples.

Methylmercury as a Phasing Vehicle for RNA Crystal Structures

Surprisingly, the primary mercury site used in phasing is not near a cysteine of L11, but is located 2.4 Å from the N3 atom of U1061, consistent with a covalent mercury-uridine N3 bond. A similar, minor mercury site at U1078 is also visible in the anomalous difference Fourier map. Although most mercury adducts of pyrimidines have been obtained at the O4 or 5 positions of the base, a mercury 1-methylthymine adduct at N3 has been obtained at alkaline pH (Kosturko et al., 1974), and methylmercury salts have been shown to denature AT-rich DNA, consistent with reaction at thymine N3 (Gruenwedel and Davidson, 1966; Gruenwedel and Davidson, 1967). Uracil is often preferred at bulge sites in RNA, so many larger RNA structures may contain solvent-accessible uracils. Therefore, methylmercury derivatization of RNA under native conditions, either prior or subsequent to crystallization, may be a generally useful method for obtaining heavy atom derivatives of RNA crystals, without the laborious incorporation of sulfur-containing ribonucleotides.

The Structure of Ribosomal Protein L11

Ribosomal protein L11 consists of two globular domains connected by a linker region. The secondary structure and a sequence alignment of the protein are shown in FIG. 4 a, and the tertiary fold is shown in FIGS. 4 b and 4 c in the context of the complex. As described below, there is some flexibility between the two domains, but the linker is short and it contains two conserved prolines (73 and 74) that provide inherent rigidity. Also, the domain interface consists primarily of conserved hydrophobic residues, notably Met52, Ile53, Pro55, Pro73 and Phe77. These observations suggest that relative orientation of the two domains has not been greatly perturbed by crystal packing requirements.

The structure of the L11 N-terminal domain (NTD) has not been previously reported. It consists of two helices packed against the concave surface of a three-stranded antiparallel beta sheet, with an overall β1-α1-α2-β2-β3 topology. The N-terminal 7 residues are disordered. One of the most distinctive and conserved regions of the L11 molecule is the proline-rich helix 1, which appears to have a crucial functional role, as described below. The electron density for this helix was weak, and the register of the sequence in this helix may be in error by one residue. The average main-chain B-factor for the domain is 72 Å² (for comparison, the average B-factor of the C-terminal domain (CTD) is 24 Å²), indicating rigid body movement of the NTD within the crystal. This flexibility is consistent with the rather limited interactions seen between the NTD and other parts of the structure, and may have functional implications (see below).

The structure of the CTD is in good agreement with the previously determined NMR structures of the CTD, both in isolation (Markus et al., 1997; Xing et al., 1997) and in the context of the L11-RNA complex (Hinck et al., 1997). The domain consists of a three-helical bundle and a short parallel two-stranded β-ribbon, with an overall α3-β4-α4-α5-β5 topology. All five secondary structure elements contribute to a conserved hydrophobic core. The domain is characterized by two extended loops that are disordered in the absence of the RNA, but which have defined structures in the complex.

The RNA-protein Interaction

The two domains of L11 are very unequally associated with RNA. The CTD-RNA interface covers over 1700 Å² of solvent accessible surface area, while the NTD-RNA interface is less than 100 Å². This difference is consistent with the observation that the RNA-binding affinity of the CTD is essentially the same as that of the full-length protein (Xing and Draper, 1996).

The CTD binds the minor groove of the 1067 stem (FIGS. 4 b, c), which is bent and flatter than the minor groove of a canonical A-form double helix. The RNA-binding surface of the CTD consists of one face of helix 5, the N-terminal end of helix 3, and loops 6 and 7 that flank helix 5. Helix 5 is positioned lengthwise in the minor groove, and the flanking loops 6 and 7 extend this minor groove binding surface and also interact with the sugar-phosphate backbones on either side of the groove. A summary of the CTD-RNA interactions observed in the crystal structure (FIG. 5 a) emphasizes that the recognition of the RNA minor groove by L11 involves primarily interactions between the protein backbone and the RNA2′ OH moieties. Approximately half of the RNA-CTD hydrogen bonds involve a main-chain amide or carbonyl, and over half of the 2′OH groups in the CTD footprint are hydrogen-bonded to the protein. This preponderance of protein backbone-RNA backbone interactions indicates that overall shape complementarity between the RNA and protein must be an important determinant of specificity.

Although binding appears to depend less on electrostatic interactions than on shape complementarity, there are a number of important salt bridges between basic sidechains and phosphate groups: lysines 93, 126 and 133 and Arg94 interact with one side of the minor groove, and lysines 80, 87 and 112 with the other side. In the former group, the sidechains are splayed away from protein, and the hydrophobic part of the sidechain contributes to surface complementarity with the RNA. Sidechains at the N-terminus of α5 and within loop 7 make particularly intimate contact with the RNA, notably Ile127 and Asn117. Asn117 points directly into the minor groove making a number of hydrogen bonding interactions, and is one of the few sidechains that formally “reads” the local RNA sequence. Two of the most important recognition elements in the RNA are the universally conserved long-range pair U1060-A1088 and the surrounding RNA internal loop that distorts to accommodate the insertion of A1088. Significantly, the RNA footprint of helix 5 encompasses this entire region of distorted RNA. The importance of the U1060-A1088 pair for L11 specificity is shown by the extremely high conservation of Gly130 and Thr131 to which these bases are hydrogen-bonded (FIG. 5 b).

The NTD bridges the interface between the 1067 and 1095 stem-loops, and it makes only a few specific interactions with the RNA (FIG. 4). Although its association with RNA is somewhat tenuous, which might be a result of its binding mode having been altered by crystal packing requirements, the high sequence conservation of the NTD residues interacting with RNA suggests that the binding mode observed in the crystal structure is relevant to the structure of the complex in solution. Moreover, as described above, the structure of the NTD-CTD interface also suggests that the orientation of the NTD has not been greatly perturbed by crystal packing. The NTD residues interacting with RNA include Lys10, Gln12, Gln30 and Lys71. Lys10 makes both main-chain and side-chain interactions with the RNA, and Gln30 probably interacts specifically with A1095. There is also electron density interacting with the Watson-Crick face of C1097, but it is not clear whether this density arises from the NTD; examination of an anomalous difference Fourier map reveals that some of this density must correspond to a mercury or cadmium site. Finally, although the proline-rich sequence in helix 1 is surface-exposed, highly conserved, and in the correct orientation for possible interactions with factors or antibiotics, it is close to but not in direct contact with RNA.

The Thiostrepton/micrococcin Binding Site

A1067 and A1095, at the ends of their respective stem-loops, have both been implicated in the binding of the antibiotics thiostrepton and micrococcin. Modification of A1067 by 2′-O methylation (Cundliffe and Thompson, 1979; Thompson et al., 1982) or transversion mutations at either site (Rosendahl and Douthwaite, 1994) confers thiostrepton resistance. It has also been shown that thiostrepton affects the reactivity of both A1067 and A1095, suggesting that these two sites are close together (Rosendahl and Douthwaite, 1994) as indeed they are in the crystal structure. As for the role of L11 in antibiotic binding, it is known that L11 is required for high affinity binding of thiostrepton to the RNA, and that binding of L11 and thiostrepton to the RNA is cooperative. Thiostrepton has a much weaker affinity for the RNA alone (Kd=0.4 μM), and it does not bind isolated L11 (Thompson et al., 1979). Two sites within the NTD of the protein have been implicated in this interaction: the mutations Pro22Ser and Pro22Thr confer thiostrepton resistance, while the antibiotic protects Tyr61 (Tyr62 in E. coli) in protein footprinting experiments (Porse et al., 1998). Recently, mutations that confer resistance to micrococcin have also been mapped to the NTD of L11 between residues 22 and 32 (Porse et al., 1999). All of these sites are located on a small surface of the NTD, near A1067 and A1095 on the RNA (FIG. 6). A prominent feature of this surface is the distinctive and highly conserved proline-rich helix, while Tyr61 is over 20 Å distant. The clustering of these sites of antibiotic resistance mutations, together with the cooperative binding data, strongly suggest that the antibiotics bind to the cleft between the RNA and the proline-rich helix 1 of the NTD.

The structure of the C-terminal domain (CTD) was previously determined by NMR in both the free (Markus et al., 1997; Xing et al., 1997) and RNA-bound (Hinck et al., 1997) forms. Our crystal structure of the CTD is similar to that of the RNA-bound form determined by NMR, except for the conformation of the large RNA-binding loop 6 which is poorly determined in the NMR studies (Hinck et al., 1997). The mean Cα root mean square difference (RMSD) for the crystal structure vs. NMR ensemble is 2.7 Å overall, or 1.6 Å when residues 86-97 of loop 6 are excluded. For comparison, the mean RMSD within the ensemble of NMR structures is 2.3 Å for main chain atoms.

Many ribosomal proteins show structural similarities to families of DNA- and RNA-binding proteins (Ramakrishnan and White, 1998). It was noted from the NMR structure that the CTD of L11 has a homeodomain-like fold (Markus et al., 1997; Xing et al., 1997), and further NMR studies on the complex suggested that the CTD uses the typical homeodomain helix to bind RNA (Hinck et al., 1997). Although the crystal structure reveals that this helix is indeed intimately associated with the RNA, its interaction does not bear any similarity to the base-specific recognition of a major groove by the homeodomains. Regarding the NTD, its overall α+β fold is similar to that seen in many other RNA-binding proteins (Ramakrishnan and White, 1998), but its β-α-α-β-β topology has not yet been observed in an RNA-binding protein.

RNA-protein Interaction

The L11-GAR RNA interaction has been probed by biochemical and NMR methods, and the crystal structure is in good agreement with the results of these studies, including a rather weak interaction between the RNA and the NTD. The RNA surface covered by the CTD corresponds fairly well to the residues protected by the binding of full-length L11 as shown by hydroxyl radical footprinting experiments (Rosendahl and Douthwaite, 1993). The RNA-binding surface of the CTD has been mapped by NMR chemical shift changes and relaxation studies (Hinck et al., 1997), and again the agreement with the crystal structure is excellent. The observation that L11 recognizes the RNA primarily by shape complementarity rather than by a sidechain-base reading of the RNA sequence is not surprising considering that the interaction occurs primarily via the minor groove. The interaction agrees with the prediction that relatively few highly conserved CTD residues would make specific sidechain contacts with RNA (Xing et al., 1997). However, the related prediction that RNA binding by the CTD would not involve extensive recognition of the RNA bases is incorrect, as most of the base pairs are recognized by either hydrogen bonding or hydrophobic interactions. However, most of these hydrogen bonds occur via main chain amides or carbonyls, rather than side chains. Finally, it is worth noting that L11 does not directly recognize the bulged-out nucleotides, which have previously been proposed as specificity determinants in ribosomal RNA-protein complexes.

Biochemical experiments have shown that L11 stabilizes the tertiary structure of the RNA, and that this is a property of the CTD (Draper and Xing, 1995; Xing and Draper, 1995). Since nearly all of the direct RNA-protein contacts within the complex are to the 1067 stem, the resulting stabilization of the RNA tertiary structure appears to be indirect. The binding of one face of helix 5 with both strands of the 1067 stem is extensive and universally conserved, and this interaction must be particularly important for stabilization of the RNA tertiary structure. Consistent with a crucial role in RNA binding, helix 5 contains most of the mutation sites that have the greatest adverse effect on binding affinity (T131V, G130A, K126A, and S134A) (Xing et al., 1997). As for the RNA-binding loops 6 and 7, both are disordered when not bound to RNA (Markus et al., 1997), but they are highly ordered in the complex, and their conformations match the groove surface perfectly. The loops contain conserved structural features, which are important in the complex and which may predispose them for RNA-binding. Although it makes many interactions with RNA and contains the other two sites most sensitive to mutation (G88P and P92G), the longer RNA-binding loop 6 is relatively poorly conserved between kingdoms, with the bacterial and archaeal loops differing significantly from the eukaryotic loops (FIG. 4A). This variability in the protein sequence correlates with variability between phylogenetic kingdoms in the base-pairing of the upper portion of the 1067 stem.

The NTD as a Molecular Switch

Prior to these structural studies, the molecular basis for cooperative binding within the RNA-L11-thiostrepton ternary complex was unknown. The crystal structure now provides a very straightforward explanation that also rationalizes the particular importance of the L11 NTD. The model also provides insights into how the GAR might function as a molecular switch.

The putative thiostrepton/micrococcin binding site is centered on a small gap between helix 1 of the NTD and the 1067/1095 region of the RNA (FIG. 6). The antibiotics are proposed to bind within this gap, possibly enlarging it somewhat, making specific interactions with the RNA on one side and further interactions with the NTD on the other side. In the absence of the NTD, the antibiotic's binding affinity would be greatly compromised, thus explaining the importance of the NTD for antibiotic binding (Xing and Draper, 1996). An alternative proposal, that thiostrepton binds directly only to the RNA and that this RNA conformation requires the presence of the NTD, is unlikely because the NTD does not appear to stabilize the RNA tertiary structure significantly, and because the NTD sites of resistance mutations are not in contact with the RNA. In a model that better accounts for previously known data and agrees with the crystal structure reported herein, the mechanism for the resistance to thiostrepton in Pro22 mutants would be a disruption of direct thiostrepton-Pro22 interaction. A similar mechanism must hold true for the micrococcin sites given the more recent data (Porse et al., 1999). Regarding the details of the interaction of thiostrepton and micrococcin with RNA, we note that these antibiotics contain an array of thiazole rings that resembles the array of prolines in the conserved proline-rich NTD helix.

The data disclosed herein suggests a potential mechanism of thiostrepton inhibition of factor-dependent GTPase activity involves restriction or “trapping” of one of the many conformational states that must occur during elongation (Cundliffe, 1986) by the antibiotic. In their analysis of the effects of the Pro22Ser and Pro22Thr mutations, Porse et al. (1998) suggest that thiostrepton binding may affect the ability of the L11 NTD to undergo a conformational change, an idea which merits closer examination in light of the crystal structure. In the structure, the CTD is rather firmly anchored to one of the two RNA subdomains, while the NTD is somewhat tenuously bound across the RNA subdomain-subdomain interface. Even in the absence of other data, this overall architecture suggests that the NTD may function as a molecular switch that reversibly associates with the GAR RNA during the elongation cycle. In light of the other data—in particular the cooperative binding of thiostrepton and full-length L11 to RNA, and the clustering of antibiotic resistance mutations to the cleft defined by A1067/A1095 and the proline-rich NTD helix—it appears even more likely that the NTD functions as a molecular switch, and that the thiazole antibiotics work by binding to the NTD-RNA interface, thereby preventing the NTD from switching between RNA-bound and RNA-free states. It is possible that the switch is coupled to, or triggered by, the binding of elongation factors. It is important to note that the NTD itself cannot provide the actual GTPase enhancing activity since L11 is not required for viability in E. coli (Stöffler et al., 1980). Therefore, the switch appears likely to function by controlling either the accessibility or the conformation of the GAR RNA.

This switch hypothesis could also explain why EF-Tu and IF2 do not footprint the 1067/1095 region of RNA, while EF-G does, even though all these factors interact with the sarcin/ricin loop (Moazed et al., 1988). The sarcin/ricin loop is known to bind to a nearby (Wilson and Noller, 1998) but distinct (Munishkin and Wool, 1997) site on EF-G. The EF-Tu-tRNA complex is similar in structure to EF-G, and the similarity is thought to be a case of molecular mimicry, with the factors binding to the same general region of the ribosome (Nissen et al., 1995). Thus the footprinting differences could be explained if EF-Tu and IF2 recognize a different conformation of the switch than EF-G does. This reasoning suggests that the two conformations of the GAR molecular switch correspond to different functional states of the ribosome.

The structure features a complex and very compact RNA fold stabilized by many bound metal ions, by a dense network of RNA tertiary interactions, and by extensive interactions with the protein. The overall architecture of the complex suggests that the N-terminal domain functions as a molecular switch, either by facilitating changes in the tertiary structure of the GAR RNA, or by controlling access to the RNA. Thiostrepton and micrococcin are proposed to bind to the NTD-RNA interface, thus locking the switch and disrupting GAR function.

Uses of the Crystal Structure Coordinates of the L11/GAR Complex

One approach enabled by the X-ray crystal structure disclosed herein is the use of the crystal coordinates for the rational design of GAR activity modulators, either de novo or by modification of known compounds. The modulators identified through use of the crystal structure coordinates will be useful for altering the rate of bacterial protein synthesis, and thereby the rate of bacterial cell growth. It is expected that, for example, an inhibitor of GAR function will inhibit bacterial cell proliferation, and will thus potentially have immediate medical usefulness.

One of skill in the art may use the structure data disclosed herein and the computer-modeling techniques described herein to develop models of target domains also selected through analysis of the crystal structure data (see below). These models can be used to provide a detailed analysis of the binding surfaces, including factors such as van der Waals contacts, electrostatic interactions and hydrogen-bonding opportunities. This information is then used with computer simulation techniques to map the favorable interaction positions for functional groups such as protons, hydroxyl groups, amine groups, divalent cations, aromatic and aliphatic functional groups, acetamide, methanol, etc. These groups may then be designed into a synthetic ligand.

The L11/GAR structure coordinates may be used to screen computationally small molecule data bases for chemical entities or compounds that may bind in whole, or in part, to the L11/GAR, to GAR, or to L11.

In addition, because the L11/GAR RNA complex may be crystallized in more than one crystal form (e.g, as a co-crystal with another factor, such as EF-G), the structure coordinates of the L11/GAR RNA, or portions thereof, as provided by this invention are useful to solve the structure of those other crystal forms of the L11/GAR RNA complex. One method that may be employed for this purpose is molecular replacement. In this method, the unknown crystal structure (i.e., that of the co-complex) may be determined using the L11/GAR complex structure coordinates of this invention as provided in FIG. 7. This method will provide an accurate structural form for the unknown crystal more quickly and efficiently than attempting to determine such information from first principles.

In addition, in accordance with this invention, the L11/GAR complex may be crystallized in co-complex with known GAR inhibitors (e.g., thiostrepton, micrococcin). The crystal structures of such complexes may then be solved by molecular replacement and compared with that of inhibitor-free L11/GAR complex. Critical sites for interaction of the known inhibitor with the L11/GAR may thus be identified at high resoultion. This information provides an additional tool for determining the most efficient binding interactions, for example, increased hydrophobic interactions, between L 11/GAR and a chemical entity or compound.

All of the complexes referred to above may be studied using well-known X-ray diffraction techniques and may be refined versus 2-3 Å resolution X-ray data to an R value of about 0.20 or less using computer software, such as X-PLOR (Yale University, ©1992, distributed by Molecular Simulations, Inc.). See, e.g., Blundel & Johnson, supra; Methods in Enzymology, 1985, vol. 114 & 115, H. W. Wyckoff et al., eds., Academic Press. The crystallographic information disclosed herein may thus be used to optimize known classes of L11/GAR inhibitors or activators.

Importantly, the X-ray crystal data disclosed herein also allows the design and synthesis of novel classes of L11/GAR inhibitors or activators (i.e., modulators). The design of compounds that bind to or modulate L11/GAR function according to this invention generally involves consideration of several factors. In particular, the compound must be capable of physically and structurally associating with L11/GAR. Non-covalent molecular interactions important in the functional association of L11/GAR with its accessory factors include hydrogen bonding, van der Waals, electrostatic and hydrophobic interactions.

It is recognized that although certain portions of the compound will not directly participate in this association with the L11/GAR, those portions may still influence the overall conformation of the molecule. This, in turn, may have a significant impact on potency. Such conformational requirements include the overall three-dimensional structure and orientation of the chemical entity or compound in relation to all or a portion of the binding site, or the spacing between functional groups of a compound comprising several chemical entities that directly interact with L11/GAR.

The potential modulating or binding effect of a chemical compound on the L11/GAR may be analyzed prior to its actual synthesis and testing by the use of computer modelling techniques. If the theoretical structure of the given compound suggests insufficient interaction and association between it and the L11/GAR, synthesis and testing of the compound is obviated. However, if computer modelling indicates a strong interaction, the molecule may then be synthesized and tested for its ability to bind to the L11/GAR domain and to inhibit using the assays described herein. In this manner, synthesis of inoperative compounds may be avoided.

A modulating or binding compound of the L11/GAR may be computationally evaluated and designed by means of a series of steps in which chemical entities or fragments are screened and selected for their ability to associate with the individual binding targets on the L11/GAR.

One skilled in the art may use one of several methods to screen chemical entities or fragments for their ability to associate with L11/GAR and more particularly with the individual binding domains comprising the L11/GAR active sites. This process may begin by visual inspection of, for example, the active site on the computer screen based on the L11/GAR RNA coordinates in FIG. 7. Selected fragments or chemical entities may then be positioned in a variety of orientations, or “docked”, within an individual binding target site of the L11/GAR as defined herein from analysis of the crystal structure data. Docking may be accomplished using software such as Quanta (Molecular Simulations, Inc., San Diego, Calif.) and Sybyl (Tripos, Inc., St. Louis, Mo.) followed by energy minimization and molecular dynamics with standard molecular mechanics forcefields, such as CHARMM (Molecular Simulations, Inc., San Diego, Calif.) and AMBER (University of California at San Francisco).

Specialized computer programs may also assist in the process of selecting fragments or chemical entities. These include:

-   1. GRID (Goodford, P. J., “A Computational Procedure for Determining     Energetically Favorable Binding Sites on Biologically Important     Macromolecules”, J. Med. Chem., 28, pp. 849-857 (1985)). GRID is     available from Oxford University, Oxford, UK. -   2. MCSS (Miranker, A. and M. Karplus, “Functionality Maps of Binding     Sites: A Multiple Copy Simultaneous Search Method.” Proteins:     Structure. Function and Genetics, 11, pp. 29-34 (1991)). MCSS is     available from Molecular Simulations, San Diego, Calif. -   3. AUTODOCK (Goodseil, D. S. and A. J. Olsen, “Automated Docking of     Substrates to Proteins by Simulated Annealing”, Proteins: Structure.     Function, and Genetics, 8, pp. 195-202 (1990)). AUTODOCK is     available from Scripps Research Institute, La Jolla, Calif. -   4. DOCK (Kuntz, I. D. et al., “A Geometric Approach to     Macromolecule-Ligand Interactions”, J. Mol. Biol., 161, pp. 269-288     (1982)). DOCK is available from University of California, San     Francisco, Calif. -   5. CERIUS II (available from Molecular Simulations, Inc., San Diego,     Calif.). -   6. Flexx (Rarey et al., 1996, J. Mol. Biol. 261: 470-489).

Once suitable chemical entities or fragments have been selected, they can be assembled into a single compound or modulator. Assembly may proceed by visual inspection of the relationship of the fragments to each other on the three-dimensional image displayed on a computer screen in relation to the structure coordinates of the L11/GAR. This would be followed by manual model building using software such as Quanta or Sybyl.

Useful programs to aid one of skill in the art in connecting the individual chemical entities or fragments include:

-   1. CAVEAT (Bartlett, P. A. et al, “CAVEAT: A Program to Facilitate     the Structure-Derived Design of Biologically Active Molecules”. In     “Molecular Recognition in Chemical and Biological Problems”, Special     Pub., Royal Chem. Soc., 78, pp. 182-196 (1989)). CAVEAT is available     from the University of California, Berkeley, Calif. -   2. 3D Database systems such as MACCS-3D (MDL Information Systems,     San Leandro, Calif.). This area is reviewed in Martin, Y. C., “3D     Database Searching in Drug Design”, J. Med. Chem., 35, pp. 2145-2154     (1992)). -   3. HOOK (available from Molecular Simulations Inc., San Diego,     Calif.).

Instead of proceeding to build an L11/GAR modulator in a step-wise fashion one fragment or chemical entity at a time as described above, modulatory L11/GAR binding compounds may be designed as a whole or “de novo” using either an empty active site or optionally including some portion(s) of a known inhibitor(s). These methods include:

-   1. LUDI (Bohm, H.-J., “The Computer Program LUDI: A New Method for     the De Novo Design of Enzyme Inhibitors”, J. Comp. Aid. Molec.     Design, 6, pp. 61-78 (1992)). LUDI is available from Molecular     Simulations, Inc., San Diego, Calif. -   2. LEGEND (Nishibata, Y. and A. Itai, Tetrahedron, 47, p. 8985     (1991)). LEGEND is available from Molecular Simulations, San Diego,     Calif. -   3. LeapFrog (available from Tripos Associates, St. Louis, Mo.).

Other molecular modelling techniques may also be employed in accordance with this invention. See, e.g., Cohen, N. C. et al., “Molecular Modeling Software and Methods for Medicinal Chemistry”, J. Med. Chem., 33, pp. 883-894 (1990). See also, Navia, M. A. and M. A. Murcko, “The Use of Structural Information in Drug Design”, Current Opinions in Structural Biology, 2, pp. 202-210 (1992); Hubbard, “Can Drugs Be Designed?”, Curr. Opin. Biotechnol., 8, pp. 696-700 (1997); and Afshar et al., “Structure-Based and Combinatorial Search for New RNA-Binding Drugs”, Curr. Opin. Biotechnol., 10, pp.59-63 (1999).

Once a compound has been designed or selected by the above methods, the efficiency with which that compound may bind to L11/GAR may be tested and optimized by computational evaluation. For example, a compound may be optimized so that in its bound state it would preferably lack repulsive electrostatic interaction with the target site. Such non-complementary (e.g., electrostatic) interactions include repulsive charge-charge, dipole-dipole and charge-dipole interactions. Specifically, the sum of all electrostatic interactions between the modulator and the enzyme when the modulator is bound to L11/GAR preferably make a neutral or favorable contribution to the enthalpy of binding.

Specific computer software is available in the art to evaluate compound deformation energy and electrostatic interaction. Examples of programs designed for such uses include:

-   Gaussian 92, revision C [M. J. Frisch, Gaussian, Inc., Pittsburgh,     Pa. ©1992]; AMBER, version 4.0 [P. A. Kollman, University of     California at San Francisco, ©1994]; -   QUANTA/CHARMM -   [Molecular Simulations, Inc., San Diego, Calif. ©.1994]; and Insight     II/Discover (Biosysm Technologies Inc., San Diego, Calif. ©1994).     These programs may be implemented, for instance, using a Silicon     Graphics workstation, 02-R10000 or IBM RISC/6000 workstation     model 550. Other hardware systems and software packages will be     known to those skilled in the art.

Once an L11/GAR-binding compound has been optimally selected or designed, as described above, substitutions may then be made in some of its atoms or side groups in order to improve or modify its binding properties. Generally, initial substitutions are conservative, i.e., the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original group. It should, of course, be understood that components known in the art to alter conformation should be avoided. Such substituted chemical compounds may then be analyzed for efficiency of fit to L11/GAR by the same computer methods described in detail, above.

Targets for Modification of L11/GAR Function

The X-ray crystal structure co-ordinates disclosed herein may be used to define structural features of the L11/GAR which represent targets for inhibition or activation of the GTPase activity of the ribosome. The following regions of the L11/GAR, defined by the X-ray co-ordinate data, represent particularly useful targets for the development of inhibitory or activating compounds.

1. L11 N Terminus:GAR RNA Interface

The putative site for binding of the antibiotics thiostrepton and micrococcin to the GAR is between the N terminus of L11 and the interface between the 1067 and 1095 stem loops of the GAR RNA. The structural data as disclosed in Table II and described herein above suggest that the N terminal lobe of L11 behaves as a rigid body that flexes about the so-called “tether sequence” between the C terminal and N terminal lobes of the protein. Therefore, the binding pocket is not limited to those residues at the interface of the L11 N terminus and the GAR RNA that are in direct contact. The binding pocket can include all of the following:

A) all exposed residues from the L11 N terminus;

B) all exposed residues from the GAR RNA that are on its L11 binding surface, including A1070, U1061, A1095, A1096, C1097, and A1098;

C) L11 amino acid residues that are in direct contact with the GAR RNA, including K10, Q12, Q30 and K71;

D) L11 amino acid residues from the helical region between P20 and H31; and

E) the L11 β sheet between Q8 and P14, and neighboring I53.

Computer simulation techniques may be used to determine which parameters of the binding pocket may be exploited in designing or screening compounds that interact with the binding pocket. Such techniques allow for the construction of structural models that can then be used in designing inhibitory/activating compounds targeted to the L11/GAR binding pocket. These techniques may involve any of the software packages described above or known in the art, and include:

A) Interactive movement of the L11 N terminus as a rigid body with concurrent geometry optimization, using, for example, Quanta.

B) Molecular dynamics simulation of the GAR RNA-L11 complex using. For example, CHARMM and/or AMBER.

C) Normal mode dynamics simulation of the GAR RNA-L11 complex using, for example, CHARMM.

D) Molecular docking of thiostrepton and/or micrococcin to the models of the binding pocket.

2. The L11 Flexible Tether or the Flexible Tether:GAR RNA Interface

The flexible tether domain of L11 and the GAR RNA surfaces that the tether domain interacts with are defined by the crystal structure coordinates disclosed in Table II and discussed herein above. The X-ray crystal data suggest that the L11 N terminus may act as a molecular switch that triggers the GTPase activity. It is thought that thiostrepton and micrococcin act by modifying the interaction between the L11 N terminus and the GAR RNA. Therefore, the region tethering the N terminal and C terminal lobes of L11, (i.e., amino acids K71 through A75) represent a target for the development of compounds that inhibit or activate GAR function, as does the domain comprising the interface of the tether region with GAR RNA residues. The GAR RNA domain interacting with the tether includes U1061, the backbone of U1060, and G1059. Any molecule that could modify the relative positioning of the L11 NTD and CTD may disrupt the funtion of the molecular switch and thereby modulate the function of the GAR. For example, this could be performed by a molecule interacting with the L11 tether domain and/or the GAR in close contact with the tether. Any molecule that could interact with both the C terminal and N terminal lobes of L11 and stabilize one orientation of the lobes relative to the alternate orientation may disrupt the function of the molecular switch and thereby disrupt the function of the GAR.

Computer simulation techniques similar to those described above for modeling the L11 N terminus:GAR RNA interface may be used to determine which parameters of the 4 way junction and Cd⁺⁺ coordination site may be exploited in designing or screening compounds that interact with or disrupt the junction/Cd⁺⁺ coordination site and/or modify the activity of the GTPase.

3. The GAR RNA:EF-G Interface

The interaction of translational elongation factor EF-G with the ribosome has been mapped by directed hydroxyl radical probing (Wilson & Noller, 1998, Cell 92: 131-139). This approach indicated that GAR RNA residues in the region of A1070 and in the region of C1100 are involved in the binding of EF-G. A1070 is included in the GAR RNA:L11 N terminal interface discussed as a target above, but is nonetheless of interest in approaches aimed at disrupting or modifying EF-G binding.

The crystal structure coordinates disclosed in Table II and discussed herein above define the structure of the GAR RNA at C1100, and the RNA bases and L11 amino acid residues around it. This structure defines a novel target for the design and/or selection of molecules that can disrupt the GAR RNA:EF-G interaction.

Computer simulation techniques similar to those described above for modeling the L11 NTD: GAR RNA interface may be used to determine which parameters of the binding pocket may be exploited in designing or screening compounds that modify the relative positioning of L11 NTD and CTD and modify the activity of the GTPase.

4. RNA Folding/Stability

The X-ray crystal structure coordinates disclosed in Table II and discussed herein above define the structure of a novel “4 way junction” fold in the ribosomal RNA in the L11/GARcomplex. The data further reveal the importance of a Cd⁺⁺ ion that occupies the center of the four way junction between bases 1056-1057 and 1086-1087. Because a ligand that can modify the folding of the RNA would be predicted to disrupt or otherwise modify the GTPase activity, this folded RNA structure represents a strong target for development of inhibitors or activators of the GTPase. Because the Cd⁺⁺ ion likely stabilizes the unusual RNA fold, the region defined by those amino acid and RNA residues interacting with the Cd⁺⁺ ion is particularly attractive as a target.

5. The L11 C Terminus:GAR RNA Interface

The domain comprising the interaction surface of the C terminal lobe of L11 and the GAR RNA is defined by the crystal structure data disclosed in Table II (X-ray co-ord's) and is described herein above. The crystal data indicate that the C terminus of L11 interacts very tightly with the GAR RNA. As such, the interaction may be difficult to disrupt. Computer simulation techniques similar to those described above for modeling the L11 N terminus:GAR RNA interface may be used to determine which parameters of the binding pocket may be exploited in designing or screening compounds that interact with the C terminal L11: GAR RNA interface domain and/or modify the activity of the GTPase.

The analysis of the various targets made possible by the crystal structure coordinate data disclosed herein, including the GAR RNA:L11 interface, the GAR RNA:L11: Micrococcin interface, the L11 N terminus:L11 C terminus interface (with or without GAR RNA), the GAR RNA:EF-G interface, and the GAR RNA:L11:EF-G interface, may be used to define specific features (e.g., a pattern of hydrogen bond donors and acceptors, a hydrophobic patch, etc.) of these targets. These features in turn define a three dimensional “pharmacophore” pattern. This pattern can then be used to screen virtual libraries of existing compounds, such as the Available Chemical Directory (MDL, Inc.) for compounds exhibiting the desired combination of chemical entities. In this screening, the quality of fit of such entities or compounds to the target site may be judged by a scoring function. The scoring function can account for shape complementarity (Katchalski-Katzir et al., 1992, Proc. Natl. Acad. Sci. USA, 89, pp.2195-2199.), estimated interaction energy (Meng et al., 1992, J.Comp. Chem., 13, pp. 505-524), surface accessibility, or a combination of these (see for example, Bohm, 1994, J. Comp. Aided Mol. Design, pp.243-256). A program such as Catalyst (MSI) can perform this task. Libraries of compounds can also be screened virtually using the coordinates of the targets and molecular docking programs such as DOCK (UCSF) or FLEXX.

Once one or more compounds have been identified as potential ligands using any of the methods described above, they may be screened for biological activity.

A variety of assays can be used to evaluate the activity of compounds designed to inhbit the activity of the L11/GAR. These include, but are not limited to: inhibition of bacterial growth, inhibition of in vitro protein synthesis using messenger RNA as a template, inhibition of the elongation phase of in vitro protein synthesis using polyU as a template, inhibition of GTP hydrolysis mediated by EF-G as described by Pestka (1970) and Rodnina et al. (1997); activation of GTP hydrolysis mediated by EF-G as described by Cundliffe and Thompson (1981). Binding of EF-G to both the L11/GAR complex and to the sarcin/ricin domain can be measured as described by Munishkin and Wool (1997, Proc. Natl. Acad. Sci. USA 94, 12280-12284; “The ribosome in pieces: Binding of elongation factor EF-G to oligoribonucleotides that mimic the sarcin/ricin and thiostrepton domains of 23S ribosomal RNA”).

In addition, compound interaction with the L11/GAR complex can be evaluated by direct binding assays. Filter binding assays that measure the ability of thiostrepton to cause retention of radiolabelled GAR RNA to nitrocellulose filters have been described by GuhaThakurta and Draper (1999; Biochemistry, 38, 3633-3640 “Protein-RNA sequence covariation in a ribosomal protein-rRNA complex”). As revealed herein, these assays can be modified to evaluate small molecules that competitively inhibit the binding of thiostrepton and/or micrococcin to the L11/GAR complex or to GAR. For molecules that do not themselves cause filter retention, the RNA may be labelled. For molecules that do cause filter retention, the RNA and/or RNA-protein complex can be immobilised on a solid support and the binding of radiolabelled thiostrepton or other known L11/GAR binding compound can be measured. Thiostrepton or micrococcin can be labelled metabolically by incorporation of 35S, 3H or 14C labelled precursors, or post-synthetically by modifcation of the molecule with radiolablled precursors. In addition thiostrepton or micrococcin can be labelled with another detectable group, including, but not limited to, fluorescent and luminescent groups.

Displacement assays can also be performed by using as reporter molecules any labelled molecule that binds to the L11/GAR complex or GAR RNA with an affinity of 50 uM or less. Suitable reporters include, but are not limited to, oligonucleotides, peptides and oligonucleotide-peptide conjugates.

Libraries for Screening According to the Invention

Inhibitors and/or activators identified according to the methods of the invention may be provided from libraries of compounds available from a number of sources or may be derived by combinatorial chemistry approaches known in the art. Such libraries include but are not limited to the available Chemical Directory, Maybridge, and natural product collections.

Compounds identified as ligands using the methods described herein may be further optimized to improve binding activity. Using the docked models of the known ligands thiostrepton and micrococcin, it is possible to identify structures of the ligand that may be altered to improve binding affinity. Similarly, features of a ligand that are identified as unimportant for binding may be excluded to reduce the molecular weight of the ligand.

EXAMPLES

In order that the invention described herein may be more fully understood, the following examples are set forth. It should be understood that these examples are for illustrative purposes only and are not to be construed as limiting this invention in any manner.

Example 1 Preparation and Analysis of L11/GAR RNA Crystal

A. Sample Preparation

The gene for T. maritima ribosomal protein L11 was cloned and overexpressed in E. coli using the T7-based expression system (Studier et al., 1990). The protein was purified b a combination of cation-exchange, hydroxylapatite and size-exclusion chromatography as reported for the purification of ribosomal protein S7 (Wimberly et al., 1997). For cocrystallization with RNA, the protein was dialysed into a buffer A containing 0.1 M KCl, 5 mM Na-cacodylate pH 6.0, 0.1 mM Na2EDTA, 1 mM DTT. A fragment of RNA corresponding to nucleotides 1111-1168 of T. maritima 23S rRNA was synthesized by in vitro run-off transcription from a linearized plasmid using T7 RNA polymerase. The plasmid contained the following elements: a T7 promoter, a self-cleaving hammerhead ribozyme to generate a homogeneous RNA 5′ end (Price et al., 1995), a template for the target RNA sequence, and a Pst I site used for plasmid linearization. RNA was purified on denaturing polyacrylamide slab gels, eluted, concentrated by ethanol precipitation, and dialyzed into buffer A. The RNA was reannealed by heating to 90° C. and slow cooling. L11 protein was added to yield a 1:1 RNA:protein mixture, which was concentrated to 0.15 mM in each component for crystallization experiments.

B. Crystallization and Structure Determination

Crystals of the complex were obtained at 4° C. using the hanging drop technique. The equimolar mixture of L11 and RNA in dialysis buffer A was mixed with an equal volume of well solution (25% glycerol, 15% PEG 4000, 0.2 M KCl, 50 mM MgCl2, 20 mM CdCl2, 1 mM DTT, 50 mM Tris pH 7.5 at 22° C.). The crystals were in the space group P212121, with cell dimensions of a=63.9 Å, b=84.3 Å and c=155.5 Å, and diffracted to better than 2.6 Å resolution using a synchrotron source. Diffraction data were collected under cryogenic conditions, and the crystals were flash-frozen by plunging into liquid nitrogen. For mercury derivatization, crystals were soaked for 24 hours in the well solution containing 1 mM CH3HgNO3 but lacking DTT. Efforts to obtain cocrystals of RNA with selenomethione-substituted L11 were unsuccessful, apparently because the preparation of selenomethionyl L11 used was at least partly misfolded.

The structure was solved using a multiwavelength anomalous diffraction (MAD) experiment (Hendrickson, 1991) on the methylmercury derivative. Straightforward isomorphous replacement was not possible because the derivative is not isomorphous with native crystals. Because the mercury L11 edge does not have a significant white line, data were collected at just two wavelengths, the inflection point of the mercury edge at 1.01 Å and a remote wavelength at 0.98 Å. This remote wavelength is near the maximum f″ for accurate measurement of anomalous differences, and is also sufficiently remote from the inflection point to give useful isomorphous differences. Data were collected from a single flash-cooled crystal at beamline X12-C of the NSLS. To optimize measurement of anomalous differences, we used the inverse beam method in which pairs of sweeps separated by 180 degrees in were collected every 30 degrees. The data were integrated and scaled using the HKL suite of programs (Otwinowski and Minor, 1997).

Phasing was done by treating MAD as a special case of MIR (Ramakrishnan and Biou, 1997; Ramakrishnan et al., 1993). Local scaling of the data, determination of initial heavy atom sites, and initial phasing was done using the program SOLVE (Terwilliger and Berendzen, 1999). Subsequent phasing was done using the program SHARP (de la Fortelle and Bricogne, 1997). A significant improvement in phasing was obtained by including several well-ordered cadmium sites in a final round of SHARP heavy atom refinement. Each round of phasing was followed by density modification with Solomon (Abrahams and Leslie, 1996). The unaveraged, solvent-flattened map revealed virtually unbroken main-chain density for the RNA and the L11 C-terminal domains of both complexes in the asymmetric unit, which were easily built using the program O (Jones and Kjeldgaard, 1997). Twofold non-crystallographic symmetry (NCS) averaging followed by solvent flattening was then carried out using NCS and solvent masks based on the RNA and C-terminal domain coordinates. The resulting map was of high quality and revealed a few minor building errors, but the L11 N-terminal domain density was still of insufficient quality to permit unambiguous fitting. Interpretation of the density for the entire L11 N-terminal domain was possible only from iterative rounds of refinement and 2F_(o)-F_(c) maps. The final model was refined to an Rfree of 27% using the program X-PLOR (Brünger, 1988) using standard parameters for protein (Engh and Huber, 1991) and nucleic acid (Parkinson et al., 1996) structure refinement. Magnesium and cadmium ions were distinguished by inspection of an anomalous difference Fourier map. Magnesium ions were distinguished from ordered waters by inspection of 2F_(o)-F_(c) maps, in which an octahedral coordination of magnesium by water and RNA ligands was often visible. A Ramachandran plot of the protein revealed only three outliers, Lys93 in the C-terminal domain, which clearly has a positive phi angle in the original experimental map, and Ala21 and Val24 in the N-terminal domain, for which the side chains are very poorly defined. Details of the data collection, phasing and refinement are shown in Table I.

Example 2 Use of the Ribosomal Protein L11/GAR Crystal Structure Coordinates to Design a Modulator of GAR Activity

Example 1 illustrates the methods involved in generating a structure of the L11/GAR RNA complex at atomic resolution. The crystal structure data make clear, for example, that the N terminus of L11 can move within the context of the L11/GAR. Because the crystal structure data, in conjunction with available biochemical data, point to a molecular switch mechanism whereby the relative position of the L11 N terminal lobe determines the activity of the GAR, it is of interest to select or design compounds that can effect restriction of modification of this movement.

1. Modeling the movement and interactions of the L11 N terminal lobe.

One of skill in the art may use the crystal structure coordinates, along with the software package Quanta to interactively model the movement of the L11 N terminus as a rigid body relative to the other GAR surfaces. This model will provide information on the many possible interactions between the L11 N terminus and the other amino acid and nucleotide residues comprising the GAR, as well as solvent interactions.

To develop a more detailed picture of the molecular interactions involving the L11 N terminal lobe in the GAR, the software packages CHARMM and AMBER may be applied by one of skill in the art to the crystal structure coordinates. These will provide a molecular dynamics simulation of the N terminal lobe of L11 within the L11/GAR RNA complex.

Similarly, CHARMM may be used by one of skill in the art to provide a normal mode dynamics simulation of the L11 N terminal lobe within the L11/GAR context.

Finally, the crystal structure coordinates allow the use of software packages such as DOCK or to simulate docking of the known GAR modulators thiostrepton and micrococcin with the GAR, thereby providing a finely detailed description of those interactions within the GAR critical to its function.

Used in combination, the software approaches described above can manipulate the crystal structure coordinate data to provide a very high resolution three dimensional model of the L11 N terminal lobe and its interactions with other portions of the GAR including van der Waals contacts, electrostatic interactions and hydrogen bonding opportunities.

2. Design of a candidate modulator compound.

Once a detailed three dimensional model of the L11/GAR has been created as described above, one of skill in the art may use the grid-based software approaches GRID or CERIUS II, and MCSS techniques (see, for example, Castro et al., 1999, Medicinal Chem. Res. 9: 98-107) to map favorable interaction positions for functional groups such as protons, hydroxyl groups, anime groups, divalent cations, aromatic and aliphatic functional groups, acetamide, methanol, etc. Once a set of favorable groups for each position are predicted, one of skill in the art may take one of two different approaches to designing a modulator.

First, one may assemble the moieties predicted to interact with the various critical parts of the L11/GAR surfaces into a single molecule. This may be accomplished by one of skill in the art using the software packages CAVEAT, MACCS-3D or HOOK. One of skill in the art may then synthesize the selected compounds for in vitro and in vivo testing for effects on GAR activity.

Alternatively, one may screen a database, such as the MDL Available Chemical Directory to potentially find existing compounds that combine the required moieties in a favorable conformation for GAR binding. The software packages Catalyst, DOCK and FLEXX may be used to advantage for this purpose by one of skill in the art.

Example 3 Assaying the Activity of a Candidate Modulator by Displacement of Thiostrepton from the GAR

Thiostrepton binding to GTPase centre RNA can be monitored by a filter binding assays (Uchiumi et al., 1995, Biol. Chem., 270(50):29889-93; Draper et al., 1988, Methods Enzymol., 164:203-20). The filter binding assay can be transformed to a 96-well format using Millipore MHAB (mixed cellulose ester) 96-well plates. The dissociation constant for the thiostrepton/GTPase centre-59 mer complex of 1 uM is in good accordance with the literature. Additionally, filter binding can show the cooperativity in binding of thiostrepton and L11. Thermotoga maritima ribosomes are known to be sensitive to thiostrepton (Londei et al., 1988, J. Bacteriol., 170(9):4353-60), although 100-fold less than B. stearothermophilus ribosomes. The affinity of thiostrepton for Thermotoga GTPase center RNA in vitro has not yet been determined.

³⁵S- or ³²P-labelled RNA is prepared by transcription in the presence of radiolabelled nucleotides. The labelled RNAs are purified by gel electrophoresis or chromatography by reverse-phase. For filter binding assays the RNA are renatured and 3,000 to 10,000 cpm of RNA are used per assay. Association constants between RNA and thiostrepton in the presence or absence of inhbitor are determined in 100 ul reactions containing 10 mM Tris-HCl (pH 7.4), 3 mM MgCl2, 175 mM NH4Cl and 5% v/v DMSO. The reaction mixtures also contain between 2 and 10 uM thiostrepton and a range of inhibitor concentrations up to 50 uM. The RNA-thiostrepton-inhibitor mixtures are incubated for 15 min at room temperature (approximately 22° C.) prior to filtration through the nitrocellulose filter membranes.

For high-throughput screening, the assay can be performed in 96-well filter plates (Multiscreen HA filtration plates, Millipore) with nitrocellulose membranes incorporated into the bottom of each well and filtered using Multiscreen vacuum Manifold (Millipore). The filters are washed once with 100 ul buffer before determining their radioactivities using Microbeta Liquid Scintillation Counter (Wallac).

The relative amounts of RNA retained in the presence and absence of inhibitor can be determined by quantitation of the radioactivity on each filter. Compounds that reduce the amount of RNA retained on the filter in a concentration dependent manner are competitive inhibitors of thiostrepton binding to the RNA.

Example 4 Binding Assays with Radioactive Thiostrepton

Binding of [³⁵S]-labelled thiostrepton to 23S RNA and ribosomes has been shown by gel filtration of RNA and RNA/L11 complexes together with thiostrepton as well as by charcoal (Norit) absorption of unbound [³⁵S]thiostrepton (Thompson et al., 1979. Eur. J. Biochem., 98(1):261-5). Using equilibrium dialysis, the dissociation constant of thiostrepton/23S RNA has been determined as 0.23 uM (Thompson & Cundliffe, 1991, Biochimie 1991, 73(7-8):1131-5). The affinity to intact ribosomes is 100-1000fold higher (Pestka et al., 1976, Anal. Biochem., 71(1):137-42).

The ability of biotinylated GTPase centre-59 mer to bind thiostrepton (as shown by filter binding) gives a route for a displacement assay employing displacement of [³H]-labelled thiostrepton (Amersham) from an immobilised GTPase centre RNA/L11 complex or from ribosomes.

Example 5 Luciferase Translation Assay

Using an E. coli S30 lysate and luciferase mRNA (Promega E. coli S30 extract system for linear templates; Cat No: L1030) the active luciferase protein can be synthesised in vitro and the relative amount of luciferase generated is monitored in a bioluminescence assay. The mRNA is either provided by coupled transcription/translation using the linearized plasmid pBESTLucTM as a template or by adding purified luciferase mRNA.

The addition of ribosome-inactivating compounds or antibiotics directed to protein biosynthesis (thiostrepton, kanamycin, chloramphenicol and others) leads to a decrease in yield of active luciferase compared to the control. Compound and antibiotic titrations can be used to determine IC50 values (see Langer et al., 1996, Anal. Biochem., 243(1):150-3).

Example 6 Additional Translation Assays

An S30 transcription/translation system (Promega) can be used to incorporate [³⁵S]methionine into protein translated from MS2 phage RNA. Translation yield is quantified after alkaline hydrolysis by acid precipitation of the synthesised peptides and scintillation counting. Whole-cell protein synthesis can be measured adding [¹⁴C]leucine to exponentially growing E. coli cells and measuring the incorporation into protein by alkaline hydrolysis and TCA precipitation (see Shinabarger et al., 1997, Antimicrob. Agents Chemother., 41(10):2132-6).

Example 7 Assay of Translation Elongation

Translation elongation is measured using isolated polysomes from E. coli MRE600 (Girbes et al., 1979, Methods Enzymol., 59:353-62), S100 extract from E. coli and poly(U) (Sigma) as a template (e.g. Grise-Miron et al., 1981, Biochim. Biophys. Acta, 656(1):103-10). Incorporation of [³H]phenylalanine into polyphenylalanine is quantified by acid precipitation and scintillation counting.

Example 8 In vitro EF-G-dependent GTP Hydrolysis

Thiostrepton acts on the tRNA translocation step of translation elongation and inhibits elongation factor G (EF-G)-dependent GTP hydrolysis (Pestka et al., 1970, Biochem. Biophys. Res. Commun., 40(3):667-74; Rodnina et al., 1997, Nature, 385:37-41). EF-G is known to contact the GTPase centre region of 23S RNA (Skold et al., 1983, Nucleic Acids Res., 11(14):4923-32; Moazed & Noller, 1986, Nature, 334:362-4). 70S ribosomes support GTP hydrolysis by EF-G in the absence of other factors normally necessary for protein synthesis. Uncoupled GTP hydrolysis and the inhibition by thiostrepton or other compounds can be measured in an assay containing purified ribosomes, purified EF-G and gamma-[³²P]-GTP (Stark&Cundliffe, 1979, J. Mol. Biol., 134(4):767-9; Lill et al., 1988, EMBO J., 8(12):3933-8).

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TABLE I Crystallographic statistics Data collection λ1 (1.008 Å) λ2 (0.980 Å) Reflections  104,096  107,907 Independent reflections   25,927   25,894 Completeness  99% (98%)*  98% (97%)* Mean (I/sigma (I))   20 (4.2)*   20 (4.5)* R_(sym) 4.1% (17%)* 4.2% (17%)* d_(min) (Å)      2.6      2.6 ƒ′ (Hg) (electrons)**   −12.0    −9.0 ƒ″ (Hg) (electrons)**      6.4      8.0 ƒ′ (Cd) (electrons)**    −0.42    −0.46 ƒ″ (Cd) (electrons)**      2.3      2.2 λ1-λ2 λ1 λ2 Phasing isomorphous anomalous anomalous R_(Cullis) (centrics) 0.50 — — R_(Kraut) (acentrics) 0.09 0.025 0.023 Phasing power 1.25 1.54 1.52 (acentrics) Mean figure of 0.39 merit (acentrics) Mean figure of 0.23 merit (centrics) Refinement Number of atoms 4196 (2474 RNA, 1524 protein, 198 water & ions) R_(cryst)/R_(free) (5% of data) 0.228/0.253 RMS deviation from ideal geometry bond lengths 0.005 Å bond angles 1.2 degrees *Values in parentheses refer to the highest resolution shell. **Values after SHARP refinement.

TABLE II HEADER RNA-PROTEIN COMPLEX 14-APR-99 ONHOLD ONE-YEAR HOLD; EXPERIMENTAL DATA, ONE-YEAR HOLD TITLE CRYSTAL STRUCTURE OF THE RIBOSOMAL PROTEIN L11-RNA COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: 23S RIBOSOMAL RNA; COMPND 3 CHAIN: C, D; COMPND 4 FRAGMENT: FRAGMENT 1051-1108; COMPND 5 MUTATION: U1108C; COMPND 6 OTHER_DETAILS: COVALENT MERCURY LIGAND AT U1061; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: RIBOSOMAL PROTEIN L11; COMPND 9 CHAIN: A, B; COMPND 10 ENGINEERED: YES; COMPND 11 OTHER_DETAILS: COVALENT MERCURY LIGAND AT CYS39 SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: THERMOTOGA MARITIMA; SOURCE 3 OTHER_DETAILS: IN VITRO TRANSCRIBED RNA; SOURCE 4 MOL_ID: 2; SOURCE 5 ORGANISM_SCIENTIFIC: THERMOTOGA MARITIMA; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); SOURCE 8 EXPRESSION_SYSTEM_PLASMID: PET13A; SOURCE 9 OTHER_DETAILS: RECOMBINANT PROTEIN KEYWDS RNA-PROTEIN COMPLEX, RNA, RIBOSOME, TRANSLOCATION, KEYWDS 2 THIOSTREPTON EXPDTA X-RAY DIFFRACTION AUTHOR B. T. WIMBERLY, R. GUYMON, J. P. MCCUTCHEON, S. W. WHITE, AUTHOR 2 V. RAMAKRISHNAN REMARK 1 REMARK 1 REFERENCE 1 REMARK 1 AUTH Y. XING, D. DRAPER REMARK 1 TITL COOPERATIVE INTERACTIONS OF RNA AND THIOSTREPTON REMARK 1 TITL 2 ANTIBIOTIC WITH TWO DOMAINS OF RIBOSOMAL PROTEIN REMARK 1 TITL 3 L11 REMARK 1 REF BIOCHEMISTRY  V. 35 1581 1996 REMARK 1 REFN ASTM BICHAW US ISSN 0006-2960 0033 REMARK 1 REFERENCE 2 REMARK 1 AUTH J. THOMPSON, F. SCHMIDT, E. CUNDLIFFE REMARK 1 TITL SITE OF ACTION OF A RIBOSOMAL RNA METHYLASE REMARK 1 TITL 2 CONFERRING RESISTANCE TO THIOSTREPTON REMARK 1 REF J. BIOL.CHEM.  V. 257 7915 1982 REMARK 1 REFN ASTM JBCHA3 US ISSN 0021-9258  0071 REMARK 1 REFERENCE 3 REMARK 1 AUTH J. THOMPSON, E. CUNDLIFFE, M. STARK REMARK 1 TITL BINDING OF THIOSTREPTON TO A COMPLEX OF 23S RNA REMARK 1 TITL 2 WITH RIBOSOMAL PROTEIN L11 REMARK 1 REF EUR. J. BIOCHEM.  V. 98 261 1979 REMARK 1 REFN ASTM EJBCAI IX ISSN 0014-2956  0262 REMARK 2 REMARK 2 RESOLUTION. 2.57 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM: X-PLOR 3.851 REMARK 3 AUTHORS: BRUNGER REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS): 2.57 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS): 20.0 REMARK 3 DATA CUTOFF  (SIGMA(F)): 0.0 REMARK 3 DATA CUTOFF HIGH  (ABS(F)): 1000000.0 REMARK 3 DATA CUTOFF LOW  (ABS(F)): 0.001 REMARK 3 COMPLETENESS (WORKING + TEST) (%): 95.5 REMARK 3 NUMBER OF REFLECTIONS:  49313 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD:  THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION: RANDOM REMARK 3 R VALUE  (WORKING SET): 0.219 REMARK 3 FREE R VALUE  : 0.254 REMARK 3 FREE R VALUE TEST SET SIZE (%): 4.9 REMARK 3 FREE R VALUE TEST SET COUNT: 2398 REMARK 3 ESTIMATED ERROR OF FREE R VALUE: 0.005 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 6 REMARK 3 BIN RESOLUTION RANGE HIGH (A): 2.57 REMARK 3 BIN RESOLUTION RANGE LOW (A): 2.73 REMARK 3 BIN COMPLETENESS (WORKING + TEST) (%): 86.2 REMARK 3 REFLECTIONS IN BIN (WORKING SET): 7101 REMARK 3 BIN R VALUE (WORKING SET): 0.386 REMARK 3 BIN FREE R VALUE  : 0.432 REMARK 3 BIN FREE R VALUE TEST SET SIZE (%): 4.5 REMARK 3 BIN FREE R VALUE TEST SET COUNT : 331 REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE: 0.024 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 1524 REMARK 3 NUCLEIC ACID ATOMS : 2474 REMARK 3 HETEROGEN ATOMS : 35 REMARK 3 SOLVENT ATOMS : 142 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2): 58.8 REMARK 3 MEAN B VALUE (OVERALL, A**2): 42.8 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2): NULL REMARK 3 B22 (A**2): NULL REMARK 3 B33 (A**2): NULL REMARK 3 B12 (A**2): NULL REMARK 3 B13 (A**2): NULL REMARK 3 B23 (A**2): NULL REMARK 3 REMARK 3 ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM LUZZATI PLOT (A): 0.32 REMARK 3 ESD FROM SIGMAA (A): 0.45 REMARK 3 LOW RESOLUTION CUTOFF (A): 5.00 REMARK 3 REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM C-V LUZZATI PLOT (A): 0.39 REMARK 3 ESD FROM C-V SIGMAA (A): 0.50 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. REMARK 3 BOND LENGTHS (A): 0.005 REMARK 3 BOND ANGLES (DEGREES): 1.0 REMARK 3 DIHEDRAL ANGLES (DEGREES): 28.8 REMARK 3 IMPROPER ANGLES (DEGREES): 1.40 REMARK 3 REMARK 3 ISOTROPIC THERMAL MODEL: RESTRAINED REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA REMARK 3 MAIN-CHAIN BOND (A**2): 3.59; 1.50 REMARK 3 MAIN-CHAIN ANGLE (A**2): 5.28; 2.00 REMARK 3 SIDE-CHAIN BOND (A**2): 6.59; 2.00 REMARK 3 SIDE-CHAIN ANGLE (A**2): 9.24; 2.50 REMARK 3 REMARK 3 NCS MODEL: RESTRAINTS REMARK 3 REMARK 3 NCS RESTRAINTS.  RMS SIGMA/WEIGHT REMARK 3 GROUP 1 POSITIONAL (A): 0.07; 50 REMARK 3 GROUP 1 B-FACTOR (A**2): 5.51; 2 REMARK 3 GROUP 2 POSITIONAL (A): 0.07; 50 REMARK 3 GROUP 2 B-FACTOR (A**2): 5.51; 2 REMARK 3 REMARK 3 PARAMETER FILE 1: DNA-RNA-MULTI-ENDO.PARAM REMARK 3 PARAMETER FILE 2: PROTEIN_REP.PARAM REMARK 3 TOPOLOGY FILE 1: DNA-RNA-MULTI-ENDO.TOP REMARK 3 TOPOLOGY FILE 2: TOPHCSDX.PRO REMARK 3 TOPOLOGY FILE 3: TOPH19.SOL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NCS RESTRAINTS APPLIED TO RNA REMARK 3 THROUGHOUT, NOT TO PROTEIN REMARK 5 REMARK 5 WARNING REMARK 5: THIS IS LAYER 1 RELEASE. REMARK 5 REMARK 5 PLEASE NOTE THAT THIS ENTRY WAS RELEASED AFTER DEPOSITOR REMARK 5 CHECKING AND APPROVAL BUT WITHOUT PDB STAFF INTERVENTION. REMARK 5 AN AUXILIARY FILE, AUX.RPT, IS AVAILABLE FROM THE REMARK 5 PDB FTP SERVER AND IS ACCESSIBLE THROUGH THE 3DB BROWSER. REMARK 5 THE FILE CONTAINS THE OUTPUT OF THE PROGRAM WHAT_CHECK AND REMARK 5 OTHER DIAGNOSTICS. REMARK 5 REMARK 5 NOMENCLATURE IN THIS ENTRY, INCLUDING HET RESIDUE NAMES REMARK 5 AND HET ATOM NAMES, HAS NOT BEEN STANDARDIZED BY THE PDB REMARK 5 PROCESSING STAFF. A LAYER 2 ENTRY WILL BE RELEASED SHORTLY REMARK 5 AFTER THIS STANDARDIZATION IS COMPLETED AND APPROVED BY THE REMARK 5 DEPOSITOR. THE LAYER 2 ENTRY WILL BE TREATED AS A REMARK 5 CORRECTION TO THIS ONE, WITH THE APPROPRIATE REVDAT RECORD. REMARK 5 REMARK 5 FURTHER INFORMATION INCLUDING VALIDATION CRITERIA USED IN REMARK 5 CHECKING THIS ENTRY AND A LIST OF MANDATORY DATA FIELDS REMARK 5 ARE AVAILABLE FROM THE PDB WEB SITE AT REMARK 5 HTTP://WWW.PDB.BNL.GOV/. REMARK 6 REMARK 6 THE ASYMMETRIC UNIT CONTAINS TWO L11-RNA COMPLEXES. COMPLEX REMARK 6 1 CONSISTS OF CHAINS A AND C, AND COMPLEX 2 CONSISTS OF REMARK 6 CHAINS B AAND D. RESIDUES 1-7 AND 141 OF CHAIN A ARE REMARK 6 DISORDERED. THE DENSITY FOR RESIDUES 8-70 OF CHAIN A WAS OF REMARK 6 SIGNIFICANTLY LOWER QUALITY THAN THE DENSITY FOR THE REMARK 6 REMAINDER OF THE ASYMMETRIC UNIT, AND THE QUALITY OF THE REMARK 6 MODEL FOR THIS N-TERMINAL DOMAIN IS LOWER THAN THAT OF THE REMARK 6 C-TERMINAL DOMAIN (RESIDUES 71-140). RESIDUES 1-70 AND 141 REMARK 6 OF CHAIN B ARE DISORDERED. THE RNA IS NUMBERED WITH THE E. REMARK 6 COLI NUMBERING TO FACILITATE COMPARISON WITH THE EXTENSIVE REMARK 6 BIOCHEMICAL DATA ON THE E. COLI RNA-L11 SYSTEM. THE E. COLI REMARK 6 RNA NUMBERING IS ALSO USED IN THE PRIMARY REFERENCE REMARK 6 DESCRIBING THIS STRUCTURE. REMARK 7 REMARK 7 TER REMARK 7 ASP: TERMINAL RESIDUE NOT SEEN IN MAPS REMARK 7 ASP: TERMINAL RESIDUE NOT SEEN IN MAPS REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE:  X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 24-SEP-1998 REMARK 200 TEMPERATURE (KELVIN): 100 REMARK 200 PH  : 8.3 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N): Y REMARK 200 RADIATION SOURCE : NSLS REMARK 200 BEAMLINE  : X12C REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L): M REMARK 200 WAVELENGTH OR RANGE (A): 0.98, 1.01 REMARK 200 MONOCHROMATOR  : SI CRYSTAL REMARK 200 OPTICS  : MIRRORS REMARK 200 REMARK 200 DETECTOR TYPE  : BRANDEIS 1K X 1 K CCD REMARK 200 DETECTOR MANUFACTURER : NULL REMARK 200 INTENSITY-INTEGRATION SOFTWARE: DENZO REMARK 200 DATA SCALING SOFTWARE : SCALEPACK REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS: 49313 REMARK 200 RESOLUTION RANGE HIGH (A): 2.57 REMARK 200 RESOLUTION RANGE LOW (A): 20.0 REMARK 200 REJECTION CRITERIA (SIGMA(I)): 0 REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%): 95.5 REMARK 200 DATA REDUNDANCY : 4.0 REMARK 200 R MERGE  (I): NULL REMARK 200 R SYM  (I): 0.041 REMARK 200 &LT; I/SIGMA(I)&GT; FOR THE DATA SET: 20 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A): 2.57 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A): 2.73 REMARK 200 COMPLETENESS FOR SHELL (%): 86.2 REMARK 200 DATA REDUNDANCY IN SHELL: 3.4 REMARK 200 R MERGE FOR SHELL (I): NULL REMARK 200 R SYM FOR SHELL (I): 0.17 REMARK 200 &LT; I/SIGMA(I)&GT; FOR SHELL : 4.3 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: MAD REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MAD REMARK 200 SOFTWARE USED: NULL REMARK 200 STARTING MODEL: NULL REMARK 200 REMARK 200 REMARK: TWO WAVELENGTH HG MAD REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 55 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.1 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: REMARK 280 25% GLYCEROL, 15% PEG 4000, 50 MM TRIS PH 7.5, REMARK 280 50 MM MGCL2, 20 MM CDCL2, 0.2 M KCL, REMARK 280 1 MM DITHIOTHREITOL, 4 DEGREES C REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X, Y, Z REMARK 290 2555 1/2 − X, −Y, 1/2 + Z REMARK 290 3555 −X, 1/2 + Y, 1/2 − Z REMARK 290 4555 1/2 + X, 1/2 − Y, −Z REMARK 290 REMARK 290 WHERE NNN -&GT; OPERATOR NUMBER REMARK 290 MMM -&GT; TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 −1.000000 0.000000 0.000000 31.94480 REMARK 290 SMTRY2 2 0.000000 −1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 77.76050 REMARK 290 SMTRY1 3 −1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 42.13010 REMARK 290 SMTRY3 3 0.000000 0.000000 −1.000000 77.76050 REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 31.94480 REMARK 290 SMTRY2 4 0.000000 −1.000000 0.000000 42.13010 REMARK 290 SMTRY3 4 0.000000 0.000000 −1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 295 REMARK 295 NON-CRYSTALLOGRAPHIC SYMMETRY REMARK 295 THE TRANSFORMATIONS PRESENTED ON THE MTRIX RECORDS BELOW REMARK 295 DESCRIBE NON-CRYSTALLOGRAPHIC RELATIONSHIPS AMONG ATOMS REMARK 295 IN THIS ENTRY. APPLYING THE APPROPRIATE MTRIX REMARK 295 TRANSFORMATION TO THE RESIDUES LISTED FIRST WILL YIELD REMARK 295 APPROXIMATE COORDINATES FOR THE RESIDUES LISTED SECOND. REMARK 295 CHAIN IDENTIFIERS GIVEN AS “?” REFER TO CHAINS FOR WHICH REMARK 295 ATOMS ARE NOT FOUND IN THIS ENTRY. REMARK 295 REMARK 295  APPLIED TO  TRANSFORMED TO REMARK 295 TRANSFORM CHAIN RESIDUES CHAIN RESIDUES RMSD REMARK 295 SSS REMARK 295 M 1 C 1051 . . . 1108 D 1051 . . . 1108 0.07 REMARK 295 M 2 A 71 . . . 140 B 71 . . . 140 0.99 REMARK 295 REMARK 295 WHERE SSS -&GT; COLUMNS 8-10 OF MTRIX RECORDS REMARK 295 REMARK 295 REMARK: REMARK 295 NCS RESTRAINTS NOT APPLIED TO PROTEIN REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M = MODEL NUMBER; RES = RESIDUE NAME; C = CHA1N REMARK 465 IDENTIFIER; SSSEQ = SEQUENCE NUMBER; I = INSERTION CODE): REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 2 REMARK 465 LYS A 3 REMARK 465 LYS A 4 REMARK 465 VAL A 5 REMARK 465 ALA A 6 REMARK 465 ALA A 7 REMARK 465 ASP A 141 REMARK 465 ALA B 2 TO ILE B 70 REMARK 465 ASP B 141 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M = MODEL NUMBER; REMARK 470 RES = RESIDUE NAME; C = CHAIN IDENTIFIER; SSEQ = SEQUENCE NUMBER; REMARK 470 I = INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470  G C1051 P O1P O2P REMARK 470  G D1051 P O1P O2P REMARK 550 REMARK 550 SEGID REMARK 550 RNA1, RNA2 REMARK 550 L111, L112 REMARK 600 REMARK 600 HETEROGEN REMARK 600 THERE ARE A TOTAL OF 8 CADMIUM IONS IN THE STRUCTURE REMARK 600 REMARK 600 THERE ARE A TOTAL OF 19 MAGNESIUM IONS IN THE STRUCTURE REMARK 600 REMARK 600 THERE ARE A TOTAL OF 8 METHYLMERCURY REMARK 600 IONS IN THE STRUCTURE. REMARK 600 THE METHYL GROUP HAS NOT BEEN MODELLED REMARK 600 FOR ANY OF THESE IONS. REMARK 600 TWO OF THE IONS ARE COVALENTLY BOUND REMARK 600 TO CYS A 39. REMARK 600 ONE IS COVALENTLY BOUND TO U C 1061. REMARK 600 ONE IS COVALENTLY BOUND TO U D 1061. REMARK 600 REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: TSR REMARK 800 SITE_DESCRIPTION: REMARK 800 PUTATIVE THIOSTREPTON/MICROCOCCIN BINDING SITE REMARK 800 REMARK 800 SITE_IDENTIFIER: TSR REMARK 800 SITE_DESCRIPTION: REMARK 800 PUTATIVE THIOSTREPTON/MICROCOCCIN BINDING SITE REMARK 800 REMARK 800 SITE_IDENTIFIER: TSR REMARK 800 SITE_DESCRIPTION: REMARK 800 PUTATIVE THIOSTREPTON/MICROCOCCIN BINDING SITE REMARK 800 DBREF A 8 140 SWS P29395 RL11_THEMA 1 141 DBREF B 71 140 SWS P29395 RL11_THEMA 1 141 DBREF C 1051 1108 PDB  1051 1108 DBREF D 1051 1108 PDB  1051 1108 SEQADV RES C 1108 GI M67498 1168 ENGINEERED MUTATION SEQADV RES D 1108 GI M67498 1168 ENGINEERED MUTATION SEQRES 1 A 140 ALA LYS LYS VAL ALA ALA GLN ILE LYS LEU GLN LEU PRO SEQRES 2 A 140 ALA GLY LYS ALA THR PRO ALA PRO PRO VAL GLY PRO ALA SEQRES 3 A 140 LEU GLY GLN HIS GLY VAL ASN ILE MET GLU PHE CYS LYS SEQRES 4 A 140 ARG PHE ASN ALA GLU THR ALA ASP LYS ALA GLY MET ILE SEQRES 5 A 140 LEU PRO VAL VAL ILE THR VAL TYR GLU ASP LYS SER PHE SEQRES 6 A 140 THR PHE ILE ILE LYS THR PRO PRO ALA SER PHE LEU LEU SEQRES 7 A 140 LYS LYS ALA ALA GLY ILE GLU LYS GLY SER SER GLU PRO SEQRES 8 A 140 LYS ARG LYS ILE VAL GLY LYS VAL THR ARG LYS GLN ILE SEQRES 9 A 140 GLU GLU ILE ALA LYS THR LYS MET PRO ASP LEU ASN ALA SEQRES 10  A 140 ASN SER LEU GLU ALA ALA MET LYS ILE ILE GLU GLY THR SEQRES 11  A 140 ALA LYS SER MET GLY ILE GLU VAL VAL ASP SEQRES 1 B 140 ALA LYS LYS VAL ALA ALA GLN ILE LYS LEU GLN LEU PRO SEQRES 2 B 140 ALA GLY LYS ALA THR PRO ALA PRO PRO VAL GLY PRO ALA SEQRES 3 B 140 LEU GLY GLN HIS GLY VAL ASN ILE MET GLU PHE CYS LYS SEQRES 4 B 140 ARG PHE ASN ALA GLU THR ALA ASP LYS ALA GLY MET ILE SEQRES 5 B 140 LEU PRO VAL VAL ILE THR VAL TYR GLU ASP LYS SER PHE SEQRES 6 B 140 THR PHE ILE ILE LYS THR PRO PRO ALA SER PHE LEU LEU SEQRES 7 B 140 LYS LYS ALA ALA GLY ILE GLU LYS GLY SER SER GLU PRO SEQRES 8 B 140 LYS ARG LYS ILE VAL GLY LYS VAL THR ARG LYS GLN ILE SEQRES 9 B 140 GLU GLU ILE ALA LYS THR LYS MET PRO ASP LEU ASN ALA SEQRES 10  B 140 ASN SER LEU GLU ALA ALA MET LYS ILE ILE GLU GLY THR SEQRES 11  B 140 ALA LYS SER MET GLY ILE GLU VAL VAL ASP SEQRES 1 C  58 G C U G G G A U G U U G G SEQRES 2 C  58 C U U A G A A G C A G C C SEQRES 3 C  58 A U C A U U U A A A G A G SEQRES 4 C  58 U G C G U A A C A G C U C SEQRES 5 C  58 A C C A G C SEQRES 1 D  58 G C U G G G A U G U U G G SEQRES 2 D  58 C U U A G A A G C A G C C SEQRES 3 D  58 A U C A U U U A A A G A G SEQRES 4 D  58 U G C G U A A C A G C U C SEQRES 5 D  58 A C C A G C HET CD 201 0 HET CD 202 0 HET CD 211 0 HET CD 302 0 HET CD 311 0 HET CD 390 0 HET CD 413 0 HET CD 414 0 SEE REMARK 600 HET MG 210 0 HET MG 214 0 HET MG 215 0 HET MG 223 0 HET MG 225 0 HET MG 226 0 HET MG 228 0 HET MG 257 0 HET MG 273 0 HET MG 318 0 HET MG 326 0 HET MG 354 0 HET MG 360 0 HET MG 365 0 HET MG 375 0 HET MG 380 0 HET MG 385 0 HET MG 397 0 HET MG 437 0 SEE REMARK 600 HET HG 227 0 HET HG 230 0 HET HG 332 0 HET HG 347 0 HET HG 415 0 HET HG 416 0 HET HG 448 0 HET HG 451 0 SEE REMARK 600 HETNAM CD CD HETNAM MG MG HETNAM HG MMC HETSYN CD CADMIUM (II) HETSYN MG MAGNESIUM (II) HETSYN HG METHYLMERCURY ION FORMUL 5 CD 8(CD1 2+) FORMUL 6 MG 19(MG1 2+) FORMUL 7 HG 8(C1 H3 HG1 1+) FORMUL 8 HOH *142(H2 O1) HELIX 1 1 PRO A  26 GLN A  30 1  5 HELIX 2 2 ILE A  35 ALA A  47 1 13 HELIX 3 3 ALA A  75 ALA A  83 1  9 HELIX 4 4 ARG A 102 ASP A 115 1 14 HELIX 5 5 LEU A 121 SER A 134 1 14 HELIX 6 6 ALA B  75 ALA B  83 1  9 HELIX 7 7 ARG B 102 ASP B 115 1 14 HELIX 8 8 LEU B 121 MET B 135 1 15 SHEET 1 A 3 LLE A  9 PRO A  14   0 SHEET 2 A 3 ILE A  53 VAL A  60 -1 N ILE A  58 O ILE A  9 SHEET 3 A 3 PHE A  66 ILE A  70 -1 N ILE A  69 O VAL A 57 SHEET 1 B 2 GLY A  98 THR A 101   0 SHEET 2 B 2 ILE A 137 VAL A 140   1 N GLU A 138 O GLY A 98 SHEET 1 C 2 GLY B  98 VAL B 100   0 SHEET 2 C 2 ILE B 137 VAL B 139   1 N GLU B 138 O GLY B 98 SITE 1 TSR 2 A C 1067 A C 1095 SITE 2 TSR 2 A D 1067 A D 1095 SITE 3 TSR 3 PRO A  22 PRO A  23 PRO A 26 CRYST1 63.890 84.260 155.510 90.00 90.00 90.00 P 21 21 21 8 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.015652 0.000000 0.000000 0.00000 SCALE2 0.000000 0.011868 0.000000 0.00000 SCALE3 0.000000 0.000000 0.006430 0.00000 MTRIX1 1  0.974505  0.101458 −0.200117  −4.54330 1 MTRIX2 1  0.097433 −0.994793 −0.029885  −3.74880 1 MTRIX3 1 −0.202107  0.009626 −0.979316 −50.69290 1 MTRIX1 2  0.973477  0.098780 −0.206364  −4.89630 1 MTRIX2 2  0.098758 −0.995057 −0.010432  −2.89050 1 MTRIX3 2 −0.206374 −0.010225 −0.978420 −50.97240 1 ATOM 1 N GLN A 8 −7.803 −11.096 −9.783 1.00 71.77 L111 N ATOM 2 CA GLN A 8 −8.476 −9.887 −9.223 1.00 79.42 L111 C ATOM 3 C GLN A 8 −8.010 −8.599 −9.897 1.00 80.19 L111 C ATOM 4 O GLN A 8 −6.857 −8.190 −9.748 1.00 77.92 L111 O ATOM 5 CB GLN A 8 −8.212 −9.788 −7.722 1.00 79.86 L111 C ATOM 6 CG GLN A 8 −9.065 −8.752 −7.016 1.00 80.16 L111 C ATOM 7 CD GLN A 8 −9.072 −8.948 −5.518 1.00 80.58 L111 C ATOM 8 OE1 GLN A 8 −8.020 −8.963 −4.881 1.00 82.16 L111 O ATOM 9 NE2 GLN A 8 −10.261 −9.104 −4.946 1.00 79.20 L111 N ATOM 10 N ILE A 9 −8.916 −7.963 −10.634 1.00 81.13 L111 N ATOM 11 CA ILE A 9 −8.604 −6.723 −11.337 1.00 80.39 L111 C ATOM 12 C ILE A 9 −9.312 −5.530 −10.699 1.00 79.13 L111 C ATOM 13 O ILE A 9 −10.338 −5.680 −10.036 1.00 78.96 L111 O ATOM 14 CB ILE A 9 −9.013 −6.804 −12.834 1.00 77.02 L111 C ATOM 15 CG1 ILE A 9 −10.534 −6.778 −12.970 1.00 77.57 L111 C ATOM 16 CG2 ILE A 9 −8.482 −8.080 −13.452 1.00 74.06 L111 C ATOM 17 CD1 ILE A 9 −11.066 −5.495 −13.552 1.00 83.48 L111 C ATOM 18 N LYS A 10 −8.752 −4.343 −10.900 1.00 80.87 L111 N ATOM 19 CA LYS A 10 −9.330 −3.121 −10.360 1.00 77.55 L111 C ATOM 20 C LYS A 10 −9.252 −2.011 −11.400 1.00 74.90 L111 C ATOM 21 O LYS A 10 −8.308 −1.945 −12.191 1.00 69.61 L111 O ATOM 22 CB LYS A 10 −8.590 −2.696 −9.089 1.00 78.72 L111 C ATOM 23 CG LYS A 10 −7.080 −2.607 −9.243 1.00 76.53 L111 C ATOM 24 CD LYS A 10 −6.482 −1.615 −8.256 1.00 76.55 L111 C ATOM 25 CE LYS A 10 −6.047 −2.300 −6.968 1.00 78.93 L111 C ATOM 26 NZ LYS A 10 −4.923 −1.584 −6.296 1.00 81.54 L111 N ATOM 27 N LEU A 11 −10.261 −1.149 −11.403 1.00 72.26 L111 N ATOM 28 CA LEU A 11 −10.311 −0.037 −12.342 1.00 77.13 L111 C ATOM 29 C LEU A 11 −11.286 1.024 −11.852 1.00 78.99 L111 C ATOM 30 O LEU A 11 −12.052 0.790 −10.915 1.00 78.52 L111 O ATOM 31 CB LEU A 11 −10.744 −0.525 −13.728 1.00 77.54 L111 C ATOM 32 CG LEU A 11 −11.051 −2.014 −13.906 1.00 72.58 L111 C ATOM 33 CD1 LEU A 11 −12.511 −2.199 −14.290 1.00 68.73 L111 C ATOM 34 CD2 LEU A 11 −10.128 −2.590 −14.969 1.00 73.75 L111 C ATOM 35 N GLN A 12 −11.255 2.189 −12.489 1.00 80.79 L111 N ATOM 36 CA GLN A 12 −12.144 3.284 −12.120 1.00 82.10 L111 C ATOM 37 C GLN A 12 −13.115 3.582 −13.261 1.00 80.51 L111 C ATOM 38 O GLN A 12 −12.791 4.320 −14.190 1.00 81.39 L111 O ATOM 39 CB GLN A 12 −11.329 4.536 −11.789 1.00 81.65 L111 C ATOM 40 CG GLN A 12 −10.068 4.267 −10.979 1.00 81.34 L111 C ATOM 41 CD GLN A 12 −9.364 5.545 −10.556 1.00 88.15 L111 C ATOM 42 OE1 GLN A 12 −9.445 6.568 −11.239 1.00 89.05 L111 O ATOM 43 NE2 GLN A 12 −8.668 5.493 −9.425 1.00 90.09 L111 N ATOM 44 N LEU A 13 −14.308 3.003 −13.184 1.00 80.02 L111 N ATOM 45 CA LEU A 13 −15.320 3.197 −14.214 1.00 79.90 L111 C ATOM 46 C LEU A 13 −16.345 4.256 −13.818 1.00 81.60 L111 C ATOM 47 O LEU A 13 −16.761 4.331 −12.659 1.00 82.22 L111 O ATOM 48 CB LEU A 13 −16.033 1.873 −14.502 1.00 73.75 L111 C ATOM 49 CG LEU A 13 −15.191 0.615 −14.276 1.00 73.16 L111 C ATOM 50 CD1 LEU A 13 −16.100 −0.586 −14.059 1.00 74.99 L111 C ATOM 51 CD2 LEU A 13 −14.277 0.397 −15.470 1.00 68.58 L111 C ATOM 52 N PRO A 14 −16.759 5.097 −14.783 1.00 80.42 L111 N ATOM 53 CA PRO A 14 −17.745 6.151 −14.511 1.00 76.54 L111 C ATOM 54 C PRO A 14 −19.065 5.553 −14.041 1.00 74.17 L111 C ATOM 55 O PRO A 14 −19.364 4.396 −14.328 1.00 73.53 L111 O ATOM 56 CB PRO A 14 −17.877 6.880 −15.846 1.00 74.99 L111 C ATOM 57 CG PRO A 14 −17.358 5.919 −16.870 1.00 77.83 L111 C ATOM 58 CD PRO A 14 −16.315 5.101 −16.188 1.00 76.88 L111 C ATOM 59 N ALA A 15 −19.844 6.349 −13.317 1.00 75.75 L111 N ATOM 60 CA ALA A 15 −21.128 5.917 −12.774 1.00 82.83 L111 C ATOM 61 C ALA A 15 −21.947 5.008 −13.691 1.00 89.65 L111 C ATOM 62 O ALA A 15 −21.711 3.800 −13.753 1.00 93.73 L111 O ATOM 63 CB ALA A 15 −21.947 7.132 −12.387 1.00 88.09 L111 C ATOM 64 N GLY A 16 −22.921 5.590 −14.387 1.00 94.26 L111 N ATOM 65 CA GLY A 16 −23.761 4.810 −15.282 1.00 98.24 L111 C ATOM 66 C GLY A 16 −23.218 4.696 −16.697 1.00 100.00 L111 C ATOM 67 O GLY A 16 −23.672 5.395 −17.607 1.00 100.00 L111 O ATOM 68 N LYS A 17 −22.239 3.813 −16.881 1.00 99.48 L111 N ATOM 69 CA LYS A 17 −21.621 3.594 −18.187 1.00 98.41 L111 C ATOM 70 C LYS A 17 −20.588 2.467 −18.117 1.00 99.13 L111 C ATOM 71 O LYS A 17 −19.851 2.351 −17.134 1.00 100.00 L111 O ATOM 72 CB LYS A 17 −20.951 4.883 −18.685 1.00 94.26 L111 C ATOM 73 CG LYS A 17 −20.492 5.822 −17.580 1.00 96.55 L111 C ATOM 74 CD LYS A 17 −21.088 7.220 −17.728 1.00 97.02 L111 C ATOM 75 CE LYS A 17 −21.564 7.773 −16.385 1.00 96.31 L111 C ATOM 76 NZ LYS A 17 −20.459 8.345 −15.556 1.00 90.28 L111 N ATOM 77 N ALA A 18 −20.545 1.642 −19.163 1.00 98.71 L111 N ATOM 78 CA ALA A 18 −19.615 0.517 −19.243 1.00 96.77 L111 C ATOM 79 C ALA A 18 −19.707 −0.148 −20.614 1.00 96.63 L111 C ATOM 80 O ALA A 18 −20.502 0.271 −21.453 1.00 98.42 L111 O ATOM 81 CB ALA A 18 −19.932 −0.500 −18.152 1.00 95.01 L111 C ATOM 82 N THR A 19 −18.872 −1.165 −20.837 1.00 96.19 L111 N ATOM 83 CA THR A 19 −18.843 −1.936 −22.089 1.00 98.62 L111 C ATOM 84 C THR A 19 −17.834 −1.538 −23.177 1.00 98.30 L111 C ATOM 85 O THR A 19 −17.439 −2.379 −23.987 1.00 94.28 L111 O ATOM 86 CB THR A 19 −20.250 −2.000 −22.756 1.00 100.00 L111 C ATOM 87 OG1 THR A 19 −21.255 −2.212 −21.753 1.00 100.00 L111 O ATOM 88 CG2 THR A 19 −20.311 −3.135 −23.772 1.00 99.76 L111 C ATOM 89 N PRO A 20 −17.392 −0.267 −23.212 1.00 100.00 L111 N ATOM 90 CA PRO A 20 −16.433 0.087 −24.268 1.00 100.00 L111 C ATOM 91 C PRO A 20 −15.174 −0.778 −24.289 1.00 100.00 L111 C ATOM 92 O PRO A 20 −14.692 −1.220 −23.246 1.00 100.00 L111 O ATOM 93 CB PRO A 20 −16.117 1.561 −23.995 1.00 100.00 L111 C ATOM 94 CG PRO A 20 −16.510 1.782 −22.568 1.00 100.00 L111 C ATOM 95 CD PRO A 20 −17.690 0.887 −22.347 1.00 100.00 L111 C ATOM 96 N ALA A 21 −14.650 −1.015 −25.487 1.00 100.00 L111 N ATOM 97 CA ALA A 21 −13.450 −1.823 −25.640 1.00 100.00 L111 C ATOM 98 C ALA A 21 −12.238 −1.115 −25.030 1.00 100.00 L111 C ATOM 99 O ALA A 21 −11.622 −1.626 −24.097 1.00 100.00 L111 O ATOM 100 CB ALA A 21 −13.204 −2.130 −27.121 1.00 100.00 L111 C ATOM 101 N PRO A 22 −11.886 0.079 −25.542 1.00 100.00 L111 N ATOM 102 CA PRO A 22 −10.725 0.773 −24.969 1.00 100.00 L111 C ATOM 103 C PRO A 22 −10.740 0.904 −23.434 1.00 100.00 L111 C ATOM 104 O PRO A 22 −9.793 0.478 −22.768 1.00 100.00 L111 O ATOM 105 CB PRO A 22 −10.726 2.127 −25.683 1.00 100.00 L111 C ATOM 106 CG PRO A 22 −11.439 1.862 −26.979 1.00 100.00 L111 C ATOM 107 CD PRO A 22 −12.496 0.845 −26.645 1.00 100.00 L111 C ATOM 108 N PRO A 23 −11.807 1.495 −22.853 1.00 100.00 L111 N ATOM 109 CA PRO A 23 −11.880 1.650 −21.390 1.00 100.00 L111 C ATOM 110 C PRO A 23 −11.941 0.338 −20.592 1.00 100.00 L111 C ATOM 111 O PRO A 23 −11.025 0.026 −19.829 1.00 100.00 L111 O ATOM 112 CB PRO A 23 −13.135 2.507 −21.173 1.00 99.53 L111 C ATOM 113 CG PRO A 23 −13.446 3.100 −22.519 1.00 100.00 L111 C ATOM 114 CD PRO A 23 −12.988 2.077 −23.513 1.00 100.00 L111 C ATOM 115 N VAL A 24 −13.020 −0.423 −20.767 1.00 100.00 L111 N ATOM 116 CA VAL A 24 −13.199 −1.689 −20.051 1.00 95.98 L111 C ATOM 117 C VAL A 24 −12.711 −2.903 −20.844 1.00 94.54 L111 C ATOM 118 O VAL A 24 −11.538 −3.272 −20.773 1.00 88.41 L111 O ATOM 119 CB VAL A 24 −14.688 −1.923 −19.689 1.00 92.89 L111 C ATOM 120 CG1 VAL A 24 −14.809 −2.320 −18.232 1.00 90.90 L111 C ATOM 121 CG2 VAL A 24 −15.504 −0.668 −19.969 1.00 91.81 L111 C ATOM 122 N GLY A 25 −13.636 −3.515 −21.584 1.00 95.43 L111 N ATOM 123 CA GLY A 25 −13.343 −4.683 −22.401 1.00 94.07 L111 C ATOM 124 C GLY A 25 −11.973 −5.312 −22.224 1.00 94.21 L111 C ATOM 125 O GLY A 25 −11.738 −6.020 −21.243 1.00 93.12 L111 O ATOM 126 N PRO A 26 −11.051 −5.081 −23.176 1.00 93.73 L111 N ATOM 127 CA PRO A 26 −9.684 −5.606 −23.165 1.00 93.06 L111 C ATOM 128 C PRO A 26 −9.110 −5.852 −21.774 1.00 94.47 L111 C ATOM 129 O PRO A 26 −8.633 −6.947 −21.480 1.00 96.39 L111 O ATOM 130 CB PRO A 26 −8.893 −4.546 −23.929 1.00 91.97 L111 C ATOM 131 CG PRO A 26 −9.909 −3.882 −24.840 1.00 86.86 L111 C ATOM 132 CD PRO A 26 −11.299 −4.278 −24.385 1.00 89.82 L111 C ATOM 133 N ALA A 27 −9.167 −4.829 −20.927 1.00 95.87 L111 N ATOM 134 CA ALA A 27 −8.647 −4.902 −19.561 1.00 96.04 L111 C ATOM 135 C ALA A 27 −8.916 −6.234 −18.858 1.00 93.76 L111 C ATOM 136 O ALA A 27 −8.098 −7.152 −18.912 1.00 89.80 L111 O ATOM 137 CB ALA A 27 −9.218 −3.755 −18.730 1.00 98.77 L111 C ATOM 138 N LEU A 28 −10.057 −6.326 −18.185 1.00 92.88 L111 N ATOM 139 CA LEU A 28 −10.424 −7.543 −17.473 1.00 92.03 L111 C ATOM 140 C LEU A 28 −10.935 −8.593 −18.454 1.00 91.54 L111 C ATOM 141 O LEU A 28 −10.992 −9.782 −18.137 1.00 91.91 L111 O ATOM 142 CB LEU A 28 −11.495 −7.237 −16.422 1.00 92.11 L111 C ATOM 143 CG LEU A 28 −12.912 −6.897 −16.898 1.00 91.83 L111 C ATOM 144 CD1 LEU A 28 −13.728 −6.405 −15.711 1.00 87.53 L111 C ATOM 145 CD2 LEU A 28 −12.870 −5.837 −17.996 1.00 89.79 L111 C ATOM 146 N GLY A 29 −11.304 −8.143 −19.650 1.00 90.13 L111 N ATOM 147 CA GLY A 29 −11.794 −9.060 −20.661 1.00 88.78 L111 C ATOM 148 C GLY A 29 −10.732 −10.074 −21.044 1.00 88.80 L111 C ATOM 149 O GLY A 29 −11.022 −11.064 −21.716 1.00 86.10 L111 O ATOM 150 N GLN A 30 −9.497 −9.826 −20.616 1.00 89.64 L111 N ATOM 151 CA GLN A 30 −8.389 −10.726 −20.919 1.00 91.11 L111 C ATOM 152 C GLN A 30 −7.986 −11.569 −19.712 1.00 91.31 L111 C ATOM 153 O GLN A 30 −6.980 −12.277 −19.747 1.00 89.05 L111 O ATOM 154 CB GLN A 30 −7.177 −9.932 −21.439 1.00 92.85 L111 C ATOM 155 CG GLN A 30 −6.545 −8.965 −20.440 1.00 90.47 L111 C ATOM 156 CD GLN A 30 −5.431 −8.119 −21.055 1.00 92.62 L111 C ATOM 157 OE1 GLN A 30 −4.260 −8.511 −21.057 1.00 93.46 L111 O ATOM 158 NE2 GLN A 30 −5.796 −6.955 −21.584 1.00 92.21 L111 N ATOM 159 N HIS A 31 −8.776 −11.489 −18.646 1.00 94.67 L111 N ATOM 160 CA HIS A 31 −8.505 −12.256 −17.432 1.00 94.53 L111 C ATOM 161 C HIS A 31 −9.521 −13.393 −17.329 1.00 93.97 L111 C ATOM 162 O HIS A 31 −9.323 −14.351 −16.582 1.00 94.95 L111 O ATOM 163 CB HIS A 31 −8.594 −11.350 −16.193 1.00 92.77 L111 C ATOM 164 CG HIS A 31 −7.423 −10.425 −16.028 1.00 90.32 L111 C ATOM 165 ND1 HIS A 31 −7.531 −9.056 −16.160 1.00 88.08 L111 N ATOM 166 CD2 HIS A 31 −6.126 −10.671 −15.729 1.00 86.03 L111 C ATOM 167 CE1 HIS A 31 −6.351 −8.500 −15.950 1.00 81.34 L111 C ATOM 168 NE2 HIS A 31 −5.480 −9.457 −15.686 1.00 84.77 L111 N ATOM 169 N GLY A 32 −10.604 −13.278 −18.094 1.00 93.26 L111 N ATOM 170 CA GLY A 32 −11.637 −14.299 −18.091 1.00 90.69 L111 C ATOM 171 C GLY A 32 −13.032 −13.721 −17.950 1.00 90.58 L111 C ATOM 172 O GLY A 32 −14.022 −14.353 −18.323 1.00 91.06 L111 O ATOM 173 N VAL A 33 −13.107 −12.509 −17.415 1.00 89.92 L111 N ATOM 174 CA VAL A 33 −14.376 −11.822 −17.196 1.00 90.50 L111 C ATOM 175 C VAL A 33 −15.254 −11.711 −18.443 1.00 88.55 L111 C ATOM 176 O VAL A 33 −14.753 −11.581 −19.560 1.00 88.34 L111 O ATOM 177 CB VAL A 33 −14.135 −10.398 −16.652 1.00 92.08 L111 C ATOM 178 CG1 VAL A 33 −15.292 −9.976 −15.770 1.00 90.59 L111 C ATOM 179 CG2 VAL A 33 −12.830 −10.351 −15.873 1.00 93.31 L111 C ATOM 180 N ASN A 34 −16.568 −11.766 −18.237 1.00 89.80 L111 N ATOM 181 CA ASN A 34 −17.533 −11.650 −19.327 1.00 94.89 L111 C ATOM 182 C ASN A 34 −18.128 −10.245 −19.290 1.00 96.48 L111 C ATOM 183 O ASN A 34 −19.141 −10.008 −18.630 1.00 97.04 L111 O ATOM 184 CB ASN A 34 −18.661 −12.681 −19.182 1.00 97.83 L111 C ATOM 185 CG ASN A 34 −18.405 −13.683 −18.072 1.00 100.00 L111 C ATOM 186 OD1 ASN A 34 −19.205 −13.813 −17.141 1.00 100.00 L111 O ATOM 187 ND2 ASN A 34 −17.291 −14.405 −18.167 1.00 100.00 L111 N ATOM 188 N ILE A 35 −17.486 −9.325 −20.006 1.00 98.20 L111 N ATOM 189 CA ILE A 35 −17.898 −7.922 −20.071 1.00 97.32 L111 C ATOM 190 C ILE A 35 −19.392 −7.651 −19.844 1.00 99.75 L111 C ATOM 191 O ILE A 35 −19.776 −7.148 −18.788 1.00 100.00 L111 O ATOM 192 CB ILE A 35 −17.478 −7.282 −21.426 1.00 95.15 L111 C ATOM 193 CG1 ILE A 35 −16.341 −8.094 −22.064 1.00 93.73 L111 C ATOM 194 CG2 ILE A 35 −17.066 −5.823 −21.213 1.00 87.68 L111 C ATOM 195 CD1 ILE A 35 −14.960 −7.824 −21.485 1.00 91.66 L111 C ATOM 196 N MET A 36 −20.220 −7.980 −20.835 1.00 100.00 L111 N ATOM 197 CA MET A 36 −21.672 −7.767 −20.773 1.00 99.82 L111 C ATOM 198 C MET A 36 −22.294 −7.868 −19.376 1.00 97.54 L111 C ATOM 199 O MET A 36 −23.032 −6.975 −18.950 1.00 95.12 L111 O ATOM 200 CB MET A 36 −22.384 −8.752 −21.713 1.00 100.00 L111 C ATOM 201 CG MET A 36 −23.911 −8.645 −21.709 1.00 100.00 L111 C ATOM 202 SD MET A 36 −24.759 −10.248 −21.810 1.00 100.00 L111 S ATOM 203 CE MET A 36 −25.601 −10.300 −20.213 1.00 97.00 L111 C ATOM 204 N GLU A 37 −22.001 −8.960 −18.674 1.00 95.35 L111 N ATOM 205 CA GLU A 37 −22.535 −9.190 −17.335 1.00 92.68 L111 C ATOM 206 C GLU A 37 −22.124 −8.100 −16.349 1.00 93.66 L111 C ATOM 207 O GLU A 37 −22.925 −7.672 −15.515 1.00 91.34 L111 O ATOM 208 CB GLU A 37 −22.071 −10.552 −16.819 1.00 90.67 L111 C ATOM 209 CG GLU A 37 −23.205 −11.512 −16.511 1.00 93.38 L111 C ATOM 210 CD GLU A 37 −22.929 −12.372 −15.290 1.00 96.55 L111 C ATOM 211 OE1 GLU A 37 −22.044 −13.254 −15.365 1.00 91.81 L111 O ATOM 212 OE2 GLU A 37 −23.600 −12.163 −14.256 1.00 99.15 L111 O ATOM 213 N PHE A 38 −20.872 −7.657 −16.449 1.00 94.99 L111 N ATOM 214 CA PHE A 38 −20.335 −6.614 −15.575 1.00 95.14 L111 C ATOM 215 C PHE A 38 −20.928 −5.243 −15.907 1.00 93.32 L111 C ATOM 216 O PHE A 38 −21.382 −4.527 −15.017 1.00 92.65 L111 O ATOM 217 CB PHE A 38 −18.802 −6.565 −15.693 1.00 93.51 L111 C ATOM 218 CG PHE A 38 −18.139 −5.586 −14.748 1.00 96.97 L111 C ATOM 219 CD1 PHE A 38 −18.716 −5.269 −13.518 1.00 98.99 L111 C ATOM 220 CD2 PHE A 38 −16.935 −4.978 −15.094 1.00 96.40 L111 C ATOM 221 CE1 PHE A 38 −18.106 −4.355 −12.651 1.00 95.25 L111 C ATOM 222 CE2 PHE A 38 −16.318 −4.064 −14.233 1.00 96.95 L111 C ATOM 223 CZ PHE A 38 −16.905 −3.754 −13.010 1.00 92.93 L111 C ATOM 224 N CYS A 39 −20.925 −4.884 −17.187 1.00 94.43 L111 N ATOM 225 CA CYS A 39 −21.461 −3.597 −17.632 1.00 95.64 L111 C ATOM 226 C CYS A 39 −22.840 −3.321 −17.044 1.00 96.32 L111 C ATOM 227 O CYS A 39 −23.051 −2.295 −16.392 1.00 95.48 L111 O ATOM 228 CB CYS A 39 −21.540 −3.563 −19.159 1.00 93.89 L111 C ATOM 229 SG CYS A 39 −19.986 −3.992 −19.971 1.00 100.00 L111 S ATOM 230 N LYS A 40 −23.774 −4.239 −17.279 1.00 96.81 L111 N ATOM 231 CA LYS A 40 −25.133 −4.101 −16.768 1.00 96.22 L111 C ATOM 232 C LYS A 40 −25.135 −4.168 −15.240 1.00 95.74 L111 C ATOM 233 O LYS A 40 −25.823 −3.389 −14.576 1.00 96.26 L111 O ATOM 234 CB LYS A 40 −26.029 −5.205 −17.339 1.00 95.66 L111 C ATOM 235 CG LYS A 40 −25.956 −5.344 −18.855 1.00 97.68 L111 C ATOM 236 CD LYS A 40 −27.132 −6.148 −19.401 1.00 95.99 L111 C ATOM 237 CE LYS A 40 −26.947 −6.475 −20.880 1.00 94.18 L111 C ATOM 238 NZ LYS A 40 −28.171 −6.189 −21.684 1.00 88.70 L111 N ATOM 239 N ARG A 41 −24.356 −5.097 −14.688 1.00 92.53 L111 N ATOM 240 CA ARG A 41 −24.262 −5.260 −13.239 1.00 89.97 L111 C ATOM 241 C ARG A 41 −23.694 −4.003 −12.582 1.00 90.13 L111 C ATOM 242 O ARG A 41 −24.306 −3.433 −11.679 1.00 91.63 L111 O ATOM 243 CB ARG A 41 −23.375 −6.459 −12.900 1.00 85.72 L111 C ATOM 244 CG ARG A 41 −24.143 −7.710 −12.526 1.00 85.51 L111 C ATOM 245 CD ARG A 41 −23.330 −8.594 −11.595 1.00 90.22 L111 C ATOM 246 NE ARG A 41 −22.610 −9.641 −12.318 1.00 88.90 L111 N ATOM 247 CZ ARG A 41 −21.670 −10.412 −11.778 1.00 87.28 L111 C ATOM 248 NH1 ARG A 41 −21.332 −10.257 −10.501 1.00 84.21 L111 N ATOM 249 NH2 ARG A 41 −21.070 −11.340 −12.511 1.00 80.87 L111 N ATOM 250 N PHE A 42 −22.517 −3.583 −13.037 1.00 87.95 L111 N ATOM 251 CA PHE A 42 −21.865 −2.393 −12.509 1.00 82.17 L111 C ATOM 252 C PHE A 42 −22.838 −1.228 −12.587 1.00 83.84 L111 C ATOM 253 O PHE A 42 −23.215 −0.648 −11.566 1.00 84.64 L111 O ATOM 254 CB PHE A 42 −20.608 −2.074 −13.325 1.00 78.71 L111 C ATOM 255 CG PHE A 42 −19.934 −0.792 −12.925 1.00 83.84 L111 C ATOM 256 CD1 PHE A 42 −19.109 −0.745 −11.802 1.00 84.59 L111 C ATOM 257 CD2 PHE A 42 −20.132 0.373 −13.662 1.00 83.65 L111 C ATOM 258 CE1 PHE A 42 −18.490 0.444 −11.417 1.00 79.21 L111 C ATOM 259 CE2 PHE A 42 −19.518 1.567 −13.289 1.00 77.97 L111 C ATOM 260 CZ PHE A 42 −18.695 1.602 −12.162 1.00 81.55 L111 C ATOM 261 N ASN A 43 −23.253 −0.906 −13.808 1.00 85.30 L111 N ATOM 262 CA ASN A 43 −24.181 0.191 −14.053 1.00 86.52 L111 C ATOM 263 C ASN A 43 −25.488 0.062 −13.284 1.00 85.43 L111 C ATOM 264 O ASN A 43 −26.281 1.000 −13.240 1.00 85.51 L111 O ATOM 265 CB ASN A 43 −24.476 0.296 −15.548 1.00 86.27 L111 C ATOM 266 CG ASN A 43 −23.265 0.716 −16.344 1.00 92.38 L111 C ATOM 267 OD1 ASN A 43 −22.347 1.340 −15.811 1.00 96.74 L111 O ATOM 268 ND2 ASN A 43 −23.249 0.374 −17.627 1.00 99.06 L111 N ATOM 269 N ALA A 44 −25.712 −1.098 −12.679 1.00 85.49 L111 N ATOM 270 CA ALA A 44 −26.930 −1.319 −11.912 1.00 84.79 L111 C ATOM 271 C ALA A 44 −26.900 −0.515 −10.618 1.00 85.21 L111 C ATOM 272 O ALA A 44 −27.668 0.433 −10.452 1.00 84.84 L111 O ATOM 273 CB ALA A 44 −27.092 −2.797 −11.603 1.00 86.85 L111 C ATOM 274 N GLU A 45 −26.005 −0.893 −9.708 1.00 85.98 L111 N ATOM 275 CA GLU A 45 −25.885 −0.211 −8.420 1.00 90.10 L111 C ATOM 276 C GLU A 45 −25.222 1.158 −8.536 1.00 89.46 L111 C ATOM 277 O GLU A 45 −25.388 2.010 −7.661 1.00 88.02 L111 O ATOM 278 CB GLU A 45 −25.103 −1.076 −7.427 1.00 89.91 L111 C ATOM 279 CG GLU A 45 −23.812 −1.641 −7.983 1.00 93.26 L111 C ATOM 280 CD GLU A 45 −23.917 −3.118 −8.293 1.00 95.55 L111 C ATOM 281 OE1 GLU A 45 −24.558 −3.844 −7.503 1.00 94.41 L111 O ATOM 282 OE2 GLU A 45 −23.360 −3.551 −9.326 1.00 98.04 L111 O ATOM 283 N THR A 46 −24.463 1.369 −9.608 1.00 89.00 L111 N ATOM 284 CA THR A 46 −23.806 2.655 −9.810 1.00 91.97 L111 C ATOM 285 C THR A 46 −24.849 3.680 −10.261 1.00 95.20 L111 C ATOM 286 O THR A 46 −24.516 4.737 −10.806 1.00 95.92 L111 O ATOM 287 CB THR A 46 −22.681 2.560 −10.865 1.00 90.40 L111 C ATOM 288 OG1 THR A 46 −23.232 2.170 −12.129 1.00 88.41 L111 O ATOM 289 CG2 THR A 46 −21.634 1.545 −10.429 1.00 87.67 L111 C ATOM 290 N ALA A 47 −26.116 3.343 −10.031 1.00 95.70 L111 N ATOM 291 CA ALA A 47 −27.237 4.208 −10.374 1.00 93.30 L111 C ATOM 292 C ALA A 47 −27.464 5.142 −9.191 1.00 95.59 L111 C ATOM 293 O ALA A 47 −27.681 6.341 −9.367 1.00 97.14 L111 O ATOM 294 CB ALA A 47 −28.488 3.373 −10.634 1.00 85.02 L111 C ATOM 295 N ASP A 48 −27.409 4.580 −7.985 1.00 98.95 L111 N ATOM 296 CA ASP A 48 −27.589 5.360 −6.764 1.00 100.00 L111 C ATOM 297 C ASP A 48 −26.667 6.582 −6.823 1.00 100.00 L111 C ATOM 298 O ASP A 48 −27.065 7.697 −6.477 1.00 100.00 L111 O ATOM 299 CB ASP A 48 −27.248 4.515 −5.526 1.00 100.00 L111 C ATOM 300 CG ASP A 48 −27.577 3.038 −5.706 1.00 100.00 L111 C ATOM 301 OD1 ASP A 48 −28.633 2.721 −6.297 1.00 100.00 L111 O ATOM 302 OD2 ASP A 48 −26.777 2.191 −5.249 1.00 100.00 L111 O ATOM 303 N LYS A 49 −25.434 6.356 −7.270 1.00 100.00 L111 N ATOM 304 CA LYS A 49 −24.440 7.419 −7.394 1.00 99.10 L111 C ATOM 305 C LYS A 49 −24.009 7.547 −8.859 1.00 98.06 L111 C ATOM 306 O LYS A 49 −23.106 6.842 −9.318 1.00 95.26 L111 O ATOM 307 CB LYS A 49 −23.226 7.105 −6.512 1.00 94.97 L111 C ATOM 308 CG LYS A 49 −23.561 6.908 −5.037 1.00 92.57 L111 C ATOM 309 CD LYS A 49 −22.956 5.619 −4.498 1.00 93.51 L111 C ATOM 310 CE LYS A 49 −21.611 5.873 −3.827 1.00 94.40 L111 C ATOM 311 NZ LYS A 49 −20.528 4.998 −4.365 1.00 88.97 L111 N ATOM 312 N ALA A 50 −24.661 8.450 −9.587 1.00 95.33 L111 N ATOM 313 CA ALA A 50 −24.360 8.653 −10.999 1.00 93.02 L111 C ATOM 314 C ALA A 50 −23.680 9.985 −11.305 1.00 91.25 L111 C ATOM 315 O ALA A 50 −23.898 10.986 −10.619 1.00 90.14 L111 O ATOM 316 CB ALA A 50 −25.636 8.522 −11.819 1.00 96.51 L111 C ATOM 317 N GLY A 51 −22.861 9.984 −12.353 1.00 89.39 L111 N ATOM 318 CA GLY A 51 −22.153 11.186 −12.752 1.00 90.09 L111 C ATOM 319 C GLY A 51 −20.709 11.173 −12.289 1.00 91.40 L111 C ATOM 320 O GLY A 51 −19.828 11.733 −12.943 1.00 91.06 L111 O ATOM 321 N MET A 52 −20.465 10.520 −11.158 1.00 91.81 L111 N ATOM 322 CA MET A 52 −19.125 10.440 −10.591 1.00 88.05 L111 C ATOM 323 C MET A 52 −18.347 9.218 −11.062 1.00 84.95 L111 C ATOM 324 O MET A 52 −18.927 8.206 −11.455 1.00 85.89 L111 O ATOM 325 CB MET A 52 −19.207 10.425 −9.065 1.00 85.66 L111 C ATOM 326 CG MET A 52 −20.358 11.236 −8.503 1.00 86.98 L111 C ATOM 327 SD MET A 52 −20.028 11.840 −6.840 1.00 94.43 L111 S ATOM 328 CE MET A 52 −18.414 12.577 −7.060 1.00 92.32 L111 C ATOM 329 N ILE A 53 −17.025 9.330 −11.021 1.00 80.70 L111 N ATOM 330 CA ILE A 53 −16.145 8.242 −11.415 1.00 76.40 L111 C ATOM 331 C ILE A 53 −15.856 7.437 −10.157 1.00 76.01 L111 C ATOM 332 O ILE A 53 −15.214 7.937 −9.238 1.00 80.34 L111 O ATOM 333 CB ILE A 53 −14.815 8.781 −11.987 1.00 72.67 L111 C ATOM 334 CG1 ILE A 53 −15.035 9.279 −13.421 1.00 73.66 L111 C ATOM 335 CG2 ILE A 53 −13.735 7.706 −11.897 1.00 69.87 L111 C ATOM 336 CD1 ILE A 53 −14.073 8.712 −14.461 1.00 67.81 L111 C ATOM 337 N LEU A 54 −16.337 6.199 −10.110 1.00 77.62 L111 N ATOM 338 CA LEU A 54 −16.123 5.355 −8.940 1.00 75.31 L111 C ATOM 339 C LEU A 54 −15.263 4.129 −9.242 1.00 73.26 L111 C ATOM 340 O LEU A 54 −15.468 3.448 −10.248 1.00 69.71 L111 O ATOM 341 CB LEU A 54 −17.471 4.913 −8.354 1.00 74.18 L111 C ATOM 342 CG LEU A 54 −18.446 4.186 −9.283 1.00 76.71 L111 C ATOM 343 CD1 LEU A 54 −19.398 3.339 −8.456 1.00 78.50 L111 C ATOM 344 CD2 LEU A 54 −19.221 5.196 −10.112 1.00 77.50 L111 C ATOM 345 N PRO A 55 −14.277 3.841 −8.368 1.00 73.50 L111 N ATOM 346 CA PRO A 55 −13.379 2.694 −8.531 1.00 73.63 L111 C ATOM 347 C PRO A 55 −13.998 1.397 −8.010 1.00 72.99 L111 C ATOM 348 O PRO A 55 −14.516 1.349 −6.895 1.00 76.87 L111 O ATOM 349 CB PRO A 55 −12.139 3.096 −7.736 1.00 69.02 L111 C ATOM 350 CG PRO A 55 −12.654 4.000 −6.669 1.00 66.68 L111 C ATOM 351 CD PRO A 55 −13.950 4.617 −7.157 1.00 72.43 L111 C ATOM 352 N VAL A 56 −13.945 0.349 −8.825 1.00 70.25 L111 N ATOM 353 CA VAL A 56 −14.496 −0.942 −8.440 1.00 70.19 L111 C ATOM 354 C VAL A 56 −13.399 −1.999 −8.486 1.00 70.07 L111 C ATOM 355 O VAL A 56 −12.502 −1.937 −9.329 1.00 67.23 L111 O ATOM 356 CB VAL A 56 −15.654 −1.361 −9.384 1.00 67.10 L111 C ATOM 357 CG1 VAL A 56 −15.246 −1.161 −10.828 1.00 67.75 L111 C ATOM 358 CG2 VAL A 56 −16.034 −2.808 −9.143 1.00 62.26 L111 C ATOM 359 N VAL A 57 −13.459 −2.956 −7.565 1.00 72.09 L111 N ATOM 360 CA VAL A 57 −12.472 −4.027 −7.527 1.00 73.93 L111 C ATOM 361 C VAL A 57 −13.121 −5.341 −7.934 1.00 76.94 L111 C ATOM 362 O VAL A 57 −13.788 −6.001 −7.131 1.00 78.31 L111 O ATOM 363 CB VAL A 57 −11.849 −4.189 −6.127 1.00 68.90 L111 C ATOM 364 CG1 VAL A 57 −10.940 −5.410 −6.104 1.00 66.82 L111 C ATOM 365 CG2 VAL A 57 −11.058 −2.948 −5.767 1.00 67.57 L111 C ATOM 366 N ILE A 58 −12.923 −5.702 −9.197 1.00 79.04 L111 N ATOM 367 CA ILE A 58 −13.467 −6.930 −9.756 1.00 77.59 L111 C ATOM 368 C ILE A 58 −12.611 −8.115 −9.319 1.00 77.59 L111 C ATOM 369 O ILE A 58 −11.383 −8.023 −9.262 1.00 73.20 L111 O ATOM 370 CB ILE A 58 −13.490 −6.863 −11.307 1.00 76.77 L111 C ATOM 371 CG1 ILE A 58 −14.689 −6.033 −11.773 1.00 79.34 L111 C ATOM 372 CG2 ILE A 58 −13.526 −8.267 −11.904 1.00 73.40 L111 C ATOM 373 CD1 ILE A 58 −15.970 −6.832 −11.963 1.00 82.47 L111 C ATOM 374 N THR A 59 −13.270 −9.224 −8.999 1.00 82.32 L111 N ATOM 375 CA THR A 59 −12.581 −10.444 −8.589 1.00 82.77 L111 C ATOM 376 C THR A 59 −13.114 −11.602 −9.430 1.00 83.16 L111 C ATOM 377 O THR A 59 −14.312 −11.888 −9.417 1.00 78.62 L111 O ATOM 378 CB THR A 59 −12.815 −10.761 −7.091 1.00 81.80 L111 C ATOM 379 OG1 THR A 59 −12.872 −9.539 −6.341 1.00 79.00 L111 O ATOM 380 CG2 THR A 59 −11.682 −11.629 −6.552 1.00 74.95 L111 C ATOM 381 N VAL A 60 −12.221 −12.256 −10.168 1.00 84.63 L111 N ATOM 382 CA VAL A 60 −12.603 −13.377 −11.022 1.00 85.45 L111 C ATOM 383 C VAL A 60 −12.140 −14.723 −10.466 1.00 85.80 L111 C ATOM 384 O VAL A 60 −10.947 −14.934 −10.228 1.00 83.46 L111 O ATOM 385 CB VAL A 60 −12.030 −13.211 −12.445 1.00 85.69 L111 C ATOM 386 CG1 VAL A 60 −12.984 −12.383 −13.295 1.00 80.95 L111 C ATOM 387 CG2 VAL A 60 −10.653 −12.563 −12.380 1.00 84.62 L111 C ATOM 388 N TYR A 61 −13.098 −15.629 −10.272 1.00 86.41 L111 N ATOM 389 CA TYR A 61 −12.827 −16.965 −9.747 1.00 88.03 L111 C ATOM 390 C TYR A 61 −12.459 −17.915 −10.877 1.00 89.54 L111 C ATOM 391 O TYR A 61 −12.885 −17.721 −12.015 1.00 93.25 L111 O ATOM 392 CB TYR A 61 −14.056 −17.486 −8.998 1.00 87.73 L111 C ATOM 393 CG TYR A 61 −14.589 −16.487 −7.999 1.00 91.62 L111 C ATOM 394 CD1 TYR A 61 −13.873 −16.187 −6.837 1.00 89.76 L111 C ATOM 395 CD2 TYR A 61 −15.772 −15.788 −8.244 1.00 89.94 L111 C ATOM 396 CE1 TYR A 61 −14.316 −15.214 −5.947 1.00 89.76 L111 C ATOM 397 CE2 TYR A 61 −16.225 −14.810 −7.358 1.00 92.12 L111 C ATOM 398 CZ TYR A 61 −15.489 −14.526 −6.214 1.00 92.07 L111 C ATOM 399 OH TYR A 61 −15.910 −13.543 −5.347 1.00 94.51 L111 O ATOM 400 N GLU A 62 −11.666 −18.936 −10.557 1.00 89.59 L111 N ATOM 401 CA GLU A 62 −11.218 −19.921 −11.541 1.00 86.30 L111 C ATOM 402 C GLU A 62 −12.248 −20.245 −12.626 1.00 84.38 L111 C ATOM 403 O GLU A 62 −11.886 −20.480 −13.779 1.00 83.12 L111 O ATOM 404 CB GLU A 62 −10.798 −21.217 −10.835 1.00 86.59 L111 C ATOM 405 CG GLU A 62 −11.842 −21.781 −9.872 1.00 98.78 L111 C ATOM 406 CD GLU A 62 −12.709 −22.865 −10.502 1.00 100.00 L111 C ATOM 407 OE1 GLU A 62 −12.149 −23.866 −11.007 1.00 100.00 L111 O ATOM 408 OE2 GLU A 62 −13.952 −22.711 −10.490 1.00 100.00 L111 O ATOM 409 N ASP A 63 −13.527 −20.246 −12.261 1.00 83.04 L111 N ATOM 410 CA ASP A 63 −14.593 −20.554 −13.210 1.00 83.65 L111 C ATOM 411 C ASP A 63 −15.045 −19.360 −14.066 1.00 89.63 L111 C ATOM 412 O ASP A 63 −16.153 −19.364 −14.609 1.00 90.46 L111 O ATOM 413 CB ASP A 63 −15.795 −21.132 −12.461 1.00 80.07 L111 C ATOM 414 CG ASP A 63 −16.738 −20.061 −11.968 1.00 79.27 L111 C ATOM 415 OD1 ASP A 63 −16.275 −19.146 −11.254 1.00 85.70 L111 O ATOM 416 OD2 ASP A 63 −17.941 −20.130 −12.298 1.00 76.37 L111 O ATOM 417 N LYS A 64 −14.188 −18.347 −14.185 1.00 91.01 L111 N ATOM 418 CA LYS A 64 −14.481 −17.150 −14.976 1.00 89.76 L111 C ATOM 419 C LYS A 64 −15.585 −16.261 −14.398 1.00 89.42 L111 C ATOM 420 O LYS A 64 −15.809 −15.149 −14.882 1.00 91.74 L111 O ATOM 421 CB LYS A 64 −14.833 −17.540 −16.418 1.00 92.48 L111 C ATOM 422 CG LYS A 64 −13.737 −17.237 −17.436 1.00 92.64 L111 C ATOM 423 CD LYS A 64 −12.362 −17.682 −16.936 1.00 89.88 L111 C ATOM 424 CE LYS A 64 −11.520 −18.269 −18.060 1.00 87.02 L111 C ATOM 425 NZ LYS A 64 −12.331 −18.548 −19.280 1.00 89.34 L111 N ATOM 426 N SER A 65 −16.280 −16.748 −13.373 1.00 88.30 L111 N ATOM 427 CA SER A 65 −17.336 −15.966 −12.738 1.00 87.60 L111 C ATOM 428 C SER A 65 −16.668 −14.827 −11.979 1.00 90.25 L111 C ATOM 429 O SER A 65 −15.443 −14.800 −11.857 1.00 94.42 L111 O ATOM 430 CB SER A 65 −18.138 −16.830 −11.766 1.00 83.90 L111 C ATOM 431 OG SER A 65 −19.255 −16.115 −11.265 1.00 86.12 L111 O ATOM 432 N PHE A 66 −17.459 −13.895 −11.456 1.00 89.68 L111 N ATOM 433 CA PHE A 66 −16.872 −12.769 −10.737 1.00 86.65 L111 C ATOM 434 C PHE A 66 −17.824 −11.963 −9.852 1.00 84.85 L111 C ATOM 435 O PHE A 66 −19.049 −12.065 −9.956 1.00 84.96 L111 O ATOM 436 CB PHE A 66 −16.207 −11.819 −11.740 1.00 83.79 L111 C ATOM 437 CG PHE A 66 −17.166 −11.224 −12.736 1.00 84.15 L111 C ATOM 438 CD1 PHE A 66 −17.849 −10.044 −12.446 1.00 84.23 L111 C ATOM 439 CD2 PHE A 66 −17.402 −11.851 −13.955 1.00 85.47 L111 C ATOM 440 CE1 PHE A 66 −18.756 −9.496 −13.358 1.00 83.49 L111 C ATOM 441 CE2 PHE A 66 −18.307 −11.312 −14.875 1.00 85.83 L111 C ATOM 442 CZ PHE A 66 −18.985 −10.132 −14.574 1.00 81.40 L111 C ATOM 443 N THR A 67 −17.223 −11.166 −8.975 1.00 83.77 L111 N ATOM 444 CA THR A 67 −17.937 −10.279 −8.065 1.00 79.66 L111 C ATOM 445 C THR A 67 −17.102 −9.009 −8.062 1.00 79.21 L111 C ATOM 446 O THR A 67 −16.005 −8.985 −8.623 1.00 78.86 L111 O ATOM 447 CB THR A 67 −17.990 −10.835 −6.630 1.00 77.12 L111 C ATOM 448 OG1 THR A 67 −16.660 −11.101 −6.169 1.00 71.17 L111 O ATOM 449 CG2 THR A 67 −18.807 −12.112 −6.585 1.00 76.03 L111 C ATOM 450 N PHE A 68 −17.603 −7.954 −7.439 1.00 77.92 L111 N ATOM 451 CA PHE A 68 −16.850 −6.711 −7.409 1.00 76.33 L111 C ATOM 452 C PHE A 68 −17.396 −5.750 −6.379 1.00 74.52 L111 C ATOM 453 O PHE A 68 −18.609 −5.594 −6.241 1.00 74.74 L111 O ATOM 454 CB PHE A 68 −16.871 −6.046 −8.789 1.00 79.76 L111 C ATOM 455 CG PHE A 68 −18.255 −5.772 −9.311 1.00 78.43 L111 C ATOM 456 CD1 PHE A 68 −18.994 −6.781 −9.922 1.00 77.56 L111 C ATOM 457 CD2 PHE A 68 −18.821 −4.506 −9.193 1.00 77.06 L111 C ATOM 458 CE1 PHE A 68 −20.276 −6.532 −10.409 1.00 79.65 L111 C ATOM 459 CE2 PHE A 68 −20.103 −4.247 −9.677 1.00 76.90 L111 C ATOM 460 CZ PHE A 68 −20.831 −5.263 −10.285 1.00 77.56 L111 C ATOM 461 N ILE A 69 −16.491 −5.105 −5.656 1.00 73.94 L111 N ATOM 462 CA ILE A 69 −16.885 −4.142 −4.644 1.00 70.90 L111 C ATOM 463 C ILE A 69 −16.752 −2.736 −5.218 1.00 71.09 L111 C ATOM 464 O ILE A 69 −15.773 −2.420 −5.901 1.00 68.28 L111 O ATOM 465 CB ILE A 69 −16.010 −4.273 −3.377 1.00 65.36 L111 C ATOM 466 CG1 ILE A 69 −14.550 −3.966 −3.709 1.00 63.63 L111 C ATOM 467 CG2 ILE A 69 −16.119 −5.682 −2.820 1.00 61.98 L111 C ATOM 468 CD1 ILE A 69 −13.850 −3.146 −2.650 1.00 54.75 L111 C ATOM 469 N ILE A 70 −17.753 −1.903 −4.962 1.00 68.20 L111 N ATOM 470 CA ILE A 70 −17.740 −0.530 −5.443 1.00 65.88 L111 C ATOM 471 C ILE A 70 −17.350 0.388 −4.283 1.00 61.84 L111 C ATOM 472 O ILE A 70 −17.975 0.367 −3.222 1.00 60.58 L111 O ATOM 473 CB ILE A 70 −19.126 −0.135 −6.022 1.00 66.46 L111 C ATOM 474 CG1 ILE A 70 −19.030 −0.026 −7.545 1.00 67.64 L111 C ATOM 475 CG2 ILE A 70 −19.608 1.187 −5.432 1.00 69.87 L111 C ATOM 476 CD1 ILE A 70 −19.695 −1.163 −8.283 1.00 63.00 L111 C ATOM 477 N LYS A 71 −16.301 1.179 −4.489 1.00 55.49 L111 N ATOM 478 CA LYS A 71 −15.820 2.092 −3.463 1.00 49.56 L111 C ATOM 479 C LYS A 71 −16.181 3.531 −3.773 1.00 51.89 L111 C ATOM 480 O LYS A 71 −16.814 3.826 −4.787 1.00 58.09 L111 O ATOM 481 CB LYS A 71 −14.301 1.996 −3.325 1.00 41.23 L111 C ATOM 482 CG LYS A 71 −13.736 0.617 −3.549 1.00 45.62 L111 C ATOM 483 CD LYS A 71 −12.280 0.573 −3.134 1.00 47.82 L111 C ATOM 484 CE LYS A 71 −12.066 −0.371 −1.962 1.00 53.59 L111 C ATOM 485 NZ LYS A 71 −10.785 −1.130 −2.085 1.00 54.56 L111 N ATOM 486 N THR A 72 −15.763 4.424 −2.883 1.00 51.64 L111 N ATOM 487 CA THR A 72 −16.005 5.851 −3.034 1.00 48.54 L111 C ATOM 488 C THR A 72 −15.040 6.390 −4.088 1.00 47.19 L111 C ATOM 489 O THR A 72 −13.919 5.896 −4.227 1.00 51.43 L111 O ATOM 490 CB THR A 72 −15.758 6.584 −1.711 1.00 49.44 L111 C ATOM 491 OG1 THR A 72 −14.374 6.469 −1.356 1.00 56.76 L111 O ATOM 492 CG2 THR A 72 −16.598 5.975 −0.602 1.00 49.50 L111 C ATOM 493 N PRO A 73 −15.463 7.409 −4.850 1.00 43.35 L111 N ATOM 494 CA PRO A 73 −14.603 7.989 −5.890 1.00 39.98 L111 C ATOM 495 C PRO A 73 −13.260 8.487 −5.357 1.00 38.40 L111 C ATOM 496 O PRO A 73 −13.153 8.908 −4.206 1.00 41.41 L111 O ATOM 497 CB PRO A 73 −15.449 9.117 −6.483 1.00 40.56 L111 C ATOM 498 CG PRO A 73 −16.536 9.360 −5.490 1.00 44.56 L111 C ATOM 499 CD PRO A 73 −16.775 8.071 −4.781 1.00 42.40 L111 C ATOM 500 N PRO A 74 −12.217 8.453 −6.198 1.00 36.48 L111 N ATOM 501 CA PRO A 74 −10.882 8.904 −5.788 1.00 35.21 L111 C ATOM 502 C PRO A 74 −10.881 10.296 −5.162 1.00 32.68 L111 C ATOM 503 O PRO A 74 −11.778 11.102 −5.406 1.00 30.40 L111 O ATOM 504 CB PRO A 74 −10.066 8.856 −7.082 1.00 37.87 L111 C ATOM 505 CG PRO A 74 −10.787 7.880 −7.956 1.00 31.11 L111 C ATOM 506 CD PRO A 74 −12.244 8.000 −7.601 1.00 35.28 L111 C ATOM 507 N ALA A 75 −9.868 10.570 −4.348 1.00 31.58 L111 N ATOM 508 CA ALA A 75 −9.763 11.862 −3.698 1.00 29.59 L111 C ATOM 509 C ALA A 75 −9.517 12.901 −4.774 1.00 34.00 L111 C ATOM 510 O ALA A 75 −10.210 13.915 −4.837 1.00 37.52 L111 O ATOM 511 CB ALA A 75 −8.618 11.856 −2.694 1.00 34.28 L111 C ATOM 512 N SER A 76 −8.532 12.638 −5.627 1.00 30.09 L111 N ATOM 513 CA SER A 76 −8.211 13.561 −6.702 1.00 31.31 L111 C ATOM 514 C SER A 76 −9.467 13.929 −7.483 1.00 31.25 L111 C ATOM 515 O SER A 76 −9.661 15.091 −7.825 1.00 36.66 L111 O ATOM 516 CB SER A 76 −7.169 12.951 −7.643 1.00 32.45 L111 C ATOM 517 OG SER A 76 −7.473 11.608 −7.957 1.00 36.38 L111 O ATOM 518 N PHE A 77 −10.323 12.946 −7.752 1.00 31.85 L111 N ATOM 519 CA PHE A 77 −11.564 13.194 −8.489 1.00 34.16 L111 C ATOM 520 C PHE A 77 −12.502 14.125 −7.734 1.00 38.37 L111 C ATOM 521 O PHE A 77 −12.919 15.160 −8.251 1.00 41.67 L111 O ATOM 522 CB PHE A 77 −12.307 11.894 −8.769 1.00 33.17 L111 C ATOM 523 CG PHE A 77 −13.623 12.095 −9.468 1.00 40.76 L111 C ATOM 524 CD1 PHE A 77 −13.667 12.357 −10.837 1.00 47.11 L111 C ATOM 525 CD2 PHE A 77 −14.818 12.034 −8.761 1.00 42.42 L111 C ATOM 526 CE1 PHE A 77 −14.880 12.554 −11.492 1.00 38.82 L111 C ATOM 527 CE2 PHE A 77 −16.041 12.230 −9.409 1.00 42.68 L111 C ATOM 528 CZ PHE A 77 −16.069 12.491 −10.777 1.00 38.85 L111 C ATOM 529 N LEU A 78 −12.852 13.743 −6.514 1.00 39.27 L111 N ATOM 530 CA LEU A 78 −13.732 14.568 −5.703 1.00 42.01 L111 C ATOM 531 C LEU A 78 −13.162 15.986 −5.625 1.00 44.64 L111 C ATOM 532 O LEU A 78 −13.892 16.967 −5.777 1.00 45.86 L111 O ATOM 533 CB LEU A 78 −13.861 13.966 −4.303 1.00 42.80 L111 C ATOM 534 CG LEU A 78 −14.640 12.646 −4.258 1.00 47.12 L111 C ATOM 535 CD1 LEU A 78 −14.485 11.973 −2.899 1.00 38.14 L111 C ATOM 536 CD2 LEU A 78 −16.108 12.925 −4.548 1.00 50.88 L111 C ATOM 537 N LEU A 79 −11.851 16.081 −5.406 1.00 43.07 L111 N ATOM 538 CA LEU A 79 −11.164 17.367 −5.309 1.00 34.91 L111 C ATOM 539 C LEU A 79 −11.352 18.182 −6.580 1.00 35.68 L111 C ATOM 540 O LEU A 79 −11.701 19.355 −6.522 1.00 36.29 L111 O ATOM 541 CB LEU A 79 −9.676 17.150 −5.056 1.00 32.85 L111 C ATOM 542 CG LEU A 79 −9.326 16.833 −3.603 1.00 29.72 L111 C ATOM 543 CD1 LEU A 79 −7.848 16.529 −3.480 1.00 33.33 L111 C ATOM 544 CD2 LEU A 79 −9.703 18.013 −2.730 1.00 29.46 L111 C ATOM 545 N LYS A 80 −11.113 17.558 −7.727 1.00 39.06 L111 N ATOM 546 CA LYS A 80 −11.292 18.235 −9.006 1.00 38.30 L111 C ATOM 547 C LYS A 80 −12.692 18.832 −8.990 1.00 39.56 L111 C ATOM 548 O LYS A 80 −12.872 20.036 −9.144 1.00 44.34 L111 O ATOM 549 CB LYS A 80 −11.191 17.239 −10.163 1.00 32.02 L111 C ATOM 550 CG LYS A 80 −9.805 17.066 −10.750 1.00 32.26 L111 C ATOM 551 CD LYS A 80 −9.758 15.821 −11.628 1.00 37.75 L111 C ATOM 552 CE LYS A 80 −8.410 15.660 −12.313 1.00 49.50 L111 C ATOM 553 NZ LYS A 80 −8.046 14.224 −12.490 1.00 54.98 L111 N ATOM 554 N LYS A 81 −13.681 17.969 −8.789 1.00 39.53 L111 N ATOM 555 CA LYS A 81 −15.070 18.386 −8.754 1.00 38.23 L111 C ATOM 556 C LYS A 81 −15.268 19.576 −7.832 1.00 41.10 L111 C ATOM 557 O LYS A 81 −15.797 20.603 −8.242 1.00 50.63 L111 O ATOM 558 CB LYS A 81 −15.949 17.230 −8.290 1.00 40.15 L111 C ATOM 559 CG LYS A 81 −17.433 17.521 −8.367 1.00 56.64 L111 C ATOM 560 CD LYS A 81 −18.209 16.317 −8.878 1.00 68.16 L111 C ATOM 561 CE LYS A 81 −19.133 15.761 −7.799 1.00 76.64 L111 C ATOM 562 NZ LYS A 81 −18.420 15.535 −6.502 1.00 78.09 L111 N ATOM 563 N ALA A 82 −14.836 19.435 −6.585 1.00 45.28 L111 N ATOM 564 CA ALA A 82 −14.976 20.500 −5.598 1.00 43.40 L111 C ATOM 565 C ALA A 82 −14.384 21.832 −6.056 1.00 49.00 L111 C ATOM 566 O ALA A 82 −15.003 22.884 −5.892 1.00 53.59 L111 O ATOM 567 CB ALA A 82 −14.330 20.076 −4.290 1.00 42.16 L111 C ATOM 568 N ALA A 83 −13.183 21.790 −6.621 1.00 48.31 L111 N ATOM 569 CA ALA A 83 −12.527 23.004 −7.089 1.00 44.61 L111 C ATOM 570 C ALA A 83 −13.115 23.458 −8.416 1.00 44.02 L111 C ATOM 571 O ALA A 83 −12.693 24.467 −8.978 1.00 50.26 L111 O ATOM 572 CB ALA A 83 −11.042 22.764 −7.236 1.00 40.08 L111 C ATOM 573 N GLY A 84 −14.086 22.699 −8.912 1.00 42.49 L111 N ATOM 574 CA GLY A 84 −14.727 23.029 −10.169 1.00 37.87 L111 C ATOM 575 C GLY A 84 −13.804 22.971 −11.370 1.00 39.67 L111 C ATOM 576 O GLY A 84 −14.127 23.511 −12.424 1.00 50.03 L111 O ATOM 577 N ILE A 85 −12.654 22.323 −11.226 1.00 37.41 L111 N ATOM 578 CA ILE A 85 −11.715 22.219 −12.334 1.00 37.65 L111 C ATOM 579 C ILE A 85 −11.826 20.868 −13.037 1.00 41.62 L111 C ATOM 580 O ILE A 85 −12.532 19.974 −12.571 1.00 45.50 L111 O ATOM 581 CB ILE A 85 −10.261 22.429 −11.863 1.00 37.93 L111 C ATOM 582 CG1 ILE A 85 −9.905 21.408 −10.784 1.00 32.73 L111 C ATOM 583 CG2 ILE A 85 −10.088 23.845 −11.336 1.00 42.04 L111 C ATOM 584 CD1 ILE A 85 −8.435 21.395 −10.442 1.00 22.67 L111 C ATOM 585 N GLU A 86 −11.126 20.728 −14.159 1.00 45.67 L111 N ATOM 586 CA GLU A 86 −11.156 19.499 −14.948 1.00 47.13 L111 C ATOM 587 C GLU A 86 −9.874 18.675 −14.831 1.00 47.71 L111 C ATOM 588 O GLU A 86 −9.882 17.460 −15.044 1.00 48.51 L111 O ATOM 589 CB GLU A 86 −11.408 19.839 −16.421 1.00 57.79 L111 C ATOM 590 CG GLU A 86 −12.374 18.896 −17.128 1.00 77.13 L111 C ATOM 591 CD GLU A 86 −13.815 19.383 −17.078 1.00 86.58 L111 C ATOM 592 OE1 GLU A 86 −14.025 20.594 −16.849 1.00 90.24 L111 O ATOM 593 OE2 GLU A 86 −14.734 18.553 −17.268 1.00 89.81 L111 O ATOM 594 N LYS A 87 −8.771 19.335 −14.499 1.00 39.94 L111 N ATOM 595 CA LYS A 87 −7.499 18.645 −14.366 1.00 38.76 L111 C ATOM 596 C LYS A 87 −6.699 19.204 −13.204 1.00 34.61 L111 C ATOM 597 O LYS A 87 −6.981 20.291 −12.715 1.00 46.69 L111 O ATOM 598 CB LYS A 87 −6.686 18.784 −15.656 1.00 41.37 L111 C ATOM 599 CG LYS A 87 −7.279 18.057 −16.847 1.00 47.04 L111 C ATOM 600 CD LYS A 87 −6.550 18.426 −18.128 1.00 53.23 L111 C ATOM 601 CE LYS A 87 −5.833 17.224 −18.724 1.00 60.76 L111 C ATOM 602 NZ LYS A 87 −6.109 15.961 −17.979 1.00 61.63 L111 N ATOM 603 N GLY A 88 −5.703 18.452 −12.759 1.00 34.29 L111 N ATOM 604 CA GLY A 88 −4.871 18.914 −11.669 1.00 33.53 L111 C ATOM 605 C GLY A 88 −3.718 19.688 −12.261 1.00 35.94 L111 C ATOM 606 O GLY A 88 −3.422 19.547 −13.445 1.00 37.03 L111 O ATOM 607 N SER A 89 −3.065 20.511 −11.453 1.00 35.86 L111 N ATOM 608 CA SER A 89 −1.941 21.285 −11.951 1.00 31.79 L111 C ATOM 609 C SER A 89 −0.968 20.358 −12.658 1.00 33.45 L111 C ATOM 610 O SER A 89 −0.868 19.185 −12.317 1.00 36.12 L111 O ATOM 611 CB SER A 89 −1.227 21.987 −10.801 1.00 30.17 L111 C ATOM 612 OG SER A 89 0.141 22.195 −11.114 1.00 29.65 L111 O ATOM 613 N SER A 90 −0.260 20.881 −13.651 1.00 36.82 L111 N ATOM 614 CA SER A 90 0.716 20.083 −14.372 1.00 35.62 L111 C ATOM 615 C SER A 90 1.981 20.112 −13.530 1.00 35.74 L111 C ATOM 616 O SER A 90 2.879 19.287 −13.692 1.00 37.58 L111 O ATOM 617 CB SER A 90 0.976 20.682 −15.758 1.00 37.33 L111 C ATOM 618 OG SER A 90 1.955 21.708 −15.701 1.00 51.94 L111 O ATOM 619 N GLU A 91 2.034 21.083 −12.625 1.00 33.32 L111 N ATOM 620 CA GLU A 91 3.166 21.246 −11.726 1.00 38.55 L111 C ATOM 621 C GLU A 91 2.619 21.648 −10.362 1.00 37.86 L111 C ATOM 622 O GLU A 91 2.553 22.832 −10.026 1.00 36.53 L111 O ATOM 623 CB GLU A 91 4.115 22.317 −12.262 1.00 42.92 L111 C ATOM 624 CG GLU A 91 4.927 21.857 −13.457 l.00 56.44 L111 C ATOM 625 CD GLU A 91 6.025 22.832 −13.841 1.00 69.04 L111 C ATOM 626 OE1 GLU A 91 6.223 23.832 −13.113 1.00 67.53 L111 O ATOM 627 OE2 GLU A 91 6.692 22.593 −14.876 1.00 73.04 L111 O ATOM 628 N PRO A 92 2.199 20.652 −9.561 1.00 39.75 L111 N ATOM 629 CA PRO A 92 1.643 20.871 −8.222 1.00 37.71 L111 C ATOM 630 C PRO A 92 2.536 21.749 −7.365 1.00 33.98 L111 C ATOM 631 O PRO A 92 3.760 21.633 −7.418 1.00 31.75 L111 O ATOM 632 CB PRO A 92 1.505 19.459 −7.655 1.00 34.90 L111 C ATOM 633 CG PRO A 92 1.371 18.596 −8.852 1.00 30.25 L111 C ATOM 634 CD PRO A 92 2.246 19.219 −9.898 1.00 39.42 L111 C ATOM 635 N LYS A 93 1.910 22.625 −6.584 1.00 30.90 L111 N ATOM 636 CA LYS A 93 2.620 23.544 −5.703 1.00 36.65 L111 C ATOM 637 C LYS A 93 3.250 24.695 −6.477 1.00 36.64 L111 C ATOM 638 O LYS A 93 3.181 25.841 −6.044 1.00 45.57 L111 O ATOM 639 CB LYS A 93 3.699 22.800 −4.907 1.00 42.76 L111 C ATOM 640 CG LYS A 93 4.532 23.681 −3.993 1.00 47.27 L111 C ATOM 641 CD LYS A 93 4.991 22.907 −2.768 1.00 53.52 L111 C ATOM 642 CE LYS A 93 5.915 23.744 −1.894 1.00 54.40 L111 C ATOM 643 NZ LYS A 93 7.235 23.085 −1.673 1.00 61.73 L111 N ATOM 644 N ARG A 94 3.864 24.394 −7.616 1.00 35.63 L111 N ATOM 645 CA ARG A 94 4.486 25.432 −8.430 1.00 29.80 L111 C ATOM 646 C ARG A 94 3.408 26.252 −9.125 1.00 32.19 L111 C ATOM 647 O ARG A 94 3.593 27.443 −9.371 1.00 36.21 L111 O ATOM 648 CB ARG A 94 5.418 24.817 −9.475 1.00 21.41 L111 C ATOM 649 CG ARG A 94 6.818 24.559 −8.966 1.00 26.71 L111 C ATOM 650 CD ARG A 94 7.779 24.180 −10.088 1.00 28.16 L111 C ATOM 651 NE ARG A 94 9.002 23.582 −9.551 1.00 40.63 L111 N ATOM 652 CZ ARG A 94 10.016 23.133 −10.289 1.00 42.98 L111 C ATOM 653 NH1 ARG A 94 9.965 23.212 −11.610 1.00 45.19 L111 N ATOM 654 NH2 ARG A 94 11.085 22.606 −9.704 1.00 48.46 L111 N ATOM 655 N LYS A 95 2.284 25.612 −9.440 1.00 28.46 L111 N ATOM 656 CA LYS A 95 1.177 26.298 −10.104 1.00 30.94 L111 C ATOM 657 C LYS A 95 −0.145 25.834 −9.542 1.00 28.39 L111 C ATOM 658 O LYS A 95 −0.511 24.679 −9.700 1.00 40.28 L111 O ATOM 659 CB LYS A 95 1.169 26.024 −11.614 1.00 36.77 L111 C ATOM 660 CG LYS A 95 2.531 25.791 −12.244 1.00 49.47 L111 C ATOM 661 CD LYS A 95 2.426 25.746 −13.765 1.00 48.94 L111 C ATOM 662 CE LYS A 95 3.782 25.970 −14.420 1.00 50.63 L111 C ATOM 663 NZ LYS A 95 3.730 25.733 −15.886 1.00 46.96 L111 N ATOM 664 N ILE A 96 −0.872 26.728 −8.892 1.00 30.02 L111 N ATOM 665 CA ILE A 96 −2.162 26.357 −8.337 1.00 31.34 L111 C ATOM 666 C ILE A 96 −3.209 26.537 −9.425 1.00 35.19 L111 C ATOM 667 O ILE A 96 −3.286 27.593 −10.048 1.00 42.96 L111 O ATOM 668 CB ILE A 96 −2.502 27.231 −7.115 1.00 33.87 L111 C ATOM 669 CG1 ILE A 96 −1.379 27.115 −6.079 1.00 33.04 L111 C ATOM 670 CG2 ILE A 96 −3.840 26.812 −6.518 1.00 28.64 L111 C ATOM 671 CD1 ILE A 96 −0.892 25.695 −5.843 i.00 35.36 L111 C ATOM 672 N VAL A 97 −4.008 25.504 −9.664 1.00 32.56 L111 N ATOM 673 CA VAL A 97 −5.022 25.570 −10.704 1.00 29.74 L111 C ATOM 674 C VAL A 97 −6.427 25.650 −10.148 1.00 36.58 L111 C ATOM 675 O VAL A 97 −7.399 25.737 −10.905 1.00 38.60 L111 O ATOM 676 CB VAL A 97 −4.930 24.351 −11.648 1.00 38.47 L111 C ATOM 677 CG1 VAL A 97 −3.502 24.185 −12.123 1.00 37.01 L111 C ATOM 678 CG2 VAL A 97 −5.403 23.086 −10.940 1.00 37.97 L111 C ATOM 679 N GLY A 98 −6.531 25.623 −8.823 1.00 35.02 L111 N ATOM 680 CA GLY A 98 −7.836 25.690 −8.192 1.00 35.16 L111 C ATOM 681 C GLY A 98 −7.744 25.779 −6.683 1.00 38.01 L111 C ATOM 682 O GLY A 98 −6.648 25.832 −6.117 1.00 38.34 L111 O ATOM 683 N LYS A 99 −8.896 25.801 −6.023 1.00 35.14 L111 N ATOM 684 CA LYS A 99 −8.911 25.883 −4.575 1.00 40.57 L111 C ATOM 685 C LYS A 99 −10.230 25.403 −3.991 1.00 42.95 L111 C ATOM 686 O LYS A 99 −11.264 25.396 −4.663 1.00 42.23 L111 O ATOM 687 CB LYS A 99 −8.634 27.320 −4.130 1.00 50.99 L111 C ATOM 688 CG LYS A 99 −9.850 28.231 −4.172 1.00 60.57 L111 C ATOM 689 CD LYS A 99 −9.469 29.678 −3.885 1.00 65.97 L111 C ATOM 690 CE LYS A 99 −10.646 30.614 −4.127 1.00 63.49 L111 C ATOM 691 NZ LYS A 99 −10.216 31.886 −4.768 1.00 65.04 L111 N ATOM 692 N VAL A 100 −10.180 24.992 −2.731 1.00 40.70 L111 N ATOM 693 CA VAL A 100 −11.361 24.511 −2.036 1.00 41.33 L111 C ATOM 694 C VAL A 100 −11.330 24.980 −0.592 1.00 41.84 L111 C ATOM 695 O VAL A 100 −10.263 25.188 −0.012 1.00 40.91 L111 O ATOM 696 CB VAL A 100 −11.440 22.973 −2.057 1.00 42.37 L111 C ATOM 697 CG1 VAL A 100 −11.840 22.498 −3.442 1.00 43.81 L111 C ATOM 698 CG2 VAL A 100 −10.102 22.377 −1.651 1.00 37.38 L111 C ATOM 699 N THR A 101 −12.511 25.145 −0.016 1.00 43.68 L111 N ATOM 700 CA THR A 101 −12.629 25.595 1.355 1.00 42.43 L111 C ATOM 701 C THR A 101 −12.362 24.454 2.321 1.00 45.89 L111 C ATOM 702 O THR A 101 −12.495 23.284 1.963 1.00 46.60 L111 O ATOM 703 CB THR A 101 −14.026 26.153 1.610 1.00 45.72 L111 C ATOM 704 OG1 THR A 101 −15.005 25.154 1.293 1.00 40.56 L111 O ATOM 705 CG2 THR A 101 −14.260 27.380 0.738 1.00 42.52 L111 C ATOM 706 N ARG A 102 −11.981 24.799 3.545 1.00 49.33 L111 N ATOM 707 CA ARG A 102 −11.701 23.797 4.565 1.00 49.44 L111 C ATOM 708 C ARG A 102 −12.925 22.925 4.792 1.00 49.34 L111 C ATOM 709 O ARG A 102 −12.807 21.744 5.115 1.00 53.45 L111 O ATOM 710 CB ARG A 102 −11.301 24.469 5.879 1.00 51.60 L111 C ATOM 711 CG ARG A 102 −10.126 23.806 6.574 1.00 64.32 L111 C ATOM 712 CD ARG A 102 −10.579 23.003 7.777 1.00 72.71 L111 C ATOM 713 NE ARG A 102 −10.495 23.786 9.006 1.00 86.85 L111 N ATOM 714 CZ ARG A 102 −10.080 23.304 10.174 1.00 96.04 L111 C ATOM 715 NH1 ARG A 102 −9.710 22.033 10.275 1.00 95.91 L111 N ATOM 716 NH2 ARG A 102 −10.033 24.095 11.242 1.00 96.71 L111 N ATOM 717 N LYS A 103 −14.103 23.514 4.626 1.00 50.48 L111 N ATOM 718 CA LYS A 103 −15.341 22.774 4.811 1.00 51.76 L111 C ATOM 719 C LYS A 103 −15.441 21.718 3.719 1.00 51.34 L111 C ATOM 720 O LYS A 103 −15.884 20.600 3.966 1.00 59.36 L111 O ATOM 721 CB LYS A 103 −16.545 23.721 4.751 1.00 53.67 L111 C ATOM 722 CG LYS A 103 −17.839 23.135 5.319 1.00 62.90 L111 C ATOM 723 CD LYS A 103 −17.717 22.781 6.806 1.00 65.48 L111 C ATOM 724 CE LYS A 103 −18.840 21.841 7.257 1.00 63.76 L111 C ATOM 725 NZ LYS A 103 −19.077 21.884 8.732 1.00 58.26 L111 N ATOM 726 N GLN A 104 −15.013 22.073 2.512 1.00 51.89 L111 N ATOM 727 CA GLN A 104 −15.052 21.145 1.388 1.00 44.08 L111 C ATOM 728 C GLN A 104 −14.161 19.939 1.664 1.00 42.43 L111 C ATOM 729 O GLN A 104 −14.519 18.804 1.347 1.00 40.53 L111 O ATOM 730 CB GLN A 104 −14.602 21.850 0.110 1.00 42.64 L111 C ATOM 731 CG GLN A 104 −15.663 22.751 −0.484 1.00 35.82 L111 C ATOM 732 CD GLN A 104 −15.242 23.354 −1.804 1.00 44.67 L111 C ATOM 733 OE1 GLN A 104 −14.303 24.154 −1.867 1.00 37.53 L111 O ATOM 734 NE2 GLN A 104 −15.936 22.975 −2.873 1.00 35.39 L111 N ATOM 735 N ILE A 105 −12.998 20.186 2.254 1.00 39.32 L111 N ATOM 736 CA ILE A 105 −12.088 19.103 2.584 1.00 35.57 L111 C ATOM 737 C ILE A 105 −12.846 18.187 3.525 1.00 41.32 L111 C ATOM 738 O ILE A 105 −12.770 16.965 3.411 1.00 46.00 L111 O ATOM 739 CB ILE A 105 −10.832 19.624 3.298 1.00 33.68 L111 C ATOM 740 CG1 ILE A 105 −9.873 20.242 2.277 1.00 32.96 L111 C ATOM 741 CG2 ILE A 105 −10.154 18.495 4.061 1.00 34.33 L111 C ATOM 742 CD1 ILE A 105 −9.501 19.321 1.131 1.00 34.42 L111 C ATOM 743 N GLU A 106 −13.584 18.800 4.448 1.00 47.08 L111 N ATOM 744 CA GLU A 106 −14.382 18.068 5.428 1.00 53.52 L111 C ATOM 745 C GLU A 106 −15.411 17.186 4.719 1.00 55.13 L111 C ATOM 746 O GLU A 106 −15.606 16.027 5.087 1.00 59.36 L111 O ATOM 747 CB GLU A 106 −15.094 19.051 6.381 1.00 50.72 L111 C ATOM 748 CG GLU A 106 −15.480 18.464 7.748 1.00 55.56 L111 C ATOM 749 CD GLU A 106 −16.029 19.504 8.734 1.00 62.03 L111 C ATOM 750 OE1 GLU A 106 −15.308 20.476 9.054 1.00 63.26 L111 O ATOM 751 OE2 GLU A 106 −17.182 19.345 9.199 1.00 53.90 L111 O ATOM 752 N GLU A 107 −16.061 17.731 3.695 1.00 51.75 L111 N ATOM 753 CA GLU A 107 −17.071 16.982 2.954 1.00 52.07 L111 C ATOM 754 C GLU A 107 −16.476 15.755 2.282 1.00 50.13 L111 C ATOM 755 O GLU A 107 −16.990 14.642 2.417 1.00 49.53 L111 O ATOM 756 CB GLU A 107 −17.720 17.871 1.891 1.00 56.84 L111 C ATOM 757 CG GLU A 107 −17.859 19.328 2.293 1.00 73.20 L111 C ATOM 758 CD GLU A 107 −18.843 20.088 1.422 1.00 81.27 L111 C ATOM 759 OE1 GLU A 107 −19.271 19.540 0.382 1.00 84.05 L111 O ATOM 760 OE2 GLU A 107 −19.187 21.237 1.779 1.00 86.15 L111 O ATOM 761 N ILE A 108 −15.391 15.973 1.549 1.00 46.89 L111 N ATOM 762 CA ILE A 108 −14.719 14.900 0.844 1.00 39.41 L111 C ATOM 763 C ILE A 108 −14.222 13.854 1.829 1.00 40.77 L111 C ATOM 764 O ILE A 108 −14.441 12.658 1.637 1.00 43.65 L111 O ATOM 765 CB ILE A 108 −13.542 15.447 0.019 1.00 38.05 L111 C ATOM 766 CG1 ILE A 108 −14.072 16.428 −1.032 1.00 36.44 L111 C ATOM 767 CG2 ILE A 108 −12.796 14.305 −0.649 1.00 41.19 L111 C ATOM 768 CD1 ILE A 108 −13.004 17.084 −1.882 1.00 31.78 L111 C ATOM 769 N ALA A 109 −13.561 14.303 2.891 1.00 40.57 L111 N ATOM 770 CA ALA A 109 −13.053 13.380 3.895 1.00 42.41 L111 C ATOM 771 C ALA A 109 −14.205 12.546 4.429 1.00 44.77 L111 C ATOM 772 O ALA A 109 −14.051 11.356 4.685 1.00 48.40 L111 O ATOM 773 CB ALA A 109 −12.393 14.140 5.032 1.00 38.72 L111 C ATOM 774 N LYS A 110 −15.365 13.174 4.589 1.00 47.97 L111 N ATOM 775 CA LYS A 110 −16.537 12.474 5.099 1.00 44.59 L111 C ATOM 776 C LYS A 110 −17.027 11.474 4.066 1.00 45.30 L111 C ATOM 777 O LYS A 110 −17.377 10.342 4.401 1.00 44.67 L111 O ATOM 778 CB LYS A 110 −17.651 13.469 5.422 1.00 45.45 L111 C ATOM 779 CG LYS A 110 −17.991 13.562 6.902 1.00 47.29 L111 C ATOM 780 CD LYS A 110 −17.733 14.963 7.448 1.00 51.84 L111 C ATOM 781 CE LYS A 110 −18.991 15.558 8.070 1.00 53.58 L111 C ATOM 782 NZ LYS A 110 −18.712 16.257 9.356 1.00 55.16 L111 N ATOM 783 N THR A 111 −17.043 11.902 2.807 1.00 44.49 L111 N ATOM 784 CA THR A 111 −17.492 11.060 1.705 1.00 42.63 L111 C ATOM 785 C THR A 111 −16.635 9.810 1.548 1.00 44.42 L111 C ATOM 786 O THR A 111 −17.149 8.707 1.375 1.00 44.77 L111 O ATOM 787 CB THR A 111 −17.452 11.830 0.376 1.00 40.13 L111 C ATOM 788 OG1 THR A 111 −18.545 12.754 0.325 1.00 46.15 L111 O ATOM 789 CG2 THR A 111 −17.552 10.871 −0.799 1.00 43.65 L111 C ATOM 790 N LYS A 112 −15.323 9.995 1.609 1.00 42.25 L111 N ATOM 791 CA LYS A 112 −14.382 8.898 1.448 1.00 42.77 L111 C ATOM 792 C LYS A 112 −14.081 8.127 2.732 1.00 43.93 L111 C ATOM 793 O LYS A 112 −13.321 7.157 2.713 1.00 47.28 L111 O ATOM 794 CB LYS A 112 −13.072 9.442 0.873 1.00 44.33 L111 C ATOM 795 CG LYS A 112 −13.129 9.772 −0.607 1.00 40.93 L111 C ATOM 796 CD LYS A 112 −11.806 9.474 −1.281 1.00 35.66 L111 C ATOM 797 CE LYS A 112 −11.377 8.032 −1.062 1.00 31.03 L111 C ATOM 798 NZ LYS A 112 −11.960 7.113 −2.076 1.00 28.57 L111 N ATOM 799 N MET A 113 −14.673 8.554 3.842 1.00 42.32 L111 N ATOM 800 CA MET A 113 −14.436 7.911 5.132 1.00 41.26 L111 C ATOM 801 C MET A 113 −14.492 6.379 5.116 1.00 39.35 L111 C ATOM 802 O MET A 113 −13.619 5.717 5.688 1.00 39.20 L111 O ATOM 803 CB MET A 113 −15.410 8.457 6.177 1.00 39.84 L111 C ATOM 804 CG MET A 113 −14.931 8.283 7.609 1.00 45.81 L111 C ATOM 805 SD MET A 113 −13.481 9.269 8.040 1.00 47.31 L111 S ATOM 806 CE MET A 113 −14.261 10.787 8.610 1.00 49.60 L111 C ATOM 807 N PRO A 114 −15.524 5.793 4.484 1.00 32.93 L111 N ATOM 808 CA PRO A 114 −15.582 4.328 4.458 1.00 29.51 L111 C ATOM 809 C PRO A 114 −14.301 3.703 3.912 1.00 35.05 L111 C ATOM 810 O PRO A 114 −13.918 2.609 4.314 1.00 41.74 L111 O ATOM 811 CB PRO A 114 −16.791 4.013 3.575 1.00 27.80 L111 C ATOM 812 CG PRO A 114 −17.214 5.307 2.967 1.00 23.57 L111 C ATOM 813 CD PRO A 114 −16.678 6.411 3.811 1.00 31.92 L111 C ATOM 814 N ASP A 115 −13.629 4.408 3.008 1.00 38.82 L111 N ATOM 815 CA ASP A 115 −12.399 3.898 2.419 1.00 36.41 L111 C ATOM 816 C ASP A 115 −11.138 4.462 3.069 1.00 36.55 L111 C ATOM 817 O ASP A 115 −10.025 4.080 2.713 1.00 40.35 L111 O ATOM 818 CB ASP A 115 −12.385 4.193 0.919 1.00 48.68 L111 C ATOM 819 CG ASP A 115 −13.453 3.418 0.162 1.00 57.41 L111 C ATOM 820 OD1 ASP A 115 −13.653 2.221 0.464 1.00 51.55 L111 O ATOM 821 OD2 ASP A 115 −14.090 4.009 −0.737 1.00 58.21 L111 O ATOM 822 N LEU A 116 −11.311 5.368 4.024 1.00 38.89 L111 N ATOM 823 CA LEU A 116 −10.178 5.969 4.720 1.00 33.57 L111 C ATOM 824 C LEU A 116 −9.916 5.199 6.007 1.00 32.97 L111 C ATOM 825 O LEU A 116 −10.817 4.567 6.547 1.00 40.69 L111 O ATOM 826 CB LEU A 116 −10.482 7.427 5.055 1.00 38.53 L111 C ATOM 827 CG LEU A 116 −9.930 8.533 4.156 1.00 37.13 L111 C ATOM 828 CD1 LEU A 116 −9.839 8.062 2.720 1.00 34.98 L111 C ATOM 829 CD2 LEU A 116 −10.837 9.742 4.261 1.00 33.33 L111 C ATOM 830 N ASN A 117 −8.686 5.256 6.501 1.00 32.67 L111 N ATOM 831 CA ASN A 117 −8.336 4.549 7.725 1.00 33.28 L111 C ATOM 832 C ASN A 117 −8.052 5.502 8.889 1.00 39.76 L111 C ATOM 833 O ASN A 117 −7.373 5.140 9.851 1.00 36.63 L111 O ATOM 834 CB ASN A 117 −7.117 3.666 7.475 1.00 23.35 L111 C ATOM 835 CG ASN A 117 −5.872 4.470 7.208 1.00 24.02 L111 C ATOM 836 OD1 ASN A 117 −5.949 5.659 6.916 1.00 31.18 L111 O ATOM 837 ND2 ASN A 117 −4.714 3.828 7.306 1.00 18.87 L111 N ATOM 838 N ALA A 118 −8.572 6.720 8.799 1.00 41.20 L111 N ATOM 839 CA ALA A 118 −8.363 7.710 9.846 1.00 41.18 L111 C ATOM 840 C ALA A 118 −9.297 7.443 11.018 1.00 43.82 L111 C ATOM 841 O ALA A 118 −10.455 7.069 10.827 1.00 45.81 L111 O ATOM 842 CB ALA A 118 −8.604 9.103 9.296 1.00 41.30 L111 C ATOM 843 N ASN A 119 −8.793 7.644 12.230 1.00 42.07 L111 N ATOM 844 CA ASN A 119 −9.589 7.419 13.429 1.00 42.41 L111 C ATOM 845 C ASN A 119 −10.370 8.660 13.847 1.00 48.14 L111 C ATOM 846 O ASN A 119 −11.141 8.625 14.807 1.00 53.14 L111 O ATOM 847 CB ASN A 119 −8.684 6.981 14.575 1.00 37.27 L111 C ATOM 848 CG ASN A 119 −8.180 5.575 14.400 1.00 33.45 L111 C ATOM 849 OD1 ASN A 119 −8.886 4.714 13.876 1.00 31.47 L111 O ATOM 850 ND2 ASN A 119 −6.951 5.328 14.837 1.00 38.73 L111 N ATOM 851 N SER A 120 −10.168 9.756 13.125 1.00 48.44 L111 N ATOM 852 CA SER A 120 −10.851 11.005 13.430 1.00 43.86 L111 C ATOM 853 C SER A 120 −11.091 11.809 12.163 1.00 45.90 L111 C ATOM 854 O SER A 120 −10.321 11.715 11.208 1.00 53.71 L111 O ATOM 855 CB SER A 120 −10.010 11.834 14.401 1.00 38.80 L111 C ATOM 856 OG SER A 120 −8.642 11.834 14.030 1.00 32.06 L111 O ATOM 857 N LEU A 121 −12.157 12.601 12.156 1.00 46.97 L111 N ATOM 858 CA LEU A 121 −12.476 13.429 11.000 1.00 44.83 L111 C ATOM 859 C LEU A 121 −11.297 14.333 10.678 1.00 45.31 L111 C ATOM 860 O LEU A 121 −11.078 14.693 9.526 1.00 52.25 L111 O ATOM 861 CB LEU A 121 −13.705 14.291 11.277 1.00 39.77 L111 C ATOM 862 CG LEU A 121 −13.904 15.469 10.325 1.00 41.18 L111 C ATOM 863 CD1 LEU A 121 −14.063 14.958 8.900 1.00 41.06 L111 C ATOM 864 CD2 LEU A 121 −15.128 16.260 10.751 1.00 41.00 L111 C ATOM 865 N GLU A 122 −10.542 14.701 11.705 1.00 46.54 L111 N ATOM 866 CA GLU A 122 −9.383 15.562 11.522 1.00 47.46 L111 C ATOM 867 C GLU A 122 −8.327 14.834 10.702 1.00 45.12 L111 C ATOM 868 O GLU A 122 −7.781 15.383 9.747 1.00 51.65 L111 O ATOM 869 CB GLU A 122 −8.807 15.962 12.881 1.00 45.32 L111 C ATOM 870 CG GLU A 122 −9.646 16.987 13.629 1.00 57.78 L111 C ATOM 871 CD GLU A 122 −10.643 16.353 14.588 1.00 63.03 L111 C ATOM 872 OE1 GLU A 122 −10.380 15.234 15.075 1.00 64.43 L111 O ATOM 873 OE2 GLU A 122 −11.690 16.979 14.857 1.00 69.35 L111 O ATOM 874 N ALA A 123 −8.045 13.593 11.083 1.00 41.17 L111 N ATOM 875 CA ALA A 123 −7.062 12.786 10.381 1.00 38.97 L111 C ATOM 876 C ALA A 123 −7.516 12.566 8.944 1.00 41.17 L111 C ATOM 877 O ALA A 123 −6.701 12.562 8.022 1.00 41.16 L111 O ATOM 878 CB ALA A 123 −6.891 11.452 11.081 1.00 36.50 L111 C ATOM 879 N ALA A 124 −8.822 12.389 8.760 1.00 36.64 L111 N ATOM 880 CA ALA A 124 −9.390 12.168 7.432 1.00 36.26 L111 C ATOM 881 C ALA A 124 −9.133 13.362 6.533 1.00 35.14 L111 C ATOM 882 O ALA A 124 −8.742 13.207 5.379 1.00 41.09 L111 O ATOM 883 CB ALA A 124 −10.886 11.914 7.533 1.00 32.82 L111 C ATOM 884 N MET A 125 −9.358 14.555 7.072 1.00 38.73 L111 N ATOM 885 CA MET A 125 −9.158 15.785 6.322 1.00 34.84 L111 C ATOM 886 C MET A 125 −7.686 15.968 6.003 1.00 31.87 L111 C ATOM 887 O MET A 125 −7.330 16.458 4.938 1.00 42.09 L111 O ATOM 888 CB MET A 125 −9.671 16.977 7.126 1.00 35.51 L111 C ATOM 889 CG MET A 125 −11.072 16.769 7.695 1.00 40.88 L111 C ATOM 890 SD MET A 125 −12.008 18.287 7.948 1.00 45.99 L111 S ATOM 891 CE MET A 125 −10.675 19.462 8.286 1.00 44.96 L111 C ATOM 892 N LYS A 126 −6.831 15.567 6.930 1.00 28.09 L111 N ATOM 893 CA LYS A 126 −5.397 15.684 6.730 1.00 28.15 L111 C ATOM 894 C LYS A 126 −5.007 14.801 5.551 1.00 30.29 L111 C ATOM 895 O LYS A 126 −4.107 15.129 4.781 1.00 32.85 L111 O ATOM 896 CB LYS A 126 −4.652 15.229 7.989 1.00 34.95 L111 C ATOM 897 CG LYS A 126 −4.010 16.351 8.781 1.00 28.05 L111 C ATOM 898 CD LYS A 126 −4.465 16.328 10.229 1.00 31.31 L111 C ATOM 899 CE LYS A 126 −3.431 15.676 11.140 1.00 39.80 L111 C ATOM 900 NZ LYS A 126 −2.064 16.271 11.016 1.00 45.29 L111 N ATOM 901 N ILE A 127 −5.691 13.669 5.417 1.00 32.92 L111 N ATOM 902 CA ILE A 127 −5.414 12.748 4.325 1.00 29.89 L111 C ATOM 903 C ILE A 127 −5.820 13.405 3.014 1.00 30.60 L111 C ATOM 904 O ILE A 127 −5.024 13.492 2.086 1.00 36.08 L111 O ATOM 905 CB ILE A 127 −6.179 11.423 4.501 1.00 23.98 L111 C ATOM 906 CG1 ILE A 127 −5.591 10.649 5.689 1.00 33.32 L111 C ATOM 907 CG2 ILE A 127 −6.074 10.590 3.234 1.00 26.83 L111 C ATOM 908 CD1 ILE A 127 −6.427 9.465 6.152 1.00 25.44 L111 C ATOM 909 N ILE A 128 −7.060 13.875 2.947 1.00 30.31 L111 N ATOM 910 CA ILE A 128 −7.559 14.543 1.756 1.00 27.70 L111 C ATOM 911 C ILE A 128 −6.681 15.730 1.359 1.00 30.19 L111 C ATOM 912 O ILE A 128 −6.406 15.939 0.181 1.00 37.83 L111 O ATOM 913 CB ILE A 128 −8.980 15.065 1.974 1.00 29.26 L111 C ATOM 914 CG1 ILE A 128 −9.911 13.906 2.325 1.00 27.20 L111 C ATOM 915 CG2 ILE A 128 −9.454 15.802 0.731 1.00 29.10 L111 C ATOM 916 CD1 ILE A 128 −9.915 12.793 1.304 1.00 21.41 L111 C ATOM 917 N GLU A 129 −6.245 16.507 2.342 1.00 27.35 L111 N ATOM 918 CA GLU A 129 −5.412 17.669 2.065 1.00 28.43 L111 C ATOM 919 C GLU A 129 −4.116 17.249 1.418 1.00 25.38 L111 C ATOM 920 O GLU A 129 −3.554 17.983 0.613 1.00 33.17 L111 O ATOM 921 CB GLU A 129 −5.092 18.429 3.348 1.00 39.34 L111 C ATOM 922 CG GLU A 129 −6.223 19.289 3.870 1.00 49.18 L111 C ATOM 923 CD GLU A 129 −6.093 19.546 5.355 1.00 57.36 L111 C ATOM 924 OE1 GLU A 129 −4.942 19.571 5.849 1.00 62.27 L111 O ATOM 925 OE2 GLU A 129 −7.136 19.716 6.024 1.00 61.09 L111 O ATOM 926 N GLY A 130 −3.634 16.071 1.785 1.00 24.18 L111 N ATOM 927 CA GLY A 130 −2.394 15.591 1.210 1.00 21.91 L111 C ATOM 928 C GLY A 130 −2.536 15.392 −0.285 1.00 23.19 L111 C ATOM 929 O GLY A 130 −1.597 15.625 −1.042 1.00 21.99 L111 O ATOM 930 N THR A 131 −3.720 14.962 −0.705 1.00 22.49 L111 N ATOM 931 CA THR A 131 −4.005 14.723 −2.111 1.00 25.94 L111 C ATOM 932 C THR A 131 −4.160 16.049 −2.849 1.00 28.86 L111 C ATOM 933 O THR A 131 −3.629 16.229 −3.946 1.00 31.66 L111 O ATOM 934 CB THR A 131 −5.292 13.896 −2.270 1.00 27.10 L111 C ATOM 935 OG1 THR A 131 −5.078 12.577 −1.747 1.00 26.23 L111 O ATOM 936 CG2 THR A 131 −5.694 13.808 −3.734 1.00 27.07 L111 C ATOM 937 N ALA A 132 −4.887 16.979 −2.241 1.00 27.56 L111 N ATOM 938 CA ALA A 132 −5.096 18.292 −2.835 1.00 26.64 L111 C ATOM 939 C ALA A 132 −3.753 18.974 −3.058 1.00 28.30 L111 C ATOM 940 O ALA A 132 −3.524 19.602 −4.084 1.00 30.29 L111 O ATOM 941 CB ALA A 132 −5.954 19.134 −1.922 1.00 32.54 L111 C ATOM 942 N LYS A 133 −2.866 18.843 −2.082 1.00 29.52 L111 N ATOM 943 CA LYS A 133 −1.545 19.443 −2.158 1.00 27.21 L111 C ATOM 944 C LYS A 133 −0.754 18.848 −3.311 1.00 30.72 L111 C ATOM 945 O LYS A 133 0.190 19.458 −3.813 1.00 34.77 L111 O ATOM 946 CB LYS A 133 −0.784 19.205 −0.846 1.00 30.61 L111 C ATOM 947 CG LYS A 133 −0.843 20.371 0.138 1.00 38.23 L111 C ATOM 948 CD LYS A 133 −0.782 19.897 1.581 1.00 35.27 L111 C ATOM 949 CE LYS A 133 0.653 19.826 2.079 1.00 45.39 L111 C ATOM 950 NZ LYS A 133 0.737 19.680 3.568 1.00 50.50 L111 N ATOM 951 N SER A 134 −1.141 17.650 −3.729 1.00 31.51 L111 N ATOM 952 CA SER A 134 −0.441 16.966 −4.807 1.00 33.04 L111 C ATOM 953 C SER A 134 −0.969 17.300 −6.202 1.00 30.13 L111 C ATOM 954 O SER A 134 −0.345 16.952 −7.198 1.00 27.50 L111 O ATOM 955 CB SER A 134 −0.510 15.452 −4.588 1.00 31.88 L111 C ATOM 956 OG SER A 134 −1.741 14.927 −5.055 1.00 23.70 L111 O ATOM 957 N MET A 135 −2.107 17.977 −6.276 1.00 26.88 L111 N ATOM 958 CA MET A 135 −2.691 18.308 −7.563 1.00 25.82 L111 C ATOM 959 C MET A 135 −2.887 19.801 −7.783 1.00 31.45 L111 C ATOM 960 O MET A 135 −3.737 20.209 −8.581 1.00 30.19 L111 O ATOM 961 CB MET A 135 −4.029 17.597 −7.711 1.00 27.23 L111 C ATOM 962 CG MET A 135 −4.974 17.857 −6.574 1.00 22.80 L111 C ATOM 963 SD MET A 135 −6.230 16.597 −6.491 1.00 37.09 L111 S ATOM 964 CE MET A 135 −7.008 16.793 −8.089 1.00 41.07 L111 C ATOM 965 N GLY A 136 −2.105 20.613 −7.078 1.00 27.82 L111 N ATOM 966 CA GLY A 136 −2.215 22.050 −7.228 1.00 22.84 L111 C ATOM 967 C GLY A 136 −3.569 22.630 −6.854 1.00 27.99 L111 C ATOM 968 O GLY A 136 −4.068 23.538 −7.515 1.00 33.90 L111 O ATOM 969 N ILE A 137 −4.181 22.099 −5.806 1.00 27.75 L111 N ATOM 970 CA ILE A 137 −5.458 22.621 −5.345 1.00 29.45 L111 C ATOM 971 C ILE A 137 −5.207 23.141 −3.934 1.00 37.77 L111 C ATOM 972 O ILE A 137 −4.722 22.409 −3.066 1.00 42.44 L111 O ATOM 973 CB ILE A 137 −6.553 21.535 −5.334 1.00 29.74 L111 C ATOM 974 CG1 ILE A 137 −6.755 20.994 −6.751 1.00 30.99 L111 C ATOM 975 CG2 ILE A 137 −7.864 22.117 −4.842 1.00 21.17 L111 C ATOM 976 CD1 ILE A 137 −7.883 19.989 −6.877 1.00 23.63 L111 C ATOM 977 N GLU A 138 −5.508 24.419 −3.723 1.00 40.79 L111 N ATOM 978 CA GLU A 138 −5.299 25.058 −2.435 1.00 39.24 L111 C ATOM 979 C GLU A 138 −6.528 25.003 −1.549 1.00 43.73 L111 C ATOM 980 O GLU A 138 −7.640 24.799 −2.031 1.00 48.97 L111 O ATOM 981 CB GLU A 138 −4.903 26.506 −2.644 1.00 41.53 L111 C ATOM 982 CG GLU A 138 −3.466 26.787 −2.294 1.00 59.35 L111 C ATOM 983 CD GLU A 138 −3.094 28.228 −2.556 1.00 67.14 L111 C ATOM 984 OE1 GLU A 138 −3.950 28.970 −3.098 1.00 59.01 L111 O ATOM 985 OE2 GLU A 138 −1.950 28.613 −2.220 1.00 67.00 L111 O ATOM 986 N VAL A 139 −6.316 25.193 −0.251 1.00 48.03 L111 N ATOM 987 CA VAL A 139 −7.404 25.171 0.725 1.00 52.55 L111 C ATOM 988 C VAL A 139 −7.561 26.549 1.370 1.00 53.32 L111 C ATOM 989 O VAL A 139 −6.578 27.164 1.782 1.00 54.50 L111 O ATOM 990 CB VAL A 139 −7.144 24.122 1.838 1.00 47.09 L111 C ATOM 991 CG1 VAL A 139 −7.486 22.741 1.332 1.00 46.28 L111 C ATOM 992 CG2 VAL A 139 −5.689 24.171 2.281 1.00 54.07 L111 C ATOM 993 N VAL A 140 −8.799 27.028 1.454 1.00 57.53 L111 N ATOM 994 CA VAL A 140 −9.076 28.334 2.045 1.00 58.40 L111 C ATOM 995 C VAL A 140 −10.295 28.298 2.970 1.00 64.90 L111 C ATOM 966 O VAL A 140 −11.243 27.540 2.674 1.00 63.16 L111 O ATOM 997 CB VAL A 140 −9.321 29.394 0.950 1.00 56.76 L111 C ATOM 998 CG1 VAL A 140 −8.207 29.343 −0.082 1.00 48.47 L111 C ATOM 999 CG2 VAL A 140 −10.667 29.156 0.288 1.00 56.93 L111 C ATOM 1000 OXT VAL A 140 −10.290 29.036 3.980 1.00 72.53 L111 O TER 1001 VAL A 140 ATOM 1002 N LYS B 71 −21.043 −5.854 −42.905 1.00 63.31 L112 N ATOM 1003 CA LYS B 71 −20.335 −6.681 −43.925 1.00 62.12 L112 C ATOM 1004 C LYS B 71 −20.331 −8.162 −43.563 1.00 64.08 L112 C ATOM 1005 O LYS B 71 −20.688 −8.546 −42.446 1.00 64.38 L112 O ATOM 1006 CB LYS B 71 −18.892 −6.202 −44.080 1.00 58.09 L112 C ATOM 1007 CG LYS B 71 −18.753 −4.928 −44.883 1.00 57.55 L112 C ATOM 1008 CD LYS B 71 −17.414 −4.877 −45.584 1.00 59.51 L112 C ATOM 1009 CE LYS B 71 −17.502 −4.091 −46.883 1.00 73.52 L112 C ATOM 1010 NZ LYS B 71 −16.276 −3.277 −47.136 1.00 74.38 L112 N ATOM 1011 N THR B 72 −19.922 −8.992 −44.517 1.00 60.82 L112 N ATOM 1012 CA THR B 72 −19.866 −10.432 −44.305 1.00 53.90 L112 C ATOM 1013 C THR B 72 −18.602 −10.793 −43.534 1.00 45.75 L112 C ATOM 1014 O THR B 72 −17.573 −10.123 −43.661 1.00 42.26 L112 O ATOM 1015 CB THR B 72 −19.881 −11.190 −45.647 1.00 54.39 L112 C ATOM 1016 OG1 THR B 72 −20.261 −10.291 −46.695 1.00 53.11 L112 O ATOM 1017 CG2 THR B 72 −20.877 −12.340 −45.603 1.00 54.95 L112 C ATOM 1018 N PRO B 73 −18.664 −11.860 −42.721 1.00 37.48 L112 N ATOM 1019 CA PRO B 73 −17.507 −12.290 −41.935 1.00 34.20 L112 C ATOM 1020 C PRO B 73 −16.302 −12.518 −42.828 1.00 36.67 L112 C ATOM 1021 O PRO B 73 −16.441 −12.715 −44.034 1.00 42.32 L112 O ATOM 1022 CB PRO B 73 −17.977 −13.578 −41.271 1.00 35.95 L112 C ATOM 1023 CG PRO B 73 −19.465 −13.478 −41.261 1.00 38.50 L112 C ATOM 1024 CD PRO B 73 −19.831 −12.733 −42.504 1.00 38.65 L112 C ATOM 1025 N PRO B 74 −15.097 −12.500 −42.247 1.00 30.98 L112 N ATOM 1026 CA PRO B 74 −13.896 −12.712 −43.056 1.00 29.22 L112 C ATOM 1027 C PRO B 74 −13.949 −14.071 −43.737 1.00 30.46 L112 C ATOM 1028 O PRO B 74 −14.664 −14.971 −43.292 1.00 34.58 L112 O ATOM 1029 CB PRO B 74 −12.755 −12.620 −42.042 1.00 26.89 L112 C ATOM 1030 CG PRO B 74 −13.334 −11.909 −40.876 1.00 16.14 L112 C ATOM 1031 CD PRO B 74 −14.773 −12.302 −40.828 1.00 24.82 L112 C ATOM 1032 N ALA B 75 −13.196 −14.217 −44.819 1.00 26.98 L112 N ATOM 1033 CA ALA B 75 −13.162 −15.472 −45.540 1.00 21.93 L112 C ATOM 1034 C ALA B 75 −12.623 −16.534 −44.597 1.00 29.69 L112 C ATOM 1035 O ALA B 75 −13.190 −17.619 −44.481 1.00 33.14 L112 O ATOM 1036 CB ALA B 75 −12.264 −15.346 −46.760 1.00 29.99 L112 C ATOM 1037 N SER B 76 −11.530 −16.210 −43.912 1.00 29.96 L112 N ATOM 1038 CA SER B 76 −10.911 −17.143 −42.978 1.00 31.14 L112 C ATOM 1039 C SER B 76 −11.908 −17.595 −41.918 1.00 36.21 L112 C ATOM 1040 O SER B 76 −11.922 −18.760 −41.517 1.00 38.58 L112 O ATOM 1041 CB SER B 76 −9.700 −16.496 −42.305 1.00 28.76 L112 C ATOM 1042 OG SER B 76 −10.103 −15.622 −41.266 1.00 33.61 L112 O ATOM 1043 N PHE B 77 −12.748 −16.674 −41.465 1.00 35.12 L112 N ATOM 1044 CA PHE B 77 −13.731 −17.018 −40.457 1.00 36.06 L112 C ATOM 1045 C PHE B 77 −14.684 −18.047 −41.025 1.00 38.63 L112 C ATOM 1046 O PHE B 77 −14.874 −19.116 −40.448 1.00 43.61 L112 O ATOM 1047 CB PHE B 77 −14.518 −15.787 −40.025 1.00 44.62 L112 C ATOM 1048 CG PHE B 77 −15.644 −16.097 −39.080 1.00 47.58 L112 C ATOM 1049 CD1 PHE B 77 −15.388 −16.347 −37.733 1.00 44.42 L112 C ATOM 1050 CD2 PHE B 77 −16.959 −16.151 −39.536 1.00 44.81 L112 C ATOM 1051 CE1 PHE B 77 −16.424 −16.646 −36.855 1.00 40.74 L112 C ATOM 1052 CE2 PHE B 77 −18.003 −16.449 −38.667 1.00 42.72 L112 C ATOM 1053 CZ PHE B 77 −17.736 −16.697 −37.322 1.00 44.82 L112 C ATOM 1054 N LEU B 78 −15.288 −17.719 −42.161 1.00 37.81 L112 N ATOM 1055 CA LEU B 78 −16.228 −18.625 −42.810 1.00 36.34 L112 C ATOM 1056 C LEU B 78 −15.574 −19.970 −43.100 1.00 31.89 L112 C ATOM 1057 O LEU B 78 −16.204 −21.017 −42.980 1.00 35.90 L112 O ATOM 1058 CB LEU B 78 −16.743 −17.998 −44.105 1.00 34.71 L112 C ATOM 1059 CG LEU B 78 −17.603 −16.750 −43.895 1.00 33.80 L112 C ATOM 1060 CD1 LEU B 78 −18.030 −16.182 −45.238 1.00 29.39 L112 C ATOM 1061 CD2 LEU B 78 −18.817 −17.113 −43.052 1.00 29.74 L112 C ATOM 1062 N LEU B 79 −14.302 −19.936 −43.474 1.00 26.28 L112 N ATOM 1063 CA LEU B 79 −13.566 −21.153 −43.765 1.00 31.61 L112 C ATOM 1064 C LEU B 79 −13.420 −22.002 −42.498 1.00 39.25 L112 C ATOM 1065 O LEU B 79 −13.727 −23.194 −42.508 1.00 40.69 L112 O ATOM 1066 CB LEU B 79 −12.192 −20.799 −44.344 1.00 31.36 L112 C ATOM 1067 CG LEU B 79 −12.229 −20.369 −45.816 1.00 25.54 L112 C ATOM 1068 CD1 LEU B 79 −10.852 −19.971 −46.314 1.00 21.73 L112 C ATOM 1069 CD2 LEU B 79 −12.763 −21.520 −46.635 1.00 23.94 L112 C ATOM 1070 N LYS B 80 −12.960 −21.384 −41.411 1.00 44.27 L112 N ATOM 1071 CA LYS B 80 −12.794 −22.078 −40.131 1.00 39.57 L112 C ATOM 1072 C LYS B 80 −14.075 −22.822 −39.785 1.00 35.79 L112 C ATOM 1073 O LYS B 80 −14.049 −23.993 −39.418 1.00 37.45 L112 O ATOM 1074 CB LYS B 80 −12.500 −21.077 −39.008 1.00 44.26 L112 C ATOM 1075 CG LYS B 80 −11.028 −20.840 −38.710 1.00 46.47 L112 C ATOM 1076 CD LYS B 80 −10.839 −19.591 −37.850 1.00 45.33 L112 C ATOM 1077 CE LYS B 80 −9.377 −19.388 −37.474 1.00 50.24 L112 C ATOM 1078 NZ LYS B 80 −9.071 −17.963 −37.174 1.00 50.61 L112 N ATOM 1079 N LYS B 81 −15.197 −22.122 −39.907 1.00 34.23 L112 N ATOM 1080 CA LYS B 81 −16.508 −22.682 −39.609 1.00 39.48 L112 C ATOM 1081 C LYS B 81 −16.845 −23.880 −40.485 1.00 42.52 L112 C ATOM 1082 O LYS B 81 −17.253 −24.929 −39.991 1.00 49.15 L112 O ATOM 1083 CB LYS B 81 −17.580 −21.607 −39.787 1.00 41.03 L112 C ATOM 1084 CG LYS B 81 −18.306 −21.234 −38.510 1.00 52.41 L112 C ATOM 1085 CD LYS B 81 −19.812 −21.200 −38.730 1.00 68.51 L112 C ATOM 1086 CE LYS B 81 −20.234 −19.983 −39.549 1.00 73.66 L112 C ATOM 1087 NZ LYS B 81 −20.152 −20.217 −41.023 1.00 71.12 L112 N ATOM 1088 N ALA B 82 −16.678 −23.722 −41.792 1.00 45.81 L112 N ATOM 1089 CA ALA B 82 −16.979 −24.800 −42.725 1.00 44.23 L112 C ATOM 1090 C ALA B 82 −16.154 −26.049 −42.431 1.00 40.55 L112 C ATOM 1091 O ALA B 82 −16.662 −27.165 −42.503 1.00 39.77 L112 O ATOM 1092 CB ALA B 82 −16.729 −24.336 −44.149 1.00 42.43 L112 C ATOM 1093 N ALA B 83 −14.882 −25.855 −42.101 1.00 35.34 L112 N ATOM 1094 CA ALA B 83 −13.990 −26.967 −41.807 1.00 33.10 L112 C ATOM 1095 C ALA B 83 −14.259 −27.559 −40.431 1.00 40.90 L112 C ATOM 1096 O ALA B 83 −13.797 −28.659 −40.123 1.00 42.00 L112 O ATOM 1097 CB ALA B 83 −12.544 −26.514 −41.898 1.00 30.83 L112 C ATOM 1098 N GLY B 84 −15.000 −26.823 −39.605 1.00 43.37 L112 N ATOM 1099 CA GLY B 84 −15.320 −27.292 −38.267 1.00 40.61 L112 C ATOM 1100 C GLY B 84 −14.164 −27.194 −37.287 1.00 41.90 L112 C ATOM 1101 O GLY B 84 −14.061 −27.997 −36.361 1.00 45.63 L112 O ATOM 1102 N ILE B 85 −13.283 −26.222 −37.495 1.00 40.72 L112 N ATOM 1103 CA ILE B 85 −12.141 −26.025 −36.612 1.00 39.23 L112 C ATOM 1104 C ILE B 85 −12.283 −24.664 −35.944 1.00 44.21 L112 C ATOM 1105 O ILE B 85 −13.168 −23.884 −36.304 1.00 48.06 L112 O ATOM 1106 CB ILE B 85 −10.801 −26.081 −37.388 1.00 34.91 L112 C ATOM 1107 CG1 ILE B 85 −10.738 −24.959 −38.423 1.00 34.57 L112 C ATOM 1108 CG2 ILE B 85 −10.657 −27.425 −38.076 1.00 33.20 L112 C ATOM 1109 CD1 ILE B 85 −9.477 −24.973 −39.258 1.00 32.16 L112 C ATOM 1110 N GLU B 86 −11.422 −24.380 −34.972 1.00 45.20 L112 N ATOM 1111 CA GLU B 86 −11.484 −23.108 −34.266 1.00 43.68 L112 C ATOM 1112 C GLU B 86 −10.261 −22.245 −34.544 1.00 41.68 L112 C ATOM 1113 O GLU B 86 −10.258 −21.049 −34.257 1.00 47.94 L112 O ATOM 1114 CB GLU B 86 −11.632 −23.347 −32.760 1.00 46.15 L112 C ATOM 1115 CG GLU B 86 −10.322 −23.581 −32.020 1.00 65.68 L112 C ATOM 1116 CD GLU B 86 −10.394 −23.163 −30.561 1.00 76.24 L112 C ATOM 1117 OE1 GLU B 86 −11.440 −23.417 −29.922 1.00 79.61 L112 O ATOM 1118 OE2 GLU B 86 −9.409 −22.580 −30.054 1.00 77.24 L112 O ATOM 1119 N LYS B 87 −9.222 −22.850 −35.103 1.00 33.13 L112 N ATOM 1120 CA LYS B 87 −8.011 −22.109 −35.416 1.00 40.07 L112 C ATOM 1121 C LYS B 87 −7.423 −22.570 −36.741 1.00 40.26 L112 C ATOM 1122 O LYS B 87 −7.610 −23.712 −37.150 1.00 46.66 L112 O ATOM 1123 CB LYS B 87 −6.973 −22.293 −34.306 1.00 43.57 L112 C ATOM 1124 CG LYS B 87 −7.240 −21.468 −33.057 1.00 57.30 L112 C ATOM 1125 CD LYS B 87 −6.210 −21.759 −31.970 1.00 60.56 L112 C ATOM 1126 CE LYS B 87 −5.750 −20.483 −31.279 1.00 59.04 L112 C ATOM 1127 NZ LYS B 87 −6.112 −19.261 −32.054 1.00 64.31 L112 N ATOM 1128 N GLY B 88 −6.725 −21.671 −37.418 1.00 34.46 L112 N ATOM 1129 CA GLY B 88 −6.110 −22.038 −38.672 1.00 33.11 L112 C ATOM 1130 C GLY B 88 −4.818 −22.742 −38.333 1.00 31.13 L112 C ATOM 1131 O GLY B 88 −4.402 −22.747 −37.180 1.00 34.45 L112 O ATOM 1132 N SER B 89 −4.183 −23.345 −39.325 1.00 31.44 L112 N ATOM 1133 CA SER B 89 −2.935 −24.043 −39.093 1.00 29.45 L112 C ATOM 1134 C SER B 89 −1.871 −23.027 −38.709 1.00 37.64 L112 C ATOM 1135 O SER B 89 −1.904 −21.889 −39.167 1.00 39.44 L112 O ATOM 1136 CB SER B 89 −2.519 −24.789 −40.357 1.00 30.04 L112 C ATOM 1137 OG SER B 89 −1.138 −25.097 −40.339 1.00 30.69 L112 O ATOM 1138 N SER B 90 −0.932 −23.437 −37.863 1.00 34.79 L112 N ATOM 1139 CA SER B 90 0.145 −22.556 −37.434 1.00 36.73 L112 C ATOM 1140 C SER B 90 1.250 −22.593 −38.480 1.00 37.59 L112 C ATOM 1141 O SER B 90 2.173 −21.778 −38.474 1.00 38.46 L112 O ATOM 1142 CB SER B 90 0.698 −23.023 −36.092 1.00 42.80 L112 C ATOM 1143 OG SER B 90 1.368 −24.265 −36.234 1.00 57.39 L112 O ATOM 1144 N GLU B 91 1.153 −23.565 −39.373 1.00 40.27 L112 N ATOM 1145 CA GLU B 91 2.122 −23.726 −40.445 1.00 44.62 L112 C ATOM 1146 C GLU B 91 1.352 −24.125 −41.697 1.00 42.72 L112 C ATOM 1147 O GLU B 91 1.316 −25.295 −42.067 1.00 49.13 L112 O ATOM 1148 CB GLU B 91 3.135 −24.812 −40.085 1.00 47.12 L112 C ATOM 1149 CG GLU B 91 4.520 −24.289 −39.768 1.00 58.48 L112 C ATOM 1150 CD GLU B 91 5.431 −25.364 −39.208 1.00 65.15 L112 C ATOM 1151 OE1 GLU B 91 5.935 −26.197 −39.997 1.00 68.92 L112 O ATOM 1152 OE2 GLU B 91 5.643 −25.374 −37.976 1.00 74.00 L112 O ATOM 1153 N PRO B 92 0.699 −23.154 −42.352 1.00 40.19 L112 N ATOM 1154 CA PRO B 92 −0.071 −23.435 −43.566 1.00 40.89 L112 C ATOM 1155 C PRO B 92 0.736 −24.213 −44.603 1.00 42.71 L112 C ATOM 1156 O PRO B 92 1.955 −24.035 −44.720 1.00 32.77 L112 O ATOM 1157 CB PRO B 92 −0.467 −22.049 −44.062 1.00 43.77 L112 C ATOM 1158 CG PRO B 92 −0.489 −21.217 −42.818 1.00 42.90 L112 C ATOM 1159 CD PRO B 92 0.642 −21.729 −41.987 1.00 35.83 L112 C ATOM 1160 N LYS B 93 0.043 −25.074 −45.346 1.00 45.71 L112 N ATOM 1161 CA LYS B 93 0.656 −25.905 −46.380 1.00 42.76 L112 C ATOM 1162 C LYS B 93 1.431 −27.073 −45.773 1.00 42.07 L112 C ATOM 1163 O LYS B 93 1.296 −28.210 −46.223 1.00 47.50 L112 O ATOM 1164 CB LYS B 93 1.588 −25.068 −47.267 1.00 46.12 L112 C ATOM 1165 CG LYS B 93 1.163 −24.984 −48.735 1.00 52.73 L112 C ATOM 1166 CD LYS B 93 −0.145 −24.214 −48.924 1.00 53.15 L112 C ATOM 1167 CE LYS B 93 0.025 −23.038 −49.883 1.00 56.74 L112 C ATOM 1168 NZ LYS B 93 0.637 −23.435 −51.187 1.00 65.38 L112 N ATOM 1169 N ARG B 94 2.232 −26.790 −44.748 1.00 39.69 L112 N ATOM 1170 CA ARG B 94 3.028 −27.815 −44.077 1.00 28.33 L112 C ATOM 1171 C ARG B 94 2.200 −28.678 −43.134 1.00 27.71 L112 C ATOM 1172 O ARG B 94 2.515 −29.841 −42.919 1.00 39.31 L112 O ATOM 1173 CB ARG B 94 4.159 −27.172 −43.282 1.00 22.60 L112 C ATOM 1174 CG ARG B 94 5.305 −26.668 −44.121 1.00 29.42 L112 C ATOM 1175 CD ARG B 94 6.358 −26.019 −43.246 1.00 31.23 L112 C ATOM 1176 NE ARG B 94 7.463 −25.486 −44.033 1.00 42.70 L112 N ATOM 1177 CZ ARG B 94 8.628 −25.108 −43.516 1.00 56.07 L112 C ATOM 1178 NH1 ARG B 94 8.833 −25.207 −42.207 1.00 58.35 L112 N ATOM 1179 NH2 ARG B 94 9.584 −24.628 −44.304 1.00 57.97 L112 N ATOM 1180 N LYS B 95 1.146 −28.110 −42.568 1.00 27.38 L112 N ATOM 1181 CA LYS B 95 0.301 −28.850 −41.645 1.00 29.34 L112 C ATOM 1182 C LYS B 95 −1.150 −28.482 −41.891 1.00 30.96 L112 C ATOM 1183 O LYS B 95 −1.551 −27.342 −41.680 1.00 36.81 L112 O ATOM 1184 CB LYS B 95 0.688 −28.513 −40.200 1.00 39.33 L112 C ATOM 1185 CG LYS B 95 0.177 −29.500 −39.158 1.00 54.73 L112 C ATOM 1186 CD LYS B 95 −0.879 −28.870 −38.249 1.00 67.65 L112 C ATOM 1187 CE LYS B 95 −0.393 −28.746 −36.801 1.00 74.12 L112 C ATOM 1188 NZ LYS B 95 −0.959 −27.548 −36.096 1.00 63.57 L112 N ATOM 1189 N ILE B 96 −1.937 −29.446 −42.345 1.00 32.10 L112 N ATOM 1190 CA ILE B 96 −3.347 −29.195 −42.614 1.00 32.15 L112 C ATOM 1191 C ILE B 96 −4.165 −29.436 −41.353 1.00 33.56 L112 C ATOM 1192 O ILE B 96 −4.075 −30.496 −40.739 1.00 42.84 L112 O ATOM 1193 CB ILE B 96 −3.863 −30.103 −43.759 1.00 28.05 L112 C ATOM 1194 CG1 ILE B 96 −3.017 −29.876 −45.014 1.00 11.50 L112 C ATOM 1195 CG2 ILE B 96 −5.330 −29.814 −44.048 1.00 19.38 L112 C ATOM 1196 CD1 ILE B 96 −2.904 −28.429 −45.429 1.00 19.93 L112 C ATOM 1197 N VAL B 97 −4.964 −28.448 −40.973 1.00 32.84 L112 N ATOM 1198 CA VAL B 97 −5.776 −28.552 −39.770 1.00 29.62 L112 C ATOM 1199 C VAL B 97 −7.232 −28.853 −40.066 1.00 29.20 L112 C ATOM 1200 O VAL B 97 −8.015 −29.112 −39.156 1.00 36.19 L112 O ATOM 1201 CB VAL B 97 −5.717 −27.246 −38.949 1.00 28.85 L112 C ATOM 1202 CG1 VAL B 97 −4.288 −26.945 −38.556 1.00 28.11 L112 C ATOM 1203 CG2 VAL B 97 −6.291 −26.094 −39.760 1.00 28.49 L112 C ATOM 1204 N GLY B 98 −7.605 −28.811 −41.337 1.00 34.31 L112 N ATOM 1205 CA GLY B 98 −8.988 −29.072 −41.685 1.00 28.21 L112 C ATOM 1206 C GLY B 98 −9.152 −29.147 −43.181 1.00 30.18 L112 C ATOM 1207 O GLY B 98 −8.192 −28.965 −43.923 1.00 30.67 L112 O ATOM 1208 N LYS B 99 −10.373 −29.402 −43.627 1.00 29.50 L112 N ATOM 1209 CA LYS B 99 −10.634 −29.516 −45.046 1.00 32.51 L112 C ATOM 1210 C LYS B 99 −12.080 −29.187 −45.374 1.00 36.44 L112 C ATOM 1211 O LYS B 99 −12.976 −29.448 −44.575 1.00 35.95 L112 O ATOM 1212 CB LYS B 99 −10.315 −30.937 −45.507 1.00 39.97 L112 C ATOM 1213 CG LYS B 99 −10.933 −32.025 −44.639 1.00 41.83 L112 C ATOM 1214 CD LYS B 99 −11.335 −33.237 −45.469 1.00 51.41 L112 C ATOM 1215 CE LYS B 99 −10.486 −34.453 −45.134 1.00 53.02 L112 C ATOM 1216 NZ LYS B 99 −11.298 −35.553 −44.538 1.00 66.17 L112 N ATOM 1217 N VAL B 100 −12.298 −28.609 −46.555 1.00 40.79 L112 N ATOM 1218 CA VAL B 100 −13.642 −28.263 −47.010 1.00 40.95 L112 C ATOM 1219 C VAL B 100 −13.871 −28.788 −48.419 1.00 41.23 L112 C ATOM 1220 O VAL B 100 −12.927 −28.948 −49.199 1.00 37.76 L112 O ATOM 1221 CB VAL B 100 −13.877 −26.742 −47.033 1.00 42.14 L112 C ATOM 1222 CG1 VAL B 100 −14.062 −26.228 −45.623 1.00 47.48 L112 C ATOM 1223 CG2 VAL B 100 −12.714 −26.049 −47.719 1.00 46.52 L112 C ATOM 1224 N THR B 101 −15.134 −29.054 −48.737 1.00 43.68 L112 N ATOM 1225 CA THR B 101 −15.505 −29.556 −50.052 1.00 44.90 L112 C ATOM 1226 C THR B 101 −15.572 −28.401 −51.030 1.00 46.97 L112 C ATOM 1227 O THR B 101 −15.847 −27.266 −50.641 1.00 49.23 L112 O ATOM 1228 CB THR B 101 −16.882 −30.228 −50.037 1.00 44.59 L112 C ATOM 1229 OG1 THR B 101 −17.875 −29.262 −49.670 1.00 47.42 L112 O ATOM 1230 CG2 THR B 101 −16.904 −31.382 −49.050 1.00 37.18 L112 C ATOM 1231 N ARG B 102 −15.319 −28.692 −52.301 1.00 47.23 L112 N ATOM 1232 CA ARG B 102 −15.376 −27.664 −53.324 1.00 42.99 L112 C ATOM 1233 C ARG B 102 −16.760 −27.046 −53.255 1.00 39.27 L112 C ATOM 1234 O ARG B 102 −16.947 −25.888 −53.609 1.00 51.83 L112 O ATOM 1235 CB ARG B 102 −15.140 −28.272 −54.708 1.00 50.12 L112 C ATOM 1236 CG ARG B 102 −14.295 −27.405 −55.639 1.00 58.67 L112 C ATOM 1237 CD ARG B 102 −12.884 −27.964 −55.821 1.00 61.68 L112 C ATOM 1238 NE ARG B 102 −12.827 −29.413 −55.632 1.00 63.94 L112 N ATOM 1239 CZ ARG B 102 −11.703 −30.124 −55.623 1.00 67.71 L112 C ATOM 1240 NH1 ARG B 102 −10.534 −29.517 −55.793 1.00 66.40 L112 N ATOM 1241 NH2 ARG B 102 −11.747 −31.442 −55.443 1.00 60.88 L112 N ATOM 1242 N LYS B 103 −17.730 −27.823 −52.786 1.00 37.67 L112 N ATOM 1243 CA LYS B 103 −19.096 −27.333 −52.664 1.00 41.92 L112 C ATOM 1244 C LYS B 103 −19.160 −26.308 −51.547 1.00 44.83 L112 C ATOM 1245 O LYS B 103 −19.856 −25.298 −51.649 1.00 49.24 L112 O ATOM 1246 CB LYS B 103 −20.056 −28.483 −52.354 1.00 49.35 L112 C ATOM 1247 CG LYS B 103 −21.265 −28.079 −51.510 1.00 57.47 L112 C ATOM 1248 CD LYS B 103 −22.244 −27.221 −52.298 1.00 66.45 L112 C ATOM 1249 CE LYS B 103 −23.683 −27.670 −52.075 1.00 76.17 L112 C ATOM 1250 NZ LYS B 103 −24.099 −27.557 −50.645 1.00 75.72 L112 N ATOM 1251 N GLN B 104 −18.434 −26.578 −50.471 1.00 44.97 L112 N ATOM 1252 CA GLN B 104 −18.412 −25.662 −49.347 1.00 43.50 L112 C ATOM 1253 C GLN B 104 −17.766 −24.359 −49.796 1.00 37.68 L112 C ATOM 1254 O GLN B 104 −18.268 −23.277 −49.500 1.00 38.95 L112 O ATOM 1255 CB GLN B 104 −17.640 −26.279 −48.181 1.00 47.34 L112 C ATOM 1256 CG GLN B 104 −18.442 −27.328 −47.425 1.00 42.38 L112 C ATOM 1257 CD GLN B 104 −17.693 −27.890 −46.237 1.00 42.53 L112 C ATOM 1258 OE1 GLN B 104 −16.603 −28.446 −46.380 1.00 35.56 L112 O ATOM 1259 NE2 GLN B 104 −18.275 −27.745 −45.050 1.00 36.61 L112 N ATOM 1260 N ILE B 105 −16.660 −24.471 −50.525 1.00 30.76 L112 N ATOM 1261 CA ILE B 105 −15.962 −23.296 −51.026 1.00 35.17 L112 C ATOM 1262 C ILE B 105 −16.931 −22.427 −51.811 1.00 39.38 L112 C ATOM 1263 O ILE B 105 −16.880 −21.202 −51.736 1.00 44.28 L112 O ATOM 1264 CB ILE B 105 −14.808 −23.678 −51.962 1.00 26.23 L112 C ATOM 1265 CG1 ILE B 105 −13.674 −24.314 −51.159 1.00 35.32 L112 C ATOM 1266 CG2 ILE B 105 −14.320 −22.442 −52.714 1.00 30.76 L112 C ATOM 1267 CD1 ILE B 105 −12.778 −23.317 −50.444 1.00 30.65 L112 C ATOM 1268 N GLU B 106 −17.815 −23.074 −52.563 1.00 44.23 L112 N ATOM 1269 CA GLU B 106 −18.800 −22.367 −53.366 1.00 48.57 L112 C ATOM 1270 C GLU B 106 −19.776 −21.590 −52.488 1.00 50.45 L112 C ATOM 1271 O GLU B 106 −20.083 −20.430 −52.769 1.00 52.09 L112 O ATOM 1272 CB GLU B 106 −19.563 −23.358 −54.249 1.00 56.57 L112 C ATOM 1273 CG GLU B 106 −20.814 −22.786 −54.920 1.00 65.87 L112 C ATOM 1274 CD GLU B 106 −21.335 −23.664 −56.053 1.00 68.27 L112 C ATOM 1275 OE1 GLU B 106 −20.505 −24.254 −56.781 1.00 62.09 L112 O ATOM 1276 OE2 GLU B 106 −22.573 −23.762 −56.214 1.00 66.69 L112 O ATOM 1277 N GLU B 107 −20.258 −22.222 −51.422 1.00 48.38 L112 N ATOM 1278 CA GLU B 107 −21.204 −21.567 −50.523 1.00 50.26 L112 C ATOM 1279 C GLU B 107 −20.610 −20.317 −49.890 1.00 50.25 L112 C ATOM 1280 O GLU B 107 −21.311 −19.332 −49.661 1.00 52.98 L112 O ATOM 1281 CB GLU B 107 −21.648 −22.527 −49.425 1.00 52.51 L112 C ATOM 1282 CG GLU B 107 −22.481 −23.685 −49.921 1.00 72.08 L112 C ATOM 1283 CD GLU B 107 −22.371 −24.896 −49.016 1.00 86.41 L112 C ATOM 1284 OE1 GLU B 107 −21.249 −25.188 −48.545 1.00 91.57 L112 O ATOM 1285 OE2 GLU B 107 −23.405 −25.554 −48.772 1.00 92.70 L112 O ATOM 1286 N ILE B 108 −19.315 −20.355 −49.602 1.00 46.38 L112 N ATOM 1287 CA ILE B 108 −18.667 −19.206 −48.999 1.00 43.09 L112 C ATOM 1288 C ILE B 108 −18.525 −18.099 −50.030 1.00 42.47 L112 C ATOM 1289 O ILE B 108 −18.815 −16.937 −49.748 1.00 47.10 L112 O ATOM 1290 CB ILE B 108 −17.272 −19.565 −48.449 1.00 42.76 L112 C ATOM 1291 CG1 ILE B 108 −17.407 −20.613 −47.345 1.00 35.09 L112 C ATOM 1292 CG2 ILE B 108 −16.592 −18.317 −47.891 1.00 31.13 L112 C ATOM 1293 CD1 ILE B 108 −16.084 −21.041 −46.747 1.00 41.11 L112 C ATOM 1294 N ALA B 109 −18.081 −18.464 −51.229 1.00 38.62 L112 N ATOM 1295 CA ALA B 109 −17.900 −17.486 −52.293 1.00 38.24 L112 C ATOM 1296 C ALA B 109 −19.208 −16.761 −52.539 1.00 37.79 L112 C ATOM 1297 O ALA B 109 −19.222 −15.562 −52.807 1.00 37.18 L112 O ATOM 1298 CB ALA B 109 −17.436 −18.172 −53.562 1.00 38.10 L112 C ATOM 1299 N LYS B 110 −20.309 −17.497 −52.437 1.00 38.29 L112 N ATOM 1300 CA LYS B 110 −21.626 −16.917 −52.647 1.00 42.58 L112 C ATOM 1301 C LYS B 110 −21.945 −15.951 −51.518 1.00 45.99 L112 C ATOM 1302 O LYS B 110 −22.468 −14.858 −51.747 1.00 55.26 L112 O ATOM 1303 CB LYS B 110 −22.689 −18.016 −52.702 1.00 39.40 L112 C ATOM 1304 CG LYS B 110 −22.558 −18.947 −53.898 1.00 51.26 L112 C ATOM 1305 CD LYS B 110 −23.911 −19.512 −54.329 1.00 60.46 L112 C ATOM 1306 CE LYS B 110 −23.897 −19.968 −55.790 1.00 63.75 L112 C ATOM 1307 NZ LYS B 110 −24.464 −21.340 −55.985 1.00 64.25 L112 N ATOM 1308 N THR B 111 −21.620 −16.357 −50.297 1.00 40.79 L112 N ATOM 1309 CA THR B 111 −21.876 −15.527 −49.134 1.00 38.24 L112 C ATOM 1310 C THR B 111 −21.088 −14.231 −49.196 1.00 42.37 L112 C ATOM 1311 O THR B 111 −21.644 −13.152 −48.998 1.00 48.64 L112 O ATOM 1312 CB THR B 111 −21.490 −16.256 −47.845 1.00 42.62 L112 C ATOM 1313 OG1 THR B 111 −22.140 −17.531 −47.812 1.00 49.22 L112 O ATOM 1314 CG2 THR B 111 −21.899 −15.441 −46.630 1.00 41.08 L112 C ATOM 1315 N LYS B 112 −19.794 −14.346 −49.479 1.00 41.09 L112 N ATOM 1316 CA LYS B 112 −18.900 −13.194 −49.544 1.00 38.50 L112 C ATOM 1317 C LYS B 112 −18.910 −12.449 −50.879 1.00 43.09 L112 C ATOM 1318 O LYS B 112 −18.246 −11.424 −51.018 1.00 40.13 L112 O ATOM 1319 CB LYS B 112 −17.467 −13.640 −49.240 1.00 35.11 L112 C ATOM 1320 CG LYS B 112 −17.124 −13.715 −47.764 1.00 33.43 L112 C ATOM 1321 CD LYS B 112 −16.011 −12.742 −47.409 1.00 29.28 L112 C ATOM 1322 CE LYS B 112 −16.567 −11.530 −46.680 1.00 35.42 L112 C ATOM 1323 NZ LYS B 112 −15.524 −10.509 −46.385 1.00 31.34 L112 N ATOM 1324 N MET B 113 −19.654 −12.957 −51.857 1.00 50.88 L112 N ATOM 1325 CA MET B 113 −19.709 −12.331 −53.180 1.00 51.11 L112 C ATOM 1326 C MET B 113 −19.879 −10.807 −53.156 1.00 49.15 L112 C ATOM 1327 O MET B 113 −19.130 −10.081 −53.813 1.00 50.15 L112 O ATOM 1328 CB MET B 113 −20.824 −12.962 −54.022 1.00 51.18 L112 C ATOM 1329 CG MET B 113 −20.717 −12.654 −55.515 1.00 47.98 L112 C ATOM 1330 SD MET B 113 −19.263 −13.400 −56.298 1.00 49.73 L112 S ATOM 1331 CE MET B 113 −18.549 −11.969 −57.088 1.00 52.43 L112 C ATOM 1332 N PRO B 114 −20.870 −10.301 −52.409 1.00 42.31 L112 N ATOM 1333 CA PRO B 114 −21.051 −8.849 −52.369 1.00 41.88 L112 C ATOM 1334 C PRO B 114 −19.781 −8.079 −51.997 1.00 44.88 L112 C ATOM 1335 O PRO B 114 −19.589 −6.945 −52.439 1.00 51.97 L112 O ATOM 1336 CB PRO B 114 −22.171 −8.646 −51.345 1.00 38.22 L112 C ATOM 1337 CG PRO B 114 −22.290 −9.946 −50.621 1.00 43.79 L112 C ATOM 1338 CD PRO B 114 −21.870 −11.000 −51.588 1.00 46.66 L112 C ATOM 1339 N ASP B 115 −18.912 −8.690 −51.197 1.00 46.07 L112 N ATOM 1340 CA ASP B 115 −17.673 −8.030 −50.785 1.00 45.61 L112 C ATOM 1341 C ASP B 115 −16.506 −8.353 −51.709 1.00 42.88 L112 C ATOM 1342 O ASP B 115 −15.435 −7.758 −51.598 1.00 47.89 L112 O ATOM 1343 CB ASP B 115 −17.292 −8.429 −49.355 1.00 51.51 L112 C ATOM 1344 CG ASP B 115 −18.431 −8.252 −48.368 1.00 50.88 L112 C ATOM 1345 OD1 ASP B 115 −19.514 −7.787 −48.779 1.00 57.98 L112 O ATOM 1346 OD2 ASP B 115 −18.240 −8.582 −47.178 1.00 59.37 L112 O ATOM 1347 N LEU B 116 −16.713 −9.298 −52.618 1.00 40.70 L112 N ATOM 1348 CA LEU B 116 −15.669 −9.698 −53.553 1.00 37.46 L112 C ATOM 1349 C LEU B 116 −15.698 −8.849 −54.819 1.00 37.00 L112 C ATOM 1350 O LEU B 116 −16.757 −8.385 −55.242 1.00 38.81 L112 O ATOM 1351 CB LEU B 116 −15.851 −11.169 −53.939 1.00 40.60 L112 C ATOM 1352 CG LEU B 116 −15.289 −12.293 −53.065 1.00 35.62 L112 C ATOM 1353 CD1 LEU B 116 −14.872 −11.765 −51.707 1.00 42.51 L112 C ATOM 1354 CD2 LEU B 116 −16.347 −13.368 −52.923 1.00 33.28 L112 C ATOM 1355 N ASN B 117 −14.535 −8.653 −55.429 1.00 32.39 L112 N ATOM 1356 CA ASN B 117 −14.467 −7.886 −56.662 1.00 32.20 L112 C ATOM 1357 C ASN B 117 −14.427 −8.835 −57.867 1.00 37.64 L112 C ATOM 1358 O ASN B 117 −14.193 −8.415 −59.001 1.00 35.01 L112 O ATOM 1359 CB ASN B 117 −13.235 −6.984 −56.655 1.00 24.31 L112 C ATOM 1360 CG ASN B 117 −11.952 −7.762 −56.709 1.00 29.72 L112 C ATOM 1361 OD1 ASN B 117 −11.914 −8.941 −56.354 1.00 32.78 L112 O ATOM 1362 ND2 ASN B 117 −10.883 −7.110 −57.154 1.00 25.55 L112 N ATOM 1363 N ALA B 118 −14.662 −10.117 −57.608 1.00 39.75 L112 N ATOM 1364 CA ALA B 118 −14.665 −11.130 −58.656 1.00 41.80 L112 C ATOM 1365 C ALA B 118 −15.862 −10.910 −59.567 1.00 45.30 L112 C ATOM 1366 O ALA B 118 −16.863 −10.330 −59.156 1.00 53.58 L112 O ATOM 1367 CB ALA B 118 −14.734 −12.512 −58.043 1.00 30.65 L112 C ATOM 1368 N ASN B 119 −15.760 −11.381 −60.804 1.00 46.03 L112 N ATOM 1369 CA ASN B 119 −16.840 −11.216 −61.766 1.00 48.46 L112 C ATOM 1370 C ASN B 119 −17.574 −12.516 −62.081 1.00 50.16 L112 C ATOM 1371 O ASN B 119 −18.557 −12.512 −62.817 1.00 55.94 L112 O ATOM 1372 CB ASN B 119 −16.287 −10.625 −63.061 1.00 49.26 L112 C ATOM 1373 CG ASN B 119 −16.023 −9.137 −62.958 1.00 50.05 L112 C ATOM 1374 OD1 ASN B 119 −16.747 −8.407 −62.269 1.00 48.95 L112 O ATOM 1375 ND2 ASN B 119 −14.981 −8.674 −63.646 1.00 48.05 L112 N ATOM 1376 N SER B 120 −17.096 −13.624 −61.527 1.00 51.92 L112 N ATOM 1377 CA SER B 120 −17.711 −14.924 −61.771 1.00 47.70 L112 C ATOM 1378 C SER B 120 −17.599 −15.828 −60.555 1.00 50.21 L112 C ATOM 1379 O SER B 120 −16.614 −15.770 −59.823 1.00 58.54 L112 O ATOM 1380 CB SER B 120 −17.034 −15.609 −62.964 1.00 46.48 L112 C ATOM 1381 OG SER B 120 −15.617 −15.558 −62.866 1.00 29.64 L112 O ATOM 1382 N LEU B 121 −18.607 −16.670 −60.346 1.00 49.76 L112 N ATOM 1383 CA LEU B 121 −18.591 −17.600 −59.225 1.00 44.29 L112 C ATOM 1384 C LEU B 121 −17.276 −18.369 −59.261 1.00 42.13 L112 C ATOM 1385 O LEU B 121 −16.669 −18.628 −58.229 1.00 45.70 L112 O ATOM 1386 CB LEU B 121 −19.760 −18.578 −59.327 1.00 41.45 L112 C ATOM 1387 CG LEU B 121 −19.784 −19.676 −58.262 1.00 41.89 L112 C ATOM 1388 CD1 LEU B 121 −19.585 −19.051 −56.890 1.00 40.55 L112 C ATOM 1389 CD2 LEU B 121 −21.102 −20.431 −58.320 1.00 32.73 L112 C ATOM 1390 N GLU B 122 −16.842 −18.722 −60.465 1.00 39.88 L112 N ATOM 1391 CA GLU B 122 −15.593 −19.447 −60.666 1.00 40.08 L112 C ATOM 1392 C GLU B 122 −14.444 −18.620 −60.091 1.00 38.04 L112 C ATOM 1393 O GLU B 122 −13.606 −19.135 −59.355 1.00 43.79 L112 O ATOM 1394 CB GLU B 122 −15.377 −19.699 −62.170 1.00 47.41 L112 C ATOM 1395 CG GLU B 122 −14.120 −20.496 −62.548 1.00 66.40 L112 C ATOM 1396 CD GLU B 122 −14.105 −20.935 −64.023 1.00 79.56 L112 C ATOM 1397 OE1 GLU B 122 −15.061 −21.614 −64.461 1.00 83.56 L112 O ATOM 1398 OE2 GLU B 122 −13.137 −20.604 −64.747 1.00 80.21 L112 O ATOM 1399 N ALA B 123 −14.416 −17.332 −60.422 1.00 37.15 L112 N ATOM 1400 CA ALA B 123 −13.369 −16.432 −59.946 1.00 31.33 L112 C ATOM 1401 C ALA B 123 −13.466 −16.220 −58.440 1.00 32.49 L112 C ATOM 1402 O ALA B 123 −12.458 −16.207 −57.736 1.00 32.50 L112 O ATOM 1403 CB ALA B 123 −13.472 −15.096 −60.655 1.00 28.73 L112 C ATOM 1404 N ALA B 124 −14.689 −16.042 −57.958 1.00 26.80 L112 N ATOM 1405 CA ALA B 124 −14.937 −15.835 −56.545 1.00 22.39 L112 C ATOM 1406 C ALA B 124 −14.365 −16.994 −55.736 1.00 30.24 L112 C ATOM 1407 O ALA B 124 −13.632 −16.790 −54.773 1.00 32.38 L112 O ATOM 1408 CB ALA B 124 −16.434 −15.714 −56.304 1.00 19.73 L112 C ATOM 1409 N MET B 125 −14.695 −18.214 −56.147 1.00 38.83 L112 N ATOM 1410 CA MET B 125 −14.232 −19.422 −55.468 1.00 34.24 L112 C ATOM 1411 C MET B 125 −12.718 −19.546 −55.464 1.00 30.68 L112 C ATOM 1412 O MET B 125 −12.142 −20.147 −54.562 1.00 39.64 L112 O ATOM 1413 CB MET B 125 −14.839 −20.659 −56.125 1.00 37.17 L112 C ATOM 1414 CG MET B 125 −16.346 −20.783 −55.948 1.00 34.83 L112 C ATOM 1415 SD MET B 125 −16.993 −22.386 −56.480 1.00 44.61 L112 S ATOM 1416 CE MET B 125 −15.586 −23.063 −57.397 1.00 33.28 L112 C ATOM 1417 N LYS B 126 −12.074 −18.991 −56.480 1.00 26.30 L112 N ATOM 1418 CA LYS B 126 −10.622 −19.038 −56.558 1.00 27.93 L112 C ATOM 1419 C LYS B 126 −10.072 −18.083 −55.503 1.00 30.79 L112 C ATOM 1420 O LYS B 126 −8.932 −18.220 −55.056 1.00 35.96 L112 O ATOM 1421 CB LYS B 126 −10.146 −18.601 −57.946 1.00 32.20 L112 C ATOM 1422 CG LYS B 126 −10.107 −19.703 −58.994 1.00 27.48 L112 C ATOM 1423 CD LYS B 126 −8.844 −19.598 −59.850 1.00 40.52 L112 C ATOM 1424 CE LYS B 126 −9.159 −19.142 −61.268 1.00 32.95 L112 C ATOM 1425 NZ LYS B 126 −9.919 −20.188 −62.011 1.00 51.40 L112 N ATOM 1426 N ILE B 127 −10.895 −17.110 −55.114 1.00 31.30 L112 N ATOM 1427 CA ILE B 127 −10.511 −16.117 −54.111 1.00 30.96 L112 C ATOM 1428 C ILE B 127 −10.523 −16.741 −52.718 1.00 28.53 L112 C ATOM 1429 O ILE B 127 −9.570 −16.587 −51.952 1.00 27.30 L112 O ATOM 1430 CB ILE B 127 −11.469 −14.899 −54.139 1.00 27.50 L112 C ATOM 1431 CG1 ILE B 127 −11.203 −14.064 −55.391 1.00 29.44 L112 C ATOM 1432 CG2 ILE B 127 −11.268 −14.038 −52.902 1.00 28.00 L112 C ATOM 1433 CD1 ILE B 127 −12.047 −12.810 −55.482 1.00 31.68 L112 C ATOM 1434 N ILE B 128 −11.608 −17.439 −52.396 1.00 20.75 L112 N ATOM 1435 CA ILE B 128 −11.731 −18.104 −51.111 1.00 18.60 L112 C ATOM 1436 C ILE B 128 −10.637 −19.152 −50.969 1.00 23.21 L112 C ATOM 1437 O ILE B 128 −9.936 −19.202 −49.960 1.00 34.11 L112 O ATOM 1438 CB ILE B 128 −13.084 −18.796 −50.975 1.00 17.63 L112 C ATOM 1439 CG1 ILE B 128 −14.208 −17.807 −51.280 1.00 17.94 L112 C ATOM 1440 CG2 ILE B 128 −13.236 −19.348 −49.581 1.00 23.67 L112 C ATOM 1441 CD1 ILE B 128 −14.138 −16.529 −50.469 1.00 20.35 L112 C ATOM 1442 N GLU B 129 −10.488 −19.985 −51.989 1.00 23.93 L112 N ATOM 1443 CA GLU B 129 −9.473 −21.025 −51.982 1.00 27.79 L112 C ATOM 1444 C GLU B 129 −8.116 −20.447 −51.612 1.00 28.96 L112 C ATOM 1445 O GLU B 129 −7.332 −21.079 −50.907 1.00 34.08 L112 O ATOM 1446 CB GLU B 129 −9.379 −21.666 −53.359 1.00 43.68 L112 C ATOM 1447 CG GLU B 129 −9.007 −23.129 −53.344 1.00 54.25 L112 C ATOM 1448 CD GLU B 129 −9.708 −23.894 −54.445 1.00 67.26 L112 C ATOM 1449 OE1 GLU B 129 −10.697 −23.356 −54.998 1.00 58.57 L112 O ATOM 1450 OE2 GLU B 129 −9.272 −25.027 −54.754 1.00 76.46 L112 O ATOM 1451 N GLY B 130 −7.836 −19.248 −52.108 1.00 29.13 L112 N ATOM 1452 CA GLY B 130 −6.571 −18.609 −51.809 1.00 23.84 L112 C ATOM 1453 C GLY B 130 −6.440 −18.423 −50.315 1.00 27.27 L112 C ATOM 1454 O GLY B 130 −5.372 −18.629 −49.735 1.00 29.16 L112 O ATOM 1455 N THR B 131 −7.536 −18.031 −49.680 1.00 19.93 L112 N ATOM 1456 CA THR B 131 −7.521 −17.839 −48.242 1.00 27.52 L112 C ATOM 1457 C THR B 131 −7.337 −19.204 −47.579 1.00 28.05 L112 C ATOM 1458 O THR B 131 −6.453 −19.383 −46.741 1.00 33.97 L112 O ATOM 1459 CB THR B 131 −8.832 −17.187 −47.758 1.00 25.95 L112 C ATOM 1460 OG1 THR B 131 −8.954 −15.883 −48.335 1.00 19.66 L112 O ATOM 1461 CG2 THR B 131 −8.836 −17.050 −46.255 1.00 29.87 L112 C ATOM 1462 N ALA B 132 −8.164 −20.167 −47.977 1.00 23.92 L112 N ATOM 1463 CA ALA B 132 −8.101 −21.523 −47.436 1.00 21.36 L112 C ATOM 1464 C ALA B 132 −6.704 −22.108 −47.505 1.00 21.61 L112 C ATOM 1465 O ALA B 132 −6.253 −22.768 −46.575 1.00 34.50 L112 O ATOM 1466 CB ALA B 132 −9.060 −22.428 −48.182 1.00 19.47 L112 C ATOM 1467 N LYS B 133 −6.015 −21.870 −48.610 1.00 25.84 L112 N ATOM 1468 CA LYS B 133 −4.674 −22.405 −48.779 1.00 29.20 L112 C ATOM 1469 C LYS B 133 −3.693 −21.721 −47.851 1.00 27.88 L112 C ATOM 1470 O LYS B 133 −2.642 −22.270 −47.530 1.00 37.04 L112 O ATOM 1471 CB LYS B 133 −4.213 −22.232 −50.230 1.00 33.18 L112 C ATOM 1472 CG LYS B 133 −5.011 −23.052 −51.235 1.00 37.46 L112 C ATOM 1473 CD LYS B 133 −4.884 −22.487 −52.640 1.00 50.67 L112 C ATOM 1474 CE LYS B 133 −3.636 −23.010 −53.343 1.00 51.75 L112 C ATOM 1475 NZ LYS B 133 −3.389 −22.329 −54.654 1.00 54.53 L112 N ATOM 1476 N SER B 134 −4.042 −20.518 −47.416 1.00 36.66 L112 N ATOM 1477 CA SER B 134 −3.168 −19.747 −46.539 1.00 36.64 L112 C ATOM 1478 C SER B 134 −3.344 −20.080 −45.066 1.00 33.11 L112 C ATOM 1479 O SER B 134 −2.635 −19.541 −44.223 1.00 37.50 L112 O ATOM 1480 CB SER B 134 −3.414 −18.252 −46.741 1.00 34.18 L112 C ATOM 1481 OG SER B 134 −4.603 −17.857 −46.080 1.00 23.48 L112 O ATOM 1482 N MET B 135 −4.281 −20.964 −44.748 1.00 29.84 L112 N ATOM 1483 CA MET B 135 −4.509 −21.312 −43.357 1.00 23.70 L112 C ATOM 1484 C MET B 135 −4.602 −22.808 −43.089 1.00 29.55 L112 C ATOM 1485 O MET B 135 −5.283 −23.242 −42.161 1.00 23.32 L112 O ATOM 1486 CB MET B 135 −5.768 −20.618 −42.857 1.00 22.94 L112 C ATOM 1487 CG MET B 135 −7.034 −21.139 −43.448 1.00 17.81 L112 C ATOM 1488 SD MET B 135 −8.303 −19.898 −43.327 1.00 34.08 L112 S ATOM 1489 CE MET B 135 −9.264 −20.525 −41.959 1.00 35.79 L112 C ATOM 1490 N GLY B 136 −3.914 −23.592 −43.910 1.00 35.43 L112 N ATOM 1491 CA GLY B 136 −3.911 −25.030 −43.728 1.00 27.07 L112 C ATOM 1492 C GLY B 136 −5.245 −25.737 −43.854 1.00 28.44 L112 C ATOM 1493 O GLY B 136 −5.524 −26.683 −43.120 1.00 30.60 L112 O ATOM 1494 N ILE B 137 −6.088 −25.289 −44.770 1.00 27.95 L112 N ATOM 1495 CA ILE B 137 −7.357 −25.966 −44.963 1.00 31.48 L112 C ATOM 1496 C ILE B 137 −7.358 −26.505 −46.389 1.00 36.97 L112 C ATOM 1497 O ILE B 137 −7.192 −25.752 −47.350 1.00 43.45 L112 O ATOM 1498 CB ILE B 137 −8.547 −25.019 −44.736 1.00 31.35 L112 C ATOM 1499 CG1 ILE B 137 −8.702 −24.756 −43.233 1.00 30.66 L112 C ATOM 1500 CG2 ILE B 137 −9.826 −25.634 −45.302 1.00 23.26 L112 C ATOM 1501 CD1 ILE B 137 −9.853 −23.843 −42.859 1.00 19.47 L112 C ATOM 1502 N GLU B 138 −7.516 −27.820 −46.508 1.00 34.70 L112 N ATOM 1503 CA GLU B 138 −7.523 −28.504 −47.793 1.00 24.78 L112 C ATOM 1504 C GLU B 138 −8.909 −28.509 −48.402 1.00 30.83 L112 C ATOM 1505 O GLU B 138 −9.911 −28.509 −47.685 1.00 25.06 L112 O ATOM 1506 CB GLU B 138 −7.065 −29.949 −47.617 1.00 33.57 L112 C ATOM 1507 CG GLU B 138 −5.717 −30.270 −48.240 1.00 53.60 L112 C ATOM 1508 CD GLU B 138 −5.435 −31.769 −48.293 1.00 61.48 L112 C ATOM 1509 OE1 GLU B 138 −6.286 −32.555 −47.810 1.00 52.54 L112 O ATOM 1510 OE2 GLU B 138 −4.359 −32.152 −48.818 1.00 61.92 L112 O ATOM 1511 N VAL B 139 −8.962 −28.518 −49.733 1.00 36.08 L112 N ATOM 1512 CA VAL B 139 −10.234 −28.552 −50.450 1.00 32.76 L112 C ATOM 1513 C VAL B 139 −10.392 −29.933 −51.077 1.00 35.50 L112 C ATOM 1514 O VAL B 139 −9.434 −30.484 −51.624 1.00 35.56 L112 O ATOM 1515 CB VAL B 139 −10.293 −27.477 −51.557 1.00 24.66 L112 C ATOM 1516 CG1 VAL B 139 −11.653 −27.507 −52.234 1.00 22.09 L112 C ATOM 1517 CG2 VAL B 139 −10.044 −26.102 −50.959 1.00 19.96 L112 C ATOM 1518 N VAL B 140 −11.593 −30.499 −50.978 1.00 39.97 L112 N ATOM 1519 CA VAL B 140 −11.862 −31.825 −51.534 1.00 47.65 L112 C ATOM 1520 C VAL B 140 −13.287 −31.934 −52.091 1.00 51.84 L112 C ATOM 1521 O VAL B 140 −13.610 −32.955 −52.740 1.00 48.50 L112 O ATOM 1522 CB VAL B 140 −11.651 −32.933 −50.467 1.00 46.88 L112 C ATOM 1523 CG1 VAL B 140 −11.479 −34.280 −51.152 1.00 53.45 L112 C ATOM 1524 CG2 VAL B 140 −10.421 −32.628 −49.615 1.00 37.90 L112 C ATOM 1525 OXT VAL B 140 −14.071 −30.988 −51.877 1.00 56.26 L112 O TER 1526 VAL B 140 ATOM 1527 O5* G C 1051 24.335 −12.173 6.313 1.00 73.26 RNA1 O ATOM 1528 C5* G C 1051 22.929 −12.367 6.147 1.00 60.23 RNA1 C ATOM 1529 C4* G C 1051 22.454 −13.612 6.854 1.00 60.92 RNA1 C ATOM 1530 O4* G C 1051 22.709 −13.474 8.275 1.00 63.63 RNA1 O ATOM 1531 C3* G C 1051 20.961 −13.878 6.747 1.00 62.37 RNA1 C ATOM 1532 O3* G C 1051 20.640 −14.594 5.557 1.00 56.24 RNA1 O ATOM 1533 C2* G C 1051 20.665 −14.668 8.018 1.00 60.79 RNA1 C ATOM 1534 O2* G C 1051 20.939 −16.050 7.900 1.00 63.11 RNA1 O ATOM 1535 C1* G C 1051 21.637 −14.032 9.016 1.00 57.61 RNA1 C ATOM 1536 N9 G C 1051 21.014 −12.959 9.786 1.00 54.68 RNA1 N ATOM 1537 C8 G C 1051 21.204 −11.607 9.624 1.00 57.52 RNA1 C ATOM 1538 N7 G C 1051 20.474 −10.887 10.430 1.00 63.57 RNA1 N ATOM 1539 C5 G C 1051 19.766 −11.817 11.176 1.00 60.31 RNA1 C ATOM 1540 C6 G C 1051 18.808 −11.631 12.205 1.00 65.69 RNA1 C ATOM 1541 O6 G C 1051 18.372 −10.568 12.669 1.00 71.42 RNA1 O ATOM 1542 N1 G C 1051 18.347 −12.847 12.698 1.00 61.97 RNA1 N ATOM 1543 C2 G C 1051 18.751 −14.081 12.257 1.00 58.15 RNA1 C ATOM 1544 N2 G C 1051 18.193 −15.135 12.861 1.00 61.86 RNA1 N ATOM 1545 N3 G C 1051 19.636 −14.269 11.294 1.00 58.41 RNA1 N ATOM 1546 C4 G C 1051 20.099 −13.101 10.802 1.00 56.62 RNA1 C ATOM 1547 P C C 1052 19.126 −14.611 5.015 1.00 50.79 RNA1 P ATOM 1548 O1P C C 1052 18.620 −13.217 4.973 1.00 58.55 RNA1 O ATOM 1549 O2P C C 1052 19.094 −15.438 3.784 1.00 67.52 RNA1 O ATOM 1550 O5* C C 1052 18.323 −15.374 6.155 1.00 48.31 RNA1 O ATOM 1551 C5* C C 1052 18.502 −16.781 6.372 1.00 35.63 RNA1 C ATOM 1552 C4* C C 1052 17.510 −17.267 7.392 1.00 38.42 RNA1 C ATOM 1553 O4* C C 1052 17.824 −16.686 8.682 1.00 47.16 RNA1 O ATOM 1554 C3* C C 1052 16.087 −16.825 7.117 1.00 44.09 RNA1 C ATOM 1555 O3* C C 1052 15.438 −17.673 6.200 1.00 49.32 RNA1 O ATOM 1556 C2* C C 1052 15.449 −16.814 8.499 1.00 46.87 RNA1 C ATOM 1557 O2* C C 1052 14.978 −18.071 8.935 1.00 46.62 RNA1 O ATOM 1558 C1* C C 1052 16.623 −16.360 9.368 1.00 48.30 RNA1 C ATOM 1559 N1 C C 1052 16.588 −14.902 9.601 1.00 47.59 RNA1 N ATOM 1560 C2 C C 1052 15.778 −14.405 10.629 1.00 47.88 RNA1 C ATOM 1561 O2 C C 1052 15.145 −15.205 11.338 1.00 45.47 RNA1 O ATOM 1562 N3 C C 1052 15.706 −13.069 10.824 1.00 51.51 RNA1 N ATOM 1563 C4 C C 1052 16.406 −12.242 10.045 1.00 47.87 RNA1 C ATOM 1564 N4 C C 1052 16.289 −10.929 10.263 1.00 45.35 RNA1 N ATOM 1565 C5 C C 1052 17.252 −12.720 9.006 1.00 42.28 RNA1 C ATOM 1566 C6 C C 1052 17.314 −14.043 8.821 1.00 43.16 RNA1 C ATOM 1567 P U C 1053 14.314 −17.067 5.236 1.00 53.77 RNA1 P ATOM 1568 O1P U C 1053 14.776 −15.724 4.784 1.00 61.48 RNA1 O ATOM 1569 O2P U C 1053 13.984 −18.106 4.231 1.00 67.30 RNA1 O ATOM 1570 O5* U C 1053 13.059 −16.888 6.196 1.00 51.10 RNA1 O ATOM 1571 C5* U C 1053 12.448 −18.032 6.809 1.00 47.98 RNA1 C ATOM 1572 C4* U C 1053 11.467 −17.603 7.868 1.00 47.08 RNA1 C ATOM 1573 O4* U C 1053 12.170 −16.895 8.917 1.00 48.31 RNA1 O ATOM 1574 C3* U C 1053 10.382 −16.641 7.423 1.00 49.60 RNA1 C ATOM 1575 O3* U C 1053 9.295 −17.321 6.812 1.00 61.44 RNA1 O ATOM 1576 C2* U C 1053 9.993 −15.961 8.730 1.00 50.47 RNA1 C ATOM 1577 O2* U C 1053 9.119 −16.731 9.531 1.00 43.66 RNA1 O ATOM 1578 C1* U C 1053 11.339 −15.875 9.443 1.00 44.87 RNA1 C ATOM 1579 N1 U C 1053 12.003 −14.575 9.247 1.00 55.73 RNA1 N ATOM 1580 C2 U C 1053 11.564 −13.505 10.018 1.00 53.37 RNA1 C ATOM 1581 O2 U C 1053 10.644 −13.591 10.824 1.00 47.71 RNA1 O ATOM 1582 N3 U C 1053 12.240 −12.328 9.807 1.00 43.32 RNA1 N ATOM 1583 C4 U C 1053 13.281 −12.110 8.928 1.00 42.60 RNA1 C ATOM 1584 O4 U C 1053 13.827 −11.008 8.906 1.00 44.05 RNA1 O ATOM 1585 C5 U C 1053 13.666 −13.253 8.157 1.00 39.63 RNA1 C ATOM 1586 C6 U C 1053 13.032 −14.415 8.336 1.00 51.41 RNA1 C ATOM 1587 P G C 1054 8.426 −16.576 5.682 1.00 62.77 RNA1 P ATOM 1588 O1P G C 1054 9.391 −15.966 4.732 1.00 48.23 RNA1 O ATOM 1589 O2P G C 1054 7.391 −17.524 5.177 1.00 63.46 RNA1 O ATOM 1590 O5* G C 1054 7.673 −15.417 6.482 1.00 57.93 RNA1 O ATOM 1591 C5* G C 1054 6.589 −15.737 7.376 1.00 58.01 RNA1 C ATOM 1592 C4* G C 1054 6.160 −14.521 8.162 1.00 54.61 RNA1 C ATOM 1593 O4* G C 1054 7.279 −14.019 8.937 1.00 57.89 RNA1 O ATOM 1594 C3* G C 1054 5.693 −13.296 7.392 1.00 56.27 RNA1 C ATOM 1595 O3* G C 1054 4.352 −13.378 6.946 1.00 61.66 RNA1 O ATOM 1596 C2* G C 1054 5.851 −12.189 8.425 1.00 52.95 RNA1 C ATOM 1597 O2* G C 1054 4.779 −12.130 9.346 1.00 49.43 RNA1 O ATOM 1598 C1* G C 1054 7.119 −12.626 9.148 1.00 47.41 RNA1 C ATOM 1599 N9 G C 1054 8.274 −11.911 8.616 1.00 41.21 RNA1 N ATOM 1600 C8 G C 1054 9.205 −12.347 7.703 1.00 35.70 RNA1 C ATOM 1601 N7 G C 1054 10.100 −11.440 7.414 1.00 39.32 RNA1 N ATOM 1602 C5 G C 1054 9.741 −10.342 8.190 1.00 34.83 RNA1 C ATOM 1603 C6 G C 1054 10.333 −9.051 8.304 1.00 30.48 RNA1 C ATOM 1604 O6 G C 1054 11.333 −8.604 7.728 1.00 27.46 RNA1 O ATOM 1605 N1 G C 1054 9.635 −8.245 9.199 1.00 30.56 RNA1 N ATOM 1606 C2 G C 1054 8.511 −8.623 9.898 1.00 43.91 RNA1 C ATOM 1607 N2 G C 1054 7.967 −7.703 10.717 1.00 37.62 RNA1 N ATOM 1608 N3 G C 1054 7.957 −9.818 9.803 1.00 43.41 RNA1 N ATOM 1609 C4 G C 1054 8.619 −10.620 8.938 1.00 41.38 RNA1 C ATOM 1610 P G C 1055 3.878 −12.469 5.704 1.00 66.88 RNA1 P ATOM 1611 O1P G C 1055 4.889 −12.575 4.612 1.00 48.03 RNA1 O ATOM 1612 O2P G C 1055 2.452 −12.820 5.440 1.00 64.70 RNA1 O ATOM 1613 O5* G C 1055 3.943 −10.971 6.248 1.00 63.61 RNA1 O ATOM 1614 C5* G C 1055 3.012 −10.512 7.237 1.00 53.95 RNA1 C ATOM 1615 C4* G C 1055 3.371 −9.125 7.706 1.00 46.33 RNA1 C ATOM 1616 O4* G C 1055 4.737 −9.107 8.201 1.00 45.69 RNA1 O ATOM 1617 C3* G C 1055 3.363 −8.001 6.687 1.00 40.52 RNA1 C ATOM 1618 O3* G C 1055 2.066 −7.500 6.421 1.00 47.06 RNA1 O ATOM 1619 C2* G C 1055 4.212 −6.943 7.377 1.00 42.04 RNA1 C ATOM 1620 O2* G C 1055 3.475 −6.224 8.348 1.00 43.70 RNA1 O ATOM 1621 C1* G C 1055 5.264 −7.798 8.076 1.00 31.41 RNA1 C ATOM 1622 N9 G C 1055 6.501 −7.839 7.307 1.00 24.39 RNA1 N ATOM 1623 C8 G C 1055 7.026 −8.888 6.592 1.00 29.37 RNA1 C ATOM 1624 N7 G C 1055 8.158 −8.591 6.005 1.00 32.88 RNA1 N ATOM 1625 C5 G C 1055 8.388 −7.266 6.352 1.00 23.47 RNA1 C ATOM 1626 C6 G C 1055 9.458 −6.393 6.013 1.00 28.67 RNA1 C ATOM 1627 O6 G C 1055 10.450 −6.622 5.314 1.00 27.35 RNA1 O ATOM 1628 N1 G C 1055 9.292 −5.136 6.584 1.00 24.95 RNA1 N ATOM 1629 C2 G C 1055 8.235 −4.763 7.377 1.00 26.92 RNA1 C ATOM 1630 N2 G C 1055 8.255 −3.513 7.838 1.00 28.71 RNA1 N ATOM 1631 N3 G C 1055 7.234 −5.561 7.696 1.00 22.90 RNA1 N ATOM 1632 C4 G C 1055 7.375 −6.789 7.155 1.00 29.13 RNA1 C ATOM 1633 P G C 1056 1.758 −6.834 4.989 1.00 49.25 RNA1 P ATOM 1634 O1P G C 1056 1.991 −7.883 3.963 1.00 42.81 RNA1 O ATOM 1635 O2P G C 1056 0.428 −6.158 5.065 1.00 37.09 RNA1 O ATOM 1636 O5* G C 1056 2.899 −5.734 4.819 1.00 32.92 RNA1 O ATOM 1637 C5* G C 1056 2.796 −4.457 5.476 1.00 35.07 RNA1 C ATOM 1638 C4* G C 1056 3.939 −3.563 5.065 1.00 31.58 RNA1 C ATOM 1639 O4* G C 1056 5.187 −4.183 5.457 1.00 35.44 RNA1 O ATOM 1640 C3* G C 1056 4.089 −3.329 3.575 1.00 34.14 RNA1 C ATOM 1641 O3* G C 1056 3.270 −2.275 3.113 1.00 39.89 RNA1 O ATOM 1642 C2* G C 1056 5.567 −3.005 3.429 1.00 33.87 RNA1 C ATOM 1643 O2* G C 1056 5.865 −1.651 3.704 1.00 36.26 RNA1 O ATOM 1644 C1* G C 1056 6.184 −3.915 4.489 1.00 31.52 RNA1 C ATOM 1645 N9 G C 1056 6.611 −5.191 3.922 1.00 35.38 RNA1 N ATOM 1646 C8 G C 1056 5.874 −6.350 3.845 1.00 33.57 RNA1 C ATOM 1647 N7 G C 1056 6.516 −7.326 3.265 1.00 40.73 RNA1 N ATOM 1648 C5 G C 1056 7.752 −6.782 2.941 1.00 37.74 RNA1 C ATOM 1649 C6 G C 1056 8.875 −7.367 2.290 1.00 41.95 RNA1 C ATOM 1650 O6 G C 1056 8.999 −8.519 1.852 1.00 52.67 RNA1 O ATOM 1651 N1 G C 1056 9.925 −6.460 2.169 1.00 34.10 RNA1 N ATOM 1652 C2 G C 1056 9.899 −5.160 2.611 1.00 28.22 RNA1 C ATOM 1653 N2 G C 1056 11.011 −4.444 2.407 1.00 29.23 RNA1 N ATOM 1654 N3 G C 1056 8.860 −4.603 3.211 1.00 30.05 RNA1 N ATOM 1655 C4 G C 1056 7.829 −5.466 3.344 1.00 33.38 RNA1 C ATOM 1656 P A C 1057 2.647 −2.350 1.636 1.00 36.51 RNA1 P ATOM 1657 O1P A C 1057 2.944 −1.053 0.973 1.00 50.45 RNA1 O ATOM 1658 O2P A C 1057 3.064 −3.614 0.988 1.00 31.54 RNA1 O ATOM 1659 O5* A C 1057 1.085 −2.420 1.900 1.00 24.51 RNA1 O ATOM 1660 C5* A C 1057 0.516 −3.490 2.659 1.00 23.76 RNA1 C ATOM 1661 C4* A C 1057 −0.421 −2.936 3.703 1.00 25.17 RNA1 C ATOM 1662 O4* A C 1057 0.346 −2.384 4.802 1.00 26.26 RNA1 O ATOM 1663 C3* A C 1057 −1.282 −1.776 3.240 1.00 26.38 RNA1 C ATOM 1664 O3* A C 1057 −2.429 −2.174 2.517 1.00 39.01 RNA1 O ATOM 1665 C2* A C 1057 −1.612 −1.068 4.542 1.00 23.04 RNA1 C ATOM 1666 O2* A C 1057 −2.658 −1.705 5.241 1.00 26.68 RNA1 O ATOM 1667 C1* A C 1057 −0.304 −1.230 5.310 1.00 20.72 RNA1 C ATOM 1668 N9 A C 1057 0.587 −0.081 5.125 1.00 25.31 RNA1 N ATOM 1669 C8 A C 1057 1.840 −0.055 4.550 1.00 24.58 RNA1 C ATOM 1670 N7 A C 1057 2.393 1.135 4.537 1.00 16.48 RNA1 N ATOM 1671 C5 A C 1057 1.445 1.949 5.143 1.00 18.96 RNA1 C ATOM 1672 C6 A C 1057 1.428 3.322 5.438 1.00 21.91 RNA1 C ATOM 1673 N6 A C 1057 2.445 4.150 5.174 1.00 18.97 RNA1 N ATOM 1674 N1 A C 1057 0.322 3.824 6.029 1.00 28.79 RNA1 N ATOM 1675 C2 A C 1057 −0.688 2.991 6.317 1.00 26.99 RNA1 C ATOM 1676 N3 A C 1057 −0.786 1.681 6.104 1.00 27.54 RNA1 N ATOM 1677 C4 A C 1057 0.326 1.215 5.505 1.00 19.03 RNA1 C ATOM 1678 P U C 1058 −2.943 −1.256 1.300 1.00 33.80 RNA1 P ATOM 1679 O1P U C 1058 −1.733 −0.731 0.608 1.00 32.34 RNA1 O ATOM 1680 O2P U C 1058 −3.967 −1.996 0.524 1.00 30.00 RNA1 O ATOM 1681 O5* U C 1058 −3.665 −0.043 2.030 1.00 29.35 RNA1 O ATOM 1682 C5* U C 1058 −4.955 −0.218 2.627 1.00 31.01 RNA1 C ATOM 1683 C4* U C 1058 −5.530 1.120 3.008 1.00 33.02 RNA1 C ATOM 1684 O4* U C 1058 −4.686 1.734 4.018 1.00 32.59 RNA1 O ATOM 1685 C3* U C 1058 −5.554 2.156 1.902 1.00 34.36 RNA1 C ATOM 1686 O3* U C 1058 −6.626 2.018 0.993 1.00 36.65 RNA1 O ATOM 1687 C2* U C 1058 −5.596 3.459 2.680 1.00 27.20 RNA1 C ATOM 1688 O2* U C 1058 −6.886 3.727 3.188 1.00 26.74 RNA1 O ATOM 1689 C1* U C 1058 −4.652 3.139 3.831 1.00 24.15 RNA1 C ATOM 1690 N1 U C 1058 −3.267 3.546 3.532 1.00 18.02 RNA1 N ATOM 1691 C2 U C 1058 −2.971 4.898 3.590 1.00 19.91 RNA1 C ATOM 1692 O2 U C 1058 −3.802 5.750 3.879 1.00 30.16 RNA1 O ATOM 1693 N3 U C 1058 −1.671 5.219 3.300 1.00 13.57 RNA1 N ATOM 1694 C4 U C 1058 −0.655 4.353 2.965 1.00 20.26 RNA1 C ATOM 1695 O4 U C 1058 0.470 4.801 2.729 1.00 30.19 RNA1 O ATOM 1696 C5 U C 1058 −1.035 2.981 2.926 1.00 12.30 RNA1 C ATOM 1697 C6 U C 1058 −2.296 2.631 3.205 1.00 13.08 RNA1 C ATOM 1698 P G C 1059 −6.470 2.631 −0.484 1.00 30.00 RNA1 P ATOM 1699 O1P G C 1059 −5.071 2.397 −0.938 1.00 16.05 RNA1 O ATOM 1700 O2P G C 1059 −7.607 2.157 −1.311 1.00 33.73 RNA1 O ATOM 1701 O5* G C 1059 −6.635 4.196 −0.256 1.00 30.83 RNA1 O ATOM 1702 C5* G C 1059 −7.854 4.731 0.279 1.00 22.74 RNA1 C ATOM 1703 C4* G C 1059 −7.798 6.231 0.278 1.00 24.79 RNA1 C ATOM 1704 O4* G C 1059 −6.727 6.667 1.149 1.00 28.49 RNA1 O ATOM 1705 C3* G C 1059 −7.475 6.869 −1.060 1.00 26.72 RNA1 C ATOM 1706 O3* G C 1059 −8.642 7.007 −1.857 1.00 34.13 RNA1 O ATOM 1707 C2* G C 1059 −6.884 8.214 −0.657 1.00 28.17 RNA1 C ATOM 1708 O2* G C 1059 −7.880 9.178 −0.371 1.00 38.10 RNA1 O ATOM 1709 C1* G C 1059 −6.157 7.860 0.640 1.00 23.13 RNA1 C ATOM 1710 N9 G C 1059 −4.721 7.665 0.480 1.00 15.04 RNA1 N ATOM 1711 C8 G C 1059 −4.064 6.490 0.206 1.00 17.72 RNA1 C ATOM 1712 N7 G C 1059 −2.766 6.634 0.130 1.00 21.45 RNA1 N ATOM 1713 C5 G C 1059 −2.552 7.989 0.360 1.00 9.82 RNA1 C ATOM 1714 C6 G C 1059 −1.344 8.740 0.392 1.00 23.72 RNA1 C ATOM 1715 O6 G C 1059 −0.177 8.344 0.216 1.00 19.54 RNA1 O ATOM 1716 N1 G C 1059 −1.585 10.082 0.661 1.00 19.14 RNA1 N ATOM 1717 C2 G C 1059 −2.822 10.638 0.874 1.00 19.08 RNA1 C ATOM 1718 N2 G C 1059 −2.837 11.957 1.125 1.00 16.35 RNA1 N ATOM 1719 N3 G C 1059 −3.955 9.953 0.844 1.00 20.08 RNA1 N ATOM 1720 C4 G C 1059 −3.746 8.641 0.582 1.00 20.00 RNA1 C ATOM 1721 P U C 1060 −8.509 7.045 −3.456 1.00 31.42 RNA1 P ATOM 1722 O1P U C 1060 −9.692 6.330 −3.996 1.00 31.37 RNA1 O ATOM 1723 O2P U C 1060 −8.243 8.446 −3.872 1.00 36.54 RNA1 O ATOM 1724 O5* U C 1060 −7.195 6.198 −3.754 1.00 22.64 RNA1 O ATOM 1725 C5* U C 1060 −7.016 5.523 −5.009 1.00 22.76 RNA1 C ATOM 1726 C4* U C 1060 −5.589 5.064 −5.145 1.00 18.28 RNA1 C ATOM 1727 O4* U C 1060 −4.739 6.232 −5.160 1.00 20.83 RNA1 O ATOM 1728 C3* U C 1060 −5.079 4.166 −4.022 1.00 28.38 RNA1 C ATOM 1729 O3* U C 1060 −4.142 3.234 −4.559 1.00 34.99 RNA1 O ATOM 1730 C2* U C 1060 −4.336 5.141 −3.110 1.00 28.41 RNA1 C ATOM 1731 O2* U C 1060 −3.277 4.523 −2.401 1.00 41.53 RNA1 O ATOM 1732 C1* U C 1060 −3.794 6.157 −4.115 1.00 23.82 RNA1 C ATOM 1733 N1 U C 1060 −3.613 7.518 −3.587 1.00 15.63 RNA1 N ATOM 1734 C2 U C 1060 −2.336 7.922 −3.245 1.00 18.51 RNA1 C ATOM 1735 O2 U C 1060 −1.353 7.193 −3.325 1.00 21.06 RNA1 O ATOM 1736 N3 U C 1060 −2.245 9.216 −2.800 1.00 13.56 RNA1 N ATOM 1737 C4 U C 1060 −3.271 10.129 −2.661 1.00 21.90 RNA1 C ATOM 1738 O4 U C 1060 −3.015 11.281 −2.293 1.00 25.73 RNA1 O ATOM 1739 C5 U C 1060 −4.559 9.632 −3.018 1.00 7.65 RNA1 C ATOM 1740 C6 U C 1060 −4.686 8.377 −3.455 1.00 23.41 RNA1 C ATOM 1741 P U C 1061 −4.622 2.136 −5.633 1.00 28.90 RNA1 P ATOM 1742 O1P U C 1061 −3.994 0.840 −5.253 1.00 34.87 RNA1 O ATOM 1743 O2P U C 1061 −6.093 2.222 −5.792 1.00 16.57 RNA1 O ATOM 1744 O5* U C 1061 −3.946 2.631 −6.983 1.00 24.02 RNA1 O ATOM 1745 C5* U C 1061 −2.514 2.667 −7.117 1.00 25.58 RNA1 C ATOM 1746 C4* U C 1061 −2.122 3.503 −8.311 1.00 31.26 RNA1 C ATOM 1747 O4* U C 1061 −2.694 2.914 −9.507 1.00 36.66 RNA1 O ATOM 1748 C3* U C 1061 −2.584 4.961 −8.290 1.00 33.14 RNA1 C ATOM 1749 O3* U C 1061 −1.601 5.740 −8.967 1.00 23.50 RNA1 O ATOM 1750 C2* U C 1061 −3.831 4.934 −9.167 1.00 32.29 RNA1 C ATOM 1751 O2* U C 1061 −4.100 6.183 −9.775 1.00 33.30 RNA1 O ATOM 1752 C1* U C 1061 −3.414 3.896 −10.205 1.00 40.61 RNA1 C ATOM 1753 N1 U C 1061 −4.461 3.257 −11.015 1.00 50.51 RNA1 N ATOM 1754 C2 U C 1061 −4.299 3.335 −12.387 1.00 62.28 RNA1 C ATOM 1755 O2 U C 1061 −3.330 3.880 −12.914 1.00 62.30 RNA1 O ATOM 1756 N3 U C 1061 −5.303 2.754 −13.123 1.00 73.69 RNA1 N ATOM 1757 C4 U C 1061 −6.427 2.110 −12.641 1.00 67.10 RNA1 C ATOM 1758 O4 U C 1061 −7.260 1.668 −13.440 1.00 68.66 RNA1 O ATOM 1759 C5 U C 1061 −6.515 2.056 −11.210 1.00 54.52 RNA1 C ATOM 1760 C6 U C 1061 −5.552 2.617 −10.463 1.00 45.73 RNA1 C ATOM 1761 P G C 1062 −0.570 6.637 −8.138 1.00 27.54 RNA1 P ATOM 1762 O1P G C 1062 −0.356 5.986 −6.813 1.00 24.54 RNA1 O ATOM 1763 O2P G C 1062 0.600 6.908 −9.017 1.00 15.00 RNA1 O ATOM 1764 O5* G C 1062 −1.358 8.001 −7.930 1.00 14.13 RNA1 O ATOM 1765 C5* G C 1062 −2.396 8.125 −6.939 1.00 22.88 RNA1 C ATOM 1766 C4* G C 1062 −2.448 9.547 −6.435 1.00 15.45 RNA1 C ATOM 1767 O4* G C 1062 −1.246 9.824 −5.677 1.00 24.75 RNA1 O ATOM 1768 C3* G C 1062 −2.438 10.568 −7.550 1.00 12.59 RNA1 C ATOM 1769 O3* G C 1062 −3.742 10.823 −8.006 1.00 33.25 RNA1 O ATOM 1770 C2* G C 1062 −1.783 11.777 −6.911 1.00 19.71 RNA1 C ATOM 1771 O2* G C 1062 −2.709 12.520 −6.141 1.00 23.78 RNA1 O ATOM 1772 C1* G C 1062 −0.751 11.111 −5.999 1.00 16.39 RNA1 C ATOM 1773 N9 G C 1062 0.564 10.927 −6.611 1.00 14.13 RNA1 N ATOM 1774 C8 G C 1062 1.229 9.734 −6.776 1.00 24.14 RNA1 C ATOM 1775 N7 G C 1062 2.388 9.866 −7.361 1.00 25.47 RNA1 N ATOM 1776 C5 G C 1062 2.495 11.229 −7.605 1.00 26.26 RNA1 C ATOM 1777 C6 G C 1062 3.527 11.966 −8.235 1.00 31.66 RNA1 C ATOM 1778 O6 G C 1062 4.572 11.542 −8.758 1.00 28.31 RNA1 O ATOM 1779 N1 G C 1062 3.246 13.328 −8.243 1.00 23.22 RNA1 N ATOM 1780 C2 G C 1062 2.108 13.904 −7.739 1.00 23.93 RNA1 C ATOM 1781 N2 G C 1062 2.025 15.238 −7.844 1.00 18.71 RNA1 N ATOM 1782 N3 G C 1062 1.125 13.226 −7.174 1.00 19.22 RNA1 N ATOM 1783 C4 G C 1062 1.384 11.902 −7.137 1.00 21.18 RNA1 C ATOM 1784 P G C 1063 −3.983 11.091 −9.564 1.00 32.90 RNA1 P ATOM 1785 O1P G C 1063 −3.162 10.105 −10.324 1.00 29.07 RNA1 O ATOM 1786 O2P G C 1063 −5.446 11.159 −9.776 1.00 28.95 RNA1 O ATOM 1787 O5* G C 1063 −3.361 12.534 −9.798 1.00 32.11 RNA1 O ATOM 1788 C5* G C 1063 −4.042 13.712 −9.342 1.00 23.86 RNA1 C ATOM 1789 C4* G C 1063 −3.302 14.944 −9.798 1.00 22.38 RNA1 C ATOM 1790 O4* G C 1063 −1.983 14.950 −9.201 1.00 24.88 RNA1 O ATOM 1791 C3* G C 1063 −3.019 15.022 −11.287 1.00 26.89 RNA1 C ATOM 1792 O3* G C 1063 −4.110 15.506 −12.042 1.00 33.17 RNA1 O ATOM 1793 C2* G C 1063 −1.806 15.936 −11.343 1.00 25.82 RNA1 C ATOM 1794 O2* G C 1063 −2.149 17.294 −11.168 1.00 34.75 RNA1 O ATOM 1795 C1* G C 1063 −1.035 15.472 −10.118 1.00 14.96 RNA1 C ATOM 1796 N9 G C 1063 −0.093 14.412 −10.461 1.00 16.28 RNA1 N ATOM 1797 C8 G C 1063 −0.201 13.070 −10.178 1.00 17.00 RNA1 C ATOM 1798 N7 G C 1063 0.820 12.373 −10.602 1.00 23.95 RNA1 N ATOM 1799 C5 G C 1063 1.644 13.309 −11.212 1.00 13.66 RNA1 C ATOM 1800 C6 G C 1063 2.898 13.151 −11.857 1.00 19.46 RNA1 C ATOM 1801 O6 G C 1063 3.555 12.117 −12.032 1.00 27.29 RNA1 O ATOM 1802 N1 G C 1063 3.385 14.363 −12.326 1.00 19.82 RNA1 N ATOM 1803 C2 G C 1063 2.749 15.571 −12.201 1.00 24.09 RNA1 C ATOM 1804 N2 G C 1063 3.385 16.631 −12.718 1.00 33.27 RNA1 N ATOM 1805 N3 G C 1063 1.579 15.731 −11.609 1.00 25.48 RNA1 N ATOM 1806 C4 G C 1063 1.091 14.569 −11.137 1.00 16.05 RNA1 C ATOM 1807 P C C 1064 −4.385 14.882 −13.495 1.00 32.63 RNA1 P ATOM 1808 O1P C C 1064 −4.311 13.399 −13.376 1.00 34.14 RNA1 O ATOM 1809 O2P C C 1064 −5.610 15.520 −14.047 1.00 34.53 RNA1 O ATOM 1810 O5* C C 1064 −3.124 15.351 −14.340 1.00 25.39 RNA1 O ATOM 1811 C5* C C 1064 −2.841 16.743 −14.483 1.00 20.47 RNA1 C ATOM 1812 C4* C C 1064 −1.510 16.945 −15.158 1.00 22.15 RNA1 C ATOM 1813 O4* C C 1064 −0.455 16.348 −14.362 1.00 25.83 RNA1 O ATOM 1814 C3* C C 1064 −1.320 16.321 −16.528 1.00 29.48 RNA1 C ATOM 1815 O3* C C 1064 −1.921 17.088 −17.565 1.00 35.84 RNA1 O ATOM 1816 C2* C C 1064 0.199 16.267 −16.648 1.00 29.04 RNA1 C ATOM 1817 O2* C C 1064 0.774 17.500 −17.036 1.00 28.73 RNA1 O ATOM 1818 C1* C C 1064 0.611 15.958 −15.212 1.00 21.28 RNA1 C ATOM 1819 N1 C C 1064 0.899 14.525 −15.020 1.00 19.09 RNA1 N ATOM 1820 C2 C C 1064 2.155 14.044 −15.409 1.00 27.83 RNA1 C ATOM 1821 O2 C C 1064 2.977 14.836 −15.897 1.00 32.73 RNA1 O ATOM 1822 N3 C C 1064 2.442 12.734 −15.247 1.00 23.67 RNA1 N ATOM 1823 C4 C C 1064 1.535 11.915 −14.716 1.00 22.40 RNA1 C ATOM 1824 N4 C C 1064 1.871 10.635 −14.564 1.00 29.03 RNA1 N ATOM 1825 C5 C C 1064 0.246 12.374 −14.314 1.00 9.70 RNA1 C ATOM 1826 C6 C C 1064 −0.027 13.674 −14.482 1.00 20.34 RNA1 C ATOM 1827 P U C 1065 −2.537 16.339 −18.853 1.00 31.56 RNA1 P ATOM 1828 O1P U C 1065 −3.488 15.293 −18.407 1.00 29.35 RNA1 O ATOM 1829 O2P U C 1065 −3.011 17.398 −19.774 1.00 46.70 RNA1 O ATOM 1830 O5* U C 1065 −1.266 15.617 −19.495 1.00 22.04 RNA1 O ATOM 1831 C5* U C 1065 −0.138 16.392 −19.935 1.00 25.90 RNA1 C ATOM 1832 C4* U C 1065 1.022 15.492 −20.286 1.00 32.86 RNA1 C ATOM 1833 O4* U C 1065 1.493 14.818 −19.094 1.00 35.71 RNA1 O ATOM 1834 C3* U C 1065 0.721 14.374 −21.270 1.00 35.55 RNA1 C ATOM 1835 O3* U C 1065 0.799 14.834 −22.609 1.00 37.39 RNA1 O ATOM 1836 C2* U C 1065 1.793 13.340 −20.939 1.00 36.11 RNA1 C ATOM 1837 O2* U C 1065 3.047 13.612 −21.536 1.00 27.98 RNA1 O ATOM 1838 C1* U C 1065 1.917 13.505 −19.423 1.00 33.40 RNA1 C ATOM 1839 N1 U C 1065 1.088 12.543 −18.676 1.00 17.15 RNA1 N ATOM 1840 C2 U C 1065 1.653 11.323 −18.364 1.00 21.75 RNA1 C ATOM 1841 O2 U C 1065 2.789 11.015 −18.700 1.00 24.53 RNA1 O ATOM 1842 N3 U C 1065 0.841 10.472 −17.652 1.00 12.86 RNA1 N ATOM 1843 C4 U C 1065 −0.454 10.708 −17.245 1.00 22.54 RNA1 C ATOM 1844 O4 U C 1065 −1.068 9.829 −16.631 1.00 33.30 RNA1 O ATOM 1845 C5 U C 1065 −0.972 11.988 −17.617 1.00 18.28 RNA1 C ATOM 1846 C6 U C 1065 −0.202 12.840 −18.300 1.00 12.72 RNA1 C ATOM 1847 P U C 1066 −0.290 14.345 −23.688 1.00 38.85 RNA1 P ATOM 1848 O1P U C 1066 −1.664 14.499 −23.126 1.00 18.29 RNA1 O ATOM 1849 O2P U C 1066 0.064 15.034 −24.964 1.00 40.95 RNA1 O ATOM 1850 O5* U C 1066 0.014 12.790 −23.851 1.00 36.40 RNA1 O ATOM 1851 C5* U C 1066 1.288 12.346 −24.350 1.00 35.84 RNA1 C ATOM 1852 C4* U C 1066 1.461 10.870 −24.107 1.00 38.35 RNA1 C ATOM 1853 O4* U C 1066 1.463 10.613 −22.679 1.00 39.66 RNA1 O ATOM 1854 C3* U C 1066 0.359 9.974 −24.652 1.00 44.84 RNA1 C ATOM 1855 O3* U C 1066 0.570 9.660 −26.021 1.00 45.33 RNA1 O ATOM 1856 C2* U C 1066 0.473 8.739 −23.769 1.00 44.55 RNA1 C ATOM 1857 O2* U C 1066 1.511 7.884 −24.213 1.00 33.40 RNA1 O ATOM 1858 C1* U C 1066 0.859 9.357 −22.421 1.00 39.47 RNA1 C ATOM 1859 N1 U C 1066 −0.301 9.556 −21.535 1.00 27.32 RNA1 N ATOM 1860 C2 U C 1066 −0.598 8.548 −20.630 1.00 27.94 RNA1 C ATOM 1861 O2 U C 1066 0.086 7.545 −20.506 1.00 31.42 RNA1 O ATOM 1862 N3 U C 1066 −1.722 8.759 −19.869 1.00 19.18 RNA1 N ATOM 1863 C4 U C 1066 −2.556 9.854 −19.905 1.00 25.49 RNA1 C ATOM 1864 O4 U C 1066 −3.565 9.870 −19.194 1.00 36.42 RNA1 O ATOM 1865 C5 U C 1066 −2.168 10.867 −20.840 1.00 19.93 RNA1 C ATOM 1866 C6 U C 1066 −1.082 10.689 −21.604 1.00 23.45 RNA1 C ATOM 1867 P A C 1067 −0.690 9.514 −27.002 1.00 46.85 RNA1 P ATOM 1868 O1P A C 1067 −1.666 10.598 −26.712 1.00 36.17 RNA1 O ATOM 1869 O2P A C 1067 −0.149 9.350 −28.374 1.00 52.36 RNA1 O ATOM 1870 O5* A C 1067 −1.379 8.151 −26.562 1.00 45.01 RNA1 O ATOM 1871 C5* A C 1067 −2.763 7.888 −26.874 1.00 42.12 RNA1 C ATOM 1872 C4* A C 1067 −3.108 6.464 −26.511 1.00 37.93 RNA1 C ATOM 1873 O4* A C 1067 −2.272 5.567 −27.279 1.00 37.30 RNA1 O ATOM 1874 C3* A C 1067 −2.805 6.123 −25.068 1.00 39.89 RNA1 C ATOM 1875 O3* A C 1067 −3.905 6.462 −24.244 1.00 44.47 RNA1 O ATOM 1876 C2* A C 1067 −2.505 4.632 −25.107 1.00 27.28 RNA1 C ATOM 1877 O2* A C 1067 −3.664 3.829 −25.084 1.00 44.22 RNA1 O ATOM 1878 C1* A C 1067 −1.845 4.494 −26.472 1.00 20.11 RNA1 C ATOM 1879 N9 A C 1067 −0.389 4.519 −26.443 1.00 16.55 RNA1 N ATOM 1880 C8 A C 1067 0.450 5.516 −26.872 1.00 13.35 RNA1 C ATOM 1881 N7 A C 1067 1.722 5.206 −26.785 1.00 21.36 RNA1 N ATOM 1882 C5 A C 1067 1.715 3.927 −26.244 1.00 6.97 RNA1 C ATOM 1883 C6 A C 1067 2.746 3.037 −25.917 1.00 18.48 RNA1 C ATOM 1884 N6 A C 1067 4.046 3.301 −26.105 1.00 25.96 RNA1 N ATOM 1885 N1 A C 1067 2.400 1.845 −25.391 1.00 13.59 RNA1 N ATOM 1886 C2 A C 1067 1.102 1.575 −25.214 1.00 28.55 RNA1 C ATOM 1887 N3 A C 1067 0.041 2.326 −25.488 1.00 23.97 RNA1 N ATOM 1888 C4 A C 1067 0.423 3.503 −26.009 1.00 16.34 RNA1 C ATOM 1889 P G C 1068 −3.632 7.060 −22.783 1.00 39.02 RNA1 P ATOM 1890 O1P G C 1068 −2.666 8.189 −22.930 1.00 31.97 RNA1 O ATOM 1891 O2P G C 1068 −4.955 7.282 −22.122 1.00 23.85 RNA1 O ATOM 1892 O5* G C 1068 −2.872 5.872 −22.052 1.00 29.64 RNA1 O ATOM 1893 C5* G C 1068 −3.560 4.650 −21.753 1.00 26.14 RNA1 C ATOM 1894 C4* G C 1068 −2.611 3.675 −21.128 1.00 30.68 RNA1 C ATOM 1895 O4* G C 1068 −1.612 3.299 −22.105 1.00 33.92 RNA1 O ATOM 1896 C3* G C 1068 −1.821 4.231 −19.956 1.00 37.79 RNA1 C ATOM 1897 O3* G C 1068 −2.586 4.140 −18.752 1.00 40.54 RNA1 O ATOM 1898 C2* G C 1068 −0.564 3.368 −19.963 1.00 31.49 RNA1 C ATOM 1899 O2* G C 1068 −0.774 2.123 −19.322 1.00 38.55 RNA1 O ATOM 1900 C1* G C 1068 −0.364 3.120 −21.463 1.00 28.77 RNA1 C ATOM 1901 N9 G C 1068 0.605 3.989 −22.123 1.00 18.63 RNA1 N ATOM 1902 C8 G C 1068 0.381 5.255 −22.612 1.00 21.10 RNA1 C ATOM 1903 N7 G C 1068 1.437 5.779 −23.177 1.00 18.47 RNA1 N ATOM 1904 C5 G C 1068 2.419 4.808 −23.047 1.00 12.57 RNA1 C ATOM 1905 C6 G C 1068 3.776 4.807 −23.476 1.00 23.53 RNA1 C ATOM 1906 O6 G C 1068 4.402 5.696 −24.076 1.00 26.90 RNA1 O ATOM 1907 N1 G C 1068 4.417 3.616 −23.140 1.00 26.41 RNA1 N ATOM 1908 C2 G C 1068 3.831 2.561 −22.479 1.00 23.88 RNA1 C ATOM 1909 N2 G C 1068 4.625 1.500 −22.232 1.00 22.10 RNA1 N ATOM 1910 N3 G C 1068 2.564 2.546 −22.085 1.00 17.30 RNA1 N ATOM 1911 C4 G C 1068 1.924 3.695 −22.396 1.00 15.61 RNA1 C ATOM 1912 P A C 1069 −2.674 5.408 −17.758 1.00 35.85 RNA1 P ATOM 1913 O1P A C 1069 −2.982 6.639 −18.536 1.00 34.22 RNA1 O ATOM 1914 O2P A C 1069 −3.551 5.029 −16.625 1.00 34.69 RNA1 O ATOM 1915 O5* A C 1069 −1.186 5.532 −17.220 1.00 22.83 RNA1 O ATOM 1916 C5* A C 1069 −0.570 4.437 −16.545 1.00 16.26 RNA1 C ATOM 1917 C4* A C 1069 0.859 4.768 −16.237 1.00 21.94 RNA1 C ATOM 1918 O4* A C 1069 1.694 4.585 −17.417 1.00 35.64 RNA1 O ATOM 1919 C3* A C 1069 1.093 6.209 −15.768 1.00 37.69 RNA1 C ATOM 1920 O3* A C 1069 2.058 6.196 −14.714 1.00 40.68 RNA1 O ATOM 1921 C2* A C 1069 1.737 6.855 −16.996 1.00 39.67 RNA1 C ATOM 1922 O2* A C 1069 2.583 7.960 −16.731 1.00 43.60 RNA1 O ATOM 1923 C1* A C 1069 2.567 5.680 −17.491 1.00 37.65 RNA1 C ATOM 1924 N9 A C 1069 3.223 5.772 −18.793 1.00 33.82 RNA1 N ATOM 1925 C8 A C 1069 2.972 6.600 −19.858 1.00 28.66 RNA1 C ATOM 1926 N7 A C 1069 3.878 6.527 −20.805 1.00 37.91 RNA1 N ATOM 1927 C5 A C 1069 4.758 5.554 −20.349 1.00 34.14 RNA1 C ATOM 1928 C6 A C 1069 5.949 5.022 −20.886 1.00 38.86 RNA1 C ATOM 1929 N6 A C 1069 6.490 5.420 −22.038 1.00 44.62 RNA1 N ATOM 1930 N1 A C 1069 6.577 4.054 −20.180 1.00 40.40 RNA1 N ATOM 1931 C2 A C 1069 6.041 3.661 −19.017 1.00 35.55 RNA1 C ATOM 1932 N3 A C 1069 4.939 4.093 −18.408 1.00 28.51 RNA1 N ATOM 1933 C4 A C 1069 4.342 5.053 −19.133 1.00 31.82 RNA1 C ATOM 1934 P A C 1070 1.715 6.875 −13.302 1.00 33.11 RNA1 P ATOM 1935 O1P A C 1070 3.039 7.134 −12.680 1.00 18.08 RNA1 O ATOM 1936 O2P A C 1070 0.734 7.989 −13.469 1.00 18.52 RNA1 O ATOM 1937 O5* A C 1070 0.968 5.723 −12.497 1.00 30.46 RNA1 O ATOM 1938 C5* A C 1070 1.690 4.589 −11.998 1.00 21.05 RNA1 C ATOM 1939 C4* A C 1070 0.844 3.851 −11.000 1.00 30.01 RNA1 C ATOM 1940 O4* A C 1070 −0.391 3.424 −11.634 1.00 25.30 RNA1 O ATOM 1941 C3* A C 1070 1.479 2.612 −10.390 1.00 36.56 RNA1 C ATOM 1942 O3* A C 1070 1.078 2.564 −9.026 1.00 37.18 RNA1 O ATOM 1943 C2* A C 1070 0.847 1.469 −11.185 1.00 37.06 RNA1 C ATOM 1944 O2* A C 1070 0.739 0.256 −10.463 1.00 48.87 RNA1 O ATOM 1945 C1* A C 1070 −0.539 2.028 −11.495 1.00 32.98 RNA1 C ATOM 1946 N9 A C 1070 −1.107 1.501 −12.735 1.00 42.72 RNA1 N ATOM 1947 C8 A C 1070 −0.659 1.702 −14.019 1.00 49.93 RNA1 C ATOM 1948 N7 A C 1070 −1.380 1.098 −14.929 1.00 50.90 RNA1 N ATOM 1949 C5 A C 1070 −2.366 0.452 −14.198 1.00 55.33 RNA1 C ATOM 1950 C6 A C 1070 −3.435 −0.367 −14.582 1.00 59.78 RNA1 C ATOM 1951 N6 A C 1070 −3.697 −0.683 −15.850 1.00 68.95 RNA1 N ATOM 1952 N1 A C 1070 −4.235 −0.857 −13.608 1.00 56.29 RNA1 N ATOM 1953 C2 A C 1070 −3.965 −0.536 −12.340 1.00 41.79 RNA1 C ATOM 1954 N3 A C 1070 −2.987 0.222 −11.854 1.00 44.24 RNA1 N ATOM 1955 C4 A C 1070 −2.212 0.692 −12.847 1.00 46.56 RNA1 C ATOM 1956 P G C 1071 2.022 1.866 −7.940 1.00 29.75 RNA1 P ATOM 1957 O1P G C 1071 1.299 1.985 −6.653 1.00 39.09 RNA1 O ATOM 1958 O2P G C 1071 2.436 0.526 −8.435 1.00 39.01 RNA1 O ATOM 1959 O5* G C 1071 3.325 2.769 −7.901 1.00 19.92 RNA1 O ATOM 1960 C5* G C 1071 3.295 4.113 −7.406 1.00 16.74 RNA1 C ATOM 1961 C4* G C 1071 4.704 4.562 −7.133 1.00 23.89 RNA1 C ATOM 1962 O4* G C 1071 5.222 3.769 −6.044 1.00 22.65 RNA1 O ATOM 1963 C3* G C 1071 5.633 4.285 −8.302 1.00 25.19 RNA1 C ATOM 1964 O3* G C 1071 5.646 5.390 −9.187 1.00 38.67 RNA1 O ATOM 1965 C2* G C 1071 6.974 4.006 −7.639 1.00 21.49 RNA1 C ATOM 1966 O2* G C 1071 7.729 5.164 −7.347 1.00 30.27 RNA1 O ATOM 1967 C1* G C 1071 6.533 3.335 −6.340 1.00 18.58 RNA1 C ATOM 1968 N9 G C 1071 6.500 1.878 −6.393 1.00 22.64 RNA1 N ATOM 1969 C8 G C 1071 5.389 1.076 −6.272 1.00 20.39 RNA1 C ATOM 1970 N7 G C 1071 5.672 −0.196 −6.315 1.00 31.29 RNA1 N ATOM 1971 C5 G C 1071 7.048 −0.236 −6.482 1.00 14.55 RNA1 C ATOM 1972 C6 G C 1071 7.922 −1.342 −6.582 1.00 28.22 RNA1 C ATOM 1973 O6 G C 1071 7.647 −2.549 −6.512 1.00 31.85 RNA1 O ATOM 1974 N1 G C 1071 9.239 −0.934 −6.762 1.00 15.53 RNA1 N ATOM 1975 C2 G C 1071 9.660 0.371 −6.818 1.00 20.27 RNA1 C ATOM 1976 N2 G C 1071 10.977 0.567 −6.997 1.00 25.10 RNA1 N ATOM 1977 N3 G C 1071 8.853 1.411 −6.707 1.00 19.36 RNA1 N ATOM 1978 C4 G C 1071 7.570 1.035 −6.546 1.00 11.18 RNA1 C ATOM 1979 P C C 1072 5.597 5.137 −10.767 1.00 27.21 RNA1 P ATOM 1980 O1P C C 1072 4.563 4.110 −11.043 1.00 30.50 RNA1 O ATOM 1981 O2P C C 1072 5.512 6.459 −11.426 1.00 25.77 RNA1 O ATOM 1982 O5* C C 1072 7.022 4.506 −11.073 1.00 15.96 RNA1 O ATOM 1983 C5* C C 1072 8.198 5.315 −11.019 1.00 23.11 RNA1 C ATOM 1984 C4* C C 1072 9.419 4.471 −11.280 1.00 32.01 RNA1 C ATOM 1985 O4* C C 1072 9.601 3.533 −10.192 1.00 36.03 RNA1 O ATOM 1986 C3* C C 1072 9.365 3.597 −12.522 1.00 30.99 RNA1 C ATOM 1987 O3* C C 1072 9.711 4.326 −13.688 1.00 33.23 RNA1 O ATOM 1988 C2* C C 1072 10.362 2.496 −12.188 1.00 29.75 RNA1 C ATOM 1989 O2* C C 1072 11.703 2.904 −12.371 1.00 34.64 RNA1 O ATOM 1990 C1* C C 1072 10.121 2.314 −10.692 1.00 29.06 RNA1 C ATOM 1991 N1 C C 1072 9.151 1.242 −10.401 1.00 21.88 RNA1 N ATOM 1992 C2 C C 1072 9.623 −0.062 −10.229 1.00 22.42 RNA1 C ATOM 1993 O2 C C 1072 10.852 −0.281 −10.328 1.00 27.87 RNA1 O ATOM 1994 N3 C C 1072 8.735 −1.053 −9.964 1.00 9.91 RNA1 N ATOM 1995 C4 C C 1072 7.430 −0.780 −9.883 1.00 19.29 RNA1 C ATOM 1996 N4 C C 1072 6.591 −1.789 −9.644 1.00 23.91 RNA1 N ATOM 1997 C5 C C 1072 6.925 0.538 −10.048 1.00 13.70 RNA1 C ATOM 1998 C6 C C 1072 7.812 1.510 −10.304 1.00 24.95 RNA1 C ATOM 1999 P A C 1073 8.702 4.336 −14.936 1.00 33.99 RNA1 P ATOM 2000 O1P A C 1073 8.504 2.919 −15.333 1.00 35.83 RNA1 O ATOM 2001 O2P A C 1073 7.512 5.181 −14.614 1.00 22.96 RNA1 O ATOM 2002 O5* A C 1073 9.551 5.050 −16.074 1.00 31.36 RNA1 O ATOM 2003 C5* A C 1073 10.772 4.462 −16.571 1.00 35.37 RNA1 C ATOM 2004 C4* A C 1073 11.245 5.227 −17.781 1.00 39.45 RNA1 C ATOM 2005 O4* A C 1073 10.229 5.143 −18.815 1.00 39.78 RNA1 O ATOM 2006 C3* A C 1073 11.400 6.713 −17.522 1.00 40.87 RNA1 C ATOM 2007 O3* A C 1073 12.673 7.017 −16.987 1.00 44.46 RNA1 O ATOM 2008 C2* A C 1073 11.147 7.327 −18.890 1.00 38.57 RNA1 C ATOM 2009 O2* A C 1073 12.279 7.252 −19.738 1.00 41.89 RNA1 O ATOM 2010 C1* A C 1073 10.054 6.409 −19.426 1.00 27.18 RNA1 C ATOM 2011 N9 A C 1073 8.713 6.872 −19.081 1.00 23.78 RNA1 N ATOM 2012 C8 A C 1073 7.835 6.282 −18.209 1.00 31.10 RNA1 C ATOM 2013 N7 A C 1073 6.685 6.903 −18.112 1.00 30.54 RNA1 N ATOM 2014 C5 A C 1073 6.819 7.979 −18.974 1.00 22.89 RNA1 C ATOM 2015 C6 A C 1073 5.948 9.015 −19.319 1.00 24.05 RNA1 C ATOM 2016 N6 A C 1073 4.711 9.130 −18.836 1.00 24.67 RNA1 N ATOM 2017 N1 A C 1073 6.391 9.940 −20.193 1.00 27.06 RNA1 N ATOM 2018 C2 A C 1073 7.627 9.815 −20.684 1.00 28.92 RNA1 C ATOM 2019 N3 A C 1073 8.539 8.879 −20.442 1.00 33.22 RNA1 N ATOM 2020 C4 A C 1073 8.066 7.979 −19.568 1.00 24.70 RNA1 C ATOM 2021 P G C 1074 12.790 8.131 −15.846 1.00 37.49 RNA1 P ATOM 2022 O1P G C 1074 11.994 7.638 −14.698 1.00 42.76 RNA1 O ATOM 2023 O2P G C 1074 14.226 8.458 −15.661 1.00 37.27 RNA1 O ATOM 2024 O5* G C 1074 12.052 9.389 −16.488 1.00 32.12 RNA1 O ATOM 2025 C5* G C 1074 12.636 10.074 −17.611 1.00 30.38 RNA1 C ATOM 2026 C4* G C 1074 11.776 11.239 −18.042 1.00 29.26 RNA1 C ATOM 2027 O4* G C 1074 10.505 10.762 −18.552 1.00 28.39 RNA1 O ATOM 2028 C3* G C 1074 11.393 12.245 −16.972 1.00 30.49 RNA1 C ATOM 2029 O3* G C 1074 12.431 13.170 −16.697 1.00 40.29 RNA1 O ATOM 2030 C2* G C 1074 10.152 12.899 −17.566 1.00 32.10 RNA1 C ATOM 2031 O2* G C 1074 10.452 13.891 −18.528 1.00 36.08 RNA1 O ATOM 2032 C1* G C 1074 9.491 11.714 −18.268 1.00 26.45 RNA1 C ATOM 2033 N9 G C 1074 8.479 11.075 −17.435 1.00 22.10 RNA1 N ATOM 2034 C8 G C 1074 8.576 9.862 −16.794 1.00 21.18 RNA1 C ATOM 2035 N7 G C 1074 7.490 9.539 −16.145 1.00 28.77 RNA1 N ATOM 2036 C5 G C 1074 6.628 10.604 −16.362 1.00 15.54 RNA1 C ATOM 2037 C6 G C 1074 5.300 10.815 −15.917 1.00 22.89 RNA1 C ATOM 2038 O6 G C 1074 4.589 10.071 −15.240 1.00 28.81 RNA1 O ATOM 2039 N1 G C 1074 4.802 12.038 −16.351 1.00 26.73 RNA1 N ATOM 2040 C2 G C 1074 5.487 12.937 −17.126 1.00 24.75 RNA1 C ATOM 2041 N2 G C 1074 4.828 14.058 −17.440 1.00 20.91 RNA1 N ATOM 2042 N3 G C 1074 6.724 12.748 −17.560 1.00 19.40 RNA1 N ATOM 2043 C4 G C 1074 7.228 11.568 −17.144 1.00 19.49 RNA1 C ATOM 2044 P C C 1075 12.535 13.826 −15.232 1.00 35.74 RNA1 P ATOM 2045 O1P C C 1075 12.251 12.757 −14.239 1.00 37.48 RNA1 O ATOM 2046 O2P C C 1075 13.814 14.574 −15.147 1.00 35.45 RNA1 O ATOM 2047 O5* C C 1075 11.326 14.864 −15.223 1.00 29.10 RNA1 O ATOM 2048 C5* C C 1075 11.373 16.035 −16.052 1.00 20.72 RNA1 C ATOM 2049 C4* C C 1075 10.144 16.884 −15.848 1.00 27.73 RNA1 C ATOM 2050 O4* C C 1075 8.980 16.162 −16.316 1.00 25.49 RNA1 O ATOM 2051 C3* C C 1075 9.804 17.254 −14.413 1.00 29.84 RNA1 C ATOM 2052 O3* C C 1075 10.548 18.355 −13.924 1.00 32.76 RNA1 O ATOM 2053 C2* C C 1075 8.311 17.537 −14.490 1.00 32.29 RNA1 C ATOM 2054 O2* C C 1075 8.018 18.838 −14.963 1.00 33.04 RNA1 O ATOM 2055 C1* C C 1075 7.860 16.488 −15.508 1.00 30.74 RNA1 C ATOM 2056 N1 C C 1075 7.407 15.259 −14.836 1.00 23.00 RNA1 N ATOM 2057 C2 C C 1075 6.083 15.178 −14.407 1.00 25.39 RNA1 C ATOM 2058 O2 C C 1075 5.320 16.133 −14.627 1.00 27.71 RNA1 O ATOM 2059 N3 C C 1075 5.666 14.063 −13.764 1.00 20.56 RNA1 N ATOM 2060 C4 C C 1075 6.518 13.054 −13.553 1.00 24.69 RNA1 C ATOM 2061 N4 C C 1075 6.067 11.975 −12.911 1.00 22.56 RNA1 N ATOM 2062 C5 C C 1075 7.870 13.108 −13.991 1.00 16.20 RNA1 C ATOM 2063 C6 C C 1075 8.269 14.217 −14.622 1.00 23.77 RNA1 C ATOM 2064 P C C 1076 10.912 18.423 −12.358 1.00 42.91 RNA1 P ATOM 2065 O1P C C 1076 11.372 17.085 −11.911 1.00 24.52 RNA1 O ATOM 2066 O2P C C 1076 11.781 19.612 −12.113 1.00 41.73 RNA1 O ATOM 2067 O5* C C 1076 9.491 18.679 −11.696 1.00 32.86 RNA1 O ATOM 2068 C5* C C 1076 8.768 19.870 −11.997 1.00 27.46 RNA1 C ATOM 2069 C4* C C 1076 7.458 19.893 −11.255 1.00 30.86 RNA1 C ATOM 2070 O4* C C 1076 6.570 18.885 −11.798 1.00 34.77 RNA1 O ATOM 2071 C3* C C 1076 7.500 19.581 −9.769 1.00 26.66 RNA1 C ATOM 2072 O3* C C 1076 7.913 20.668 −8.961 1.00 36.57 RNA1 O ATOM 2073 C2* C C 1076 6.062 19.172 −9.499 1.00 32.47 RNA1 C ATOM 2074 O2* C C 1076 5.198 20.290 −9.410 1.00 32.97 RNA1 O ATOM 2075 C1* C C 1076 5.735 18.385 −10.765 1.00 34.29 RNA1 C ATOM 2076 N1 C C 1076 6.012 16.945 −10.577 1.00 22.34 RNA1 N ATOM 2077 C2 C C 1076 5.036 16.150 −9.959 1.00 24.18 RNA1 C ATOM 2078 O2 C C 1076 3.977 16.680 −9.577 1.00 25.15 RNA1 O ATOM 2079 N3 C C 1076 5.271 14.825 −9.784 1.00 20.85 RNA1 N ATOM 2080 C4 C C 1076 6.428 14.295 −10.185 1.00 21.45 RNA1 C ATOM 2081 N4 C C 1076 6.611 12.987 −9.994 1.00 19.48 RNA1 N ATOM 2082 C5 C C 1076 7.446 15.083 −10.805 1.00 18.25 RNA1 C ATOM 2083 C6 C C 1076 7.196 16.389 −10.984 1.00 25.90 RNA1 C ATOM 2084 P A C 1077 8.725 20.374 −7.602 1.00 34.53 RNA1 P ATOM 2085 O1P A C 1077 9.776 19.366 −7.891 1.00 32.29 RNA1 O ATOM 2086 O2P A C 1077 9.115 21.689 −7.025 1.00 55.02 RNA1 O ATOM 2087 O5* A C 1077 7.641 19.691 −6.652 1.00 22.72 RNA1 O ATOM 2088 C5* A C 1077 6.447 20.399 −6.283 1.00 17.11 RNA1 C ATOM 2089 C4* A C 1077 5.461 19.477 −5.601 1.00 26.56 RNA1 C ATOM 2090 O4* A C 1077 5.058 18.423 −6.514 1.00 34.54 RNA1 O ATOM 2091 C3* A C 1077 5.916 18.724 −4.357 1.00 32.85 RNA1 C ATOM 2092 O3* A C 1077 5.872 19.511 −3.175 1.00 37.36 RNA1 O ATOM 2093 C2* A C 1077 4.913 17.576 −4.297 1.00 36.94 RNA1 C ATOM 2094 O2* A C 1077 3.661 17.943 −3.748 1.00 32.73 RNA1 O ATOM 2095 C1* A C 1077 4.723 17.255 −5.778 1.00 32.51 RNA1 C ATOM 2096 N9 A C 1077 5.612 16.160 −6.172 1.00 27.14 RNA1 N ATOM 2097 C8 A C 1077 6.830 16.224 −6.802 1.00 22.59 RNA1 C ATOM 2098 N7 A C 1077 7.406 15.054 −6.959 1.00 28.95 RNA1 N ATOM 2099 C5 A C 1077 6.500 14.158 −6.405 1.00 23.18 RNA1 C ATOM 2100 C6 A C 1077 6.524 12.758 −6.252 1.00 29.03 RNA1 C ATOM 2101 N6 A C 1077 7.543 11.984 −6.643 1.00 32.89 RNA1 N ATOM 2102 N1 A C 1077 5.454 12.174 −5.669 1.00 23.42 RNA1 N ATOM 2103 C2 A C 1077 4.443 12.948 −5.259 1.00 10.65 RNA1 C ATOM 2104 N3 A C 1077 4.309 14.266 −5.338 1.00 26.74 RNA1 N ATOM 2105 C4 A C 1077 5.385 14.821 −5.930 1.00 26.08 RNA1 C ATOM 2106 P U C 1078 6.978 19.284 −2.026 1.00 29.17 RNA1 P ATOM 2107 O1P U C 1078 8.330 19.420 −2.616 1.00 22.94 RNA1 O ATOM 2108 O2P U C 1078 6.586 20.141 −0.877 1.00 41.57 RNA1 O ATOM 2109 O5* U C 1078 6.828 17.754 −1.608 1.00 29.90 RNA1 O ATOM 2110 C5* U C 1078 5.706 17.287 −0.830 1.00 21.78 RNA1 C ATOM 2111 C4* U C 1078 5.789 15.785 −0.649 1.00 21.19 RNA1 C ATOM 2112 O4* U C 1078 5.732 15.157 −1.957 1.00 29.99 RNA1 O ATOM 2113 C3* U C 1078 7.075 15.241 −0.031 1.00 27.77 RNA1 C ATOM 2114 O3* U C 1078 7.057 15.184 1.390 1.00 36.77 RNA1 O ATOM 2115 C2* U C 1078 7.094 13.812 −0.554 1.00 34.85 RNA1 C ATOM 2116 O2* U C 1078 6.229 12.972 0.191 1.00 32.65 RNA1 O ATOM 2117 C1* U C 1078 6.532 13.986 −1.963 1.00 28.35 RNA1 C ATOM 2118 N1 U C 1078 7.611 14.137 −2.955 1.00 21.70 RNA1 N ATOM 2119 C2 U C 1078 8.275 12.987 −3.352 1.00 27.00 RNA1 C ATOM 2120 O2 U C 1078 7.975 11.872 −2.946 1.00 29.58 RNA1 O ATOM 2121 N3 U C 1078 9.305 13.189 −4.238 1.00 24.66 RNA1 N ATOM 2122 C4 U C 1078 9.728 14.393 −4.760 1.00 26.71 RNA1 C ATOM 2123 O4 U C 1078 10.714 14.417 −5.504 1.00 44.05 RNA1 O ATOM 2124 C5 U C 1078 8.978 15.530 −4.320 1.00 18.54 RNA1 C ATOM 2125 C6 U C 1078 7.970 15.368 −3.459 1.00 19.12 RNA1 C ATOM 2126 P C C 1079 7.168 16.527 2.260 1.00 28.61 RNA1 P ATOM 2127 O1P C C 1079 7.780 16.107 3.544 1.00 34.30 RNA1 O ATOM 2128 O2P C C 1079 7.770 17.644 1.487 1.00 31.33 RNA1 O ATOM 2129 O5* C C 1079 5.641 16.867 2.520 1.00 13.04 RNA1 O ATOM 2130 C5* C C 1079 4.851 15.965 3.271 1.00 17.43 RNA1 C ATOM 2131 C4* C C 1079 3.398 16.246 3.064 1.00 19.74 RNA1 C ATOM 2132 O4* C C 1079 2.954 15.688 1.803 1.00 26.36 RNA1 O ATOM 2133 C3* C C 1079 2.556 15.540 4.098 1.00 25.66 RNA1 C ATOM 2134 O3* C C 1079 2.525 16.312 5.278 1.00 37.56 RNA1 O ATOM 2135 C2* C C 1079 1.217 15.382 3.394 1.00 27.27 RNA1 C ATOM 2136 O2* C C 1079 0.452 16.573 3.416 1.00 25.00 RNA1 O ATOM 2137 C1* C C 1079 1.672 15.091 1.963 1.00 17.88 RNA1 C ATOM 2138 N1 C C 1079 1.795 13.641 1.677 1.00 17.52 RNA1 N ATOM 2139 C2 C C 1079 0.629 12.878 1.441 1.00 19.34 RNA1 C ATOM 2140 O2 C C 1079 −0.488 13.427 1.500 1.00 24.52 RNA1 O ATOM 2141 N3 C C 1079 0.748 11.561 1.159 1.00 15.18 RNA1 N ATOM 2142 C4 C C 1079 1.955 10.994 1.111 1.00 20.12 RNA1 C ATOM 2143 N4 C C 1079 2.018 9.691 0.814 1.00 14.62 RNA1 N ATOM 2144 C5 C C 1079 3.150 11.734 1.359 1.00 16.35 RNA1 C ATOM 2145 C6 C C 1079 3.025 13.040 1.635 1.00 14.99 RNA1 C ATOM 2146 P A C 1080 2.747 15.593 6.692 1.00 32.18 RNA1 P ATOM 2147 O1P A C 1080 3.901 14.668 6.598 1.00 27.65 RNA1 O ATOM 2148 O2P A C 1080 2.748 16.674 7.711 1.00 42.21 RNA1 O ATOM 2149 O5* A C 1080 1.413 14.745 6.853 1.00 24.30 RNA1 O ATOM 2150 C5* A C 1080 0.157 15.421 6.836 1.00 25.92 RNA1 C ATOM 2151 C4* A C 1080 −0.967 14.459 6.593 1.00 27.37 RNA1 C ATOM 2152 O4* A C 1080 −0.902 13.924 5.248 1.00 35.15 RNA1 O ATOM 2153 C3* A C 1080 −1.028 13.223 7.462 1.00 26.09 RNA1 C ATOM 2154 O3* A C 1080 −1.528 13.489 8.759 1.00 36.10 RNA1 O ATOM 2155 C2* A C 1080 −1.956 12.331 6.651 1.00 33.11 RNA1 C ATOM 2156 O2* A C 1080 −3.309 12.717 6.787 1.00 32.80 RNA1 O ATOM 2157 C1* A C 1080 −1.510 12.643 5.223 1.00 26.83 RNA1 C ATOM 2158 N9 A C 1080 −0.538 11.650 4.767 1.00 16.76 RNA1 N ATOM 2159 C8 A C 1080 0.838 11.722 4.719 1.00 20.21 RNA1 C ATOM 2160 N7 A C 1080 1.411 10.609 4.319 1.00 8.53 RNA1 N ATOM 2161 C5 A C 1080 0.340 9.754 4.073 1.00 7.38 RNA1 C ATOM 2162 C6 A C 1080 0.273 8.414 3.649 1.00 15.76 RNA1 C ATOM 2163 N6 A C 1080 1.348 7.660 3.376 1.00 25.46 RNA1 N ATOM 2164 N1 A C 1080 −0.952 7.859 3.514 1.00 17.62 RNA1 N ATOM 2165 C2 A C 1080 −2.029 8.606 3.785 1.00 16.21 RNA1 C ATOM 2166 N3 A C 1080 −2.095 9.868 4.192 1.00 17.28 RNA1 N ATOM 2167 C4 A C 1080 −0.861 10.389 4.323 1.00 7.47 RNA1 C ATOM 2168 P U C 1081 −1.136 12.505 9.973 1.00 29.01 RNA1 P ATOM 2169 O1P U C 1081 0.273 12.088 9.807 1.00 19.32 RNA1 O ATOM 2170 O2P U C 1081 −1.558 13.151 11.237 1.00 36.17 RNA1 O ATOM 2171 O5* U C 1081 −2.072 11.248 9.708 1.00 27.53 RNA1 O ATOM 2172 C5* U C 1081 −3.469 11.439 9.421 1.00 34.97 RNA1 C ATOM 2173 C4* U C 1081 −4.093 10.146 8.967 1.00 39.34 RNA1 C ATOM 2174 O4* U C 1081 −3.488 9.719 7.725 1.00 36.64 RNA1 O ATOM 2175 C3* U C 1081 −3.908 8.982 9.922 1.00 36.77 RNA1 C ATOM 2176 O3* U C 1081 −4.954 9.001 10.888 1.00 49.64 RNA1 O ATOM 2177 C2* U C 1081 −4.001 7.774 9.001 1.00 31.27 RNA1 C ATOM 2178 O2* U C 1081 −5.344 7.418 8.739 1.00 35.76 RNA1 O ATOM 2179 C1* U C 1081 −3.375 8.311 7.713 1.00 27.99 RNA1 C ATOM 2180 N1 U C 1081 −1.959 7.966 7.513 1.00 16.45 RNA1 N ATOM 2181 C2 U C 1081 −1.659 6.684 7.082 1.00 15.53 RNA1 C ATOM 2182 O2 U C 1081 −2.511 5.822 6.912 1.00 24.70 RNA1 O ATOM 2183 N3 U C 1081 −0.328 6.446 6.856 1.00 6.42 RNA1 N ATOM 2184 C4 U C 1081 0.717 7.335 7.015 1.00 17.75 RNA1 C ATOM 2185 O4 U C 1081 1.850 7.005 6.656 1.00 12.74 RNA1 O ATOM 2186 C5 U C 1081 0.332 8.627 7.495 1.00 15.50 RNA1 C ATOM 2187 C6 U C 1081 −0.961 8.890 7.724 1.00 17.69 RNA1 C ATOM 2188 P U C 1082 −4.709 8.375 12.348 1.00 43.16 RNA1 P ATOM 2189 O1P U C 1082 −3.513 9.034 12.942 1.00 33.87 RNA1 O ATOM 2190 O2P U C 1082 −6.019 8.423 13.060 1.00 35.46 RNA1 O ATOM 2191 O5* U C 1082 −4.357 6.855 12.050 1.00 39.66 RNA1 O ATOM 2192 C5* U C 1082 −5.388 5.949 11.643 1.00 36.85 RNA1 C ATOM 2193 C4* U C 1082 −4.834 4.563 11.500 1.00 35.35 RNA1 C ATOM 2194 O4* U C 1082 −4.024 4.471 10.301 1.00 27.83 RNA1 O ATOM 2195 C3* U C 1082 −3.895 4.106 12.600 1.00 42.67 RNA1 C ATOM 2196 O3* U C 1082 −4.544 3.677 13.786 1.00 48.43 RNA1 O ATOM 2197 C2* U C 1082 −3.130 2.979 11.925 1.00 41.00 RNA1 C ATOM 2198 O2* U C 1082 −3.847 1.757 11.941 1.00 43.11 RNA1 O ATOM 2199 C1* U C 1082 −3.000 3.510 10.496 1.00 29.73 RNA1 C ATOM 2200 N1 U C 1082 −1.691 4.146 10.281 1.00 21.48 RNA1 N ATOM 2201 C2 U C 1082 −0.650 3.342 9.826 1.00 24.74 RNA1 C ATOM 2202 O2 U C 1082 −0.781 2.155 9.573 1.00 35.44 RNA1 O ATOM 2203 N3 U C 1082 0.552 3.980 9.678 1.00 16.73 RNA1 N ATOM 2204 C4 U C 1082 0.825 5.303 9.921 1.00 20.16 RNA1 C ATOM 2205 O4 U C 1082 1.963 5.730 9.715 1.00 29.48 RNA1 O ATOM 2206 C5 U C 1082 −0.293 6.069 10.378 1.00 15.77 RNA1 C ATOM 2207 C6 U C 1082 −1.485 5.479 10.536 1.00 20.32 RNA1 C ATOM 2208 P U C 1083 −3.685 3.548 15.138 1.00 44.11 RNA1 P ATOM 2209 O1P U C 1083 −3.013 4.855 15.416 1.00 33.72 RNA1 O ATOM 2210 O2P U C 1083 −4.550 2.923 16.170 1.00 44.56 RNA1 O ATOM 2211 O5* U C 1083 −2.554 2.515 14.732 1.00 26.53 RNA1 O ATOM 2212 C5* U C 1083 −1.204 2.710 15.133 1.00 27.01 RNA1 C ATOM 2213 C4* U C 1083 −0.310 1.810 14.328 1.00 35.50 RNA1 C ATOM 2214 O4* U C 1083 0.049 2.450 13.077 1.00 37.83 RNA1 O ATOM 2215 C3* U C 1083 1.014 1.490 14.985 1.00 42.54 RNA1 C ATOM 2216 O3* U C 1083 0.829 0.394 15.868 1.00 53.77 RNA1 O ATOM 2217 C2* U C 1083 1.899 1.142 13.797 1.00 40.40 RNA1 C ATOM 2218 O2* U C 1083 1.676 −0.184 13.354 1.00 50.14 RNA1 O ATOM 2219 C1* U C 1083 1.383 2.112 12.733 1.00 31.81 RNA1 C ATOM 2220 N1 U C 1083 2.176 3.350 12.641 1.00 27.07 RNA1 N ATOM 2221 C2 U C 1083 3.403 3.291 11.995 1.00 27.98 RNA1 C ATOM 2222 O2 U C 1083 3.842 2.278 11.491 1.00 38.26 RNA1 O ATOM 2223 N3 U C 1083 4.101 4.471 11.959 1.00 27.06 RNA1 N ATOM 2224 C4 U C 1083 3.711 5.686 12.480 1.00 29.89 RNA1 C ATOM 2225 O4 U C 1083 4.463 6.660 12.376 1.00 35.97 RNA1 O ATOM 2226 C5 U C 1083 2.432 5.676 13.120 1.00 28.35 RNA1 C ATOM 2227 C6 U C 1083 1.726 4.538 13.180 1.00 34.18 RNA1 C ATOM 2228 P A C 1084 1.531 0.409 17.308 1.00 46.22 RNA1 P ATOM 2229 O1P A C 1084 1.502 1.811 17.819 1.00 47.82 RNA1 O ATOM 2230 O2P A C 1084 0.915 −0.683 18.102 1.00 45.99 RNA1 O ATOM 2231 O5* A C 1084 3.037 0.024 16.984 1.00 32.44 RNA1 O ATOM 2232 C5* A C 1084 4.103 0.403 17.854 1.00 26.01 RNA1 C ATOM 2233 C4* A C 1084 5.395 −0.104 17.293 1.00 30.31 RNA1 C ATOM 2234 O4* A C 1084 5.314 −1.544 17.185 1.00 39.98 RNA1 O ATOM 2235 C3* A C 1084 5.631 0.378 15.881 1.00 31.04 RNA1 C ATOM 2236 O3* A C 1084 6.308 1.611 15.926 1.00 35.76 RNA1 O ATOM 2237 C2* A C 1084 6.448 −0.741 15.252 1.00 34.39 RNA1 C ATOM 2238 O2* A C 1084 7.825 −0.635 15.548 1.00 29.53 RNA1 O ATOM 2239 C1* A C 1084 5.872 −1.970 15.956 1.00 36.40 RNA1 C ATOM 2240 N9 A C 1084 4.827 −2.698 15.230 1.00 38.88 RNA1 N ATOM 2241 C8 A C 1084 3.464 −2.577 15.388 1.00 38.21 RNA1 C ATOM 2242 N7 A C 1084 2.770 −3.432 14.677 1.00 33.92 RNA1 N ATOM 2243 C5 A C 1084 3.737 −4.151 13.984 1.00 35.92 RNA1 C ATOM 2244 C6 A C 1084 3.648 −5.222 13.069 1.00 34.35 RNA1 C ATOM 2245 N6 A C 1084 2.493 −5.781 12.695 1.00 38.02 RNA1 N ATOM 2246 N1 A C 1084 4.802 −5.704 12.551 1.00 36.24 RNA1 N ATOM 2247 C2 A C 1084 5.960 −5.145 12.935 1.00 38.72 RNA1 C ATOM 2248 N3 A C 1084 6.173 −4.143 13.790 1.00 34.15 RNA1 N ATOM 2249 C4 A C 1084 5.007 −3.689 14.291 1.00 36.93 RNA1 C ATOM 2250 P A C 1085 5.839 2.793 14.965 1.00 32.91 RNA1 P ATOM 2251 O1P A C 1085 4.351 2.768 14.939 1.00 23.95 RNA1 O ATOM 2252 O2P A C 1085 6.554 4.030 15.366 1.00 36.15 RNA1 O ATOM 2253 O5* A C 1085 6.414 2.342 13.557 1.00 34.02 RNA1 O ATOM 2254 C5* A C 1085 7.826 2.172 13.384 1.00 35.68 RNA1 C ATOM 2255 C4* A C 1085 8.100 1.383 12.136 1.00 40.49 RNA1 C ATOM 2256 O4* A C 1085 7.592 0.035 12.283 1.00 46.64 RNA1 O ATOM 2257 C3* A C 1085 7.426 1.921 10.889 1.00 37.28 RNA1 C ATOM 2258 O3* A C 1085 8.249 2.933 10.322 1.00 38.08 RNA1 O ATOM 2259 C2* A C 1085 7.311 0.685 10.002 1.00 36.45 RNA1 C ATOM 2260 O2* A C 1085 8.496 0.425 9.278 1.00 44.66 RNA1 O ATOM 2261 C1* A C 1085 7.122 −0.432 11.032 1.00 36.77 RNA1 C ATOM 2262 N9 A C 1085 5.743 −0.875 11.198 1.00 24.80 RNA1 N ATOM 2263 C8 A C 1085 4.754 −0.265 11.923 1.00 28.92 RNA1 C ATOM 2264 N7 A C 1085 3.606 −0.896 11.888 1.00 28.93 RNA1 N ATOM 2265 C5 A C 1085 3.857 −2.000 11.087 1.00 22.34 RNA1 C ATOM 2266 C6 A C 1085 3.040 −3.060 10.664 1.00 26.52 RNA1 C ATOM 2267 N6 A C 1085 1.749 −3.175 11.000 1.00 26.24 RNA1 N ATOM 2268 N1 A C 1085 3.596 −4.006 9.874 1.00 25.01 RNA1 N ATOM 2269 C2 A C 1085 4.889 −3.875 9.532 1.00 27.90 RNA1 C ATOM 2270 N3 A C 1085 5.758 −2.920 9.864 1.00 23.94 RNA1 N ATOM 2271 C4 A C 1085 5.171 −2.002 10.654 1.00 23.81 RNA1 C ATOM 2272 P A C 1086 7.578 4.220 9.636 1.00 38.44 RNA1 P ATOM 2273 O1P A C 1086 6.238 4.440 10.244 1.00 21.00 RNA1 O ATOM 2274 O2P A C 1086 8.578 5.315 9.641 1.00 32.04 RNA1 O ATOM 2275 O5* A C 1086 7.359 3.750 8.133 1.00 44.64 RNA1 O ATOM 2276 C5* A C 1086 8.465 3.286 7.337 1.00 27.97 RNA1 C ATOM 2277 C4* A C 1086 7.965 2.407 6.217 1.00 34.03 RNA1 C ATOM 2278 O4* A C 1086 7.509 1.138 6.753 1.00 34.69 RNA1 O ATOM 2279 C3* A C 1086 6.759 2.929 5.455 1.00 38.31 RNA1 C ATOM 2280 O3* A C 1086 7.095 3.913 4.484 1.00 30.65 RNA1 O ATOM 2281 C2* A C 1086 6.166 1.659 4.850 1.00 40.89 RNA1 C ATOM 2282 O2* A C 1086 6.734 1.284 3.610 1.00 37.38 RNA1 O ATOM 2283 C1* A C 1086 6.488 0.616 5.925 1.00 29.88 RNA1 C ATOM 2284 N9 A C 1086 5.326 0.253 6.739 1.00 26.28 RNA1 N ATOM 2285 C8 A C 1086 4.885 −1.015 7.018 1.00 26.71 RNA1 C ATOM 2286 N7 A C 1086 3.748 −1.049 7.675 1.00 32.50 RNA1 N ATOM 2287 C5 A C 1086 3.437 0.289 7.869 1.00 23.83 RNA1 C ATOM 2288 C6 A C 1086 2.346 0.926 8.486 1.00 32.24 RNA1 C ATOM 2289 N6 A C 1086 1.320 0.274 9.042 1.00 40.46 RNA1 N ATOM 2290 N1 A C 1086 2.340 2.275 8.508 1.00 27.06 RNA1 N ATOM 2291 C2 A C 1086 3.359 2.928 7.943 1.00 26.31 RNA1 C ATOM 2292 N3 A C 1086 4.435 2.444 7.329 1.00 27.72 RNA1 N ATOM 2293 C4 A C 1086 4.413 1.102 7.323 1.00 23.09 RNA1 C ATOM 2294 P G C 1087 6.254 5.281 4.430 1.00 30.97 RNA1 P ATOM 2295 O1P G C 1087 4.896 4.969 3.921 1.00 19.34 RNA1 O ATOM 2296 O2P G C 1087 6.402 5.980 5.734 1.00 46.09 RNA1 O ATOM 2297 O5* G C 1087 7.006 6.141 3.329 1.00 29.62 RNA1 O ATOM 2298 C5* G C 1087 8.108 6.998 3.667 1.00 28.45 RNA1 C ATOM 2299 C4* G C 1087 8.911 7.283 2.428 1.00 31.27 RNA1 C ATOM 2300 O4* G C 1087 9.604 6.075 2.060 1.00 35.33 RNA1 O ATOM 2301 C3* G C 1087 8.034 7.656 1.244 1.00 31.37 RNA1 C ATOM 2302 O3* G C 1087 7.978 9.077 1.163 1.00 19.46 RNA1 O ATOM 2303 C2* G C 1087 8.776 7.064 0.049 1.00 32.80 RNA1 C ATOM 2304 O2* G C 1087 9.745 7.961 −0.462 1.00 29.59 RNA1 O ATOM 2305 C1* G C 1087 9.484 5.854 0.674 1.00 27.32 RNA1 C ATOM 2306 N9 G C 1087 8.899 4.525 0.520 1.00 19.62 RNA1 N ATOM 2307 C8 G C 1087 7.596 4.129 0.735 1.00 23.90 RNA1 C ATOM 2308 N7 G C 1087 7.429 2.836 0.618 1.00 9.45 RNA1 N ATOM 2309 C5 G C 1087 8.685 2.359 0.273 1.00 16.55 RNA1 C ATOM 2310 C6 G C 1087 9.128 1.036 0.007 1.00 25.58 RNA1 C ATOM 2311 O6 G C 1087 8.476 −0.016 0.029 1.00 25.76 RNA1 O ATOM 2312 N1 G C 1087 10.483 1.004 −0.307 1.00 13.38 RNA1 N ATOM 2313 C2 G C 1087 11.309 2.103 −0.354 1.00 25.58 RNA1 C ATOM 2314 N2 G C 1087 12.595 1.870 −0.653 1.00 21.09 RNA1 N ATOM 2315 N3 G C 1087 10.906 3.341 −0.116 1.00 22.18 RNA1 N ATOM 2316 C4 G C 1087 9.596 3.394 0.191 1.00 16.33 RNA1 C ATOM 2317 P A C 1088 6.677 9.862 1.669 1.00 23.48 RNA1 P ATOM 2318 O1P A C 1088 6.035 9.121 2.788 1.00 34.67 RNA1 O ATOM 2319 O2P A C 1088 7.106 11.267 1.858 1.00 30.75 RNA1 O ATOM 2320 O5* A C 1088 5.683 9.810 0.434 1.00 34.79 RNA1 O ATOM 2321 C5* A C 1088 6.166 10.084 −0.886 1.00 33.74 RNA1 C ATOM 2322 C4* A C 1088 5.808 8.952 −1.804 1.00 29.37 RNA1 C ATOM 2323 O4* A C 1088 4.376 8.744 −1.752 1.00 30.18 RNA1 O ATOM 2324 C3* A C 1088 6.153 9.200 −3.261 1.00 27.75 RNA1 C ATOM 2325 O3* A C 1088 6.465 7.951 −3.847 1.00 19.39 RNA1 O ATOM 2326 C2* A C 1088 4.848 9.717 −3.842 1.00 20.69 RNA1 C ATOM 2327 O2* A C 1088 4.730 9.462 −5.224 1.00 39.54 RNA1 O ATOM 2328 C1* A C 1088 3.821 8.926 −3.035 1.00 19.38 RNA1 C ATOM 2329 N9 A C 1088 2.553 9.623 −2.868 1.00 12.67 RNA1 N ATOM 2330 C8 A C 1088 1.291 9.132 −3.089 1.00 19.49 RNA1 C ATOM 2331 N7 A C 1088 0.338 9.996 −2.842 1.00 19.80 RNA1 N ATOM 2332 C5 A C 1088 1.019 11.134 −2.432 1.00 11.03 RNA1 C ATOM 2333 C6 A C 1088 0.578 12.406 −2.033 1.00 14.84 RNA1 C ATOM 2334 N6 A C 1088 −0.708 12.768 −1.988 1.00 13.38 RNA1 N ATOM 2335 N1 A C 1088 1.517 13.309 −1.680 1.00 16.35 RNA1 N ATOM 2336 C2 A C 1088 2.807 12.952 −1.736 1.00 16.68 RNA1 C ATOM 2337 N3 A C 1088 3.343 11.792 −2.099 1.00 19.47 RNA1 N ATOM 2338 C4 A C 1088 2.383 10.917 −2.440 1.00 11.60 RNA1 C ATOM 2339 P G C 1089 7.282 7.896 −5.216 1.00 26.48 RNA1 P ATOM 2340 O1P G C 1089 7.768 9.270 −5.525 1.00 30.79 RNA1 O ATOM 2341 O2P G C 1089 6.437 7.171 −6.198 1.00 18.45 RNA1 O ATOM 2342 O5* G C 1089 8.548 7.011 −4.853 1.00 14.93 RNA1 O ATOM 2343 C5* G C 1089 9.568 7.515 −3.971 1.00 29.50 RNA1 C ATOM 2344 C4* G C 1089 10.362 6.367 −3.400 1.00 26.25 RNA1 C ATOM 2345 O4* G C 1089 9.469 5.554 −2.600 1.00 34.26 RNA1 O ATOM 2346 C3* G C 1089 10.981 5.439 −4.439 1.00 20.63 RNA1 C ATOM 2347 O3* G C 1089 12.197 4.922 −3.925 1.00 28.79 RNA1 O ATOM 2348 C2* G C 1089 9.965 4.305 −4.531 1.00 28.82 RNA1 C ATOM 2349 O2* G C 1089 10.543 3.072 −4.908 1.00 40.76 RNA1 O ATOM 2350 C1* G C 1089 9.439 4.238 −3.099 1.00 19.76 RNA1 C ATOM 2351 N9 G C 1089 8.069 3.749 −2.988 1.00 15.09 RNA1 N ATOM 2352 C8 G C 1089 6.930 4.499 −2.817 1.00 17.24 RNA1 C ATOM 2353 N7 G C 1089 5.848 3.773 −2.729 1.00 20.25 RNA1 N ATOM 2354 C5 G C 1089 6.301 2.466 −2.857 1.00 14.36 RNA1 C ATOM 2355 C6 G C 1089 5.590 1.243 −2.839 1.00 23.53 RNA1 C ATOM 2356 O6 G C 1089 4.368 1.060 −2.704 1.00 38.04 RNA1 O ATOM 2357 N1 G C 1089 6.442 0.156 −2.998 1.00 10.56 RNA1 N ATOM 2358 C2 G C 1089 7.801 0.235 −3.159 1.00 16.75 RNA1 C ATOM 2359 N2 G C 1089 8.456 −0.931 −3.305 1.00 18.05 RNA1 N ATOM 2360 N3 G C 1089 8.475 1.369 −3.178 1.00 14.70 RNA1 N ATOM 2361 C4 G C 1089 7.668 2.437 −3.022 1.00 10.92 RNA1 C ATOM 2362 P U C 1090 13.585 5.675 −4.221 1.00 43.14 RNA1 P ATOM 2363 O1P U C 1090 13.436 6.453 −5.476 1.00 42.35 RNA1 O ATOM 2364 O2P U C 1090 14.010 6.371 −2.971 1.00 42.92 RNA1 O ATOM 2365 O5* U C 1090 14.587 4.467 −4.490 1.00 39.62 RNA1 O ATOM 2366 C5* U C 1090 15.989 4.585 −4.207 1.00 45.78 RNA1 C ATOM 2367 C4* U C 1090 16.693 3.275 −4.492 1.00 55.27 RNA1 C ATOM 2368 O4* U C 1090 16.237 2.246 −3.570 1.00 55.21 RNA1 O ATOM 2369 C3* U C 1090 16.455 2.661 −5.862 1.00 53.66 RNA1 C ATOM 2370 O3* U C 1090 17.267 3.222 −6.875 1.00 51.89 RNA1 O ATOM 2371 C2* U C 1090 16.781 1.194 −5.637 1.00 48.18 RNA1 C ATOM 2372 O2* U C 1090 18.172 0.949 −5.690 1.00 54.31 RNA1 O ATOM 2373 C1* U C 1090 16.271 0.979 −4.213 1.00 41.15 RNA1 C ATOM 2374 N1 U C 1090 14.922 0.387 −4.190 1.00 41.07 RNA1 N ATOM 2375 C2 U C 1090 14.823 −0.998 −4.283 1.00 36.51 RNA1 C ATOM 2376 O2 U C 1090 15.792 −1.730 −4.388 1.00 37.99 RNA1 O ATOM 2377 N3 U C 1090 13.542 −1.493 −4.256 1.00 24.06 RNA1 N ATOM 2378 C4 U C 1090 12.374 −0.772 −4.150 1.00 29.36 RNA1 C ATOM 2379 O4 U C 1090 11.297 −1.373 −4.078 1.00 32.44 RNA1 O ATOM 2380 C5 U C 1090 12.554 0.649 −4.068 1.00 27.73 RNA1 C ATOM 2381 C6 U C 1090 13.788 1.167 −4.087 1.00 33.24 RNA1 C ATOM 2382 P G C 1091 16.725 3.245 −8.383 1.00 58.06 RNA1 P ATOM 2383 O1P G C 1091 15.277 3.599 −8.351 1.00 49.18 RNA1 O ATOM 2384 O2P G C 1091 17.668 4.074 −9.177 1.00 62.85 RNA1 O ATOM 2385 O5* G C 1091 16.838 1.724 −8.851 1.00 59.36 RNA1 O ATOM 2386 C5* G C 1091 18.123 1.141 −9.135 1.00 62.76 RNA1 C ATOM 2387 C4* G C 1091 18.029 −0.370 −9.212 1.00 62.76 RNA1 C ATOM 2388 O4* G C 1091 17.448 −0.882 −7.980 1.00 57.83 RNA1 O ATOM 2389 C3* G C 1091 17.168 −0.998 −10.302 1.00 67.15 RNA1 C ATOM 2390 O3* G C 1091 17.800 −1.073 −11.581 1.00 73.47 RNA1 O ATOM 2391 C2* G C 1091 16.911 −2.391 −9.736 1.00 63.68 RNA1 C ATOM 2392 O2* G C 1091 17.997 −3.276 −9.939 1.00 66.38 RNA1 O ATOM 2393 C1* G C 1091 16.766 −2.098 −8.243 1.00 52.76 RNA1 C ATOM 2394 N9 G C 1091 15.354 −1.954 −7.902 1.00 42.68 RNA1 N ATOM 2395 C8 G C 1091 14.638 −0.795 −7.717 1.00 43.79 RNA1 C ATOM 2396 N7 G C 1091 13.368 −1.009 −7.490 1.00 42.36 RNA1 N ATOM 2397 C5 G C 1091 13.243 −2.392 −7.512 1.00 31.07 RNA1 C ATOM 2398 C6 G C 1091 12.100 −3.220 −7.342 1.00 32.80 RNA1 C ATOM 2399 O6 G C 1091 10.926 −2.886 −7.133 1.00 29.29 RNA1 O ATOM 2400 N1 G C 1091 12.427 −4.567 −7.442 1.00 27.53 RNA1 N ATOM 2401 C2 G C 1091 13.687 −5.057 −7.676 1.00 37.58 RNA1 C ATOM 2402 N2 G C 1091 13.806 −6.387 −7.734 1.00 43.37 RNA1 N ATOM 2403 N3 G C 1091 14.754 −4.300 −7.840 1.00 37.83 RNA1 N ATOM 2404 C4 G C 1091 14.461 −2.989 −7.748 1.00 34.74 RNA1 C ATOM 2405 P C C 1092 16.901 −1.334 −12.902 1.00 78.16 RNA1 P ATOM 2406 O1P C C 1092 15.717 −0.429 −12.869 1.00 76.90 RNA1 O ATOM 2407 O2P C C 1092 17.813 −1.307 −14.079 1.00 77.44 RNA1 O ATOM 2408 O5* C C 1092 16.360 −2.822 −12.721 1.00 69.64 RNA1 O ATOM 2409 C5* C C 1092 17.277 −3.929 −12.693 1.00 63.11 RNA1 C ATOM 2410 C4* C C 1092 16.536 −5.243 −12.604 1.00 59.28 RNA1 C ATOM 2411 O4* C C 1092 15.859 −5.364 −11.322 1.00 50.31 RNA1 O ATOM 2412 C3* C C 1092 15.433 −5.487 −13.621 1.00 60.54 RNA1 C ATOM 2413 O3* C C 1092 15.910 −5.898 −14.893 1.00 61.03 RNA1 O ATOM 2414 C2* C C 1092 14.614 −6.580 −12.949 1.00 56.00 RNA1 C ATOM 2415 O2* C C 1092 15.155 −7.875 −13.128 1.00 59.60 RNA1 O ATOM 2416 C1* C C 1092 14.704 −6.175 −11.477 1.00 46.68 RNA1 C ATOM 2417 N1 C C 1092 13.500 −5.411 −11.103 1.00 45.69 RNA1 N ATOM 2418 C2 C C 1092 12.311 −6.125 −10.845 1.00 48.75 RNA1 C ATOM 2419 O2 C C 1092 12.334 −7.367 −10.877 1.00 35.22 RNA1 O ATOM 2420 N3 C C 1092 11.175 −5.443 −10.568 1.00 40.06 RNA1 N ATOM 2421 C4 C C 1092 11.191 −4.109 −10.529 1.00 43.65 RNA1 C ATOM 2422 N4 C C 1092 10.043 −3.483 −10.269 1.00 38.14 RNA1 N ATOM 2423 C5 C C 1092 12.386 −3.357 −10.759 1.00 43.83 RNA1 C ATOM 2424 C6 C C 1092 13.508 −4.043 −11.036 1.00 48.70 RNA1 C ATOM 2425 P G C 1093 15.082 −5.497 −16.210 1.00 59.69 RNA1 P ATOM 2426 O1P G C 1093 14.954 −4.014 −16.213 1.00 64.26 RNA1 O ATOM 2427 O2P G C 1093 15.706 −6.182 −17.376 1.00 68.36 RNA1 O ATOM 2428 O5* G C 1093 13.629 −6.109 −15.961 1.00 39.18 RNA1 O ATOM 2429 C5* G C 1093 13.440 −7.525 −15.810 1.00 34.94 RNA1 C ATOM 2430 C4* G C 1093 12.017 −7.828 −15.395 1.00 40.12 RNA1 C ATOM 2431 O4* G C 1093 11.737 −7.199 −14.117 1.00 45.67 RNA1 O ATOM 2432 C3* G C 1093 10.929 −7.304 −16.315 1.00 43.53 RNA1 C ATOM 2433 O3* G C 1093 10.687 −8.168 −17.410 1.00 48.03 RNA1 O ATOM 2434 C2* G C 1093 9.720 −7.183 −15.391 1.00 41.69 RNA1 C ATOM 2435 O2* G C 1093 8.996 −8.389 −15.229 1.00 27.92 RNA1 O ATOM 2436 C1* G C 1093 10.381 −6.769 −14.075 1.00 38.16 RNA1 C ATOM 2437 N9 G C 1093 10.350 −5.318 −13.870 1.00 36.77 RNA1 N ATOM 2438 C8 G C 1093 11.401 −4.431 −13.970 1.00 34.83 RNA1 C ATOM 2439 N7 G C 1093 11.048 −3.190 −13.762 1.00 32.06 RNA1 N ATOM 2440 C5 G C 1093 9.685 −3.259 −13.505 1.00 27.72 RNA1 C ATOM 2441 C6 G C 1093 8.752 −2.231 −13.223 1.00 27.54 RNA1 C ATOM 2442 O6 G C 1093 8.947 −1.013 −13.160 1.00 34.45 RNA1 O ATOM 2443 N1 G C 1093 7.475 −2.743 −13.014 1.00 19.53 RNA1 N ATOM 2444 C2 G C 1093 7.136 −4.075 −13.075 1.00 19.64 RNA1 C ATOM 2445 N2 G C 1093 5.851 −4.382 −12.830 1.00 17.24 RNA1 N ATOM 2446 N3 G C 1093 7.993 −5.040 −13.352 1.00 21.92 RNA1 N ATOM 2447 C4 G C 1093 9.241 −4.566 −13.554 1.00 25.99 RNA1 C ATOM 2448 P U C 1094 10.214 −7.545 −18.808 1.00 48.86 RNA1 P ATOM 2449 O1P U C 1094 11.019 −6.314 −19.033 1.00 51.40 RNA1 O ATOM 2450 O2P U C 1094 10.225 −8.631 −19.820 1.00 62.99 RNA1 O ATOM 2451 O5* U C 1094 8.700 −7.137 −18.549 1.00 35.14 RNA1 O ATOM 2452 C5* U C 1094 7.726 −8.151 −18.319 1.00 39.65 RNA1 C ATOM 2453 C4* U C 1094 6.342 −7.561 −18.289 1.00 45.60 RNA1 C ATOM 2454 O4* U C 1094 6.086 −6.907 −17.022 1.00 47.84 RNA1 O ATOM 2455 C3* U C 1094 6.030 −6.503 −19.328 1.00 46.03 RNA1 C ATOM 2456 O3* U C 1094 5.775 −7.078 −20.601 1.00 56.79 RNA1 O ATOM 2457 C2* U C 1094 4.829 −5.786 −18.713 1.00 44.04 RNA1 C ATOM 2458 O2* U C 1094 3.588 −6.431 −18.943 1.00 37.76 RNA1 O ATOM 2459 C1* U C 1094 5.168 −5.844 −17.219 1.00 44.47 RNA1 C ATOM 2460 N1 U C 1094 5.770 −4.589 −16.742 1.00 26.87 RNA1 N ATOM 2461 C2 U C 1094 4.909 −3.585 −16.329 1.00 22.09 RNA1 C ATOM 2462 O2 U C 1094 3.691 −3.719 −16.288 1.00 25.93 RNA1 O ATOM 2463 N3 U C 1094 5.519 −2.419 −15.962 1.00 13.38 RNA1 N ATOM 2464 C4 U C 1094 6.869 −2.159 −15.947 1.00 36.16 RNA1 C ATOM 2465 O4 U C 1094 7.263 −1.036 −15.621 1.00 36.16 RNA1 O ATOM 2466 C5 U C 1094 7.696 −3.256 −16.357 1.00 27.39 RNA1 C ATOM 2467 C6 U C 1094 7.131 −4.404 −16.729 1.00 19.00 RNA1 C ATOM 2468 P A C 1095 6.404 −6.394 −21.913 1.00 56.22 RNA1 P ATOM 2469 O1P A C 1095 7.761 −5.866 −21.571 1.00 36.24 RNA1 O ATOM 2470 O2P A C 1095 6.257 −7.345 −23.045 1.00 62.45 RNA1 O ATOM 2471 O5* A C 1095 5.420 −5.169 −22.156 1.00 37.34 RNA1 O ATOM 2472 C5* A C 1095 5.858 −3.993 −22.836 1.00 26.88 RNA1 C ATOM 2473 C4* A C 1095 4.732 −3.002 −22.897 1.00 25.01 RNA1 C ATOM 2474 O4* A C 1095 3.576 −3.668 −23.451 1.00 31.13 RNA1 O ATOM 2475 C3* A C 1095 4.254 −2.489 −21.555 1.00 30.12 RNA1 C ATOM 2476 O3* A C 1095 5.068 −1.403 −21.134 1.00 47.22 RNA1 O ATOM 2477 C2* A C 1095 2.797 −2.116 −21.824 1.00 32.85 RNA1 C ATOM 2478 O2* A C 1095 2.630 −0.839 −22.418 1.00 29.79 RNA1 O ATOM 2479 C1* A C 1095 2.395 −3.179 −22.845 1.00 21.93 RNA1 C ATOM 2480 N9 A C 1095 1.649 −4.328 −22.333 1.00 17.01 RNA1 N ATOM 2481 C8 A C 1095 2.142 −5.568 −21.985 1.00 21.36 RNA1 C ATOM 2482 N7 A C 1095 1.211 −6.424 −21.627 1.00 21.32 RNA1 N ATOM 2483 C5 A C 1095 0.031 −5.696 −21.729 1.00 10.86 RNA1 C ATOM 2484 C6 A C 1095 −1.315 −6.037 −21.498 1.00 23.82 RNA1 C ATOM 2485 N6 A C 1095 −1.717 −7.254 −21.118 1.00 35.80 RNA1 N ATOM 2486 N1 A C 1095 −2.249 −5.076 −21.679 1.00 30.20 RNA1 N ATOM 2487 C2 A C 1095 −1.844 −3.861 −22.076 1.00 23.15 RNA1 C ATOM 2488 N3 A C 1095 −0.610 −3.423 −22.337 1.00 20.47 RNA1 N ATOM 2489 C4 A C 1095 0.289 −4.399 −22.143 1.00 9.00 RNA1 C ATOM 2490 P A C 1096 5.554 −1.325 −19.607 1.00 33.71 RNA1 P ATOM 2491 O1P A C 1096 5.985 −2.689 −19.209 1.00 38.06 RNA1 O ATOM 2492 O2P A C 1096 6.505 −0.198 −19.472 1.00 30.42 RNA1 O ATOM 2493 O5* A C 1096 4.203 −0.950 −18.856 1.00 19.71 RNA1 O ATOM 2494 C5* A C 1096 3.610 0.332 −19.065 1.00 17.59 RNA1 C ATOM 2495 C4* A C 1096 2.176 0.335 −18.609 1.00 25.20 RNA1 C ATOM 2496 O4* A C 1096 1.399 −0.548 −19.452 1.00 36.18 RNA1 O ATOM 2497 C3* A C 1096 1.916 −0.155 −17.197 1.00 31.52 RNA1 C ATOM 2498 O3* A C 1096 2.158 0.858 −16.224 1.00 40.13 RNA1 O ATOM 2499 C2* A C 1096 0.458 −0.589 −17.277 1.00 29.94 RNA1 C ATOM 2500 O2* A C 1096 −0.436 0.497 −17.220 1.00 33.53 RNA1 O ATOM 2501 C1* A C 1096 0.392 −1.181 −18.684 1.00 28.76 RNA1 C ATOM 2502 N9 A C 1096 0.682 −2.615 −18.662 1.00 29.57 RNA1 N ATOM 2503 C8 A C 1096 1.915 −3.230 −18.760 1.00 20.07 RNA1 C ATOM 2504 N7 A C 1096 1.862 −4.536 −18.673 1.00 16.60 RNA1 N ATOM 2505 C5 A C 1096 0.506 −4.803 −18.515 1.00 21.73 RNA1 C ATOM 2506 C6 A C 1096 −0.207 −6.004 −18.372 1.00 21.62 RNA1 C ATOM 2507 N6 A C 1096 0.376 −7.207 −18.386 1.00 30.29 RNA1 N ATOM 2508 N1 A C 1096 −1.551 −5.928 −18.222 1.00 19.53 RNA1 N ATOM 2509 C2 A C 1096 −2.130 −4.715 −18.234 1.00 19.83 RNA1 C ATOM 2510 N3 A C 1096 −1.565 −3.512 −18.377 1.00 21.31 RNA1 N ATOM 2511 C4 A C 1096 −0.231 −3.630 −18.511 1.00 13.07 RNA1 C ATOM 2512 P C C 1097 2.770 0.451 −14.795 1.00 34.58 RNA1 P ATOM 2513 O1P C C 1097 3.901 −0.488 −15.013 1.00 24.95 RNA1 O ATOM 2514 O2P C C 1097 3.010 1.716 −14.062 1.00 42.37 RNA1 O ATOM 2515 O5* C C 1097 1.558 −0.333 −14.115 1.00 33.44 RNA1 O ATOM 2516 C5* C C 1097 1.711 −1.664 −13.564 1.00 27.30 RNA1 C ATOM 2517 C4* C C 1097 0.347 −2.298 −13.386 1.00 34.16 RNA1 C ATOM 2518 O4* C C 1097 −0.067 −2.943 −14.625 1.00 37.39 RNA1 O ATOM 2519 C3* C C 1097 0.219 −3.406 −12.354 1.00 33.88 RNA1 C ATOM 2520 O3* C C 1097 0.093 −2.924 −11.025 1.00 36.37 RNA1 O ATOM 2521 C2* C C 1097 −1.041 −4.120 −12.816 1.00 36.19 RNA1 C ATOM 2522 O2* C C 1097 −2.214 −3.415 −12.457 1.00 31.86 RNA1 O ATOM 2523 C1* C C 1097 −0.865 −4.089 −14.334 1.00 35.36 RNA1 C ATOM 2524 N1 C C 1097 −0.146 −5.311 −14.780 1.00 29.78 RNA1 N ATOM 2525 C2 C C 1097 −0.859 −6.537 −14.895 1.00 31.29 RNA1 C ATOM 2526 O2 C C 1097 −2.097 −6.552 −14.732 1.00 30.74 RNA1 O ATOM 2527 N3 C C 1097 −0.175 −7.667 −15.188 1.00 27.52 RNA1 N ATOM 2528 C4 C C 1097 1.146 −7.616 −15.390 1.00 35.55 RNA1 C ATOM 2529 N4 C C 1097 1.788 −8.764 −15.640 1.00 38.53 RNA1 N ATOM 2530 C5 C C 1097 1.874 −6.389 −15.338 1.00 27.77 RNA1 C ATOM 2531 C6 C C 1097 1.197 −5.275 −15.036 1.00 24.47 RNA1 C ATOM 2532 P A C 1098 1.072 −3.493 −9.886 1.00 38.47 RNA1 P ATOM 2533 O1P A C 1098 2.477 −3.131 −10.212 1.00 22.01 RNA1 O ATOM 2534 O2P A C 1098 0.484 −3.068 −8.588 1.00 56.40 RNA1 O ATOM 2535 O5* A C 1098 0.959 −5.079 −10.023 1.00 40.54 RNA1 O ATOM 2536 C5* A C 1098 −0.328 −5.740 −9.972 1.00 47.03 RNA1 C ATOM 2537 C4* A C 1098 −0.192 −7.201 −10.348 1.00 50.05 RNA1 C ATOM 2538 O4* A C 1098 0.276 −7.310 −11.720 1.00 43.04 RNA1 O ATOM 2539 C3* A C 1098 0.819 −8.007 −9.544 1.00 59.35 RNA1 C ATOM 2540 O3* A C 1098 0.289 −8.467 −8.305 1.00 57.94 RNA1 O ATOM 2541 C2* A C 1098 1.170 −9.146 −10.496 1.00 54.42 RNA1 C ATOM 2542 O2* A C 1098 0.229 −10.203 −10.479 1.00 63.88 RNA1 O ATOM 2543 C1* A C 1098 1.125 −8.440 −11.851 1.00 42.41 RNA1 C ATOM 2544 N9 A C 1098 2.456 −7.982 −12.247 1.00 29.98 RNA1 N ATOM 2545 C8 A C 1098 2.967 −6.709 −12.213 1.00 32.72 RNA1 C ATOM 2546 N7 A C 1098 4.222 −6.633 −12.588 1.00 34.32 RNA1 N ATOM 2547 C5 A C 1098 4.557 −7.942 −12.902 1.00 34.44 RNA1 C ATOM 2548 C6 A C 1098 5.751 −8.533 −13.363 1.00 43.55 RNA1 C ATOM 2549 N6 A C 1098 6.879 −7.852 −13.597 1.00 39.58 RNA1 N ATOM 2550 N1 A C 1098 5.746 −9.866 −13.579 1.00 48.91 RNA1 N ATOM 2551 C2 A C 1098 4.615 −10.549 −13.348 1.00 42.95 RNA1 C ATOM 2552 N3 A C 1098 3.435 −10.108 −12.916 1.00 35.82 RNA1 N ATOM 2553 C4 A C 1098 3.474 −8.782 −12.708 1.00 35.65 RNA1 C ATOM 2554 P G C 1099 1.238 −8.516 −7.006 1.00 52.26 RNA1 P ATOM 2555 O1P G C 1099 1.696 −7.137 −6.706 1.00 52.99 RNA1 O ATOM 2556 O2P G C 1099 0.511 −9.287 −5.970 1.00 54.62 RNA1 O ATOM 2557 O5* G C 1099 2.513 −9.346 −7.481 1.00 43.47 RNA1 O ATOM 2558 C5* G C 1099 2.413 −10.749 −7.772 1.00 41.68 RNA1 C ATOM 2559 C4* G C 1099 3.735 −11.273 −8.271 1.00 42.05 RNA1 C ATOM 2560 O4* G C 1099 4.033 −10.671 −9.554 1.00 43.83 RNA1 O ATOM 2561 C3* G C 1099 4.938 −10.934 −7.409 1.00 48.09 RNA1 C ATOM 2562 O3* G C 1099 5.100 −11.821 −6.317 1.00 58.27 RNA1 O ATOM 2563 C2* G C 1099 6.089 −10.992 −8.402 1.00 50.43 RNA1 C ATOM 2564 O2* G C 1099 6.588 −12.296 −8.639 1.00 57.02 RNA1 O ATOM 2565 C1* G C 1099 5.426 −10.432 −9.660 1.00 44.89 RNA1 C ATOM 2566 N9 G C 1099 5.639 −8.989 −9.729 1.00 45.65 RNA1 N ATOM 2567 C8 G C 1099 4.714 −7.993 −9.515 1.00 38.56 RNA1 C ATOM 2568 N7 G C 1099 5.228 −6.796 −9.584 1.00 41.94 RNA1 N ATOM 2569 C5 G C 1099 6.569 −7.014 −9.873 1.00 34.92 RNA1 C ATOM 2570 C6 G C 1099 7.631 −6.094 −10.053 1.00 42.48 RNA1 C ATOM 2571 O6 G C 1099 7.601 −4.857 −9.985 1.00 44.46 RNA1 O ATOM 2572 N1 G C 1099 8.829 −6.746 −10.336 1.00 41.82 RNA1 N ATOM 2573 C2 G C 1099 8.982 −8.108 −10.437 1.00 42.77 RNA1 C ATOM 2574 N2 G C 1099 10.211 −8.548 −10.736 1.00 31.50 RNA1 N ATOM 2575 N3 G C 1099 8.001 −8.974 −10.262 1.00 31.12 RNA1 N ATOM 2576 C4 G C 1099 6.832 −8.362 −9.984 1.00 33.36 RNA1 C ATOM 2577 P C C 1100 5.772 −11.286 −4.956 1.00 62.31 RNA1 P ATOM 2578 O1P C C 1100 5.270 −9.914 −4.687 1.00 56.23 RNA1 O ATOM 2579 O2P C C 1100 5.583 −12.348 −3.934 1.00 65.10 RNA1 O ATOM 2580 O5* C C 1100 7.320 −11.188 −5.316 1.00 45.54 RNA1 O ATOM 2581 C5* C C 1100 8.052 −12.366 −5.670 1.00 43.72 RNA1 C ATOM 2582 C4* C C 1100 9.458 −12.015 −6.069 1.00 40.97 RNA1 C ATOM 2583 O4* C C 1100 9.429 −11.213 −7.276 1.00 44.70 RNA1 O ATOM 2584 C3* C C 1100 10.249 −11.173 −5.087 1.00 43.30 RNA1 C ATOM 2585 O3* C C 1100 10.817 −11.913 −4.022 1.00 57.32 RNA1 O ATOM 2586 C2* C C 1100 11.306 −10.543 −5.980 1.00 45.40 RNA1 C ATOM 2587 O2* C C 1100 12.407 −11.390 −6.236 1.00 41.08 RNA1 O ATOM 2588 C1* C C 1100 10.508 −10.293 −7.258 1.00 40.42 RNA1 C ATOM 2589 N1 C C 1100 9.968 −8.923 −7.239 1.00 34.22 RNA1 N ATOM 2590 C2 C C 1100 10.851 −7.860 −7.450 1.00 34.09 RNA1 C ATOM 2591 O2 C C 1100 12.043 −8.112 −7.698 1.00 30.44 RNA1 O ATOM 2592 N3 C C 1100 10.390 −6.595 −7.377 1.00 32.20 RNA1 N ATOM 2593 C4 C C 1100 9.102 −6.369 −7.112 1.00 36.06 RNA1 C ATOM 2594 N4 C C 1100 8.695 −5.101 −7.023 1.00 42.37 RNA1 N ATOM 2595 C5 C C 1100 8.173 −7.432 −6.920 1.00 31.00 RNA1 C ATOM 2596 C6 C C 1100 8.643 −8.681 −6.995 1.00 29.98 RNA1 C ATOM 2597 P U C 1101 11.026 −11.199 −2.592 1.00 60.70 RNA1 P ATOM 2598 O1P U C 1101 9.727 −10.588 −2.196 1.00 50.26 RNA1 O ATOM 2599 O2P U C 1101 11.694 −12.160 −1.673 1.00 70.90 RNA1 O ATOM 2600 O5* U C 1101 12.055 −10.024 −2.904 1.00 44.87 RNA1 O ATOM 2601 C5* U C 1101 13.364 −10.316 −3.411 1.00 39.54 RNA1 C ATOM 2602 C4* U C 1101 14.139 −9.041 −3.619 1.00 45.93 RNA1 C ATOM 2603 O4* U C 1101 13.487 −8.234 −4.635 1.00 53.56 RNA1 O ATOM 2604 C3* U C 1101 14.232 −8.111 −2.424 1.00 45.04 RNA1 C ATOM 2605 O3* U C 1101 15.241 −8.491 −1.503 1.00 55.35 RNA1 O ATOM 2606 C2* U C 1101 14.519 −6.767 −3.078 1.00 45.97 RNA1 C ATOM 2607 O2* U C 1101 15.875 −6.620 −3.450 1.00 43.86 RNA1 O ATOM 2608 C1* U C 1101 13.668 −6.856 −4.341 1.00 43.43 RNA1 C ATOM 2609 N1 U C 1101 12.349 −6.220 −4.172 1.00 40.87 RNA1 N ATOM 2610 C2 U C 1101 12.289 −4.831 −4.234 1.00 35.67 RNA1 C ATOM 2611 O2 U C 1101 13.277 −4.130 −4.420 1.00 34.43 RNA1 O ATOM 2612 N3 U C 1101 11.032 −4.294 −4.067 1.00 27.89 RNA1 N ATOM 2613 C4 U C 1101 9.851 −4.983 −3.852 1.00 38.34 RNA1 C ATOM 2614 O4 U C 1101 8.792 −4.355 −3.727 1.00 30.79 RNA1 O ATOM 2615 C5 U C 1101 9.993 −6.408 −3.801 1.00 38.67 RNA1 C ATOM 2616 C6 U C 1101 11.204 −6.965 −3.959 1.00 40.99 RNA1 C ATOM 2617 P C C 1102 15.110 −8.040 0.038 1.00 56.93 RNA1 P ATOM 2618 O1P C C 1102 13.690 −8.220 0.458 1.00 45.32 RNA1 O ATOM 2619 O2P C C 1102 16.195 −8.697 0.810 1.00 59.07 RNA1 O ATOM 2620 O5* C C 1102 15.415 −6.479 0.002 1.00 47.10 RNA1 O ATOM 2621 C5* C C 1102 16.687 −6.002 −0.447 1.00 40.92 RNA1 C ATOM 2622 C4* C C 1102 16.706 −4.495 −0.480 1.00 41.54 RNA1 C ATOM 2623 O4* C C 1102 15.809 −4.001 −1.511 1.00 45.86 RNA1 O ATOM 2624 C3* C C 1102 16.235 −3.772 0.769 1.00 43.22 RNA1 C ATOM 2625 O3* C C 1102 17.189 −3.732 1.814 1.00 49.70 RNA1 O ATOM 2626 C2* C C 1102 15.910 −2.389 0.227 1.00 45.44 RNA1 C ATOM 2627 O2* C C 1102 17.061 −1.587 0.031 1.00 39.52 RNA1 O ATOM 2628 C1* C C 1102 15.294 −2.733 −1.125 1.00 41.32 RNA1 C ATOM 2629 N1 C C 1102 13.822 −2.807 −1.006 1.00 35.07 RNA1 N ATOM 2630 C2 C C 1102 13.091 −1.607 −0.999 1.00 35.73 RNA1 C ATOM 2631 O2 C C 1102 13.700 −0.530 −1.134 1.00 40.70 RNA1 O ATOM 2632 N3 C C 1102 11.748 −1.649 −0.843 1.00 24.21 RNA1 N ATOM 2633 C4 C C 1102 11.131 −2.821 −0.703 1.00 25.56 RNA1 C ATOM 2634 N4 C C 1102 9.805 −2.813 −0.534 1.00 27.04 RNA1 N ATOM 2635 C5 C C 1102 11.844 −4.056 −0.726 1.00 25.22 RNA1 C ATOM 2636 C6 C C 1102 13.175 −4.004 −0.880 1.00 29.24 RNA1 C ATOM 2637 P A C 1103 16.678 −3.598 3.336 1.00 46.37 RNA1 P ATOM 2638 O1P A C 1103 15.453 −4.431 3.507 1.00 34.79 RNA1 O ATOM 2639 O2P A C 1103 17.841 −3.806 4.238 1.00 53.23 RNA1 O ATOM 2640 O5* A C 1103 16.223 −2.077 3.443 1.00 50.88 RNA1 O ATOM 2641 C5* A C 1103 17.095 −1.012 3.017 1.00 45.92 RNA1 C ATOM 2642 C4* A C 1103 16.368 0.307 3.082 1.00 42.03 RNA1 C ATOM 2643 O4* A C 1103 15.249 0.282 2.164 1.00 42.45 RNA1 O ATOM 2644 C3* A C 1103 15.748 0.629 4.431 1.00 46.34 RNA1 C ATOM 2645 O3* A C 1103 16.697 1.231 5.297 1.00 50.61 RNA1 O ATOM 2646 C2* A C 1103 14.604 1.568 4.068 1.00 40.60 RNA1 C ATOM 2647 O2* A C 1103 15.018 2.911 3.913 1.00 43.99 RNA1 O ATOM 2648 C1* A C 1103 14.163 1.007 2.714 1.00 35.23 RNA1 C ATOM 2649 N9 A C 1103 13.007 0.114 2.815 1.00 24.56 RNA1 N ATOM 2650 C8 A C 1103 12.964 −1.259 2.771 1.00 12.09 RNA1 C ATOM 2651 N7 A C 1103 11.755 −1.754 2.912 1.00 21.27 RNA1 N ATOM 2652 C5 A C 1103 10.949 −0.629 3.052 1.00 11.33 RNA1 C ATOM 2653 C6 A C 1103 9.566 −0.469 3.247 1.00 17.54 RNA1 C ATOM 2654 N6 A C 1103 8.699 −1.485 3.341 1.00 18.44 RNA1 N ATOM 2655 N1 A C 1103 9.091 0.792 3.351 1.00 23.77 RNA1 N ATOM 2656 C2 A C 1103 9.947 1.810 3.270 1.00 20.47 RNA1 C ATOM 2657 N3 A C 1103 11.262 1.789 3.093 1.00 25.40 RNA1 N ATOM 2658 C4 A C 1103 11.706 0.525 2.990 1.00 22.14 RNA1 C ATOM 2659 P C C 1104 16.907 0.637 6.771 1.00 47.34 RNA1 P ATOM 2660 O1P C C 1104 17.274 −0.801 6.656 1.00 47.39 RNA1 O ATOM 2661 O2P C C 1104 17.809 1.572 7.493 1.00 49.59 RNA1 O ATOM 2662 O5* C C 1104 15.454 0.717 7.410 1.00 32.80 RNA1 O ATOM 2663 C5* C C 1104 14.847 1.985 7.660 1.00 32.89 RNA1 C ATOM 2664 C4* C C 1104 13.409 1.804 8.055 1.00 33.67 RNA1 C ATOM 2665 O4* C C 1104 12.654 1.301 6.924 1.00 36.61 RNA1 O ATOM 2666 C3* C C 1104 13.151 0.793 9.157 1.00 44.60 RNA1 C ATOM 2667 O3* C C 1104 13.379 1.321 10.455 1.00 47.83 RNA1 O ATOM 2668 C2* C C 1104 11.699 0.409 8.912 1.00 41.50 RNA1 C ATOM 2669 O2* C C 1104 10.802 1.363 9.443 1.00 39.51 RNA1 O ATOM 2670 C1* C C 1104 11.635 0.426 7.382 1.00 35.38 RNA1 C ATOM 2671 N1 C C 1104 11.881 −0.915 6.818 1.00 26.79 RNA1 N ATOM 2672 C2 C C 1104 10.807 −1.804 6.699 1.00 30.49 RNA1 C ATOM 2673 O2 C C 1104 9.672 −1.426 7.039 1.00 25.17 RNA1 O ATOM 2674 N3 C C 1104 11.031 −3.049 6.216 1.00 35.06 RNA1 N ATOM 2675 C4 C C 1104 12.264 −3.412 5.850 1.00 35.48 RNA1 C ATOM 2676 N4 C C 1104 12.440 −4.649 5.381 1.00 39.73 RNA1 N ATOM 2677 C5 C C 1104 13.370 −2.524 5.948 1.00 26.28 RNA1 C ATOM 2678 C6 C C 1104 13.137 −1.298 6.432 1.00 26.38 RNA1 C ATOM 2679 P C C 1105 13.943 0.357 11.610 1.00 45.15 RNA1 P ATOM 2680 O1P C C 1105 14.937 −0.579 11.008 1.00 37.59 RNA1 O ATOM 2681 O2P C C 1105 14.345 1.217 12.749 1.00 50.66 RNA1 O ATOM 2682 O5* C C 1105 12.669 −0.496 12.036 1.00 27.84 RNA1 O ATOM 2683 C5* C C 1105 11.541 0.141 12.636 1.00 26.44 RNA1 C ATOM 2684 C4* C C 1105 10.431 −0.855 12.852 1.00 36.80 RNA1 C ATOM 2685 O4* C C 1105 9.967 −1.354 11.569 1.00 46.02 RNA1 O ATOM 2686 C3* C C 1105 10.793 −2.111 13.623 1.00 39.57 RNA1 C ATOM 2687 O3* C C 1105 10.794 −1.905 15.026 1.00 48.60 RNA1 O ATOM 2688 C2* C C 1105 9.713 −3.084 13.169 1.00 42.79 RNA1 C ATOM 2689 O2* C C 1105 8.473 −2.848 13.811 1.00 36.52 RNA1 O ATOM 2690 C1* C C 1105 9.576 −2.714 11.693 1.00 39.01 RNA1 C ATOM 2691 N1 C C 1105 10.448 −3.539 10.827 1.00 31.92 RNA1 N ATOM 2692 C2 C C 1105 10.029 −4.832 10.461 1.00 29.04 RNA1 C ATOM 2693 O2 C C 1105 8.934 −5.259 10.875 1.00 27.41 RNA1 O ATOM 2694 N3 C C 1105 10.831 −5.584 9.672 1.00 26.50 RNA1 N ATOM 2695 C4 C C 1105 12.005 −5.100 9.255 1.00 26.95 RNA1 C ATOM 2696 N4 C C 1105 12.768 −5.879 8.473 1.00 32.01 RNA1 N ATOM 2697 C5 C C 1105 12.453 −3.798 9.614 1.00 31.44 RNA1 C ATOM 2698 C6 C C 1105 11.652 −3.059 10.389 1.00 27.18 RNA1 C ATOM 2699 P A C 1106 11.685 −2.860 15.964 1.00 49.11 RNA1 P ATOM 2700 O1P A C 1106 12.987 −3.106 15.282 1.00 36.36 RNA1 O ATOM 2701 O2P A C 1106 11.676 −2.277 17.331 1.00 55.01 RNA1 O ATOM 2702 O5* A C 1106 10.861 −4.222 15.988 1.00 33.45 RNA1 O ATOM 2703 C5* A C 1106 9.507 −4.255 16.482 1.00 40.30 RNA1 C ATOM 2704 C4* A C 1106 8.910 −5.628 16.280 1.00 55.66 RNA1 C ATOM 2705 O4* A C 1106 8.774 −5.892 14.859 1.00 57.89 RNA1 O ATOM 2706 C3* A C 1106 9.747 −6.785 16.804 1.00 61.21 RNA1 C ATOM 2707 O3* A C 1106 9.552 −7.004 18.196 1.00 63.93 RNA1 O ATOM 2708 C2* A C 1106 9.287 −7.945 15.928 1.00 60.31 RNA1 C ATOM 2709 O2* A C 1106 8.040 −8.478 16.344 1.00 54.72 RNA1 O ATOM 2710 C1* A C 1106 9.104 −7.244 14.582 1.00 50.43 RNA1 C ATOM 2711 N9 A C 1106 10.327 −7.245 13.772 1.00 40.12 RNA1 N ATOM 2712 C8 A C 1106 11.297 −6.265 13.730 1.00 43.18 RNA1 C ATOM 2713 N7 A C 1106 12.279 −6.522 12.899 1.00 35.92 RNA1 N ATOM 2714 C5 A C 1106 11.940 −7.754 12.356 1.00 35.80 RNA1 C ATOM 2715 C6 A C 1106 12.574 −8.570 11.401 1.00 32.97 RNA1 C ATOM 2716 N6 A C 1106 13.721 −8.242 10.791 1.00 42.58 RNA1 N ATOM 2717 N1 A C 1106 11.984 −9.744 11.088 1.00 28.98 RNA1 N ATOM 2718 C2 A C 1106 10.831 −10.065 11.694 1.00 37.34 RNA1 C ATOM 2719 N3 A C 1106 10.132 −9.379 12.601 1.00 37.05 RNA1 N ATOM 2720 C4 A C 1106 10.746 −8.218 12.893 1.00 37.35 RNA1 C ATOM 2721 P G C 1107 10.770 −7.554 19.093 1.00 58.93 RNA1 P ATOM 2722 O1P G C 1107 12.057 −7.023 18.562 1.00 36.85 RNA1 O ATOM 2723 O2P G C 1107 10.406 −7.307 20.512 1.00 61.45 RNA1 O ATOM 2724 O5* G C 1107 10.741 −9.124 18.823 1.00 57.72 RNA1 O ATOM 2725 C5* G C 1107 9.559 −9.898 19.117 1.00 58.74 RNA1 C ATOM 2726 C4* G C 1107 9.678 −11.278 18.520 1.00 65.40 RNA1 C ATOM 2727 O4* G C 1107 9.633 −11.183 17.073 1.00 61.43 RNA1 O ATOM 2728 C3* G C 1107 10.983 −11.999 18.818 1.00 66.79 RNA1 C ATOM 2729 O3* G C 1107 10.969 −12.653 20.079 1.00 66.96 RNA1 O ATOM 2730 C2* G C 1107 11.110 −12.966 17.647 1.00 65.40 RNA1 C ATOM 2731 O2* G C 1107 10.392 −14.174 17.833 1.00 59.25 RNA1 O ATOM 2732 C1* G C 1107 10.509 −12.142 16.504 1.00 56.87 RNA1 C ATOM 2733 N9 G C 1107 11.541 −11.428 15.759 1.00 46.90 RNA1 N ATOM 2734 C8 G C 1107 11.980 −10.140 15.964 1.00 49.14 RNA1 C ATOM 2735 N7 G C 1107 12.952 −9.797 15.163 1.00 45.19 RNA1 N ATOM 2736 C5 G C 1107 13.159 −10.921 14.374 1.00 43.33 RNA1 C ATOM 2737 C6 G C 1107 14.092 −11.155 13.326 1.00 44.94 RNA1 C ATOM 2738 O6 G C 1107 14.953 −10.387 12.869 1.00 41.91 RNA1 O ATOM 2739 N1 G C 1107 13.958 −12.437 12.803 1.00 44.05 RNA1 N ATOM 2740 C2 G C 1107 13.048 −13.374 13.227 1.00 48.45 RNA1 C ATOM 2741 N2 G C 1107 13.071 −14.553 12.597 1.00 49.02 RNA1 N ATOM 2742 N3 G C 1107 12.177 −13.169 14.198 1.00 48.55 RNA1 N ATOM 2743 C4 G C 1107 12.289 −11.932 14.725 1.00 47.37 RNA1 C ATOM 2744 P C C 1108 12.345 −12.840 20.886 1.00 71.15 RNA1 P ATOM 2745 O1P C C 1108 13.100 −11.558 20.849 1.00 59.46 RNA1 O ATOM 2746 O2P C C 1108 12.015 −13.463 22.194 1.00 75.00 RNA1 O ATOM 2747 O5* C C 1108 13.155 −13.893 20.010 1.00 72.84 RNA1 O ATOM 2748 C5* C C 1108 12.697 −15.251 19.876 1.00 75.04 RNA1 C ATOM 2749 C4* C C 1108 13.581 −16.004 18.914 1.00 76.03 RNA1 C ATOM 2750 O4* C C 1108 13.459 −15.420 17.592 1.00 73.82 RNA1 O ATOM 2751 C3* C C 1108 15.073 −15.954 19.208 1.00 77.22 RNA1 C ATOM 2752 O3* C C 1108 15.576 −16.622 20.377 1.00 76.14 RNA1 O ATOM 2753 C2* C C 1108 15.696 −16.220 17.844 1.00 77.82 RNA1 C ATOM 2754 O2* C C 1108 15.731 −17.593 17.507 1.00 80.53 RNA1 O ATOM 2755 C1* C C 1108 14.705 −15.511 16.916 1.00 74.18 RNA1 C ATOM 2756 N1 C C 1108 15.147 −14.151 16.545 1.00 69.37 RNA1 N ATOM 2757 C2 C C 1108 15.946 −13.987 15.400 1.00 64.11 RNA1 C ATOM 2758 O2 C C 1108 16.232 −14.979 14.713 1.00 63.69 RNA1 O ATOM 2759 N3 C C 1108 16.383 −12.750 15.074 1.00 59.38 RNA1 N ATOM 2760 C4 C C 1108 16.047 −11.702 15.829 1.00 57.06 RNA1 C ATOM 2761 N4 C C 1108 16.508 −10.503 15.472 1.00 58.03 RNA1 N ATOM 2762 C5 C C 1108 15.224 −11.837 16.984 1.00 61.31 RNA1 C ATOM 2763 C6 C C 1108 14.801 −13.066 17.303 1.00 67.15 RNA1 C TER 2764 C C 1108 ATOM 2765 O5* G D 1051 13.368 11.108 −58.535 1.00 55.60 RNA2 O ATOM 2766 C5* G D 1051 14.100 12.302 −58.210 1.00 63.32 RNA2 C ATOM 2767 C4* G D 1051 13.550 13.505 −58.939 1.00 61.69 RNA2 C ATOM 2768 O4* G D 1051 13.809 13.364 −60.359 1.00 66.02 RNA2 O ATOM 2769 C3* G D 1051 12.043 13.659 −58.835 1.00 59.67 RNA2 C ATOM 2770 O3* G D 1051 11.661 14.349 −57.659 1.00 53.26 RNA2 O ATOM 2771 C2* G D 1051 11.684 14.404 −60.113 1.00 58.82 RNA2 C ATOM 2772 O2* G D 1051 11.873 15.801 −60.015 1.00 62.26 RNA2 O ATOM 2773 C1* G D 1051 12.691 13.815 −61.102 1.00 58.27 RNA2 C ATOM 2774 N9 G D 1051 12.147 12.672 −61.833 1.00 55.11 RNA2 N ATOM 2775 C8 G D 1051 12.505 11.352 −61.693 1.00 57.64 RNA2 C ATOM 2776 N7 G D 1051 11.830 10.552 −62.472 1.00 63.74 RNA2 N ATOM 2777 C5 G D 1051 10.976 11.393 −63.171 1.00 59.62 RNA2 C ATOM 2778 C6 G D 1051 10.002 11.100 −64.162 1.00 54.61 RNA2 C ATOM 2779 O6 G D 1051 9.687 9.999 −64.634 1.00 56.94 RNA2 O ATOM 2780 N1 G D 1051 9.366 12.254 −64.606 1.00 52.85 RNA2 N ATOM 2781 C2 G D 1051 9.629 13.525 −64.157 1.00 48.26 RNA2 C ATOM 2782 N2 G D 1051 8.910 14.509 −64.707 1.00 49.20 RNA2 N ATOM 2783 N3 G D 1051 10.531 13.811 −63.237 1.00 51.58 RNA2 N ATOM 2784 C4 G D 1051 11.163 12.707 −62.791 1.00 56.30 RNA2 C ATOM 2785 P C D 1052 10.243 14.024 −56.983 1.00 59.48 RNA2 P ATOM 2786 O1P C D 1052 10.050 12.549 −57.013 1.00 61.66 RNA2 O ATOM 2787 O2P C D 1052 10.183 14.741 −55.688 1.00 73.92 RNA2 O ATOM 2788 O5* C D 1052 9.194 14.690 −57.976 1.00 41.41 RNA2 O ATOM 2789 C5* C D 1052 9.295 16.081 −58.307 1.00 47.28 RNA2 C ATOM 2790 C4* C D 1052 8.298 16.442 −59.376 1.00 45.31 RNA2 C ATOM 2791 O4* C D 1052 8.683 15.855 −60.645 1.00 50.63 RNA2 O ATOM 2792 C3* C D 1052 6.892 15.933 −59.137 1.00 47.61 RNA2 C ATOM 2793 O3* C D 1052 6.174 16.759 −58.247 1.00 56.07 RNA2 O ATOM 2794 C2* C D 1052 6.301 15.896 −60.540 1.00 49.42 RNA2 C ATOM 2795 O2* C D 1052 5.816 17.144 −60.990 1.00 40.34 RNA2 O ATOM 2796 C1* C D 1052 7.518 15.487 −61.371 1.00 50.98 RNA2 C ATOM 2797 N1 C D 1052 7.546 14.031 −61.621 1.00 53.95 RNA2 N ATOM 2798 C2 C D 1052 6.704 13.502 −62.611 1.00 53.59 RNA2 C ATOM 2799 O2 C D 1052 5.974 14.271 −63.253 1.00 52.10 RNA2 O ATOM 2800 N3 C D 1052 6.705 12.169 −62.838 1.00 59.04 RNA2 N ATOM 2801 C4 C D 1052 7.499 11.370 −62.120 1.00 65.70 RNA2 C ATOM 2802 N4 C D 1052 7.459 10.056 −62.374 1.00 66.17 RNA2 N ATOM 2803 C5 C D 1052 8.369 11.880 −61.110 1.00 59.37 RNA2 C ATOM 2804 C6 C D 1052 8.363 13.202 −60.898 1.00 55.97 RNA2 C ATOM 2805 P U D 1053 5.067 16.101 −57.298 1.00 63.43 RNA2 P ATOM 2806 O1P U D 1053 5.641 14.831 −56.780 1.00 62.31 RNA2 O ATOM 2807 O2P U D 1053 4.576 17.128 −56.343 1.00 74.13 RNA2 O ATOM 2808 O5* U D 1053 3.889 15.763 −58.312 1.00 57.11 RNA2 O ATOM 2809 C5* U D 1053 3.199 16.820 −58.990 1.00 48.12 RNA2 C ATOM 2810 C4* U D 1053 2.185 16.257 −59.953 1.00 50.31 RNA2 C ATOM 2811 O4* U D 1053 2.860 15.628 −61.074 1.00 49.75 RNA2 O ATOM 2812 C3* U D 1053 1.277 15.164 −59.421 1.00 50.89 RNA2 C ATOM 2813 O3* U D 1053 0.202 15.634 −58.629 1.00 56.33 RNA2 O ATOM 2814 C2* U D 1053 0.818 14.477 −60.698 1.00 50.72 RNA2 C ATOM 2815 O2* U D 1053 −0.225 15.175 −61.357 1.00 48.82 RNA2 O ATOM 2816 C1* U D 1053 2.091 14.528 −61.540 1.00 43.49 RNA2 C ATOM 2817 N1 U D 1053 2.881 13.292 −61.391 1.00 42.34 RNA2 N ATOM 2818 C2 U D 1053 2.501 12.182 −62.141 1.00 40.65 RNA2 C ATOM 2819 O2 U D 1053 1.564 12.193 −62.926 1.00 43.48 RNA2 O ATOM 2820 N3 U D 1053 3.258 11.057 −61.935 1.00 32.60 RNA2 N ATOM 2821 C4 U D 1053 4.329 10.920 −61.079 1.00 48.03 RNA2 C ATOM 2822 O4 U D 1053 4.880 9.822 −60.973 1.00 58.30 RNA2 O ATOM 2823 C5 U D 1053 4.670 12.106 −60.352 1.00 43.77 RNA2 C ATOM 2824 C6 U D 1053 3.954 13.222 −60.528 1.00 44.26 RNA2 C ATOM 2825 P G D 1054 −0.300 14.738 −57.393 1.00 63.07 RNA2 P ATOM 2826 O1P G D 1054 0.909 14.253 −56.659 1.00 56.57 RNA2 O ATOM 2827 O2P G D 1054 −1.342 15.504 −56.670 1.00 55.48 RNA2 O ATOM 2828 O5* G D 1054 −0.993 13.484 −58.088 1.00 55.82 RNA2 O ATOM 2829 C5* G D 1054 −2.203 13.659 −58.842 1.00 63.34 RNA2 C ATOM 2830 C4* G D 1054 −2.607 12.376 −59.540 1.00 61.66 RNA2 C ATOM 2831 O4* G D 1054 −1.612 11.993 −60.529 1.00 57.48 RNA2 O ATOM 2832 C3* G D 1054 −2.785 11.116 −58.707 1.00 58.52 RNA2 C ATOM 2833 O3* G D 1054 −4.027 11.063 −58.021 1.00 50.20 RNA2 O ATOM 2834 C2* G D 1054 −2.702 10.021 −59.766 1.00 54.72 RNA2 C ATOM 2835 O2* G D 1054 −3.915 9.849 −60.469 1.00 57.84 RNA2 O ATOM 2836 C1* G D 1054 −1.657 10.588 −60.723 1.00 42.15 RNA2 C ATOM 2837 N9 G D 1054 −0.347 10.004 −60.453 1.00 43.98 RNA2 N ATOM 2838 C8 G D 1054 0.686 10.525 −59.707 1.00 48.29 RNA2 C ATOM 2839 N7 G D 1054 1.715 9.721 −59.624 1.00 48.90 RNA2 N ATOM 2840 C5 G D 1054 1.340 8.607 −60.367 1.00 43.87 RNA2 C ATOM 2841 C6 G D 1054 2.037 7.396 −60.634 1.00 37.83 RNA2 C ATOM 2842 O6 G D 1054 3.167 7.050 −60.252 1.00 35.95 RNA2 O ATOM 2843 N1 G D 1054 1.279 6.539 −61.428 1.00 42.56 RNA2 N ATOM 2844 C2 G D 1054 0.013 6.807 −61.901 1.00 45.28 RNA2 C ATOM 2845 N2 G D 1054 −0.567 5.854 −62.647 1.00 42.14 RNA2 N ATOM 2846 N3 G D 1054 −0.642 7.925 −61.659 1.00 40.97 RNA2 N ATOM 2847 C4 G D 1054 0.074 8.774 −60.892 1.00 45.06 RNA2 C ATOM 2848 P G D 1055 −4.174 10.115 −56.729 1.00 60.11 RNA2 P ATOM 2849 O1P G D 1055 −3.012 10.347 −55.817 1.00 52.31 RNA2 O ATOM 2850 O2P G D 1055 −5.562 10.287 −56.226 1.00 45.31 RNA2 O ATOM 2851 O5* G D 1055 −4.016 8.633 −57.297 1.00 61.25 RNA2 O ATOM 2852 C5* G D 1055 −5.060 8.044 −58.084 1.00 49.39 RNA2 C ATOM 2853 C4* G D 1055 −4.631 6.705 −58.643 1.00 46.06 RNA2 C ATOM 2854 O4* G D 1055 −3.395 6.848 −59.392 1.00 46.04 RNA2 O ATOM 2855 C3* G D 1055 −4.322 5.571 −57.678 1.00 46.58 RNA2 C ATOM 2856 O3* G D 1055 −5.478 4.904 −57.197 1.00 44.61 RNA2 O ATOM 2857 C2* G D 1055 −3.512 4.627 −58.556 1.00 50.61 RNA2 C ATOM 2858 O2* G D 1055 −4.337 3.844 −59.397 1.00 57.17 RNA2 O ATOM 2859 C1* G D 1055 −2.719 5.604 −59.419 1.00 37.93 RNA2 C ATOM 2860 N9 G D 1055 −1.364 5.764 −58.905 1.00 28.75 RNA2 N ATOM 2861 C8 G D 1055 −0.813 6.849 −58.266 1.00 28.74 RNA2 C ATOM 2862 N7 G D 1055 0.437 6.662 −57.928 1.00 31.82 RNA2 N ATOM 2863 C5 G D 1055 0.725 5.377 −58.371 1.00 24.53 RNA2 C ATOM 2864 C6 G D 1055 1.924 4.619 −58.293 1.00 28.90 RNA2 C ATOM 2865 O6 G D 1055 3.010 4.943 −57.807 1.00 32.85 RNA2 O ATOM 2866 N1 G D 1055 1.771 3.360 −58.862 1.00 26.15 RNA2 N ATOM 2867 C2 G D 1055 0.615 2.884 −59.432 1.00 32.58 RNA2 C ATOM 2868 N2 G D 1055 0.658 1.635 −59.922 1.00 28.69 RNA2 N ATOM 2869 N3 G D 1055 −0.505 3.580 −59.514 1.00 26.67 RNA2 N ATOM 2870 C4 G D 1055 −0.377 4.809 −58.971 1.00 28.85 RNA2 C ATOM 2871 P G D 1056 −5.427 4.178 −55.764 1.00 41.37 RNA2 P ATOM 2872 O1P G D 1056 −5.088 5.212 −54.752 1.00 49.91 RNA2 O ATOM 2873 O2P G D 1056 −6.660 3.370 −55.603 1.00 41.24 RNA2 O ATOM 2874 O5* G D 1056 −4.173 3.205 −55.857 1.00 31.72 RNA2 O ATOM 2875 C5* G D 1056 −4.288 1.915 −56.458 1.00 26.06 RNA2 C ATOM 2876 C4* G D 1056 −2.992 1.163 −56.310 1.00 30.23 RNA2 C ATOM 2877 O4* G D 1056 −1.926 1.929 −56.923 1.00 33.12 RNA2 O ATOM 2878 C3* G D 1056 −2.520 0.944 −54.886 1.00 25.25 RNA2 C ATOM 2879 O3* G D 1056 −3.091 −0.214 −54.323 1.00 32.82 RNA2 O ATOM 2880 C2* G D 1056 −1.015 0.792 −55.044 1.00 30.19 RNA2 C ATOM 2881 O2* G D 1056 −0.631 −0.515 −55.418 1.00 28.72 RNA2 O ATOM 2882 C1* G D 1056 −0.728 1.769 −56.181 1.00 29.85 RNA2 C ATOM 2883 N9 G D 1056 −0.326 3.081 −55.682 1.00 33.20 RNA2 N ATOM 2884 C8 G D 1056 −1.142 4.165 −55.453 1.00 31.51 RNA2 C ATOM 2885 N7 G D 1056 −0.496 5.205 −55.003 1.00 40.50 RNA2 N ATOM 2886 C5 G D 1056 0.825 4.784 −54.926 1.00 37.25 RNA2 C ATOM 2887 C6 G D 1056 1.985 5.481 −54.505 1.00 45.50 RNA2 C ATOM 2888 O6 G D 1056 2.078 6.654 −54.106 1.00 54.00 RNA2 O ATOM 2889 N1 G D 1056 3.122 4.677 −54.584 1.00 42.27 RNA2 N ATOM 2890 C2 G D 1056 3.138 3.372 −55.020 1.00 38.28 RNA2 C ATOM 2891 N2 G D 1056 4.337 2.765 −55.040 1.00 33.41 RNA2 N ATOM 2892 N3 G D 1056 2.060 2.712 −55.413 1.00 35.91 RNA2 N ATOM 2893 C4 G D 1056 0.947 3.474 −55.341 1.00 31.74 RNA2 C ATOM 2894 P A D 1057 −3.445 −0.241 −52.765 1.00 34.80 RNA2 P ATOM 2895 O1P A D 1057 −2.899 −1.503 −52.213 1.00 40.31 RNA2 O ATOM 2896 O2P A D 1057 −3.058 1.055 −52.152 1.00 39.35 RNA2 O ATOM 2897 O5* A D 1057 −5.027 −0.331 −52.754 1.00 19.58 RNA2 O ATOM 2898 C5* A D 1057 −5.823 0.724 −53.304 1.00 24.68 RNA2 C ATOM 2899 C4* A D 1057 −6.915 0.144 −54.161 1.00 26.68 RNA2 C ATOM 2900 O4* A D 1057 −6.359 −0.301 −55.425 1.00 40.11 RNA2 O ATOM 2901 C3* A D 1057 −7.560 −1.100 −53.585 1.00 30.27 RNA2 C ATOM 2902 O3* A D 1057 −8.559 −0.816 −52.635 1.00 35.52 RNA2 O ATOM 2903 C2* A D 1057 −8.090 −1.811 −54.820 1.00 30.75 RNA2 C ATOM 2904 O2* A D 1057 −9.317 −1.270 −55.268 1.00 24.78 RNA2 O ATOM 2905 C1* A D 1057 −6.991 −1.506 −55.834 1.00 16.37 RNA2 C ATOM 2906 N9 A D 1057 −5.973 −2.559 −55.883 1.00 21.50 RNA2 N ATOM 2907 C8 A D 1057 −4.626 −2.445 −55.613 1.00 18.28 RNA2 C ATOM 2908 N7 A D 1057 −3.962 −3.566 −55.754 1.00 23.67 RNA2 N ATOM 2909 C5 A D 1057 −4.935 −4.484 −56.140 1.00 21.49 RNA2 C ATOM 2910 C6 A D 1057 −4.872 −5.852 −56.447 1.00 17.73 RNA2 C ATOM 2911 N6 A D 1057 −3.748 −6.569 −56.412 1.00 22.33 RNA2 N ATOM 2912 N1 A D 1057 −6.019 −6.470 −56.797 1.00 29.29 RNA2 N ATOM 2913 C2 A D 1057 −7.150 −5.753 −56.829 1.00 30.01 RNA2 C ATOM 2914 N3 A D 1057 −7.337 −4.465 −56.559 1.00 24.69 RNA2 N ATOM 2915 C4 A D 1057 −6.177 −3.879 −56.219 1.00 18.45 RNA2 C ATOM 2916 P U D 1058 −8.746 −1.807 −51.399 1.00 30.93 RNA2 P ATOM 2917 O1P U D 1058 −7.361 −2.213 −50.993 1.00 24.94 RNA2 O ATOM 2918 O2P U D 1058 −9.669 −1.203 −50.402 1.00 29.08 RNA2 O ATOM 2919 O5* U D 1058 −9.464 −3.068 −52.042 1.00 30.31 RNA2 O ATOM 2920 C5* U D 1058 −10.859 −3.043 −52.331 1.00 28.81 RNA2 C ATOM 2921 C4* U D 1058 −11.349 −4.440 −52.592 1.00 31.83 RNA2 C ATOM 2922 O4* U D 1058 −10.668 −4.953 −53.765 1.00 33.24 RNA2 O ATOM 2923 C3* U D 1058 −11.031 −5.471 −51.520 1.00 33.13 RNA2 C ATOM 2924 O3* U D 1058 −11.925 −5.479 −50.425 1.00 32.98 RNA2 O ATOM 2925 C2* U D 1058 −11.084 −6.772 −52.299 1.00 29.12 RNA2 C ATOM 2926 O2* U D 1058 −12.414 −7.204 −52.513 1.00 29.74 RNA2 O ATOM 2927 C1* U D 1058 −10.455 −6.348 −53.622 1.00 26.32 RNA2 C ATOM 2928 N1 U D 1058 −9.008 −6.614 −53.638 1.00 21.34 RNA2 N ATOM 2929 C2 U D 1058 −8.608 −7.932 −53.803 1.00 24.87 RNA2 C ATOM 2930 O2 U D 1058 −9.402 −8.853 −53.938 1.00 31.94 RNA2 O ATOM 2931 N3 U D 1058 −7.253 −8.136 −53.799 1.00 8.92 RNA2 N ATOM 2932 C4 U D 1058 −6.273 −7.188 −53.647 1.00 22.44 RNA2 C ATOM 2933 O4 U D 1058 −5.088 −7.533 −53.685 1.00 18.08 RNA2 O ATOM 2934 C5 U D 1058 −6.759 −5.848 −53.482 1.00 22.73 RNA2 C ATOM 2935 C6 U D 1058 −8.080 −5.614 −53.488 1.00 18.95 RNA2 C ATOM 2936 P G D 1059 −11.432 −6.089 −49.022 1.00 29.43 RNA2 P ATOM 2937 O1P G D 1059 −9.995 −5.757 −48.812 1.00 18.78 RNA2 O ATOM 2938 O2P G D 1059 −12.431 −5.724 −47.993 1.00 38.92 RNA2 O ATOM 2939 O5* G D 1059 −11.490 −7.659 −49.247 1.00 34.42 RNA2 O ATOM 2940 C5* G D 1059 −12.729 −8.312 −49.534 1.00 29.33 RNA2 C ATOM 2941 C4* G D 1059 −12.525 −9.801 −49.573 1.00 27.67 RNA2 C ATOM 2942 O4* G D 1059 −11.608 −10.126 −50.645 1.00 28.30 RNA2 O ATOM 2943 C3* G D 1059 −11.883 −10.411 −48.339 1.00 32.02 RNA2 C ATOM 2944 O3* G D 1059 −12.840 −10.666 −47.314 1.00 37.54 RNA2 O ATOM 2945 C2* G D 1059 −11.260 −11.691 −48.887 1.00 27.34 RNA2 C ATOM 2946 O2* G D 1059 −12.207 −12.736 −48.993 1.00 21.26 RNA2 O ATOM 2947 C1* G D 1059 −10.838 −11.258 −50.289 1.00 18.26 RNA2 C ATOM 2948 N9 G D 1059 −9.425 −10.920 −50.414 1.00 11.76 RNA2 N ATOM 2949 C8 G D 1059 −8.846 −9.686 −50.262 1.00 10.37 RNA2 C ATOM 2950 N7 G D 1059 −7.552 −9.700 −50.455 1.00 15.12 RNA2 N ATOM 2951 C5 G D 1059 −7.260 −11.026 −50.747 1.00 5.51 RNA2 C ATOM 2952 C6 G D 1059 −6.022 −11.652 −51.055 1.00 15.78 RNA2 C ATOM 2953 O6 G D 1059 −4.892 −11.145 −51.124 1.00 17.40 RNA2 O ATOM 2954 N1 G D 1059 −6.184 −13.009 −51.300 1.00 12.54 RNA2 N ATOM 2955 C2 G D 1059 −7.377 −13.685 −51.256 1.00 23.87 RNA2 C ATOM 2956 N2 G D 1059 −7.326 −14.997 −51.540 1.00 21.07 RNA2 N ATOM 2957 N3 G D 1059 −8.536 −13.119 −50.962 1.00 20.56 RNA2 N ATOM 2958 C4 G D 1059 −8.404 −11.794 −50.723 1.00 17.53 RNA2 C ATOM 2959 P U D 1060 −12.363 −10.713 −45.780 1.00 31.30 RNA2 P ATOM 2960 O1P U D 1060 −13.473 −10.167 −44.963 1.00 29.83 RNA2 O ATOM 2961 O2P U D 1060 −11.840 −12.074 −45.484 1.00 37.29 RNA2 O ATOM 2962 O5* U D 1060 −11.129 −9.708 −45.745 1.00 25.29 RNA2 O ATOM 2963 C5* U D 1060 −10.735 −9.064 −44.527 1.00 22.54 RNA2 C ATOM 2964 C4* U D 1060 −9.378 −−8.435 −44.692 1.00 22.65 RNA2 C ATOM 2965 O4* U D 1060 −8.401 −9.481 −44.882 1.00 24.56 RNA2 O ATOM 2966 C3* U D 1060 −9.238 −7.481 −45.870 1.00 26.03 RNA2 C ATOM 2967 O3* U D 1060 −8.303 −6.454 −45.522 1.00 41.53 RNA2 O ATOM 2968 C2* U D 1060 −8.608 −8.361 −46.946 1.00 31.11 RNA2 C ATOM 2969 O2* U D 1060 −7.808 −7.616 −47.841 1.00 45.38 RNA2 O ATOM 2970 C1* U D 1060 −7.735 −9.299 −46.110 1.00 26.61 RNA2 C ATOM 2971 N1 U D 1060 −7.519 −10.632 −46.690 1.00 21.85 RNA2 N ATOM 2972 C2 U D 1060 −6.291 −10.898 −47.261 1.00 23.55 RNA2 C ATOM 2973 O2 U D 1060 −5.402 −10.063 −47.355 1.00 21.48 RNA2 O ATOM 2974 N3 U D 1060 −6.141 −12.182 −47.726 1.00 25.97 RNA2 N ATOM 2975 C4 U D 1060 −7.076 −13.199 −47.691 1.00 28.32 RNA2 C ATOM 2976 O4 U D 1060 −6.778 −14.311 −48.139 1.00 27.53 RNA2 O ATOM 2977 C5 U D 1060 −8.329 −12.837 −47.107 1.00 18.41 RNA2 C ATOM 2978 C6 U D 1060 −8.507 −11.600 −46.642 1.00 21.87 RNA2 C ATOM 2979 P U D 1061 −8.630 −5.419 −44.325 1.00 28.91 RNA2 P ATOM 2980 O1P U D 1061 −8.173 −4.091 −44.810 1.00 33.68 RNA2 O ATOM 2981 O2P U D 1061 −10.037 −5.590 −43.863 1.00 15.62 RNA2 O ATOM 2982 O5* U D 1061 −7.649 −5.888 −43.161 1.00 19.70 RNA2 O ATOM 2983 C5* U D 1061 −6.225 −5.745 −43.301 1.00 18.21 RNA2 C ATOM 2984 C4* U D 1061 −5.514 −6.526 −42.225 1.00 27.99 RNA2 C ATOM 2985 O4* U D 1061 −5.894 −5.996 −40.927 1.00 36.85 RNA2 O ATOM 2986 C3* U D 1061 −5.800 −8.028 −42.181 1.00 29.80 RNA2 C ATOM 2987 O3* U D 1061 −4.608 −8.696 −41.772 1.00 33.59 RNA2 O ATOM 2988 C2* U D 1061 −6.812 −8.151 −41.043 1.00 33.22 RNA2 C ATOM 2989 O2* U D 1061 −6.748 −9.417 −40.415 1.00 27.78 RNA2 O ATOM 2990 C1* U D 1061 −6.313 −7.055 −40.102 1.00 42.74 RNA2 C ATOM 2991 N1 U D 1061 −7.205 −6.543 −39.046 1.00 44.96 RNA2 N ATOM 2992 C2 U D 1061 −6.737 −6.649 −37.742 1.00 53.51 RNA2 C ATOM 2993 O2 U D 1061 −5.650 −7.143 −37.464 1.00 44.65 RNA2 O ATOM 2994 N3 U D 1061 −7.579 −6.157 −36.776 1.00 60.76 RNA2 N ATOM 2995 C4 U D 1061 −8.811 −5.585 −36.961 1.00 51.80 RNA2 C ATOM 2996 O4 U D 1061 −9.435 −5.195 −35.977 1.00 48.61 RNA2 O ATOM 2997 C5 U D 1061 −9.240 −5.508 −38.333 1.00 40.80 RNA2 C ATOM 2998 C6 U D 1061 −8.440 −5.979 −39.307 1.00 43.37 RNA2 C ATOM 2999 P G D 1062 −3.700 −9.466 −42.848 1.00 33.56 RNA2 P ATOM 3000 O1P G D 1062 −3.835 −8.777 −44.158 1.00 35.31 RNA2 O ATOM 3001 O2P G D 1062 −2.353 −9.644 −42.252 1.00 21.04 RNA2 O ATOM 3002 O5* G D 1062 −4.367 −10.905 −42.956 1.00 30.74 RNA2 O ATOM 3003 C5* G D 1062 −5.563 −11.128 −43.737 1.00 36.95 RNA2 C ATOM 3004 C4* G D 1062 −5.583 −12.554 −44.235 1.00 30.45 RNA2 C ATOM 3005 O4* G D 1062 −4.531 −12.739 −45.222 1.00 26.47 RNA2 O ATOM 3006 C3* G D 1062 −5.264 −13.550 −43.139 1.00 20.89 RNA2 C ATOM 3007 O3* G D 1062 −6.428 −13.905 −42.431 1.00 31.67 RNA2 O ATOM 3008 C2* G D 1062 −4.625 −14.707 −43.894 1.00 23.56 RNA2 C ATOM 3009 O2* G D 1062 −5.589 −15.567 −44.466 1.00 18.76 RNA2 O ATOM 3010 C1* G D 1062 −3.854 −13.963 −44.988 1.00 16.90 RNA2 C ATOM 3011 N9 G D 1062 −2.473 −13.642 −44.620 1.00 13.03 RNA2 N ATOM 3012 C8 G D 1062 −1.919 −12.387 −44.523 1.00 19.49 RNA2 C ATOM 3013 N7 G D 1062 −0.660 −12.404 −44.173 1.00 13.70 RNA2 N ATOM 3014 C5 G D 1062 −0.362 −13.749 −44.024 1.00 14.04 RNA2 C ATOM 3015 C6 G D 1062 0.850 −14.379 −43.651 1.00 24.18 RNA2 C ATOM 3016 O6 G D 1062 1.933 −13.852 −43.356 1.00 29.04 RNA2 O ATOM 3017 N1 G D 1062 0.723 −15.765 −43.634 1.00 22.87 RNA2 N ATOM 3018 C2 G D 1062 −0.427 −16.456 −43.927 1.00 30.15 RNA2 C ATOM 3019 N2 G D 1062 −0.349 −17.795 −43.849 1.00 24.93 RNA2 N ATOM 3020 N3 G D 1062 −1.570 −15.878 −44.269 1.00 30.88 RNA2 N ATOM 3021 C4 G D 1062 −1.466 −14.531 −44.300 1.00 16.88 RNA2 C ATOM 3022 P G D 1063 −6.322 −14.242 −40.874 1.00 28.41 RNA2 P ATOM 3023 O1P G D 1063 −5.463 −13.199 −40.266 1.00 27.32 RNA2 O ATOM 3024 O2P G D 1063 −7.701 −14.468 −40.367 1.00 29.73 RNA2 O ATOM 3025 O5* G D 1063 −5.523 −15.617 −40.821 1.00 30.17 RNA2 O ATOM 3026 C5* G D 1063 −6.184 −16.864 −41.087 1.00 24.95 RNA2 C ATOM 3027 C4* G D 1063 −5.241 −18.011 −40.832 1.00 20.87 RNA2 C ATOM 3028 O4* G D 1063 −4.075 −17.850 −41.677 1.00 27.19 RNA2 O ATOM 3029 C3* G D 1063 −4.659 −18.092 −39.434 1.00 26.89 RNA2 C ATOM 3030 O3* G D 1063 −5.539 −18.706 −38.508 1.00 40.50 RNA2 O ATOM 3031 C2* G D 1063 −3.373 −18.869 −39.659 1.00 23.40 RNA2 C ATOM 3032 O2* G D 1063 −3.601 −20.256 −39.810 1.00 29.18 RNA2 O ATOM 3033 C1* G D 1063 −2.919 −18.297 −40.994 1.00 21.30 RNA2 C ATOM 3034 N9 G D 1063 −2.022 −17.158 −40.820 1.00 18.48 RNA2 N ATOM 3035 C8 G D 1063 −2.309 −15.827 −41.016 1.00 13.94 RNA2 C ATOM 3036 N7 G D 1063 −1.283 −15.044 −40.798 1.00 19.66 RNA2 N ATOM 3037 C5 G D 1063 −0.260 −15.909 −40.428 1.00 17.05 RNA2 C ATOM 3038 C6 G D 1063 1.093 −15.646 −40.066 1.00 24.81 RNA2 C ATOM 3039 O6 G D 1063 1.680 −14.559 −39.999 1.00 27.63 RNA2 O ATOM 3040 N1 G D 1063 1.776 −16.819 −39.756 1.00 29.06 RNA2 N ATOM 3041 C2 G D 1063 1.234 −18.080 −39.781 1.00 24.76 RNA2 C ATOM 3042 N2 G D 1063 2.051 −19.081 −39.433 1.00 26.32 RNA2 N ATOM 3043 N3 G D 1063 −0.018 −18.340 −40.119 1.00 25.89 RNA2 N ATOM 3044 C4 G D 1063 −0.702 −17.217 −40.429 1.00 24.85 RNA2 C ATOM 3045 P C D 1064 −5.606 −18.145 −37.003 1.00 33.12 RNA2 P ATOM 3046 O1P C D 1064 −5.740 −16.669 −37.090 1.00 33.72 RNA2 O ATOM 3047 O2P C D 1064 −6.628 −18.934 −36.261 1.00 34.10 RNA2 O ATOM 3048 O5* C D 1064 −4.159 −18.476 −36.424 1.00 27.13 RNA2 O ATOM 3049 C5* C D 1064 −3.695 −19.826 −36.395 1.00 16.79 RNA2 C ATOM 3050 C4* C D 1064 −2.235 −19.884 −36.032 1.00 25.70 RNA2 C ATOM 3051 O4* C D 1064 −1.436 −19.190 −37.022 1.00 29.89 RNA2 O ATOM 3052 C3* C D 1064 −1.813 −19.250 −34.720 1.00 29.70 RNA2 C ATOM 3053 O3* C D 1064 −2.095 −20.085 −33.611 1.00 37.04 RNA2 O ATOM 3054 C2* C D 1064 −0.315 −19.047 −34.923 1.00 30.06 RNA2 C ATOM 3055 O2* C D 1064 0.445 −20.216 −34.696 1.00 28.38 RNA2 O ATOM 3056 C1* C D 1064 −0.251 −18.704 −36.409 1.00 30.33 RNA2 C ATOM 3057 N1 C D 1064 −0.140 −17.251 −36.627 1.00 20.71 RNA2 N ATOM 3058 C2 C D 1064 1.114 −16.655 −36.474 1.00 24.44 RNA2 C ATOM 3059 O2 C D 1064 2.086 −17.365 −36.175 1.00 30.49 RNA2 O ATOM 3060 N3 C D 1064 1.237 −15.325 −36.654 1.00 26.69 RNA2 N ATOM 3061 C4 C D 1064 0.170 −14.591 −36.976 1.00 20.50 RNA2 C ATOM 3062 N4 C D 1064 0.347 −13.279 −37.141 1.00 22.60 RNA2 N ATOM 3063 C5 C D 1064 −1.120 −15.169 −37.143 1.00 10.11 RNA2 C ATOM 3064 C6 C D 1064 −1.229 −16.492 −36.962 1.00 23.85 RNA2 C ATOM 3065 P U D 1065 −2.513 −19.420 −32.214 1.00 35.56 RNA2 P ATOM 3066 O1P U D 1065 −3.615 −18.460 −32.467 1.00 26.06 RNA2 O ATOM 3067 O2P U D 1065 −2.716 −20.527 −31.248 1.00 43.50 RNA2 O ATOM 3068 O5* U D 1065 −1.209 −18.600 −31.807 1.00 27.70 RNA2 O ATOM 3069 C5* U D 1065 0.044 −19.282 −31.609 1.00 30.92 RNA2 C ATOM 3070 C4* U D 1065 1.168 −18.287 −31.469 1.00 30.67 RNA2 C ATOM 3071 O4* U D 1065 1.332 −17.559 −32.713 1.00 39.57 RNA2 O ATOM 3072 C3* U D 1065 0.951 −17.209 −30.423 1.00 36.18 RNA2 C ATOM 3073 O3* U D 1065 1.285 −17.667 −29.123 1.00 36.24 RNA2 O ATOM 3074 C2* U D 1065 1.843 −16.076 −30.921 1.00 38.21 RNA2 C ATOM 3075 O2* U D 1065 3.207 −16.224 −30.578 1.00 34.14 RNA2 O ATOM 3076 C1* U D 1065 1.692 −16.216 −32.437 1.00 34.96 RNA2 C ATOM 3077 N1 U D 1065 0.645 −15.327 −32.968 1.00 22.93 RNA2 N ATOM 3078 C2 U D 1065 1.028 −14.066 −33.377 1.00 24.04 RNA2 C ATOM 3079 O2 U D 1065 2.187 −13.674 −33.325 1.00 20.47 RNA2 O ATOM 3080 N3 U D 1065 0.008 −13.276 −33.849 1.00 17.91 RNA2 N ATOM 3081 C4 U D 1065 −1.325 −13.612 −33.954 1.00 25.02 RNA2 C ATOM 3082 O4 U D 1065 −2.125 −12.793 −34.424 1.00 30.88 RNA2 O ATOM 3083 C5 U D 1065 −1.640 −14.934 −33.511 1.00 26.71 RNA2 C ATOM 3084 C6 U D 1065 −0.670 −15.727 −33.046 1.00 28.23 RNA2 C ATOM 3085 P U D 1066 0.342 −17.279 −27.876 1.00 35.54 RNA2 P ATOM 3086 O1P U D 1066 −1.089 −17.498 −28.212 1.00 19.51 RNA2 O ATOM 3087 O2P U D 1066 0.927 −17.960 −26.692 1.00 43.24 RNA2 O ATOM 3088 O5* U D 1066 0.552 −15.708 −27.728 1.00 32.79 RNA2 O ATOM 3089 C5* U D 1066 1.867 −15.163 −27.509 1.00 39.57 RNA2 C ATOM 3090 C4* U D 1066 1.853 −13.664 −27.695 1.00 41.26 RNA2 C ATOM 3091 O4* U D 1066 1.606 −13.339 −29.088 1.00 50.01 RNA2 O ATOM 3092 C3* U D 1066 0.773 −12.909 −26.935 1.00 46.81 RNA2 C ATOM 3093 O3* U D 1066 1.137 −12.653 −25.587 1.00 47.16 RNA2 O ATOM 3094 C2* U D 1066 0.645 −11.626 −27.743 1.00 45.38 RNA2 C ATOM 3095 O2* U D 1066 1.671 −10.702 −27.422 1.00 47.24 RNA2 O ATOM 3096 C1* U D 1066 0.848 −12.142 −29.168 1.00 44.66 RNA2 C ATOM 3097 N1 U D 1066 −0.437 −12.423 −29.835 1.00 36.02 RNA2 N ATOM 3098 C2 U D 1066 −1.001 −11.401 −30.583 1.00 31.01 RNA2 C ATOM 3099 O2 U D 1066 −0.450 −10.325 −30.752 1.00 24.12 RNA2 O ATOM 3100 N3 U D 1066 −2.231 −11.687 −31.131 1.00 26.04 RNA2 N ATOM 3101 C4 U D 1066 −2.939 −12.872 −31.028 1.00 32.10 RNA2 C ATOM 3102 O4 U D 1066 −4.082 −12.941 −31.501 1.00 32.26 RNA2 O ATOM 3103 C5 U D 1066 −2.276 −13.895 −30.271 1.00 27.27 RNA2 C ATOM 3104 C6 U D 1066 −1.080 −13.644 −29.712 1.00 35.51 RNA2 C ATOM 3105 P A D 1067 0.011 −12.695 −24.442 1.00 41.56 RNA2 P ATOM 3106 O1P A D 1067 −0.869 −13.868 −24.667 1.00 35.90 RNA2 O ATOM 3107 O2P A D 1067 0.710 −12.532 −23.138 1.00 61.37 RNA2 O ATOM 3108 O5* A D 1067 −0.877 −11.403 −24.702 1.00 37.80 RNA2 O ATOM 3109 C5* A D 1067 −2.175 −11.275 −24.099 1.00 33.78 RNA2 C ATOM 3110 C4* A D 1067 −2.689 −9.870 −24.284 1.00 40.27 RNA2 C ATOM 3111 O4* A D 1067 −1.791 −8.952 −23.617 1.00 40.68 RNA2 O ATOM 3112 C3* A D 1067 −2.714 −9.402 −25.727 1.00 40.11 RNA2 C ATOM 3113 O3* A D 1067 −3.918 −9.794 −26.362 1.00 46.79 RNA2 O ATOM 3114 C2* A D 1067 −2.560 −7.892 −25.606 1.00 33.18 RNA2 C ATOM 3115 O2* A D 1067 −3.785 −7.245 −25.315 1.00 34.55 RNA2 O ATOM 3116 C1* A D 1067 −1.637 −7.782 −24.394 1.00 30.38 RNA2 C ATOM 3117 N9 A D 1067 −0.216 −7.636 −24.699 1.00 18.52 RNA2 N ATOM 3118 C8 A D 1067 0.791 −8.539 −24.462 1.00 19.03 RNA2 C ATOM 3119 N7 A D 1067 1.987 −8.090 −24.769 1.00 23.17 RNA2 N ATOM 3120 C5 A D 1067 1.748 −6.814 −25.262 1.00 12.64 RNA2 C ATOM 3121 C6 A D 1067 2.605 −5.811 −25.748 1.00 16.33 RNA2 C ATOM 3122 N6 A D 1067 3.934 −5.945 −25.831 1.00 21.10 RNA2 N ATOM 3123 N1 A D 1067 2.046 −4.651 −26.154 1.00 17.93 RNA2 N ATOM 3124 C2 A D 1067 0.714 −4.518 −26.077 1.00 24.51 RNA2 C ATOM 3125 N3 A D 1067 −0.197 −5.388 −25.642 1.00 23.41 RNA2 N ATOM 3126 C4 A D 1067 0.393 −6.528 −25.240 1.00 22.32 RNA2 C ATOM 3127 P G D 1068 −3.863 −10.352 −27.861 1.00 37.45 RNA2 P ATOM 3128 O1P G D 1068 −2.775 −11.365 −27.915 1.00 32.87 RNA2 O ATOM 3129 O2P G D 1068 −5.247 −10.719 −28.265 1.00 30.61 RNA2 O ATOM 3130 O5* G D 1068 −3.399 −9.084 −28.697 1.00 34.59 RNA2 O ATOM 3131 C5* G D 1068 −4.254 −7.938 −28.794 1.00 32.91 RNA2 C ATOM 3132 C4* G D 1068 −3.550 −6.828 −29.521 1.00 39.65 RNA2 C ATOM 3133 O4* G D 1068 −2.460 −6.334 −28.708 1.00 34.36 RNA2 O ATOM 3134 C3* G D 1068 −2.908 −7.218 −30.840 1.00 41.96 RNA2 C ATOM 3135 O3* G D 1068 −3.874 −7.194 −31.893 1.00 38.73 RNA2 O ATOM 3136 C2* G D 1068 −1.811 −6.168 −30.989 1.00 37.55 RNA2 C ATOM 3137 O2* G D 1068 −2.315 −4.944 −31.487 1.00 54.39 RNA2 O ATOM 3138 C1* G D 1068 −1.382 −5.951 −29.535 1.00 22.83 RNA2 C ATOM 3139 N9 G D 1068 −0.226 −6.739 −29.134 1.00 20.42 RNA2 N ATOM 3140 C8 G D 1068 −0.246 −8.011 −28.616 1.00 22.08 RNA2 C ATOM 3141 N7 G D 1068 0.944 −8.464 −28.328 1.00 22.50 RNA2 N ATOM 3142 C5 G D 1068 1.803 −7.433 −28.683 1.00 10.90 RNA2 C ATOM 3143 C6 G D 1068 3.211 −7.347 −28.595 1.00 18.64 RNA2 C ATOM 3144 O6 G D 1068 4.011 −8.196 −28.176 1.00 32.91 RNA2 O ATOM 3145 N1 G D 1068 3.679 −6.123 −29.060 1.00 12.16 RNA2 N ATOM 3146 C2 G D 1068 2.894 −5.115 −29.547 1.00 13.74 RNA2 C ATOM 3147 N2 G D 1068 3.543 −4.013 −29.960 1.00 20.53 RNA2 N ATOM 3148 N3 G D 1068 1.575 −5.179 −29.629 1.00 16.63 RNA2 N ATOM 3149 C4 G D 1068 1.100 −6.360 −29.184 1.00 16.14 RNA2 C ATOM 3150 P A D 1069 −3.995 −8.447 −32.902 1.00 27.21 RNA2 P ATOM 3151 O1P A D 1069 −4.082 −9.718 −32.124 1.00 34.28 RNA2 O ATOM 3152 O2P A D 1069 −5.070 −8.102 −33.864 1.00 29.02 RNA2 O ATOM 3153 O5* A D 1069 −2.601 −8.445 −33.661 1.00 13.61 RNA2 O ATOM 3154 C5* A D 1069 −2.231 −7.337 −34.472 1.00 12.04 RNA2 C ATOM 3155 C4* A D 1069 −0.867 −7.557 −35.055 1.00 21.87 RNA2 C ATOM 3156 O4* A D 1069 0.149 −7.322 −34.046 1.00 32.63 RNA2 O ATOM 3157 C3* A D 1069 −0.590 −8.954 −35.628 1.00 35.90 RNA2 C ATOM 3158 O3* A D 1069 0.162 −8.819 −36.833 1.00 43.63 RNA2 O ATOM 3159 C2* A D 1069 0.352 −9.560 −34.592 1.00 35.57 RNA2 C ATOM 3160 O2* A D 1069 1.241 −10.526 −35.127 1.00 44.23 RNA2 O ATOM 3161 C1* A D 1069 1.127 −8.311 −34.199 1.00 42.00 RNA2 C ATOM 3162 N9 A D 1069 2.031 −8.358 −33.054 1.00 38.32 RNA2 N ATOM 3163 C8 A D 1069 2.071 −9.207 −31.976 1.00 30.76 RNA2 C ATOM 3164 N7 A D 1069 3.141 −9.059 −31.233 1.00 35.91 RNA2 N ATOM 3165 C5 A D 1069 3.827 −8.017 −31.841 1.00 33.30 RNA2 C ATOM 3166 C6 A D 1069 5.053 −7.392 −31.552 1.00 39.74 RNA2 C ATOM 3167 N6 A D 1069 5.850 −7.751 −30.540 1.00 50.68 RNA2 N ATOM 3168 N1 A D 1069 5.443 −6.375 −32.353 1.00 41.06 RNA2 N ATOM 3169 C2 A D 1069 4.649 −6.022 −33.371 1.00 43.25 RNA2 C ATOM 3170 N3 A D 1069 3.483 −6.540 −33.747 1.00 36.03 RNA2 N ATOM 3171 C4 A D 1069 3.131 −7.548 −32.935 1.00 31.57 RNA2 C ATOM 3172 P A D 1070 −0.353 −9.514 −38.183 1.00 39.29 RNA2 P ATOM 3173 O1P A D 1070 0.847 −9.589 −39.057 1.00 23.58 RNA2 O ATOM 3174 O2P A D 1070 −1.128 −10.747 −37.873 1.00 27.46 RNA2 O ATOM 3175 O5* A D 1070 −1.376 −8.452 −38.783 1.00 32.87 RNA2 O ATOM 3176 C5* A D 1070 −0.906 −7.233 −39.388 1.00 32.49 RNA2 C ATOM 3177 C4* A D 1070 −2.018 −6.594 −40.179 1.00 35.94 RNA2 C ATOM 3178 O4* A D 1070 −3.134 −6.304 −39.296 1.00 34.73 RNA2 O ATOM 3179 C3* A D 1070 −1.665 −5.292 −40.885 1.00 39.27 RNA2 C ATOM 3180 O3* A D 1070 −2.329 −5.275 −42.147 1.00 42.75 RNA2 O ATOM 3181 C2* A D 1070 −2.248 −4.225 −39.960 1.00 39.48 RNA2 C ATOM 3182 O2* A D 1070 −2.656 −3.052 −40.635 1.00 46.91 RNA2 O ATOM 3183 C1* A D 1070 −3.468 −4.935 −39.379 1.00 38.47 RNA2 C ATOM 3184 N9 A D 1070 −3.821 −4.467 −38.038 1.00 42.60 RNA2 N ATOM 3185 C8 A D 1070 −3.112 −4.646 −36.878 1.00 43.81 RNA2 C ATOM 3186 N7 A D 1070 −3.690 −4.133 −35.822 1.00 45.93 RNA2 N ATOM 3187 C5 A D 1070 −4.854 −3.570 −36.318 1.00 44.50 RNA2 C ATOM 3188 C6 A D 1070 −5.898 −2.873 −35.697 1.00 50.91 RNA2 C ATOM 3189 N6 A D 1070 −5.936 −2.617 −34.390 1.00 62.29 RNA2 N ATOM 3190 N1 A D 1070 −6.915 −2.441 −36.474 1.00 49.05 RNA2 N ATOM 3191 C2 A D 1070 −6.870 −2.698 −37.783 1.00 37.67 RNA2 C ATOM 3192 N3 A D 1070 −5.940 −3.344 −38.485 1.00 40.26 RNA2 N ATOM 3193 C4 A D 1070 −4.946 −3.761 −37.683 1.00 42.22 RNA2 C ATOM 3194 P G D 1071 −1.684 −4.476 −43.382 1.00 30.55 RNA2 P ATOM 3195 O1P G D 1071 −2.623 −4.642 −44.520 1.00 33.24 RNA2 O ATOM 3196 O2P G D 1071 −1.310 −3.114 −42.932 1.00 42.96 RNA2 O ATOM 3197 O5* G D 1071 −0.331 −5.246 −43.697 1.00 21.65 RNA2 O ATOM 3198 C5* G D 1071 −0.333 −6.592 −44.214 1.00 29.38 RNA2 C ATOM 3199 C4* G D 1071 1.026 −6.907 −44.779 1.00 23.80 RNA2 C ATOM 3200 O4* G D 1071 1.238 −6.061 −45.928 1.00 28.20 RNA2 O ATOM 3201 C3* G D 1071 2.141 −6.557 −43.811 1.00 30.81 RNA2 C ATOM 3202 O3* G D 1071 2.441 −7.666 −42.979 1.00 41.31 RNA2 O ATOM 3203 C2* G D 1071 3.288 −6.132 −44.719 1.00 22.22 RNA2 C ATOM 3204 O2* G D 1071 4.080 −7.199 −45.191 1.00 28.60 RNA2 O ATOM 3205 C1* G D 1071 2.532 −5.498 −45.883 1.00 21.88 RNA2 C ATOM 3206 N9 G D 1071 2.369 −4.053 −45.773 1.00 20.68 RNA2 N ATOM 3207 C8 G D 1071 1.186 −3.366 −45.636 1.00 17.70 RNA2 C ATOM 3208 N7 G D 1071 1.347 −2.072 −45.623 1.00 24.21 RNA2 N ATOM 3209 C5 G D 1071 2.716 −1.895 −45.742 1.00 13.42 RNA2 C ATOM 3210 C6 G D 1071 3.478 −0.710 −45.794 1.00 24.45 RNA2 C ATOM 3211 O6 G D 1071 3.078 0.460 −45.758 1.00 34.15 RNA2 O ATOM 3212 N1 G D 1071 4.841 −0.981 −45.904 1.00 15.33 RNA2 N ATOM 3213 C2 G D 1071 5.395 −2.241 −45.961 1.00 23.28 RNA2 C ATOM 3214 N2 G D 1071 6.734 −2.306 −46.052 1.00 12.46 RNA2 N ATOM 3215 N3 G D 1071 4.686 −3.356 −45.925 1.00 19.68 RNA2 N ATOM 3216 C4 G D 1071 3.363 −3.109 −45.817 1.00 12.68 RNA2 C ATOM 3217 P C D 1072 2.695 −7.430 −41.419 1.00 33.36 RNA2 P ATOM 3218 O1P C D 1072 1.653 −6.490 −40.920 1.00 33.81 RNA2 O ATOM 3219 O2P C D 1072 2.864 −8.759 −40.777 1.00 35.75 RNA2 O ATOM 3220 O5* C D 1072 4.090 −6.677 −41.393 1.00 20.85 RNA2 O ATOM 3221 C5* C D 1072 5.294 −7.370 −41.724 1.00 18.04 RNA2 C ATOM 3222 C4* C D 1072 6.458 −6.420 −41.676 1.00 27.13 RNA2 C ATOM 3223 O4* C D 1072 6.309 −5.437 −42.729 1.00 37.39 RNA2 O ATOM 3224 C3* C D 1072 6.577 −5.591 −40.408 1.00 33.89 RNA2 C ATOM 3225 O3* C D 1072 7.216 −6.295 −39.352 1.00 27.21 RNA2 O ATOM 3226 C2* C D 1072 7.364 −4.376 −40.882 1.00 36.24 RNA2 C ATOM 3227 O2* C D 1072 8.753 −4.637 −40.967 1.00 40.82 RNA2 O ATOM 3228 C1* C D 1072 6.803 −4.182 −42.291 1.00 32.40 RNA2 C ATOM 3229 N1 C D 1072 5.704 −3.196 −42.347 1.00 21.10 RNA2 N ATOM 3230 C2 C D 1072 6.015 −1.860 −42.594 1.00 22.51 RNA2 C ATOM 3231 O2 C D 1072 7.206 −1.541 −42.755 1.00 32.30 RNA2 O ATOM 3232 N3 C D 1072 5.016 −0.947 −42.647 1.00 18.99 RNA2 N ATOM 3233 C4 C D 1072 3.750 −1.327 −42.456 1.00 23.03 RNA2 C ATOM 3234 N4 C D 1072 2.795 −0.389 −42.506 1.00 21.64 RNA2 N ATOM 3235 C5 C D 1072 3.405 −2.681 −42.204 1.00 18.92 RNA2 C ATOM 3236 C6 C D 1072 4.404 −3.575 −42.160 1.00 22.99 RNA2 C ATOM 3237 P A D 1073 6.502 −6.360 −37.915 1.00 37.37 RNA2 P ATOM 3238 O1P A D 1073 6.300 −4.954 −37.487 1.00 30.80 RNA2 O ATOM 3239 O2P A D 1073 5.328 −7.287 −37.972 1.00 26.29 RNA2 O ATOM 3240 O5* A D 1073 7.614 −6.996 −36.980 1.00 33.33 RNA2 O ATOM 3241 C5* A D 1073 8.842 −6.293 −36.711 1.00 45.87 RNA2 C ATOM 3242 C4* A D 1073 9.614 −7.024 −35.651 1.00 39.23 RNA2 C ATOM 3243 O4* A D 1073 8.804 −7.060 −34.451 1.00 42.33 RNA2 O ATOM 3244 C3* A D 1073 9.847 −8.484 −35.996 1.00 42.31 RNA2 C ATOM 3245 O3* A D 1073 11.022 −8.666 −36.753 1.00 46.57 RNA2 O ATOM 3246 C2* A D 1073 9.902 −9.161 −34.638 1.00 40.15 RNA2 C ATOM 3247 O2* A D 1073 11.169 −9.047 −34.018 1.00 50.42 RNA2 O ATOM 3248 C1* A D 1073 8.866 −8.350 −33.866 1.00 29.91 RNA2 C ATOM 3249 N9 A D 1073 7.532 −8.935 −33.963 1.00 24.96 RNA2 N ATOM 3250 C8 A D 1073 6.453 −8.438 −34.648 1.00 25.01 RNA2 C ATOM 3251 N7 A D 1073 5.373 −9.170 −34.534 1.00 31.09 RNA2 N ATOM 3252 C5 A D 1073 5.770 −10.224 −33.727 1.00 16.48 RNA2 C ATOM 3253 C6 A D 1073 5.085 −11.338 −33.237 1.00 25.59 RNA2 C ATOM 3254 N6 A D 1073 3.804 −11.589 −33.504 1.00 28.23 RNA2 N ATOM 3255 N1 A D 1073 5.765 −12.201 −32.456 1.00 25.23 RNA2 N ATOM 3256 C2 A D 1073 7.053 −11.951 −32.200 1.00 27.30 RNA2 C ATOM 3257 N3 A D 1073 7.811 −10.937 −32.608 1.00 31.09 RNA2 N ATOM 3258 C4 A D 1073 7.099 −10.097 −33.375 1.00 27.01 RNA2 C ATOM 3259 P G D 1074 11.030 −9.753 −37.924 1.00 43.98 RNA2 P ATOM 3260 O1P G D 1074 9.978 −9.343 −38.892 1.00 47.14 RNA2 O ATOM 3261 O2P G D 1074 12.435 −9.917 −38.384 1.00 36.10 RNA2 O ATOM 3262 O5* G D 1074 10.556 −11.084 −37.192 1.00 30.43 RNA2 O ATOM 3263 C5* G D 1074 11.408 −11.715 −36.230 1.00 29.08 RNA2 C ATOM 3264 C4* G D 1074 10.753 −12.951 −35.675 1.00 27.13 RNA2 C ATOM 3265 O4* G D 1074 9.559 −12.586 −34.940 1.00 25.79 RNA2 O ATOM 3266 C3* G D 1074 10.260 −13.964 −36.689 1.00 34.21 RNA2 C ATOM 3267 O3* G D 1074 11.289 −14.803 −37.175 1.00 42.20 RNA2 O ATOM 3268 C2* G D 1074 9.202 −14.730 −35.908 1.00 33.31 RNA2 C ATOM 3269 O2* G D 1074 9.747 −15.738 −35.080 1.00 37.22 RNA2 O ATOM 3270 C1* G D 1074 8.598 −13.621 −35.049 1.00 21.21 RNA2 C ATOM 3271 N9 G D 1074 7.387 −13.070 −35.648 1.00 27.34 RNA2 N ATOM 3272 C8 G D 1074 7.235 −11.852 −36.268 1.00 27.08 RNA2 C ATOM 3273 N7 G D 1074 6.017 −11.640 −36.688 1.00 25.47 RNA2 N ATOM 3274 C5 G D 1074 5.325 −12.787 −36.327 1.00 19.99 RNA2 C ATOM 3275 C6 G D 1074 3.966 −13.130 −36.504 1.00 30.58 RNA2 C ATOM 3276 O6 G D 1074 3.063 −12.460 −37.021 1.00 35.90 RNA2 O ATOM 3277 N1 G D 1074 3.687 −14.396 −35.992 1.00 36.16 RNA2 N ATOM 3278 C2 G D 1074 4.597 −15.219 −35.379 1.00 34.56 RNA2 C ATOM 3279 N2 G D 1074 4.134 −16.400 −34.936 1.00 34.63 RNA2 N ATOM 3280 N3 G D 1074 5.868 −14.906 −35.205 1.00 31.20 RNA2 N ATOM 3281 C4 G D 1074 6.159 −13.683 −35.695 1.00 23.24 RNA2 C ATOM 3282 P C D 1075 11.130 −15.471 −38.624 1.00 45.43 RNA2 P ATOM 3283 O1P C D 1075 10.527 −14.447 −39.520 1.00 54.78 RNA2 O ATOM 3284 O2P C D 1075 12.430 −16.096 −38.995 1.00 41.18 RNA2 O ATOM 3285 O5* C D 1075 10.046 −16.607 −38.379 1.00 33.77 RNA2 O ATOM 3286 C5* C D 1075 10.384 −17.767 −37.609 1.00 31.73 RNA2 C ATOM 3287 C4* C D 1075 9.233 −18.737 −37.587 1.00 31.50 RNA2 C ATOM 3288 O4* C D 1075 8.122 −18.137 −36.879 1.00 31.95 RNA2 O ATOM 3289 C3* C D 1075 8.653 −19.112 −38.940 1.00 34.59 RNA2 C ATOM 3290 O3* C D 1075 9.390 −20.130 −39.596 1.00 42.98 RNA2 O ATOM 3291 C2* C D 1075 7.239 −19.539 −38.581 1.00 30.88 RNA2 C ATOM 3292 O2* C D 1075 7.175 −20.852 −38.064 1.00 24.97 RNA2 O ATOM 3293 C1* C D 1075 6.902 −18.546 −37.472 1.00 31.01 RNA2 C ATOM 3294 N1 C D 1075 6.223 −17.355 −38.013 1.00 26.90 RNA2 N ATOM 3295 C2 C D 1075 4.831 −17.388 −38.173 1.00 32.07 RNA2 C ATOM 3296 O2 C D 1075 4.206 −18.407 −37.825 1.00 31.32 RNA2 O ATOM 3297 N3 C D 1075 4.204 −16.313 −38.700 1.00 31.52 RNA2 N ATOM 3298 C4 C D 1075 4.908 −15.237 −39.059 1.00 24.70 RNA2 C ATOM 3299 N4 C D 1075 4.246 −14.208 −39.592 1.00 23.21 RNA2 N ATOM 3300 C5 C D 1075 6.320 −15.169 −38.892 1.00 20.78 RNA2 C ATOM 3301 C6 C D 1075 6.932 −16.239 −38.370 1.00 26.55 RNA2 C ATOM 3302 P C D 1076 9.458 −20.140 −41.200 1.00 41.54 RNA2 P ATOM 3303 O1P C D 1076 9.719 −18.749 −41.663 1.00 42.90 RNA2 O ATOM 3304 O2P C D 1076 10.363 −21.241 −41.628 1.00 43.49 RNA2 O ATOM 3305 O5* C D 1076 7.973 −20.524 −41.614 1.00 36.12 RNA2 O ATOM 3306 C5* C D 1076 7.448 −21.808 −41.272 1.00 35.93 RNA2 C ATOM 3307 C4* C D 1076 6.024 −21.941 −41.742 1.00 36.70 RNA2 C ATOM 3308 O4* C D 1076 5.179 −21.022 −41.003 1.00 41.67 RNA2 O ATOM 3309 C3* C D 1076 5.735 −21.611 −43.198 1.00 33.47 RNA2 C ATOM 3310 O3* C D 1076 6.076 −22.654 −44.099 1.00 41.74 RNA2 O ATOM 3311 C2* C D 1076 4.240 −21.334 −43.160 1.00 38.53 RNA2 C ATOM 3312 O2* C D 1076 3.483 −22.530 −43.103 1.00 31.60 RNA2 O ATOM 3313 C1* C D 1076 4.107 −20.590 −41.831 1.00 39.34 RNA2 C ATOM 3314 N1 C D 1076 4.199 −19.124 −42.018 1.00 25.11 RNA2 N ATOM 3315 C2 C D 1076 3.048 −18.421 −42.397 1.00 28.28 RNA2 C ATOM 3316 O2 C D 1076 1.978 −19.045 −42.536 1.00 22.07 RNA2 O ATOM 3317 N3 C D 1076 3.127 −17.083 −42.605 1.00 27.17 RNA2 N ATOM 3318 C4 C D 1076 4.293 −16.452 −42.451 1.00 27.03 RNA2 C ATOM 3319 N4 C D 1076 4.330 −15.136 −42.681 1.00 24.90 RNA2 N ATOM 3320 C5 C D 1076 5.475 −17.140 −42.056 1.00 21.98 RNA2 C ATOM 3321 C6 C D 1076 5.384 −18.460 −41.849 1.00 26.59 RNA2 C ATOM 3322 P A D 1077 6.603 −22.281 −45.575 1.00 39.40 RNA2 P ATOM 3323 O1P A D 1077 7.618 −21.198 −45.455 1.00 25.39 RNA2 O ATOM 3324 O2P A D 1077 6.965 −23.549 −46.255 1.00 45.75 RNA2 O ATOM 3325 O5* A D 1077 5.308 −21.688 −46.290 1.00 35.32 RNA2 O ATOM 3326 C5* A D 1077 4.132 −22.496 −46.434 1.00 30.36 RNA2 C ATOM 3327 C4* A D 1077 2.948 −21.659 −46.863 1.00 39.87 RNA2 C ATOM 3328 O4* A D 1077 2.657 −20.660 −45.852 1.00 36.52 RNA2 O ATOM 3329 C3* A D 1077 3.067 −20.856 −48.149 1.00 35.06 RNA2 C ATOM 3330 O3* A D 1077 2.842 −21.640 −49.313 1.00 33.77 RNA2 O ATOM 3331 C2* A D 1077 1.981 −19.801 −47.965 1.00 41.16 RNA2 C ATOM 3332 O2* A D 1077 0.677 −20.271 −48.264 1.00 33.46 RNA2 O ATOM 3333 C1* A D 1077 2.078 −19.520 −46.466 1.00 37.76 RNA2 C ATOM 3334 N9 A D 1077 2.924 −18.352 −46.211 1.00 25.78 RNA2 N ATOM 3335 C8 A D 1077 4.243 −18.300 −45.836 1.00 18.19 RNA2 C ATOM 3336 N7 A D 1077 4.722 −17.081 −45.756 1.00 17.18 RNA2 N ATOM 3337 C5 A D 1077 3.639 −16.275 −46.087 1.00 18.35 RNA2 C ATOM 3338 C6 A D 1077 3.492 −14.874 −46.208 1.00 24.31 RNA2 C ATOM 3339 N6 A D 1077 4.486 −13.996 −46.008 1.00 25.10 RNA2 N ATOM 3340 N1 A D 1077 2.277 −14.401 −46.558 1.00 22.28 RNA2 N ATOM 3341 C2 A D 1077 1.285 −15.278 −46.776 1.00 17.11 RNA2 C ATOM 3342 N3 A D 1077 1.302 −16.604 −46.702 1.00 22.31 RNA2 N ATOM 3343 C4 A D 1077 2.522 −17.044 −46.352 1.00 17.88 RNA2 C ATOM 3344 P U D 1078 3.650 −21.306 −50.662 1.00 27.11 RNA2 P ATOM 3345 O1P U D 1078 5.104 −21.343 −50.374 1.00 20.77 RNA2 O ATOM 3346 O2P U D 1078 3.091 −22.176 −51.728 1.00 43.45 RNA2 O ATOM 3347 O5* U D 1078 3.288 −19.785 −50.981 1.00 30.32 RNA2 O ATOM 3348 C5* U D 1078 1.985 −19.408 −51.478 1.00 30.56 RNA2 C ATOM 3349 C4* U D 1078 1.896 −17.901 −51.631 1.00 32.53 RNA2 C ATOM 3350 O4* U D 1078 2.062 −17.283 −50.329 1.00 27.97 RNA2 O ATOM 3351 C3* U D 1078 2.967 −17.244 −52.497 1.00 36.01 RNA2 C ATOM 3352 O3* U D 1078 2.620 −17.183 −53.871 1.00 42.75 RNA2 O ATOM 3353 C2* U D 1078 2.990 −15.821 −51.961 1.00 36.74 RNA2 C ATOM 3354 O2* U D 1078 1.935 −15.045 −52.493 1.00 40.26 RNA2 O ATOM 3355 C1* U D 1078 2.744 −16.048 −50.472 1.00 35.91 RNA2 C ATOM 3356 N1 U D 1078 4.015 −16.102 −49.729 1.00 25.89 RNA2 N ATOM 3357 C2 U D 1078 4.637 −14.892 −49.423 1.00 35.33 RNA2 C ATOM 3358 O2 U D 1078 4.167 −13.800 −49.730 1.00 30.93 RNA2 O ATOM 3359 N3 U D 1078 5.830 −15.008 −48.749 1.00 28.65 RNA2 N ATOM 3360 C4 U D 1078 6.455 −16.177 −48.357 1.00 30.34 RNA2 C ATOM 3361 O4 U D 1078 7.555 −16.119 −47.795 1.00 39.15 RNA2 O ATOM 3362 C5 U D 1078 5.749 −17.376 −48.699 1.00 25.89 RNA2 C ATOM 3363 C6 U D 1078 4.584 −17.300 −49.355 1.00 28.67 RNA2 C ATOM 3364 P C D 1079 2.674 −18.503 −54.775 1.00 37.89 RNA2 P ATOM 3365 O1P C D 1079 2.944 −18.013 −56.153 1.00 39.80 RNA2 O ATOM 3366 O2P C D 1079 3.558 −19.539 −54.176 1.00 37.02 RNA2 O ATOM 3367 O5* C D 1079 1.167 −18.996 −54.704 1.00 15.08 RNA2 O ATOM 3368 C5* C D 1079 0.145 −18.192 −55.288 1.00 23.37 RNA2 C ATOM 3369 C4* C D 1079 −1.208 −18.608 −54.795 1.00 19.59 RNA2 C ATOM 3370 O4* C D 1079 −1.438 −18.079 −53.467 1.00 27.26 RNA2 O ATOM 3371 C3* C D 1079 −2.308 −17.995 −55.628 1.00 31.62 RNA2 C ATOM 3372 O3* C D 1079 −2.525 −18.767 −56.789 1.00 35.58 RNA2 O ATOM 3373 C2* C D 1079 −3.484 −17.941 −54.667 1.00 27.16 RNA2 C ATOM 3374 O2* C D 1079 −4.148 −19.180 −54.551 1.00 30.55 RNA2 O ATOM 3375 C1* C D 1079 −2.774 −17.609 −53.357 1.00 19.20 RNA2 C ATOM 3376 N1 C D 1079 −2.738 −16.155 −53.087 1.00 15.42 RNA2 N ATOM 3377 C2 C D 1079 −3.891 −15.525 −52.594 1.00 14.73 RNA2 C ATOM 3378 O2 C D 1079 −4.922 −16.196 −52.423 1.00 22.43 RNA2 O ATOM 3379 N3 C D 1079 −3.853 −14.203 −52.319 1.00 15.70 RNA2 N ATOM 3380 C4 C D 1079 −2.730 −13.512 −52.513 1.00 19.14 RNA2 C ATOM 3381 N4 C D 1079 −2.733 −12.219 −52.194 1.00 18.52 RNA2 N ATOM 3382 C5 C D 1079 −1.550 −14.119 −53.033 1.00 14.27 RNA2 C ATOM 3383 C6 C D 1079 −1.598 −15.430 −53.303 1.00 9.72 RNA2 C ATOM 3384 P A D 1080 −2.665 −18.025 −58.200 1.00 33.84 RNA2 P ATOM 3385 O1P A D 1080 −1.604 −16.982 −58.302 1.00 29.98 RNA2 O ATOM 3386 O2P A D 1080 −2.762 −19.085 −59.240 1.00 51.18 RNA2 O ATOM 3387 O5* A D 1080 −4.078 −17.315 −58.069 1.00 18.89 RNA2 O ATOM 3388 C5* A D 1080 −5.228 −18.109 −57.802 1.00 23.14 RNA2 C ATOM 3389 C4* A D 1080 −6.362 −17.256 −57.316 1.00 29.15 RNA2 C ATOM 3390 O4* A D 1080 −6.077 −16.724 −55.997 1.00 31.88 RNA2 O ATOM 3391 C3* A D 1080 −6.704 −16.028 −58.131 1.00 27.12 RNA2 C ATOM 3392 O3* A D 1080 −7.427 −16.344 −59.312 1.00 35.45 RNA2 O ATOM 3393 C2* A D 1080 −7.520 −15.221 −57.129 1.00 24.68 RNA2 C ATOM 3394 O2* A D 1080 −8.839 −15.710 −57.002 1.00 23.19 RNA2 O ATOM 3395 C1* A D 1080 −6.774 −15.502 −55.826 1.00 22.08 RNA2 C ATOM 3396 N9 A D 1080 −5.817 −14.431 −55.545 1.00 19.19 RNA2 N ATOM 3397 C8 A D 1080 −4.460 −14.391 −55.773 1.00 21.24 RNA2 C ATOM 3398 N7 A D 1080 −3.911 −13.232 −55.485 1.00 17.04 RNA2 N ATOM 3399 C5 A D 1080 −4.974 −12.465 −55.021 1.00 10.07 RNA2 C ATOM 3400 C6 A D 1080 −5.061 −11.132 −54.578 1.00 15.82 RNA2 C ATOM 3401 N6 A D 1080 −4.019 −10.295 −54.529 1.00 19.09 RNA2 N ATOM 3402 N1 A D 1080 −6.271 −10.680 −54.183 1.00 20.36 RNA2 N ATOM 3403 C2 A D 1080 −7.317 −11.517 −54.229 1.00 15.92 RNA2 C ATOM 3404 N3 A D 1080 −7.362 −12.783 −54.626 1.00 14.17 RNA2 N ATOM 3405 C4 A D 1080 −6.145 −13.200 −55.023 1.00 9.63 RNA2 C ATOM 3406 P U D 1081 −7.413 −15.312 −60.548 1.00 31.28 RNA2 P ATOM 3407 O1P U D 1081 −6.027 −14.791 −60.717 1.00 8.76 RNA2 O ATOM 3408 O2P U D 1081 −8.089 −15.971 −61.696 1.00 35.73 RNA2 O ATOM 3409 O5* U D 1081 −8.356 −14.144 −60.021 1.00 18.56 RNA2 O ATOM 3410 C5* U D 1081 −9.643 −14.457 −59.459 1.00 22.44 RNA2 C ATOM 3411 C4* U D 1081 −10.276 −13.222 −58.867 1.00 34.63 RNA2 C ATOM 3412 O4* U D 1081 −9.471 −12.728 −57.771 1.00 31.00 RNA2 O ATOM 3413 C3* U D 1081 −10.406 −12.045 −59.817 1.00 37.02 RNA2 C ATOM 3414 O3* U D 1081 −11.605 −12.172 −60.569 1.00 43.64 RNA2 O ATOM 3415 C2* U D 1081 −10.429 −10.844 −58.874 1.00 32.75 RNA2 C ATOM 3416 O2* U D 1081 −11.714 −10.603 −58.330 1.00 30.48 RNA2 O ATOM 3417 C1* U D 1081 −9.499 −11.311 −57.756 1.00 21.25 RNA2 C ATOM 3418 N1 U D 1081 −8.115 −10.826 −57.857 1.00 8.85 RNA2 N ATOM 3419 C2 U D 1081 −7.839 −9.537 −57.429 1.00 18.01 RNA2 C ATOM 3420 O2 U D 1081 −8.706 −8.754 −57.039 1.00 20.38 RNA2 O ATOM 3421 N3 U D 1081 −6.515 −9.190 −57.477 1.00 4.56 RNA2 N ATOM 3422 C4 U D 1081 −5.463 −9.977 −57.902 1.00 19.29 RNA2 C ATOM 3423 O4 U D 1081 −4.306 −9.560 −57.785 1.00 17.28 RNA2 O ATOM 3424 C5 U D 1081 −5.838 −11.273 −58.364 1.00 8.37 RNA2 C ATOM 3425 C6 U D 1081 −7.118 −11.640 −58.331 1.00 9.01 RNA2 C ATOM 3426 P U D 1082 −11.700 −11.511 −62.026 1.00 37.21 RNA2 P ATOM 3427 O1P U D 1082 −10.555 −11.984 −62.849 1.00 30.04 RNA2 O ATOM 3428 O2P U D 1082 −13.101 −11.726 −62.489 1.00 36.07 RNA2 O ATOM 3429 O5* U D 1082 −11.463 −9.962 −61.755 1.00 48.61 RNA2 O ATOM 3430 C5* U D 1082 −12.470 −9.172 −61.107 1.00 49.13 RNA2 C ATOM 3431 C4* U D 1082 −12.043 −7.729 −61.052 1.00 45.78 RNA2 C ATOM 3432 O4* U D 1082 −11.006 −7.553 −60.054 1.00 41.16 RNA2 O ATOM 3433 C3* U D 1082 −11.417 −7.176 −62.317 1.00 45.00 RNA2 C ATOM 3434 O3* U D 1082 −12.349 −6.822 −63.321 1.00 44.91 RNA2 O ATOM 3435 C2* U D 1082 −10.633 −5.979 −61.801 1.00 41.47 RNA2 C ATOM 3436 O2* U D 1082 −11.449 −4.837 −61.628 1.00 38.13 RNA2 O ATOM 3437 C1* U D 1082 −10.147 −6.497 −60.448 1.00 34.17 RNA2 C ATOM 3438 N1 U D 1082 −8.767 −6.998 −60.524 1.00 21.76 RNA2 N ATOM 3439 C2 U D 1082 −7.752 −6.093 −60.271 1.00 27.58 RNA2 C ATOM 3440 O2 U D 1082 −7.961 −4.925 −59.983 1.00 39.33 RNA2 O ATOM 3441 N3 U D 1082 −6.482 −6.599 −60.370 1.00 17.32 RNA2 N ATOM 3442 C4 U D 1082 −6.125 −7.886 −60.687 1.00 19.81 RNA2 C ATOM 3443 O4 U D 1082 −4.925 −8.184 −60.736 1.00 21.01 RNA2 O ATOM 3444 C5 U D 1082 −7.228 −8.767 −60.933 1.00 16.38 RNA2 C ATOM 3445 C6 U D 1082 −8.483 −8.304 −60.843 1.00 16.69 RNA2 C ATOM 3446 P U D 1083 −11.820 −6.597 −64.817 1.00 43.63 RNA2 P ATOM 3447 O1P U D 1083 −11.131 −7.845 −65.255 1.00 40.26 RNA2 O ATOM 3448 O2P U D 1083 −12.950 −6.055 −65.619 1.00 45.21 RNA2 O ATOM 3449 O5* U D 1083 −10.714 −5.466 −64.618 1.00 33.40 RNA2 O ATOM 3450 C5* U D 1083 −9.461 −5.509 −65.306 1.00 21.92 RNA2 C ATOM 3451 C4* U D 1083 −8.508 −4.519 −64.689 1.00 33.84 RNA2 C ATOM 3452 O4* U D 1083 −7.824 −5.125 −63.563 1.00 30.68 RNA2 O ATOM 3453 C3* U D 1083 −7.392 −4.060 −65.607 1.00 39.61 RNA2 C ATOM 3454 O3* U D 1083 −7.851 −2.983 −66.405 1.00 47.78 RNA2 O ATOM 3455 C2* U D 1083 −6.301 −3.633 −64.635 1.00 38.07 RNA2 C ATOM 3456 O2* U D 1083 −6.517 −2.326 −64.141 1.00 48.19 RNA2 O ATOM 3457 C1* U D 1083 −6.486 −4.647 −63.504 1.00 32.72 RNA2 C ATOM 3458 N1 U D 1083 −5.568 −5.793 −63.608 1.00 23.49 RNA2 N ATOM 3459 C2 U D 1083 −4.251 −5.604 −63.225 1.00 27.40 RNA2 C ATOM 3460 O2 U D 1083 −3.823 −4.541 −62.823 1.00 42.53 RNA2 O ATOM 3461 N3 U D 1083 −3.447 −6.710 −63.335 1.00 31.74 RNA2 N ATOM 3462 C4 U D 1083 −3.809 −7.963 −63.784 1.00 30.45 RNA2 C ATOM 3463 O4 U D 1083 −2.962 −8.863 −63.823 1.00 30.78 RNA2 O ATOM 3464 C5 U D 1083 −5.183 −8.081 −64.168 1.00 19.97 RNA2 C ATOM 3465 C6 U D 1083 −5.995 −7.019 −64.069 1.00 27.83 RNA2 C ATOM 3466 P A D 1084 −7.438 −2.912 −67.949 1.00 45.35 RNA2 P ATOM 3467 O1P A D 1084 −7.390 −4.295 −68.485 1.00 47.07 RNA2 O ATOM 3468 O2P A D 1084 −8.323 −1.906 −68.587 1.00 48.86 RNA2 O ATOM 3469 O5* A D 1084 −5.952 −2.353 −67.903 1.00 30.12 RNA2 O ATOM 3470 C5* A D 1084 −5.051 −2.560 −68.990 1.00 25.41 RNA2 C ATOM 3471 C4* A D 1084 −3.717 −1.960 −68.652 1.00 29.72 RNA2 C ATOM 3472 O4* A D 1084 −3.876 −0.534 −68.496 1.00 39.52 RNA2 O ATOM 3473 C3* A D 1084 −3.174 −2.444 −67.326 1.00 26.49 RNA2 C ATOM 3474 O3* A D 1084 −2.405 −3.601 −67.544 1.00 36.34 RNA2 O ATOM 3475 C2* A D 1084 −2.346 −1.271 −66.828 1.00 33.86 RNA2 C ATOM 3476 O2* A D 1084 −1.043 −1.267 −67.373 1.00 28.54 RNA2 O ATOM 3477 C1* A D 1084 −3.138 −0.086 −67.379 1.00 30.15 RNA2 C ATOM 3478 N9 A D 1084 −4.093 0.522 −66.459 1.00 28.36 RNA2 N ATOM 3479 C8 A D 1084 −5.439 0.258 −66.342 1.00 28.20 RNA2 C ATOM 3480 N7 A D 1084 −6.058 1.041 −65.494 1.00 25.56 RNA2 N ATOM 3481 C5 A D 1084 −5.050 1.861 −65.004 1.00 22.38 RNA2 C ATOM 3482 C6 A D 1084 −5.061 2.922 −64.088 1.00 27.67 RNA2 C ATOM 3483 N6 A D 1084 −6.165 3.359 −63.482 1.00 38.68 RNA2 N ATOM 3484 N1 A D 1084 −3.884 3.530 −63.815 1.00 34.84 RNA2 N ATOM 3485 C2 A D 1084 −2.776 3.091 −64.434 1.00 37.58 RNA2 C ATOM 3486 N3 A D 1084 −2.641 2.106 −65.322 1.00 27.16 RNA2 N ATOM 3487 C4 A D 1084 −3.830 1.530 −65.569 1.00 29.13 RNA2 C ATOM 3488 P A D 1085 −2.533 −4.824 −66.531 1.00 33.05 RNA2 P ATOM 3489 O1P A D 1085 −3.976 −4.945 −66.187 1.00 26.54 RNA2 O ATOM 3490 O2P A D 1085 −1.809 −5.987 −67.103 1.00 37.42 RNA2 O ATOM 3491 O5* A D 1085 −1.708 −4.311 −65.275 1.00 37.64 RNA2 O ATOM 3492 C5* A D 1085 −0.321 −3.983 −65.415 1.00 34.30 RNA2 C ATOM 3493 C4* A D 1085 0.137 −3.193 −64.225 1.00 40.98 RNA2 C ATOM 3494 O4* A D 1085 −0.509 −1.900 −64.217 1.00 45.08 RNA2 O ATOM 3495 C3* A D 1085 −0.209 −3.817 −62.888 1.00 33.48 RNA2 C ATOM 3496 O3* A D 1085 0.816 −4.734 −62.538 1.00 33.50 RNA2 O ATOM 3497 C2* A D 1085 −0.260 −2.614 −61.955 1.00 33.78 RNA2 C ATOM 3498 O2* A D 1085 1.022 −2.252 −61.488 1.00 36.97 RNA2 O ATOM 3499 C1* A D 1085 −0.762 −1.506 −62.885 1.00 29.69 RNA2 C ATOM 3500 N9 A D 1085 −2.183 −1.205 −62.769 1.00 20.61 RNA2 N ATOM 3501 C8 A D 1085 −3.232 −1.910 −63.299 1.00 32.48 RNA2 C ATOM 3502 N7 A D 1085 −4.406 −1.388 −63.038 1.00 31.65 RNA2 N ATOM 3503 C5 A D 1085 −4.110 −0.263 −62.285 1.00 23.98 RNA2 C ATOM 3504 C6 A D 1085 −4.922 0.724 −61.710 1.00 27.87 RNA2 C ATOM 3505 N6 A D 1085 −6.253 0.732 −61.813 1.00 35.25 RNA2 N ATOM 3506 N1 A D 1085 −4.315 1.716 −61.023 1.00 23.17 RNA2 N ATOM 3507 C2 A D 1085 −2.975 1.709 −60.936 1.00 28.66 RNA2 C ATOM 3508 N3 A D 1085 −2.102 0.838 −61.439 1.00 29.00 RNA2 N ATOM 3509 C4 A D 1085 −2.742 −0.137 −62.110 1.00 24.43 RNA2 C ATOM 3510 P A D 1086 0.438 −6.094 −61.782 1.00 32.76 RNA2 P ATOM 3511 O1P A D 1086 −0.961 −6.454 −62.137 1.00 17.94 RNA2 O ATOM 3512 O2P A D 1086 1.532 −7.068 −62.001 1.00 30.14 RNA2 O ATOM 3513 O5* A D 1086 0.451 −5.671 −60.253 1.00 42.21 RNA2 O ATOM 3514 C5* A D 1086 1.644 −5.155 −59.645 1.00 32.88 RNA2 C ATOM 3515 C4* A D 1086 1.288 −4.326 −58.440 1.00 36.41 RNA2 C ATOM 3516 O4* A D 1086 0.612 −3.114 −58.860 1.00 29.39 RNA2 O ATOM 3517 C3* A D 1086 0.303 −4.967 −57.481 1.00 36.90 RNA2 C ATOM 3518 O3* A D 1086 0.922 −5.900 −56.613 1.00 33.24 RNA2 O ATOM 3519 C2* A D 1086 −0.287 −3.768 −56.748 1.00 42.63 RNA2 C ATOM 3520 O2* A D 1086 0.470 −3.347 −55.630 1.00 53.18 RNA2 O ATOM 3521 C1* A D 1086 −0.267 −2.692 −57.839 1.00 38.42 RNA2 C ATOM 3522 N9 A D 1086 −1.590 −2.432 −58.407 1.00 27.17 RNA2 N ATOM 3523 C8 A D 1086 −2.195 −1.210 −58.569 1.00 27.28 RNA2 C ATOM 3524 N7 A D 1086 −3.431 −1.285 −59.001 1.00 32.05 RNA2 N ATOM 3525 C5 A D 1086 −3.644 −2.647 −59.160 1.00 25.72 RNA2 C ATOM 3526 C6 A D 1086 −4.765 −3.385 −59.572 1.00 30.69 RNA2 C ATOM 3527 N6 A D 1086 −5.930 −2.832 −59.910 1.00 37.15 RNA2 N ATOM 3528 N1 A D 1086 −4.650 −4.731 −59.619 1.00 26.67 RNA2 N ATOM 3529 C2 A D 1086 −3.484 −5.284 −59.271 1.00 27.74 RNA2 C ATOM 3530 N3 A D 1086 −2.360 −4.697 −58.860 1.00 32.46 RNA2 N ATOM 3531 C4 A D 1086 −2.510 −3.363 −58.824 1.00 28.26 RNA2 C ATOM 3532 P G D 1087 0.286 −7.364 −56.455 1.00 31.77 RNA2 P ATOM 3533 O1P G D 1087 −0.973 −7.249 −55.682 1.00 28.82 RNA2 O ATOM 3534 O2P G D 1087 0.266 −8.020 −57.788 1.00 46.35 RNA2 O ATOM 3535 O5* G D 1087 1.337 −8.122 −55.545 1.00 32.87 RNA2 O ATOM 3536 C5* G D 1087 2.401 −8.899 −56.109 1.00 29.23 RNA2 C ATOM 3537 C4* G D 1087 3.449 −9.109 −55.061 1.00 33.39 RNA2 C ATOM 3538 O4* G D 1087 4.062 −7.829 −54.802 1.00 39.61 RNA2 O ATOM 3539 C3* G D 1087 2.847 −9.568 −53.742 1.00 26.85 RNA2 C ATOM 3540 O3* G D 1087 2.937 −10.985 −53.689 1.00 26.33 RNA2 O ATOM 3541 C2* G D 1087 3.745 −8.914 −52.696 1.00 29.63 RNA2 C ATOM 3542 O2* G D 1087 4.887 −9.702 −52.418 1.00 30.88 RNA2 O ATOM 3543 C1* G D 1087 4.196 −7.635 −53.412 1.00 31.58 RNA2 C ATOM 3544 N9 G D 1087 3.534 −6.370 −53.099 1.00 24.38 RNA2 N ATOM 3545 C8 G D 1087 2.184 −6.105 −53.015 1.00 13.22 RNA2 C ATOM 3546 N7 G D 1087 1.926 −4.837 −52.821 1.00 6.56 RNA2 N ATOM 3547 C5 G D 1087 3.176 −4.240 −52.743 1.00 11.78 RNA2 C ATOM 3548 C6 G D 1087 3.536 −2.887 −52.546 1.00 26.38 RNA2 C ATOM 3549 O6 G D 1087 2.796 −1.905 −52.394 1.00 28.30 RNA2 O ATOM 3550 N1 G D 1087 4.919 −2.723 −52.537 1.00 19.38 RNA2 N ATOM 3551 C2 G D 1087 5.836 −3.736 −52.697 1.00 26.46 RNA2 C ATOM 3552 N2 G D 1087 7.138 −3.390 −52.661 1.00 19.48 RNA2 N ATOM 3553 N3 G D 1087 5.509 −4.997 −52.881 1.00 20.61 RNA2 N ATOM 3554 C4 G D 1087 4.176 −5.176 −52.894 1.00 16.45 RNA2 C ATOM 3555 P A D 1088 1.639 −11.888 −53.962 1.00 30.91 RNA2 P ATOM 3556 O1P A D 1088 0.713 −11.203 −54.900 1.00 35.03 RNA2 O ATOM 3557 O2P A D 1088 2.152 −13.234 −54.286 1.00 39.93 RNA2 O ATOM 3558 O5* A D 1088 0.937 −11.965 −52.543 1.00 35.70 RNA2 O ATOM 3559 C5* A D 1088 1.728 −12.195 −51.367 1.00 40.71 RNA2 C ATOM 3560 C4* A D 1088 1.473 −11.114 −50.352 1.00 31.86 RNA2 C ATOM 3561 O4* A D 1088 0.051 −11.035 −50.098 1.00 31.43 RNA2 O ATOM 3562 C3* A D 1088 2.134 −11.354 −49.008 1.00 28.62 RNA2 C ATOM 3563 O3* A D 1088 2.454 −10.092 −48.453 1.00 22.01 RNA2 O ATOM 3564 C2* A D 1088 1.032 −12.007 −48.192 1.00 19.87 RNA2 C ATOM 3565 O2* A D 1088 1.196 −11.783 −46.811 1.00 35.87 RNA2 O ATOM 3566 C1* A D 1088 −0.209 −11.301 −48.739 1.00 17.80 RNA2 C ATOM 3567 N9 A D 1088 −1.421 −12.106 −48.687 1.00 8.11 RNA2 N ATOM 3568 C8 A D 1088 −2.654 −11.733 −48.221 1.00 11.14 RNA2 C ATOM 3569 N7 A D 1088 −3.559 −12.675 −48.317 1.00 26.75 RNA2 N ATOM 3570 C5 A D 1088 −2.873 −13.743 −48.883 1.00 15.31 RNA2 C ATOM 3571 C6 A D 1088 −3.272 −15.045 −49.241 1.00 15.70 RNA2 C ATOM 3572 N6 A D 1088 −4.511 −15.516 −49.067 1.00 17.72 RNA2 N ATOM 3573 N1 A D 1088 −2.343 −15.856 −49.789 1.00 9.16 RNA2 N ATOM 3574 C2 A D 1088 −1.099 −15.388 −49.957 1.00 14.79 RNA2 C ATOM 3575 N3 A D 1088 −0.603 −14.189 −49.657 1.00 18.20 RNA2 N ATOM 3576 C4 A D 1088 −1.555 −13.405 −49.117 1.00 14.12 RNA2 C ATOM 3577 P G D 1089 3.501 −9.994 −47.248 1.00 27.70 RNA2 P ATOM 3578 O1P G D 1089 4.147 −11.322 −47.068 1.00 28.27 RNA2 O ATOM 3579 O2P G D 1089 2.776 −9.361 −46.117 1.00 25.52 RNA2 O ATOM 3580 O5* G D 1089 4.606 −8.988 −47.785 1.00 22.53 RNA2 O ATOM 3581 C5* G D 1089 5.471 −9.357 −48.871 1.00 30.86 RNA2 C ATOM 3582 C4* G D 1089 5.959 −8.118 −49.573 1.00 24.73 RNA2 C ATOM 3583 O4* G D 1089 4.810 −7.428 −50.122 1.00 31.53 RNA2 O ATOM 3584 C3* G D 1089 6.676 −7.119 −48.676 1.00 23.96 RNA2 C ATOM 3585 O3* G D 1089 7.692 −6.491 −49.437 1.00 35.59 RNA2 O ATOM 3586 C2* G D 1089 5.581 −6.109 −48.333 1.00 26.26 RNA2 C ATOM 3587 O2* G D 1089 6.055 −4.799 −48.099 1.00 39.73 RNA2 O ATOM 3588 C1* G D 1089 4.742 −6.120 −49.602 1.00 26.61 RNA2 C ATOM 3589 N9 G D 1089 3.339 −5.773 −49.400 1.00 22.30 RNA2 N ATOM 3590 C8 G D 1089 2.265 −6.629 −49.311 1.00 19.61 RNA2 C ATOM 3591 N7 G D 1089 1.123 −6.007 −49.184 1.00 20.16 RNA2 N ATOM 3592 C5 G D 1089 1.468 −4.661 −49.171 1.00 20.55 RNA2 C ATOM 3593 C6 G D 1089 0.653 −3.505 −49.059 1.00 26.65 RNA2 C ATOM 3594 O6 G D 1089 −0.582 −3.435 −48.934 1.00 34.44 RNA2 O ATOM 3595 N1 G D 1089 1.415 −2.339 −49.098 1.00 18.23 RNA2 N ATOM 3596 C2 G D 1089 2.782 −2.292 −49.218 1.00 22.47 RNA2 C ATOM 3597 N2 G D 1089 3.341 −1.065 −49.215 1.00 23.99 RNA2 N ATOM 3598 N3 G D 1089 3.551 −3.365 −49.325 1.00 21.65 RNA2 N ATOM 3599 C4 G D 1089 2.832 −4.504 −49.293 1.00 15.76 RNA2 C ATOM 3600 P U D 1090 9.177 −7.107 −49.459 1.00 46.88 RNA2 P ATOM 3601 O1P U D 1090 9.375 −7.944 −48.246 1.00 47.63 RNA2 O ATOM 3602 O2P U D 1090 9.376 −7.711 −50.800 1.00 46.50 RNA2 O ATOM 3603 O5* U D 1090 10.098 −5.811 −49.333 1.00 47.06 RNA2 O ATOM 3604 C5* U D 1090 11.428 −5.782 −49.876 1.00 48.58 RNA2 C ATOM 3605 C4* U D 1090 12.040 −4.407 −49.703 1.00 55.86 RNA2 C ATOM 3606 O4* U D 1090 11.307 −3.422 −50.482 1.00 58.42 RNA2 O ATOM 3607 C3* U D 1090 12.027 −3.835 −48.296 1.00 57.85 RNA2 C ATOM 3608 O3* U D 1090 13.074 −4.330 −47.488 1.00 54.72 RNA2 O ATOM 3609 C2* U D 1090 12.152 −2.336 −48.538 1.00 56.90 RNA2 C ATOM 3610 O2* U D 1090 13.486 −1.912 −48.750 1.00 55.53 RNA2 O ATOM 3611 C1* U D 1090 11.345 −2.164 −49.823 1.00 47.41 RNA2 C ATOM 3612 N1 U D 1090 9.971 −1.713 −49.552 1.00 39.04 RNA2 N ATOM 3613 C2 U D 1090 9.769 −0.350 −49.369 1.00 41.49 RNA2 C ATOM 3614 O2 U D 1090 10.675 0.475 −49.415 1.00 47.92 RNA2 O ATOM 3615 N3 U D 1090 8.468 0.014 −49.123 1.00 33.29 RNA2 N ATOM 3616 C4 U D 1090 7.371 −0.820 −49.033 1.00 35.37 RNA2 C ATOM 3617 O4 U D 1090 6.255 −0.333 −48.820 1.00 43.33 RNA2 O ATOM 3618 C5 U D 1090 7.660 −2.210 −49.227 1.00 26.33 RNA2 C ATOM 3619 C6 U D 1090 8.916 −2.599 −49.476 1.00 31.79 RNA2 C ATOM 3620 P G D 1091 12.865 −4.400 −45.899 1.00 63.03 RNA2 P ATOM 3621 O1P G D 1091 11.489 −4.915 −45.629 1.00 48.47 RNA2 O ATOM 3622 O2P G D 1091 14.047 −5.119 −45.346 1.00 63.48 RNA2 O ATOM 3623 O5* G D 1091 12.909 −2.874 −45.434 1.00 53.82 RNA2 O ATOM 3624 C5* G D 1091 14.160 −2.173 −45.369 1.00 60.37 RNA2 C ATOM 3625 C4* G D 1091 13.939 −0.687 −45.231 1.00 57.35 RNA2 C ATOM 3626 O4* G D 1091 13.057 −0.232 −46.291 1.00 51.52 RNA2 O ATOM 3627 C3* G D 1091 13.275 −0.168 −43.964 1.00 64.14 RNA2 C ATOM 3628 O3* G D 1091 14.165 −0.050 −42.851 1.00 71.95 RNA2 O ATOM 3629 C2* G D 1091 12.766 1.197 −44.414 1.00 59.80 RNA2 C ATOM 3630 O2* G D 1091 13.774 2.190 −44.402 1.00 67.83 RNA2 O ATOM 3631 C1* G D 1091 12.345 0.913 −45.854 1.00 48.17 RNA2 C ATOM 3632 N9 G D 1091 10.912 0.647 −45.911 1.00 35.24 RNA2 N ATOM 3633 C8 G D 1091 10.281 −0.571 −45.991 1.00 35.20 RNA2 C ATOM 3634 N7 G D 1091 8.979 −0.474 −45.954 1.00 29.59 RNA2 N ATOM 3635 C5 G D 1091 8.739 0.890 −45.858 1.00 21.43 RNA2 C ATOM 3636 C6 G D 1091 7.518 1.604 −45.771 1.00 32.33 RNA2 C ATOM 3637 O6 G D 1091 6.364 1.159 −45.749 1.00 43.19 RNA2 O ATOM 3638 N1 G D 1091 7.731 2.976 −45.699 1.00 28.62 RNA2 N ATOM 3639 C2 G D 1091 8.961 3.582 −45.701 1.00 39.37 RNA2 C ATOM 3640 N2 G D 1091 8.965 4.920 −45.626 1.00 34.96 RNA2 N ATOM 3641 N3 G D 1091 10.107 2.925 −45.772 1.00 32.50 RNA2 N ATOM 3642 C4 G D 1091 9.920 1.594 −45.848 1.00 25.53 RNA2 C ATOM 3643 P C D 1092 13.560 0.093 −41.358 1.00 80.57 RNA2 P ATOM 3644 O1P C D 1092 12.499 −0.941 −41.171 1.00 72.16 RNA2 O ATOM 3645 O2P C D 1092 14.702 0.146 −40.409 1.00 77.36 RNA2 O ATOM 3646 O5* C D 1092 12.841 1.520 −41.356 1.00 67.00 RNA2 O ATOM 3647 C5* C D 1092 13.608 2.728 −41.517 1.00 47.50 RNA2 C ATOM 3648 C4* C D 1092 12.721 3.950 −41.413 1.00 46.89 RNA2 C ATOM 3649 O4* C D 1092 11.785 3.999 −42.524 1.00 47.64 RNA2 O ATOM 3650 C3* C D 1092 11.825 4.069 −40.193 1.00 48.58 RNA2 C ATOM 3651 O3* C D 1092 12.485 4.523 −39.029 1.00 50.53 RNA2 O ATOM 3652 C2* C D 1092 10.775 5.069 −40.650 1.00 46.94 RNA2 C ATOM 3653 O2* C D 1092 11.196 6.411 −40.524 1.00 56.76 RNA2 O ATOM 3654 C1* C D 1092 10.610 4.694 −42.122 1.00 44.37 RNA2 C ATOM 3655 N1 C D 1092 9.429 3.823 −42.282 1.00 40.91 RNA2 N ATOM 3656 C2 C D 1092 8.155 4.415 −42.217 1.00 43.01 RNA2 C ATOM 3657 O2 C D 1092 8.072 5.647 −42.083 1.00 41.14 RNA2 O ATOM 3658 N3 C D 1092 7.056 3.632 −42.298 1.00 33.92 RNA2 N ATOM 3659 C4 C D 1092 7.188 2.312 −42.444 1.00 39.14 RNA2 C ATOM 3660 N4 C D 1092 6.075 1.577 −42.496 1.00 35.85 RNA2 N ATOM 3661 C5 C D 1092 8.469 1.685 −42.538 1.00 31.59 RNA2 C ATOM 3662 C6 C D 1092 9.552 2.471 −42.458 1.00 35.03 RNA2 C ATOM 3663 P G D 1093 11.977 4.012 −37.593 1.00 51.96 RNA2 P ATOM 3664 O1P G D 1093 11.975 2.526 −37.626 1.00 48.41 RNA2 O ATOM 3665 O2P G D 1093 12.764 4.724 −36.553 1.00 64.77 RNA2 O ATOM 3666 O5* G D 1093 10.458 4.492 −37.515 1.00 35.20 RNA2 O ATOM 3667 C5* G D 1093 10.122 5.886 −37.581 1.00 24.69 RNA2 C ATOM 3668 C4* G D 1093 8.630 6.056 −37.704 1.00 29.37 RNA2 C ATOM 3669 O4* G D 1093 8.164 5.435 −38.930 1.00 34.30 RNA2 O ATOM 3670 C3* G D 1093 7.808 5.387 −36.620 1.00 33.91 RNA2 C ATOM 3671 O3* G D 1093 7.738 6.175 −35.452 1.00 53.14 RNA2 O ATOM 3672 C2* G D 1093 6.454 5.194 −37.289 1.00 36.57 RNA2 C ATOM 3673 O2* G D 1093 5.628 6.344 −37.254 1.00 23.38 RNA2 O ATOM 3674 C1* G D 1093 6.871 4.878 −38.726 1.00 33.38 RNA2 C ATOM 3675 N9 G D 1093 6.940 3.436 −38.961 1.00 31.32 RNA2 N ATOM 3676 C8 G D 1093 8.073 2.656 −39.054 1.00 27.97 RNA2 C ATOM 3677 N7 G D 1093 7.812 1.389 −39.243 1.00 30.70 RNA2 N ATOM 3678 C5 G D 1093 6.424 1.326 −39.280 1.00 27.66 RNA2 C ATOM 3679 C6 G D 1093 5.563 0.215 −39.451 1.00 30.04 RNA2 C ATOM 3680 O6 G D 1093 5.866 −0.977 −39.608 1.00 42.76 RNA2 O ATOM 3681 N1 G D 1093 4.222 0.596 −39.422 1.00 21.84 RNA2 N ATOM 3682 C2 G D 1093 3.770 1.881 −39.247 1.00 13.29 RNA2 C ATOM 3683 N2 G D 1093 2.437 2.046 −39.237 1.00 19.33 RNA2 N ATOM 3684 N3 G D 1093 4.564 2.926 −39.091 1.00 16.91 RNA2 N ATOM 3685 C4 G D 1093 5.869 2.579 −39.115 1.00 23.30 RNA2 C ATOM 3686 P U D 1094 7.627 5.455 −34.022 1.00 46.64 RNA2 P ATOM 3687 O1P U D 1094 8.556 4.303 −34.026 1.00 32.38 RNA2 O ATOM 3688 O2P U D 1094 7.774 6.516 −32.989 1.00 56.93 RNA2 O ATOM 3689 O5* U D 1094 6.124 4.934 −33.989 1.00 26.86 RNA2 O ATOM 3690 C5* U D 1094 5.051 5.877 −33.932 1.00 35.20 RNA2 C ATOM 3691 C4* U D 1094 3.735 5.172 −33.742 1.00 45.98 RNA2 C ATOM 3692 O4* U D 1094 3.308 4.545 −34.978 1.00 50.88 RNA2 O ATOM 3693 C3* U D 1094 3.692 4.055 −32.717 1.00 39.85 RNA2 C ATOM 3694 O3* U D 1094 3.600 4.551 −31.387 1.00 48.03 RNA2 O ATOM 3695 C2* U D 1094 2.457 3.270 −33.154 1.00 40.06 RNA2 C ATOM 3696 O2* U D 1094 1.243 3.843 −32.701 1.00 44.52 RNA2 O ATOM 3697 C1* U D 1094 2.527 3.400 −34.678 1.00 45.26 RNA2 C ATOM 3698 N1 U D 1094 3.134 2.217 −35.313 1.00 38.99 RNA2 N ATOM 3699 C2 U D 1094 2.294 1.148 −35.606 1.00 29.79 RNA2 C ATOM 3700 O2 U D 1094 1.083 1.180 −35.422 1.00 31.88 RNA2 O ATOM 3701 N3 U D 1094 2.920 0.043 −36.124 1.00 17.61 RNA2 N ATOM 3702 C4 U D 1094 4.262 −0.105 −36.384 1.00 31.42 RNA2 C ATOM 3703 O4 U D 1094 4.679 −1.193 −36.785 1.00 23.03 RNA2 O ATOM 3704 C5 U D 1094 5.062 1.053 −36.093 1.00 28.82 RNA2 C ATOM 3705 C6 U D 1094 4.485 2.147 −35.584 1.00 23.80 RNA2 C ATOM 3706 P A D 1095 4.523 3.907 −30.234 1.00 43.63 RNA2 P ATOM 3707 O1P A D 1095 5.870 3.607 −30.802 1.00 36.61 RNA2 O ATOM 3708 O2P A D 1095 4.416 4.772 −29.033 1.00 64.56 RNA2 O ATOM 3709 O5* A D 1095 3.794 2.535 −29.896 1.00 28.91 RNA2 O ATOM 3710 C5* A D 1095 4.511 1.451 −29.281 1.00 29.01 RNA2 C ATOM 3711 C4* A D 1095 3.579 0.291 −29.049 1.00 27.64 RNA2 C ATOM 3712 O4* A D 1095 2.506 0.741 −28.191 1.00 38.10 RNA2 O ATOM 3713 C3* A D 1095 2.890 −0.216 −30.302 1.00 32.19 RNA2 C ATOM 3714 O3* A D 1095 3.698 −1.186 −30.964 1.00 40.82 RNA2 O ATOM 3715 C2* A D 1095 1.575 −0.772 −29.769 1.00 37.08 RNA2 C ATOM 3716 O2* A D 1095 1.705 −2.077 −29.240 1.00 37.59 RNA2 O ATOM 3717 C1* A D 1095 1.278 0.195 −28.623 1.00 27.61 RNA2 C ATOM 3718 N9 A D 1095 0.397 1.313 −28.956 1.00 26.65 RNA2 N ATOM 3719 C8 A D 1095 0.753 2.601 −29.290 1.00 20.45 RNA2 C ATOM 3720 N7 A D 1095 −0.273 3.404 −29.463 1.00 27.16 RNA2 N ATOM 3721 C5 A D 1095 −1.376 2.587 −29.246 1.00 16.61 RNA2 C ATOM 3722 C6 A D 1095 −2.765 2.837 −29.271 1.00 25.70 RNA2 C ATOM 3723 N6 A D 1095 −3.303 4.034 −29.520 1.00 29.59 RNA2 N ATOM 3724 N1 A D 1095 −3.596 1.799 −29.023 1.00 28.34 RNA2 N ATOM 3725 C2 A D 1095 −3.060 0.599 −28.761 1.00 25.38 RNA2 C ATOM 3726 N3 A D 1095 −1.775 0.240 −28.702 1.00 28.20 RNA2 N ATOM 3727 C4 A D 1095 −0.977 1.292 −28.955 1.00 21.18 RNA2 C ATOM 3728 P A D 1096 3.829 −1.151 −32.569 1.00 34.70 RNA2 P ATOM 3729 O1P A D 1096 4.017 0.256 −32.992 1.00 37.33 RNA2 O ATOM 3730 O2P A D 1096 4.838 −2.167 −32.962 1.00 24.34 RNA2 O ATOM 3731 O5* A D 1096 2.383 −1.617 −33.047 1.00 20.77 RNA2 O ATOM 3732 C5* A D 1096 1.913 −2.930 −32.724 1.00 19.81 RNA2 C ATOM 3733 C4* A D 1096 0.421 −3.021 −32.910 1.00 22.36 RNA2 C ATOM 3734 O4* A D 1096 −0.262 −2.200 −31.934 1.00 23.18 RNA2 O ATOM 3735 C3* A D 1096 −0.119 −2.546 −34.243 1.00 23.44 RNA2 C ATOM 3736 O3* A D 1096 0.028 −3.536 −35.249 1.00 37.12 RNA2 O ATOM 3737 C2* A D 1096 −1.575 −2.237 −33.914 1.00 26.79 RNA2 C ATOM 3738 O2* A D 1096 −2.392 −3.387 −33.889 1.00 29.84 RNA2 O ATOM 3739 C1* A D 1096 −1.458 −1.686 −32.493 1.00 23.36 RNA2 C ATOM 3740 N9 A D 1096 −1.373 −0.228 −32.496 1.00 24.90 RNA2 N ATOM 3741 C8 A D 1096 −0.240 0.551 −32.560 1.00 30.09 RNA2 C ATOM 3742 N7 A D 1096 −0.485 1.838 −32.573 1.00 29.53 RNA2 N ATOM 3743 C5 A D 1096 −1.870 1.914 −32.507 1.00 21.47 RNA2 C ATOM 3744 C6 A D 1096 −2.751 3.005 −32.479 1.00 23.47 RNA2 C ATOM 3745 N6 A D 1096 −2.348 4.281 −32.511 1.00 30.56 RNA2 N ATOM 3746 N1 A D 1096 −4.075 2.741 −32.411 1.00 23.77 RNA2 N ATOM 3747 C2 A D 1096 −4.471 1.460 −32.368 1.00 24.81 RNA2 C ATOM 3748 N3 A D 1096 −3.736 0.349 −32.383 1.00 22.60 RNA2 N ATOM 3749 C4 A D 1096 −2.429 0.650 −32.454 1.00 13.49 RNA2 C ATOM 3750 P C D 1097 0.158 −3.087 −36.781 1.00 28.43 RNA2 P ATOM 3751 O1P C D 1097 1.274 −2.107 −36.889 1.00 25.96 RNA2 O ATOM 3752 O2P C D 1097 0.208 −4.341 −37.575 1.00 39.67 RNA2 O ATOM 3753 O5* C D 1097 −1.234 −2.357 −37.037 1.00 17.23 RNA2 O ATOM 3754 C5* C D 1097 −1.317 −1.078 −37.691 1.00 20.94 RNA2 C ATOM 3755 C4* C D 1097 −2.742 −0.584 −37.636 1.00 29.32 RNA2 C ATOM 3756 O4* C D 1097 −3.029 −0.045 −36.315 1.00 40.36 RNA2 O ATOM 3757 C3* C D 1097 −3.106 0.550 −38.569 1.00 29.37 RNA2 C ATOM 3758 O3* C D 1097 −3.388 0.082 −39.870 1.00 44.58 RNA2 O ATOM 3759 C2* C D 1097 −4.341 1.126 −37.895 1.00 33.92 RNA2 C ATOM 3760 O2* C D 1097 −5.487 0.330 −38.113 1.00 32.32 RNA2 O ATOM 3761 C1* C D 1097 −3.945 1.037 −36.423 1.00 34.10 RNA2 C ATOM 3762 N1 C D 1097 −3.265 2.289 −36.012 1.00 31.44 RNA2 N ATOM 3763 C2 C D 1097 −4.047 3.417 −35.683 1.00 27.94 RNA2 C ATOM 3764 O2 C D 1097 −5.285 3.313 −35.669 1.00 29.21 RNA2 O ATOM 3765 N3 C D 1097 −3.427 4.588 −35.390 1.00 30.98 RNA2 N ATOM 3766 C4 C D 1097 −2.090 4.658 −35.404 1.00 44.95 RNA2 C ATOM 3767 N4 C D 1097 −1.519 5.838 −35.133 1.00 50.64 RNA2 N ATOM 3768 C5 C D 1097 −1.275 3.522 −35.698 1.00 39.09 RNA2 C ATOM 3769 C6 C D 1097 −1.897 2.370 −35.988 1.00 32.35 RNA2 C ATOM 3770 P A D 1098 −2.688 0.785 −41.132 1.00 43.71 RNA2 P ATOM 3771 O1P A D 1098 −1.216 0.563 −41.059 1.00 24.08 RNA2 O ATOM 3772 O2P A D 1098 −3.449 0.343 −42.334 1.00 56.53 RNA2 O ATOM 3773 O5* A D 1098 −2.952 2.337 −40.908 1.00 42.07 RNA2 O ATOM 3774 C5* A D 1098 −4.281 2.842 −40.702 1.00 41.90 RNA2 C ATOM 3775 C4* A D 1098 −4.225 4.295 −40.292 1.00 49.33 RNA2 C ATOM 3776 O4* A D 1098 −3.523 4.414 −39.025 1.00 47.73 RNA2 O ATOM 3777 C3* A D 1098 −3.462 5.219 −41.229 1.00 50.90 RNA2 C ATOM 3778 O3* A D 1098 −4.263 5.645 −42.324 1.00 54.47 RNA2 O ATOM 3779 C2* A D 1098 −3.057 6.363 −40.303 1.00 47.39 RNA2 C ATOM 3780 O2* A D 1098 −4.104 7.289 −40.085 1.00 53.57 RNA2 O ATOM 3781 C1* A D 1098 −2.781 5.621 −38.995 1.00 36.88 RNA2 C ATOM 3782 N9 A D 1098 −1.365 5.289 −38.851 1.00 28.68 RNA2 N ATOM 3783 C8 A D 1098 −0.744 4.078 −39.051 1.00 36.76 RNA2 C ATOM 3784 N7 A D 1098 0.560 4.120 −38.906 1.00 27.01 RNA2 N ATOM 3785 C5 A D 1098 0.813 5.442 −38.575 1.00 32.11 RNA2 C ATOM 3786 C6 A D 1098 2.004 6.136 −38.311 1.00 39.08 RNA2 C ATOM 3787 N6 A D 1098 3.217 5.578 −38.364 1.00 35.79 RNA2 N ATOM 3788 N1 A D 1098 1.907 7.447 −37.996 1.00 37.08 RNA2 N ATOM 3789 C2 A D 1098 0.692 8.013 −37.969 1.00 35.02 RNA2 C ATOM 3790 N3 A D 1098 −0.498 7.470 −38.214 1.00 31.17 RNA2 N ATOM 3791 C4 A D 1098 −0.366 6.169 −38.516 1.00 35.12 RNA2 C ATOM 3792 P G D 1099 −3.598 5.799 −43.783 1.00 57.31 RNA2 P ATOM 3793 O1P G D 1099 −3.062 4.481 −44.215 1.00 60.32 RNA2 O ATOM 3794 O2P G D 1099 −4.589 6.508 −44.640 1.00 60.85 RNA2 O ATOM 3795 O5* G D 1099 −2.349 6.753 −43.537 1.00 41.11 RNA2 O ATOM 3796 C5* G D 1099 −2.543 8.130 −43.169 1.00 50.07 RNA2 C ATOM 3797 C4* G D 1099 −1.216 8.782 −42.888 1.00 47.05 RNA2 C ATOM 3798 O4* G D 1099 −0.626 8.173 −41.712 1.00 46.92 RNA2 O ATOM 3799 C3* G D 1099 −0.174 8.588 −43.975 1.00 54.47 RNA2 C ATOM 3800 O3* G D 1099 −0.305 9.517 −45.036 1.00 55.05 RNA2 O ATOM 3801 C2* G D 1099 1.139 8.720 −43.217 1.00 48.61 RNA2 C ATOM 3802 O2* G D 1099 1.553 10.057 −43.029 1.00 55.32 RNA2 O ATOM 3803 C1* G D 1099 0.781 8.073 −41.878 1.00 40.34 RNA2 C ATOM 3804 N9 G D 1099 1.140 6.659 −41.891 1.00 34.55 RNA2 N ATOM 3805 C8 G D 1099 0.293 5.577 −41.965 1.00 33.18 RNA2 C ATOM 3806 N7 G D 1099 0.926 4.437 −42.047 1.00 37.87 RNA2 N ATOM 3807 C5 G D 1099 2.270 4.787 −42.007 1.00 28.79 RNA2 C ATOM 3808 C6 G D 1099 3.437 3.978 −42.083 1.00 36.73 RNA2 C ATOM 3809 O6 G D 1099 3.519 2.747 −42.210 1.00 46.32 RNA2 O ATOM 3810 N1 G D 1099 4.596 4.744 −42.006 1.00 30.92 RNA2 N ATOM 3811 C2 G D 1099 4.630 6.113 −41.873 1.00 40.47 RNA2 C ATOM 3812 N2 G D 1099 5.847 6.678 −41.812 1.00 23.42 RNA2 N ATOM 3813 N3 G D 1099 3.549 6.876 −41.805 1.00 31.10 RNA2 N ATOM 3814 C4 G D 1099 2.415 6.152 −41.883 1.00 28.17 RNA2 C ATOM 3815 P C D 1100 0.097 9.071 −46.522 1.00 56.56 RNA2 P ATOM 3816 O1P C D 1100 −0.323 7.657 −46.716 1.00 63.87 RNA2 O ATOM 3817 O2P C D 1100 −0.407 10.115 −47.447 1.00 69.36 RNA2 O ATOM 3818 O5* C D 1100 1.688 9.106 −46.507 1.00 39.12 RNA2 O ATOM 3819 C5* C D 1100 2.380 10.337 −46.298 1.00 32.71 RNA2 C ATOM 3820 C4* C D 1100 3.863 10.098 −46.207 1.00 40.37 RNA2 C ATOM 3821 O4* C D 1100 4.155 9.281 −45.042 1.00 45.57 RNA2 O ATOM 3822 C3* C D 1100 4.502 9.335 −47.356 1.00 48.34 RNA2 C ATOM 3823 O3* C D 1100 4.774 10.136 −48.495 1.00 58.69 RNA2 O ATOM 3824 C2* C D 1100 5.771 8.784 −46.718 1.00 42.72 RNA2 C ATOM 3825 O2* C D 1100 6.840 9.707 −46.670 1.00 45.27 RNA2 O ATOM 3826 C1* C D 1100 5.289 8.466 −45.303 1.00 36.28 RNA2 C ATOM 3827 N1 C D 1100 4.897 7.048 −45.234 1.00 33.17 RNA2 N ATOM 3828 C2 C D 1100 5.910 6.083 −45.177 1.00 37.72 RNA2 C ATOM 3829 O2 C D 1100 7.090 6.461 −45.104 1.00 37.78 RNA2 O ATOM 3830 N3 C D 1100 5.582 4.772 −45.201 1.00 34.10 RNA2 N ATOM 3831 C4 C D 1100 4.299 4.409 −45.268 1.00 36.21 RNA2 C ATOM 3832 N4 C D 1100 4.024 3.103 −45.330 1.00 35.52 RNA2 N ATOM 3833 C5 C D 1100 3.242 5.369 −45.283 1.00 32.04 RNA2 C ATOM 3834 C6 C D 1100 3.583 6.665 −45.263 1.00 33.05 RNA2 C ATOM 3835 P U D 1101 4.754 9.460 −49.951 1.00 59.64 RNA2 P ATOM 3836 O1P U D 1101 3.464 8.731 −50.077 1.00 53.79 RNA2 O ATOM 3837 O2P U D 1101 5.117 10.490 −50.957 1.00 73.54 RNA2 O ATOM 3838 O5* U D 1101 5.931 8.390 −49.894 1.00 44.03 RNA2 O ATOM 3839 C5* U D 1101 7.275 8.809 −49.652 1.00 37.19 RNA2 C ATOM 3840 C4* U D 1101 8.197 7.620 −49.625 1.00 44.44 RNA2 C ATOM 3841 O4* U D 1101 7.844 6.748 −48.520 1.00 47.50 RNA2 O ATOM 3842 C3* U D 1101 8.140 6.710 −50.836 1.00 49.53 RNA2 C ATOM 3843 O3* U D 1101 8.892 7.203 −51.930 1.00 55.95 RNA2 O ATOM 3844 C2* U D 1101 8.681 5.396 −50.286 1.00 46.03 RNA2 C ATOM 3845 O2* U D 1101 10.091 5.371 −50.196 1.00 46.23 RNA2 O ATOM 3846 C1* U D 1101 8.097 5.396 −48.875 1.00 41.37 RNA2 C ATOM 3847 N1 U D 1101 6.840 4.627 −48.800 1.00 33.41 RNA2 N ATOM 3848 C2 U D 1101 6.935 3.238 −48.784 1.00 34.44 RNA2 C ATOM 3849 O2 U D 1101 8.011 2.640 −48.812 1.00 33.60 RNA2 O ATOM 3850 N3 U D 1101 5.730 2.575 −48.737 1.00 17.93 RNA2 N ATOM 3851 C4 U D 1101 4.466 3.143 −48.705 1.00 36.01 RNA2 C ATOM 3852 O4 U D 1101 3.465 2.411 −48.702 1.00 25.00 RNA2 O ATOM 3853 C5 U D 1101 4.457 4.577 −48.714 1.00 24.85 RNA2 C ATOM 3854 C6 U D 1101 5.610 5.251 −48.760 1.00 26.88 RNA2 C ATOM 3855 P C D 1102 8.485 6.763 −53.418 1.00 41.89 RNA2 P ATOM 3856 O1P C D 1102 7.001 6.821 −53.510 1.00 43.20 RNA2 O ATOM 3857 O2P C D 1102 9.312 7.542 −54.372 1.00 53.94 RNA2 O ATOM 3858 O5* C D 1102 8.938 5.240 −53.483 1.00 38.14 RNA2 O ATOM 3859 C5* C D 1102 10.317 4.889 −53.306 1.00 37.05 RNA2 C ATOM 3860 C4* C D 1102 10.494 3.390 −53.332 1.00 45.27 RNA2 C ATOM 3861 O4* C D 1102 9.855 2.793 −52.168 1.00 52.28 RNA2 O ATOM 3862 C3* C D 1102 9.872 2.637 −54.498 1.00 54.50 RNA2 C ATOM 3863 O3* C D 1102 10.597 2.706 −55.716 1.00 57.12 RNA2 O ATOM 3864 C2* C D 1102 9.784 1.219 −53.949 1.00 52.66 RNA2 C ATOM 3865 O2* C D 1102 11.017 0.522 −54.000 1.00 56.57 RNA2 O ATOM 3866 C1* C D 1102 9.401 1.482 −52.493 1.00 46.15 RNA2 C ATOM 3867 N1 C D 1102 7.932 1.399 −52.330 1.00 28.20 RNA2 N ATOM 3868 C2 C D 1102 7.331 0.128 −52.307 1.00 22.69 RNA2 C ATOM 3869 O2 C D 1102 8.053 −0.881 −52.366 1.00 35.31 RNA2 O ATOM 3870 N3 C D 1102 5.988 0.028 −52.219 1.00 9.49 RNA2 N ATOM 3871 C4 C D 1102 5.246 1.129 −52.135 1.00 16.43 RNA2 C ATOM 3872 N4 C D 1102 3.922 0.979 −52.052 1.00 15.53 RNA2 N ATOM 3873 C5 C D 1102 5.825 2.433 −52.133 1.00 15.77 RNA2 C ATOM 3874 C6 C D 1102 7.158 2.521 −52.229 1.00 21.76 RNA2 C ATOM 3875 P A D 1103 9.806 2.525 −57.105 1.00 47.42 RNA2 P ATOM 3876 O1P A D 1103 8.514 3.264 −57.011 1.00 38.37 RNA2 O ATOM 3877 O2P A D 1103 10.747 2.818 −58.216 1.00 57.18 RNA2 O ATOM 3878 O5* A D 1103 9.456 0.974 −57.138 1.00 48.19 RNA2 O ATOM 3879 C5* A D 1103 10.493 −0.015 −56.995 1.00 51.39 RNA2 C ATOM 3880 C4* A D 1103 9.894 −1.397 −56.965 1.00 45.50 RNA2 C ATOM 3881 O4* A D 1103 8.978 −1.488 −55.847 1.00 45.01 RNA2 O ATOM 3882 C3* A D 1103 9.053 −1.764 −58.178 1.00 51.96 RNA2 C ATOM 3883 O3* A D 1103 9.867 −2.246 −59.243 1.00 53.83 RNA2 O ATOM 3884 C2* A D 1103 8.095 −2.817 −57.622 1.00 48.46 RNA2 C ATOM 3885 O2* A D 1103 8.635 −4.125 −57.578 1.00 47.52 RNA2 O ATOM 3886 C1* A D 1103 7.882 −2.316 −56.192 1.00 43.28 RNA2 C ATOM 3887 N9 A D 1103 6.646 −1.549 −56.032 1.00 30.89 RNA2 N ATOM 3888 C8 A D 1103 6.477 −0.189 −55.914 1.00 25.35 RNA2 C ATOM 3889 N7 A D 1103 5.222 0.179 −55.797 1.00 26.03 RNA2 N ATOM 3890 C5 A D 1103 4.519 −1.019 −55.836 1.00 17.17 RNA2 C ATOM 3891 C6 A D 1103 3.149 −1.314 −55.759 1.00 19.87 RNA2 C ATOM 3892 N6 A D 1103 2.193 −0.387 −55.623 1.00 16.79 RNA2 N ATOM 3893 N1 A D 1103 2.784 −2.616 −55.828 1.00 26.16 RNA2 N ATOM 3894 C2 A D 1103 3.737 −3.548 −55.965 1.00 23.04 RNA2 C ATOM 3895 N3 A D 1103 5.055 −3.394 −56.049 1.00 30.58 RNA2 N ATOM 3896 C4 A D 1103 5.384 −2.090 −55.977 1.00 28.62 RNA2 C ATOM 3897 P C D 1104 9.699 −1.627 −60.718 1.00 44.57 RNA2 P ATOM 3898 O1P C D 1104 9.942 −0.162 −60.644 1.00 47.15 RNA2 O ATOM 3899 O2P C D 1104 10.506 −2.463 −61.648 1.00 47.11 RNA2 O ATOM 3900 O5* C D 1104 8.160 −1.850 −61.042 1.00 36.26 RNA2 O ATOM 3901 C5* C D 1104 7.642 −3.172 −61.211 1.00 34.08 RNA2 C ATOM 3902 C4* C D 1104 6.144 −3.130 −61.321 1.00 33.02 RNA2 C ATOM 3903 O4* C D 1104 5.569 −2.739 −60.048 1.00 35.45 RNA2 O ATOM 3904 C3* C D 1104 5.595 −2.113 −62.301 1.00 36.26 RNA2 C ATOM 3905 O3* C D 1104 5.633 −2.561 −63.643 1.00 42.96 RNA2 O ATOM 3906 C2* C D 1104 4.183 −1.890 −61.780 1.00 35.20 RNA2 C ATOM 3907 O2* C D 1104 3.297 −2.916 −62.185 1.00 38.85 RNA2 O ATOM 3908 C1* C D 1104 4.408 −1.952 −60.268 1.00 31.46 RNA2 C ATOM 3909 N1 C D 1104 4.636 −0.606 −59.702 1.00 26.13 RNA2 N ATOM 3910 C2 C D 1104 3.528 0.178 −59.334 1.00 24.36 RNA2 C ATOM 3911 O2 C D 1104 2.386 −0.295 −59.447 1.00 21.42 RNA2 O ATOM 3912 N3 C D 1104 3.735 1.428 −58.865 1.00 27.00 RNA2 N ATOM 3913 C4 C D 1104 4.981 1.900 −58.745 1.00 31.66 RNA2 C ATOM 3914 N4 C D 1104 5.140 3.147 −58.292 1.00 37.50 RNA2 N ATOM 3915 C5 C D 1104 6.120 1.119 −59.087 1.00 19.85 RNA2 C ATOM 3916 C6 C D 1104 5.906 −0.115 −59.554 1.00 26.62 RNA2 C ATOM 3917 P C D 1105 5.825 −1.489 −64.826 1.00 42.78 RNA2 P ATOM 3918 O1P C D 1105 6.805 −0.460 −64.381 1.00 36.29 RNA2 O ATOM 3919 O2P C D 1105 6.074 −2.246 −66.084 1.00 51.04 RNA2 O ATOM 3920 O5* C D 1105 4.397 −0.802 −64.932 1.00 18.59 RNA2 O ATOM 3921 C5* C D 1105 3.253 −1.574 −65.316 1.00 29.02 RNA2 C ATOM 3922 C4* C D 1105 2.021 −0.711 −65.320 1.00 36.00 RNA2 C ATOM 3923 O4* C D 1105 1.741 −0.275 −63.965 1.00 45.01 RNA2 O ATOM 3924 C3* C D 1105 2.122 0.582 −66.111 1.00 43.97 RNA2 C ATOM 3925 O3* C D 1105 1.919 0.405 −67.505 1.00 50.57 RNA2 O ATOM 3926 C2* C D 1105 1.060 1.451 −65.447 1.00 42.61 RNA2 C ATOM 3927 O2* C D 1105 −0.259 1.147 −65.873 1.00 33.02 RNA2 O ATOM 3928 C1* C D 1105 1.225 1.048 −63.983 1.00 40.14 RNA2 C ATOM 3929 N1 C D 1105 2.173 1.938 −63.273 1.00 34.85 RNA2 N ATOM 3930 C2 C D 1105 1.704 3.161 −62.765 1.00 30.45 RNA2 C ATOM 3931 O2 C D 1105 0.516 3.473 −62.939 1.00 29.26 RNA2 O ATOM 3932 N3 C D 1105 2.558 3.975 −62.106 1.00 32.19 RNA2 N ATOM 3933 C4 C D 1105 3.836 3.622 −61.956 1.00 39.46 RNA2 C ATOM 3934 N4 C D 1105 4.644 4.466 −61.298 1.00 41.48 RNA2 N ATOM 3935 C5 C D 1105 4.346 2.391 −62.471 1.00 36.86 RNA2 C ATOM 3936 C6 C D 1105 3.488 1.587 −63.114 1.00 34.30 RNA2 C ATOM 3937 P A D 1106 2.559 1.463 −68.538 1.00 47.42 RNA2 P ATOM 3938 O1P A D 1106 3.960 1.743 −68.117 1.00 33.03 RNA2 O ATOM 3939 O2P A D 1106 2.297 0.944 −69.905 1.00 51.03 RNA2 O ATOM 3940 O5* A D 1106 1.674 2.772 −68.323 1.00 38.12 RNA2 O ATOM 3941 C5* A D 1106 0.283 2.777 −68.706 1.00 43.96 RNA2 C ATOM 3942 C4* A D 1106 −0.340 4.129 −68.452 1.00 51.41 RNA2 C ATOM 3943 O4* A D 1106 −0.379 4.381 −67.026 1.00 57.25 RNA2 O ATOM 3944 C3* A D 1106 0.391 5.331 −69.029 1.00 56.31 RNA2 C ATOM 3945 O3* A D 1106 0.086 5.559 −70.396 1.00 55.12 RNA2 O ATOM 3946 C2* A D 1106 −0.076 6.467 −68.126 1.00 56.95 RNA2 C ATOM 3947 O2* A D 1106 −1.351 6.970 −68.478 1.00 57.32 RNA2 O ATOM 3948 C1* A D 1106 −0.169 5.761 −66.776 1.00 49.81 RNA2 C ATOM 3949 N9 A D 1106 1.065 5.896 −66.003 1.00 39.90 RNA2 N ATOM 3950 C8 A D 1106 2.098 4.994 −65.902 1.00 41.00 RNA2 C ATOM 3951 N7 A D 1106 3.070 5.388 −65.116 1.00 41.71 RNA2 N ATOM 3952 C5 A D 1106 2.652 6.635 −64.672 1.00 37.31 RNA2 C ATOM 3953 C6 A D 1106 3.238 7.572 −63.805 1.00 36.44 RNA2 C ATOM 3954 N6 A D 1106 4.419 7.389 −63.208 1.00 40.12 RNA2 N ATOM 3955 N1 A D 1106 2.563 8.720 −63.570 1.00 38.29 RNA2 N ATOM 3956 C2 A D 1106 1.380 8.904 −64.178 1.00 37.00 RNA2 C ATOM 3957 N3 A D 1106 0.726 8.097 −65.014 1.00 37.07 RNA2 N ATOM 3958 C4 A D 1106 1.423 6.965 −65.219 1.00 37.01 RNA2 C ATOM 3959 P G D 1107 1.186 6.251 −71.341 1.00 60.89 RNA2 P ATOM 3960 O1P G D 1107 2.513 5.650 −71.037 1.00 51.64 RNA2 O ATOM 3961 O2P G D 1107 0.665 6.218 −72.732 1.00 66.72 RNA2 O ATOM 3962 O5* G D 1107 1.226 7.763 −70.838 1.00 59.43 RNA2 O ATOM 3963 C5* G D 1107 0.098 8.639 −71.043 1.00 70.93 RNA2 C ATOM 3964 C4* G D 1107 0.341 9.984 −70.392 1.00 70.62 RNA2 C ATOM 3965 O4* G D 1107 0.347 9.841 −68.945 1.00 70.80 RNA2 O ATOM 3966 C3* G D 1107 1.673 10.648 −70.701 1.00 69.85 RNA2 C ATOM 3967 O3* G D 1107 1.703 11.337 −71.937 1.00 68.76 RNA2 O ATOM 3968 C2* G D 1107 1.852 11.589 −69.519 1.00 71.85 RNA2 C ATOM 3969 O2* G D 1107 1.134 12.799 −69.666 1.00 74.63 RNA2 O ATOM 3970 C1* G D 1107 1.278 10.751 −68.377 1.00 66.31 RNA2 C ATOM 3971 N9 G D 1107 2.356 9.990 −67.753 1.00 61.03 RNA2 N ATOM 3972 C8 G D 1107 2.765 8.710 −68.056 1.00 64.56 RNA2 C ATOM 3973 N7 G D 1107 3.811 8.330 −67.371 1.00 62.08 RNA2 N ATOM 3974 C5 G D 1107 4.100 9.417 −66.555 1.00 59.12 RNA2 C ATOM 3975 C6 G D 1107 5.134 9.600 −65.598 1.00 54.80 RNA2 C ATOM 3976 O6 G D 1107 6.035 8.812 −65.270 1.00 51.34 RNA2 O ATOM 3977 N1 G D 1107 5.056 10.854 −65.001 1.00 50.79 RNA2 N ATOM 3978 C2 G D 1107 4.109 11.810 −65.287 1.00 54.33 RNA2 C ATOM 3979 N2 G D 1107 4.199 12.959 −64.606 1.00 51.64 RNA2 N ATOM 3980 N3 G D 1107 3.146 11.653 −66.176 1.00 49.03 RNA2 N ATOM 3981 C4 G D 1107 3.201 10.443 −66.769 1.00 58.09 RNA2 C ATOM 3982 P C D 1108 3.118 11.599 −72.654 1.00 71.56 RNA2 P ATOM 3983 O1P C D 1108 3.923 10.353 −72.579 1.00 60.79 RNA2 O ATOM 3984 O2P C D 1108 2.828 12.209 −73.977 1.00 78.78 RNA2 O ATOM 3985 O5* C D 1108 3.837 12.677 −71.723 1.00 69.28 RNA2 O ATOM 3986 C5* C D 1108 3.274 13.992 −71.536 1.00 65.61 RNA2 C ATOM 3987 C4* C D 1108 4.139 14.809 −70.605 1.00 60.04 RNA2 C ATOM 3988 O4* C D 1108 4.193 14.171 −69.304 1.00 61.74 RNA2 O ATOM 3989 C3* C D 1108 5.598 14.965 −71.001 1.00 60.53 RNA2 C ATOM 3990 O3* C D 1108 5.901 15.783 −72.134 1.00 66.71 RNA2 O ATOM 3991 C2* C D 1108 6.282 15.272 −69.677 1.00 63.96 RNA2 C ATOM 3992 O2* C D 1108 6.155 16.631 −69.306 1.00 69.72 RNA2 O ATOM 3993 C1* C D 1108 5.457 14.420 −68.706 1.00 64.54 RNA2 C ATOM 3994 N1 C D 1108 6.098 13.130 −68.372 1.00 61.20 RNA2 N ATOM 3995 C2 C D 1108 7.127 13.116 −67.417 1.00 59.89 RNA2 C ATOM 3996 O2 C D 1108 7.454 14.179 −66.867 1.00 54.39 RNA2 O ATOM 3997 N3 C D 1108 7.739 11.946 −67.119 1.00 60.31 RNA2 N ATOM 3998 C4 C D 1108 7.359 10.821 −67.728 1.00 62.68 RNA2 C ATOM 3999 N4 C D 1108 7.999 9.689 −67.411 1.00 63.03 RNA2 N ATOM 4000 C5 C D 1108 6.308 10.803 −68.693 1.00 64.65 RNA2 C ATOM 4001 C6 C D 1108 5.711 11.968 −68.982 1.00 64.25 RNA2 C TER 4002 C D 1108 HETATM 4003 CD CD 201 4.250 −2.291 −5.735 0.91 77.47 CD HETATM 4004 CD CD 202 5.716 1.827 1.431 0.91 32.35 CD HETATM 4005 O HOH 205 7.540 −4.792 −0.436 1.00 19.29 O HETATM 4006 O HOH 209 8.097 9.026 −9.315 1.00 27.99 O HETATM 4007 MG MG 210 7.174 1.073 −14.750 1.00 31.99 MG HETATM 4008 CD CD 211 3.380 6.488 −27.905 0.91 47.98 CD HETATM 4009 O HOH 213 −0.304 4.175 −0.867 1.00 38.63 O HETATM 4010 MG MG 214 −17.505 21.323 11.148 1.00 36.28 MG HETATM 4011 MG MG 215 −1.702 7.910 −11.196 1.00 23.07 MG HETATM 4012 O HOH 216 −3.510 9.209 −16.056 1.00 43.93 O HETATM 4013 O HOH 217 −4.416 −0.858 −2.563 1.00 53.29 O HETATM 4014 O HOH 218 6.288 −5.327 −3.385 1.00 23.44 O HETATM 4015 O HOH 221 −1.778 1.682 −3.132 1.00 35.80 O HETATM 4016 O HOH 222 −6.849 10.117 −5.442 1.00 24.81 O HETATM 4017 MG MG 223 14.749 −5.902 12.250 1.00 36.97 MG HETATM 4018 MG MG 225 19.765 −8.266 10.030 1.00 41.29 MG HETATM 4019 MG MG 226 4.983 5.583 −14.224 1.00 17.24 MG HETATM 4020 HG HG 227 10.163 10.934 −4.731 0.10 21.14 HG HETATM 4021 MG MG 228 0.368 −4.197 15.065 1.00 49.67 MG HETATM 4022 HG HG 230 −4.955 2.266 −15.287 0.41 65.01 HG HETATM 4023 O HOH 232 17.184 −8.123 12.078 1.00 46.90 O HETATM 4024 O HOH 233 5.132 −9.156 11.493 1.00 39.77 O HETATM 4025 O HOH 235 −2.182 2.520 −0.424 1.00 32.75 O HETATM 4026 O HOH 236 3.337 3.950 −2.832 1.00 22.74 O HETATM 4027 O HOH 237 −0.294 3.992 −4.949 1.00 41.19 O HETATM 4028 O HOH 238 3.987 7.706 −7.271 1.00 22.33 O HETATM 4029 O HOH 239 −2.682 1.061 −25.220 1.00 28.52 O HETATM 4030 O HOH 241 −0.901 −1.716 11.637 1.00 34.24 O HETATM 4031 O HOH 243 13.905 −12.456 1.182 1.00 61.18 O HETATM 4032 O HOH 244 −6.595 6.151 4.226 1.00 33.67 O HETATM 4033 O HOH 245 −10.614 11.084 18.691 1.00 47.29 O HETATM 4034 O HOH 246 2.153 6.645 −5.263 1.00 42.17 O HETATM 4035 O HOH 254 1.596 7.517 −28.596 1.00 20.43 O HETATM 4036 O HOH 255 5.496 5.982 −27.129 1.00 15.56 O HETATM 4037 O HOH 256 5.082 7.342 −29.082 1.00 15.30 O HETATM 4038 MG MG 257 4.272 8.284 −11.053 1.00 18.63 MG HETATM 4039 O HOH 258 5.759 9.095 −9.332 1.00 22.95 O HETATM 4040 O HOH 259 5.439 8.750 −13.001 1.00 29.22 O HETATM 4041 O HOH 260 3.112 6.893 −9.834 1.00 15.63 O HETATM 4042 O HOH 261 2.565 9.752 −11.319 1.00 21.45 O HETATM 4043 O HOH 262 2.003 −1.889 −6.293 1.00 39.08 O HETATM 4044 O HOH 263 6.523 −2.887 −3.470 1.00 31.47 O HETATM 4045 O HOH 264 5.691 −4.152 −6.413 1.00 49.36 O HETATM 4046 O HOH 265 13.164 −1.037 −13.541 1.00 53.81 O HETATM 4047 O HOH 266 1.658 −4.440 −6.534 1.00 54.55 O HETATM 4048 O HOH 267 4.147 −0.985 −10.097 1.00 21.21 O HETATM 4049 O HOH 268 7.729 0.998 −17.041 1.00 32.76 O HETATM 4050 O HOH 269 9.473 0.412 −15.439 1.00 22.86 O HETATM 4051 O HOH 270 5.281 1.436 −15.928 1.00 30.01 O HETATM 4052 O HOH 271 5.086 −1.392 −12.878 1.00 29.98 O HETATM 4053 O HOH 272 5.284 18.973 −15.526 1.00 29.56 O HETATM 4054 MG MG 273 5.268 8.632 9.371 1.00 35.80 MG HETATM 4055 O HOH 274 4.009 8.265 7.258 1.00 21.81 O HETATM 4056 O HOH 275 6.536 8.905 7.475 1.00 34.86 O HETATM 4057 O HOH 276 3.058 8.060 9.657 1.00 31.13 O HETATM 4058 O HOH 277 5.081 6.362 8.463 1.00 31.02 O HETATM 4059 O HOH 278 3.600 10.499 8.517 1.00 50.03 O HETATM 4060 CD CD 302 0.011 −4.071 −53.380 0.91 31.52 CD HETATM 4061 O HOH 305 1.845 2.702 −51.597 1.00 14.19 O HETATM 4062 CD CD 311 4.100 −9.327 −24.111 0.91 76.29 CD HETATM 4063 O HOH 313 −1.010 −7.500 −47.833 1.00 40.72 O HETATM 4064 MG MG 318 1.219 3.097 −48.942 1.00 17.48 MG HETATM 4065 O HOH 322 −10.157 −13.890 −44.431 1.00 41.81 O HETATM 4066 MG MG 326 2.778 −7.878 −38.005 1.00 11.66 MG HETATM 4067 O HOH 327 9.652 −2.170 −38.994 1.00 44.35 O HETATM 4068 HG HG 332 −7.089 −5.545 −35.006 0.60 82.38 HG HETATM 4069 O HOH 333 1.493 −12.458 −57.479 1.00 39.19 O HETATM 4070 O HOH 335 −4.211 7.242 −62.792 1.00 49.93 O HETATM 4071 O HOH 336 −7.759 −5.212 −49.585 1.00 35.75 O HETATM 4072 O HOH 338 −3.953 −6.679 −45.543 1.00 38.41 O HETATM 4073 O HOH 339 0.508 −10.010 −44.801 1.00 28.38 O HETATM 4074 O HOH 340 −8.610 1.401 −65.472 1.00 31.42 O HETATM 4075 O HOH 343 5.058 −10.891 −43.391 1.00 29.07 O HETATM 4076 O HOH 345 5.817 −19.070 −33.612 1.00 35.77 O HETATM 4077 O HOH 346 8.758 −14.281 −46.244 1.00 40.41 O HETATM 4078 HG HG 347 6.715 −12.669 −48.448 0.20 54.24 HG HETATM 4079 O HOH 349 5.113 −13.530 −54.095 1.00 42.05 O HETATM 4080 O HOH 352 6.195 −6.263 −57.438 1.00 39.69 O HETATM 4081 O HOH 353 12.125 3.149 −49.649 1.00 38.23 O HETATM 4082 MG MG 354 11.145 8.122 −61.981 1.00 29.67 MG HETATM 4083 O HOH 355 10.792 7.517 −64.576 1.00 68.09 O HETATM 4084 O HOH 356 12.630 7.721 −60.264 1.00 42.56 O HETATM 4085 O HOH 357 13.374 7.731 −62.491 1.00 44.36 O HETATM 4086 O HOH 358 8.902 7.560 −61.857 1.00 47.98 O HETATM 4087 MG MG 360 6.237 6.431 −66.914 1.00 28.74 MG HETATM 4088 O HOH 361 6.408 4.325 −65.550 1.00 56.01 O HETATM 4089 O HOH 362 8.361 5.765 −66.746 1.00 36.18 O HETATM 4090 O HOH 363 4.653 5.030 −68.186 1.00 40.11 O HETATM 4091 O HOH 364 7.146 6.368 −64.453 1.00 50.71 O HETATM 4092 MG MG 365 4.856 8.795 −57.034 1.00 57.29 MG HETATM 4093 O HOH 367 5.981 7.693 −58.709 1.00 45.32 O HETATM 4094 O HOH 368 2.602 9.503 −57.044 1.00 34.21 O HETATM 4095 O HOH 369 −3.740 −7.741 −49.878 1.00 34.52 O HETATM 4096 O HOH 371 −4.630 −7.088 −47.848 1.00 47.42 O HETATM 4097 O HOH 372 −1.660 −6.106 −49.542 1.00 29.15 O HETATM 4098 O HOH 373 −6.163 −7.124 −50.377 1.00 43.85 O HETATM 4099 O HOH 374 −4.330 −5.161 −49.766 1.00 36.71 O HETATM 4100 MG MG 375 −4.006 −10.777 −39.969 1.00 19.68 MG HETATM 4101 O HOH 376 −3.858 −12.278 −36.949 1.00 28.95 O HETATM 4102 O HOH 377 −2.097 −12.249 −40.683 1.00 38.24 O HETATM 4103 O HOH 378 −5.782 −11.177 −38.567 1.00 48.85 O HETATM 4104 O HOH 379 −3.396 −9.585 −37.760 1.00 53.51 O HETATM 4105 MG MG 380 1.544 −10.560 −40.973 1.00 15.03 MG HETATM 4106 O HOH 381 0.239 −9.278 −41.992 1.00 24.23 O HETATM 4107 O HOH 382 3.079 −11.151 −39.552 1.00 29.52 O HETATM 4108 O HOH 383 2.890 −11.254 −42.623 1.00 28.59 O HETATM 4109 O HOH 384 0.497 −12.218 −40.320 1.00 24.46 O HETATM 4110 MG MG 385 4.975 −3.399 −36.540 1.00 26.05 MG HETATM 4111 O HOH 386 4.351 −3.722 −38.893 1.00 47.91 O HETATM 4112 O HOH 387 6.538 −3.279 −34.525 1.00 52.58 O HETATM 4113 O HOH 388 6.829 −2.324 −37.582 1.00 23.58 O HETATM 4114 O HOH 389 2.776 −4.208 −36.379 1.00 47.45 O HETATM 4115 CD CD 390 −0.220 −0.169 −45.971 1.00 66.34 CD HETATM 4116 O HOH 391 1.204 0.456 −48.678 1.00 26.12 O HETATM 4117 O HOH 392 −2.039 −0.298 −44.457 1.00 74.79 O HETATM 4118 O HOH 394 −2.332 −1.375 −46.858 1.00 55.72 O HETATM 4119 O HOH 395 0.735 −1.415 −41.666 1.00 23.21 O HETATM 4120 O HOH 396 −2.289 1.508 −46.080 1.00 38.73 O HETATM 4121 MG MG 397 −1.117 −10.966 −60.412 1.00 36.18 MG HETATM 4122 O HOH 399 −2.144 −9.538 −58.861 1.00 29.70 O HETATM 4123 O HOH 400 1.112 −10.642 −59.923 1.00 66.19 O HETATM 4124 O HOH 401 −3.291 −10.503 −60.904 1.00 35.31 O HETATM 4125 O HOH 402 −2.294 −12.413 −59.078 1.00 39.66 O HETATM 4126 O HOH 403 −1.467 −8.797 −61.459 1.00 53.05 O HETATM 4127 O HOH 404 −12.040 −30.139 −41.430 1.00 41.13 O HETATM 4128 O HOH 405 −2.445 −24.982 −35.646 1.00 41.49 O HETATM 4129 O HOH 406 −12.232 −9.609 −53.785 1.00 19.82 O HETATM 4130 O HOH 407 −10.736 −14.577 −49.559 1.00 27.37 O HETATM 4131 O HOH 408 −18.946 −19.067 −62.962 1.00 48.41 O HETATM 4132 O HOH 409 −19.414 −10.463 −60.502 1.00 52.79 O HETATM 4133 O HOH 410 −6.651 −19.456 −54.939 1.00 26.78 O HETATM 4134 O HOH 411 −2.899 −18.491 −49.891 1.00 31.34 O HETATM 4135 O HOH 412 −4.041 −25.738 −47.368 1.00 61.51 O HETATM 4136 CD CD 413 −13.027 8.492 10.933 0.10 33.43 CD HETATM 4137 CD CD 414 −11.592 5.003 −2.412 0.10 14.13 CD HETATM 4138 HG HG 415 −23.456 −2.491 −20.626 0.10 35.19 HG HETATM 4139 HG HG 416 −17.183 −2.624 −19.816 0.10 45.02 HG HETATM 4140 O HOH 418 −0.113 29.557 −9.189 1.00 36.18 O HETATM 4141 O HOH 419 −1.958 16.568 4.135 1.00 22.82 O HETATM 4142 O HOH 420 0.874 15.995 −1.216 1.00 36.22 O HETATM 4143 O HOH 421 −0.098 21.800 −5.101 1.00 35.12 O HETATM 4144 O HOH 422 −1.412 23.130 −2.906 1.00 36.67 O HETATM 4145 O HOH 423 −3.317 24.792 0.592 1.00 45.31 O HETATM 4146 O HOH 424 0.019 9.295 −10.598 1.00 36.37 O HETATM 4147 O HOH 425 −2.568 8.364 −13.958 1.00 50.92 O HETATM 4148 O HOH 426 −2.689 18.373 −24.066 1.00 34.21 O HETATM 4149 O HOH 427 7.170 6.156 −29.910 1.00 17.29 O HETATM 4150 O HOH 428 8.929 4.171 −22.749 1.00 41.67 O HETATM 4151 O HOH 429 12.036 0.863 −14.965 1.00 42.52 O HETATM 4152 O HOH 431 −1.202 8.279 12.504 1.00 41.33 O HETATM 4153 O HOH 432 8.485 7.265 7.104 1.00 46.57 O HETATM 4154 O HOH 434 4.018 10.172 4.758 1.00 37.32 O HETATM 4155 O HOH 435 18.225 −9.006 −2.120 1.00 60.80 O HETATM 4156 MG MG 437 11.760 −10.915 4.311 1.00 47.79 MG HETATM 4157 O HOH 438 12.113 −10.561 1.951 1.00 58.11 O HETATM 4158 O HOH 440 14.043 −10.435 3.845 1.00 43.62 O HETATM 4159 O HOH 441 9.524 −10.398 4.381 1.00 41.20 O HETATM 4160 O HOH 442 11.946 −13.321 4.538 1.00 65.98 O HETATM 4161 O HOH 443 12.227 −8.461 4.164 1.00 61.70 O HETATM 4162 O HOH 444 1.040 4.817 −2.689 1.00 32.93 O HETATM 4163 O HOH 445 4.226 0.914 2.202 1.00 3.57 O HETATM 4164 O HOH 446 6.340 −0.071 1.151 1.00 19.50 O HETATM 4165 O HOH 447 4.234 3.232 1.596 1.00 12.18 O HETATM 4166 HG HG 448 −4.015 −8.066 −15.150 0.10 21.04 HG HETATM 4167 O HOH 450 −4.907 −3.163 −52.117 1.00 24.48 O HETATM 4168 HG HG 451 −5.485 5.932 −35.358 0.10 26.20 HG HETATM 4169 O HOH 452 −4.427 1.650 −44.668 1.00 47.88 O HETATM 4170 O HOH 453 −6.126 −4.197 −47.630 1.00 40.28 O HETATM 4171 O HOH 454 −14.902 −5.184 −53.399 1.00 41.04 O HETATM 4172 O HOH 455 2.198 −31.615 −45.895 1.00 38.45 O HETATM 4173 O HOH 456 −0.111 −29.053 −48.914 1.00 37.64 O HETATM 4174 O HOH 457 5.023 −28.677 −39.390 1.00 42.30 O HETATM 4175 O HOH 459 −8.700 −0.565 −36.045 1.00 32.85 O HETATM 4176 O HOH 460 −1.593 −4.423 −51.572 1.00 28.40 O HETATM 4177 O HOH 461 −1.729 −3.181 −53.813 1.00 2.00 O HETATM 4178 O HOH 462 −1.294 −5.593 −53.672 1.00 22.25 O HETATM 4179 O HOH 463 0.388 −1.958 −53.133 1.00 27.43 O MASTER  320 0 35 8 7 0 3 12 4175 4 0 32 END 

1. A method for identifying a potential modulator of ribosomal protein L11/GAR activity, comprising the steps of: a) providing the atomic co-ordinates of the L11 GTPase Activating Region (L11/GAR) in Table II, thereby defining a three-dimensional structure of the L11/GAR; b) using said three dimensional structure of the L11/GAR to design or select a potential modulator by computer modeling; c) providing said potential modulator; and d) physically contacting said potential modulator with L11/GAR to determine the ability of said potential modulator to modulate L11/GAR activity, wherein a modulator of L11/GAR activity is identified.
 2. The method according to claim 1, wherein said potential modulator is designed de novo.
 3. The method according to claim 1, wherein said potential modulator is designed from a known modulator.
 4. The method according to claim 1, wherein said step of employing said three-dimensional structure to design or select said potential modulator comprises the steps of: a) identifying chemical entities or fragments with the potential to bind said L11/GAR; and b) assembling the identified chemical entities or fragments into a single molecule to provide the structure of said potential modulator.
 5. The method according to claim 4, wherein said potential modulator is designed de novo.
 6. The method according to claim 4, wherein said potential modulator is designed from a known modulator. 